3LWQA

Structure of h/aca rnp bound to a substrate rna containing 3mu
Total Genus 92
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
92
sequence length
326
structure length
316
Chain Sequence
ILPADIKREVLIKDENAETNPDWGFPPEKRPIEMHIQFGVINLDKPPGPTSHEVVAWIKKILNLEKAGHGGTLDPKVSGVLPVALEKATRVVQALLPAGKEYVALMHLHGDVPEDKIIQVMKEFEGEIIQRLRTRKVYYIEVLEIEGRDVLFRVGVEAGTYIRSLIHHIGLALGVGAHMSELRRTRSGPFKEDETLITLHDLVDYYYFWKEDGIEEYFRKAIQPMEKAVEHLPKVWIKDSAVAAVTHGADLAVPGIAKLHAGIKRGDLVAIMTLKDELVALGKAMMTSQEMLEKTKGIAVDVEKVFMPRDWYPKLW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Functional and Structural Impact of Target Uridine Substitutions on the H/ACA Ribonucleoprotein Particle Pseudouridine Synthase .
pubmed doi rcsb
molecule keywords Pseudouridine synthase Cbf5
molecule tags Isomerase/rna binding protein/rna
source organism Pyrococcus furiosus
total genus 92
structure length 316
sequence length 326
ec nomenclature ec 5.4.99.25: tRNA pseudouridine(55) synthase.
pdb deposition date 2010-02-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01472 PUA PUA domain
A PF01509 TruB_N TruB family pseudouridylate synthase (N terminal domain)
A PF08068 DKCLD DKCLD (NUC011) domain
A PF16198 TruB_C_2 tRNA pseudouridylate synthase B C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.30.130.70 Mainly Beta Roll Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 3lwqA01
3.30.2350.10 Alpha Beta 2-Layer Sandwich Pseudouridine synthase Pseudouridine synthase 3lwqA02
3LWPA 1SGVA 1R3FA 1ZL3A 3UAIA 3HJWA 4LABA 2APOA 3MQKA 2RFKA 1V9KA 3DH3A 1ZE2A 1V9FA 3LWOA 4LGTA 1KSKA 3HAXA 1R3EA 2AB4A 1QYUA 3U28A 2I82A 3LWQA 2HVYA 3LWVA 1K8WA 3LWRA 3HJYA 1PRZA 2ISTA 3ZV0C 1KSVA 2AUSA 1XPIA 1ZE1A 1KSLA 2EY4A
chains in the Genus database with same CATH superfamily
2CX0A 3MQKA 1J2BA 3IUWA 1TE7A 3LJCA 3U28A 4Q1TA 2DP9A 2HVYA 1SQWA 3LWRA 3HJYA 2ISTA 3M6VA 3ZV0C 1KSVA 4CI3B 1KSLA 2Q07A 1ZL3A 3UAIA 3HJWA 3VSEA 3DH3A 3LWOA 3HAXA 1XNEA 1QYUA 2J5VA 3LWQA 1PRZA 2E5OA 1IT7A 1SB7A 4CI2B 2CWWA 1XPIA 1IQ8A 1ZE1A 2EY4A 1UOYA 1WK2A 3M4XA 3LWPA 1R3FA 1WXWA 4LABA 2APOA 2J5TA 3M6WA 1V9KA 4TZ4C 1V9FA 4LGTA 3M6XA 1ZS7A 1S04A 1R3EA 3M6UA 4CI1B 3D79A 1SZWA 1IT8A 3LDFA 2Z0TA 3C0KA 2AS0A 2AUSA 1T5YA 2KKUA 1SGVA 3M65A 1Q7HA 1Z2ZA 2RFKA 1ZE2A 2B78A 1KSKA 2AB4A 2I82A 1SI7A 3LWVA 1K8WA 1WXXA 2CX1A 4DMGA 2ANEA 1ZBOA 2P38A 2FRXA
chains in the Genus database with same CATH topology
3M4XA 3LWPA 1SGVA 1R3FA 1ZL3A 3UAIA 3HJWA 4LABA 2APOA 3MQKA 1Z2ZA 3M6WA 2RFKA 1V9KA 3DH3A 1ZE2A 1V9FA 3LWOA 4LGTA 3M6XA 1KSKA 3HAXA 3M6UA 1R3EA 2AB4A 1QYUA 3U28A 2I82A 3LWQA 1SI7A 2HVYA 3LWVA 1SZWA 1K8WA 3LWRA 3HJYA 2FRXA 1PRZA 2ISTA 3M6VA 1SB7A 3ZV0C 1KSVA 2AUSA 1XPIA 1ZE1A 1KSLA 2EY4A 1UOYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LWP A;  1SGV A;  1R3F A;  1ZL3 A;  3UAI A;  3HJW A;  4LAB A;  2APO A;  3MQK A;  2RFK A;  1V9K A;  3DH3 A;  1ZE2 A;  1V9F A;  3LWO A;  4LGT A;  1KSK A;  3HAX A;  1R3E A;  2AB4 A;  1QYU A;  3U28 A;  2I82 A;  3LWQ A;  2HVY A;  3LWV A;  1K8W A;  3LWR A;  3HJY A;  1PRZ A;  2IST A;  3ZV0 C;  1KSV A;  2AUS A;  1XPI A;  1ZE1 A;  1KSL A;  2EY4 A; 
#chains in the Genus database with same CATH topology
 2CX0 A;  3MQK A;  1J2B A;  3IUW A;  1TE7 A;  3LJC A;  3U28 A;  4Q1T A;  2DP9 A;  2HVY A;  1SQW A;  3LWR A;  3HJY A;  2IST A;  3M6V A;  3ZV0 C;  1KSV A;  4CI3 B;  1KSL A;  2Q07 A;  1ZL3 A;  3UAI A;  3HJW A;  3VSE A;  3DH3 A;  3LWO A;  3HAX A;  1XNE A;  1QYU A;  2J5V A;  3LWQ A;  1PRZ A;  2E5O A;  1IT7 A;  1SB7 A;  4CI2 B;  2CWW A;  1XPI A;  1IQ8 A;  1ZE1 A;  2EY4 A;  1UOY A;  1WK2 A;  3M4X A;  3LWP A;  1R3F A;  1WXW A;  4LAB A;  2APO A;  2J5T A;  3M6W A;  1V9K A;  4TZ4 C;  1V9F A;  4LGT A;  3M6X A;  1ZS7 A;  1S04 A;  1R3E A;  3M6U A;  4CI1 B;  3D79 A;  1SZW A;  1IT8 A;  3LDF A;  2Z0T A;  3C0K A;  2AS0 A;  2AUS A;  1T5Y A;  2KKU A;  1SGV A;  3M65 A;  1Q7H A;  1Z2Z A;  2RFK A;  1ZE2 A;  2B78 A;  1KSK A;  2AB4 A;  2I82 A;  1SI7 A;  3LWV A;  1K8W A;  1WXX A;  2CX1 A;  4DMG A;  2ANE A;  1ZBO A;  2P38 A;  2FRX A; 
#chains in the Genus database with same CATH homology
 3M4X A;  3LWP A;  1SGV A;  1R3F A;  1ZL3 A;  3UAI A;  3HJW A;  4LAB A;  2APO A;  3MQK A;  1Z2Z A;  3M6W A;  2RFK A;  1V9K A;  3DH3 A;  1ZE2 A;  1V9F A;  3LWO A;  4LGT A;  3M6X A;  1KSK A;  3HAX A;  3M6U A;  1R3E A;  2AB4 A;  1QYU A;  3U28 A;  2I82 A;  3LWQ A;  1SI7 A;  2HVY A;  3LWV A;  1SZW A;  1K8W A;  3LWR A;  3HJY A;  2FRX A;  1PRZ A;  2IST A;  3M6V A;  1SB7 A;  3ZV0 C;  1KSV A;  2AUS A;  1XPI A;  1ZE1 A;  1KSL A;  2EY4 A;  1UOY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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