3M4AA

Crystal structure of a bacterial topoisomerase ib in complex with dna reveals a secondary dna binding site
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
337
structure length
304
Chain Sequence
PSRTELLARRARIARLAVPPAYQDVYVSPDAENELQAFGRDAARLQYRYHPDFVALKKWQRLTRFAGALPTLKVATTADLRASGLPPRKVMALMTRLLHVARFRVGSDIYARQHKTYGLSTLRQRHVVVDGNTVTFRFKGKHGVSQHKATSDRTLAANMQKLLDLPGPWLFQTVDAGGERRRIHSTELNAYLREVIGPFTAKDFRTWGGTLLAAEYLAQQGTESSERQAKKVLVDCVKFVADDLGNTPAVTRGSYICPVIFDRYLDGKVLDDYEPRTERQEAELEGLTRSEGALKRMLESERTL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of a bacterial topoisomerase IB in complex with DNA reveals a secondary DNA binding site.
pubmed doi rcsb
molecule tags Isomerase/dna
source organism Deinococcus radiodurans
molecule keywords Putative Type I topoisomerase
total genus 109
structure length 304
sequence length 337
ec nomenclature
pdb deposition date 2010-03-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01028 Topoisom_I Eukaryotic DNA topoisomerase I, catalytic core
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.132.120 Mainly Alpha Orthogonal Bundle Topoisomerase I; Chain A, domain 4 Topoisomerase I; Chain A, domain 4 3m4aA02
3.30.66.10 Alpha Beta 2-Layer Sandwich Viral Topoisomerase I DNA topoisomerase I domain 3m4aA01
3.90.15.10 Alpha Beta Alpha-Beta Complex Topoisomerase I; Chain A, domain 3 Topoisomerase I; Chain A, domain 3 3m4aA03
1R49A 1EJ9A 1NH3A 1SC7A 1TL8A 1RRJA 1VCCA 1A41A 1SEUA 2H7FX 1A36A 3M4AA 1A35A 1LPQA 1RR8C 2F4QA 3IGCA 1A31A 2B9SA 1T8IA 1K4SA 2H7GX 1K4TA
chains in the Genus database with same CATH superfamily
1R49A 1SFOA 3K5LA 3HKZA 1I3QA 4Q5VA 2R93A 2R4GA 1RRJA 1SMYD 2A6HD 2BE5D 1VCCA 1A41A 1YNJD 1TWGA 1TGOA 2JA5A 1Y1VA 4OYDB 2H7FX 4C2MA 4NOKA 3P9AA 2A69D 3K59A 1EH1A 4KB4A 1A31A 5JSNB 1EK8A 3SJRA 4FYDA 2E2IA 4AYBA 2PMZA 5CQGA 1SC7A 4QCLA 5MLC9 1TL8A 4FGUA 2NVYA 1WQFA 3DU5A 3GTPA 1GE9A 3K5OA 1V9MA 4LMOA 1MIUA 1I6VD 3LHPS 4D3YA 1A35A 1HQMD 4L8IA 4F3EA 3WVOA 1TWFA 3DU6A 2B63A 1I50A 4GFQA 2F4QA 1ISEA 3MAQA 2B9SA 1IW7D 1TWCA 2A68D 1K83A 4O26A 4Q5GA 1T8IA 1IS1A 4JLRC 1EJ9A 3IAYA 3GTMA 1Q8IA 1WQGA 1YNND 4IP9A 2WB1A 4IP8A 1WCMA 4KB2A 1TWAA 3FKIA 3K58A 4NOMA 1Y698 3M4AA 2CW0D 4KC6A 1LPQA 2YU9A 1RR8C 3GTGA 2VUMA 1R9TA 3K5MA 2R7ZA 3GTKA 4FXDA 2B9SB 3K57A 1K4TA 3KYLA 3K5NA 3LF9A 3GTQA 3GTOA 2Y0SA 2R92A 2A6ED 1NH3A 4D3ZA 2JA7A 2JA6A 1TWHA 4QIWA 4AHCA 3GTLA 2NVXA 2WAQA 2E2HA 1SEUA 4KAWX 3H0GA 5C9HA 1DD5A 2O5JD 5JSBB 1A36A 4EJ3A 1WQHA 4NOLA 4AN8A 3IGCA 4H3TA 1Y1WA 1R5ZA 4KDDA 1ZYRD 3CQZA 1K4SA 2H7GX 3GTJA
chains in the Genus database with same CATH topology
1R49A 1SFOA 3K5LA 3HKZA 1I3QA 4Q5VA 2R93A 2R4GA 1RRJA 1SMYD 2A6HD 2BE5D 1VCCA 1A41A 1YNJD 1TWGA 1TGOA 2JA5A 1Y1VA 4OYDB 2H7FX 4C2MA 4NOKA 3P9AA 2A69D 3K59A 1EH1A 4KB4A 1A31A 5JSNB 1EK8A 3SJRA 4FYDA 2E2IA 4AYBA 2PMZA 5CQGA 1SC7A 4QCLA 5MLC9 1TL8A 4FGUA 2NVYA 1WQFA 3DU5A 3GTPA 1GE9A 3K5OA 1V9MA 4LMOA 1MIUA 1I6VD 3LHPS 4D3YA 1A35A 1HQMD 4L8IA 4F3EA 3WVOA 1TWFA 3DU6A 2B63A 1I50A 4GFQA 2F4QA 1ISEA 3MAQA 2B9SA 1IW7D 1TWCA 2A68D 1K83A 4O26A 4Q5GA 1T8IA 1IS1A 4JLRC 1EJ9A 3IAYA 3GTMA 1Q8IA 1WQGA 1YNND 4IP9A 2WB1A 4IP8A 1WCMA 4KB2A 1TWAA 3FKIA 3K58A 4NOMA 1Y698 3M4AA 2CW0D 4KC6A 1LPQA 2YU9A 1RR8C 3GTGA 2VUMA 1R9TA 3K5MA 2R7ZA 3GTKA 4FXDA 2B9SB 3K57A 1K4TA 3KYLA 3K5NA 3LF9A 3GTQA 3GTOA 2Y0SA 2R92A 2A6ED 1NH3A 4D3ZA 2JA7A 2JA6A 1TWHA 4QIWA 4AHCA 3GTLA 2NVXA 2WAQA 2E2HA 1SEUA 4KAWX 3H0GA 5C9HA 1DD5A 2O5JD 5JSBB 1A36A 4EJ3A 1WQHA 4NOLA 4AN8A 3IGCA 4H3TA 1Y1WA 1R5ZA 4KDDA 1ZYRD 3CQZA 1K4SA 2H7GX 3GTJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1R49 A;  1EJ9 A;  1NH3 A;  1SC7 A;  1TL8 A;  1RRJ A;  1VCC A;  1A41 A;  1SEU A;  2H7F X;  1A36 A;  3M4A A;  1A35 A;  1LPQ A;  1RR8 C;  2F4Q A;  3IGC A;  1A31 A;  2B9S A;  1T8I A;  1K4S A;  2H7G X;  1K4T A; 
#chains in the Genus database with same CATH topology
 1R49 A;  1SFO A;  3K5L A;  3HKZ A;  1I3Q A;  4Q5V A;  2R93 A;  2R4G A;  1RRJ A;  1SMY D;  2A6H D;  2BE5 D;  1VCC A;  1A41 A;  1YNJ D;  1TWG A;  1TGO A;  2JA5 A;  1Y1V A;  4OYD B;  2H7F X;  4C2M A;  4NOK A;  3P9A A;  2A69 D;  3K59 A;  1EH1 A;  4KB4 A;  1A31 A;  5JSN B;  1EK8 A;  3SJR A;  4FYD A;  2E2I A;  4AYB A;  2PMZ A;  5CQG A;  1SC7 A;  4QCL A;  5MLC 9;  1TL8 A;  4FGU A;  2NVY A;  1WQF A;  3DU5 A;  3GTP A;  1GE9 A;  3K5O A;  1V9M A;  4LMO A;  1MIU A;  1I6V D;  3LHP S;  4D3Y A;  1A35 A;  1HQM D;  4L8I A;  4F3E A;  3WVO A;  1TWF A;  3DU6 A;  2B63 A;  1I50 A;  4GFQ A;  2F4Q A;  1ISE A;  3MAQ A;  2B9S A;  1IW7 D;  1TWC A;  2A68 D;  1K83 A;  4O26 A;  4Q5G A;  1T8I A;  1IS1 A;  4JLR C;  1EJ9 A;  3IAY A;  3GTM A;  1Q8I A;  1WQG A;  1YNN D;  4IP9 A;  2WB1 A;  4IP8 A;  1WCM A;  4KB2 A;  1TWA A;  3FKI A;  3K58 A;  4NOM A;  1Y69 8;  3M4A A;  2CW0 D;  4KC6 A;  1LPQ A;  2YU9 A;  1RR8 C;  3GTG A;  2VUM A;  1R9T A;  3K5M A;  2R7Z A;  3GTK A;  4FXD A;  2B9S B;  3K57 A;  1K4T A;  3KYL A;  3K5N A;  3LF9 A;  3GTQ A;  3GTO A;  2Y0S A;  2R92 A;  2A6E D;  1NH3 A;  4D3Z A;  2JA7 A;  2JA6 A;  1TWH A;  4QIW A;  4AHC A;  3GTL A;  2NVX A;  2WAQ A;  2E2H A;  1SEU A;  4KAW X;  3H0G A;  5C9H A;  1DD5 A;  2O5J D;  5JSB B;  1A36 A;  4EJ3 A;  1WQH A;  4NOL A;  4AN8 A;  3IGC A;  4H3T A;  1Y1W A;  1R5Z A;  4KDD A;  1ZYR D;  3CQZ A;  1K4S A;  2H7G X;  3GTJ A; 
#chains in the Genus database with same CATH homology
 1R49 A;  1SFO A;  3K5L A;  3HKZ A;  1I3Q A;  4Q5V A;  2R93 A;  2R4G A;  1RRJ A;  1SMY D;  2A6H D;  2BE5 D;  1VCC A;  1A41 A;  1YNJ D;  1TWG A;  1TGO A;  2JA5 A;  1Y1V A;  4OYD B;  2H7F X;  4C2M A;  4NOK A;  3P9A A;  2A69 D;  3K59 A;  1EH1 A;  4KB4 A;  1A31 A;  5JSN B;  1EK8 A;  3SJR A;  4FYD A;  2E2I A;  4AYB A;  2PMZ A;  5CQG A;  1SC7 A;  4QCL A;  5MLC 9;  1TL8 A;  4FGU A;  2NVY A;  1WQF A;  3DU5 A;  3GTP A;  1GE9 A;  3K5O A;  1V9M A;  4LMO A;  1MIU A;  1I6V D;  3LHP S;  4D3Y A;  1A35 A;  1HQM D;  4L8I A;  4F3E A;  3WVO A;  1TWF A;  3DU6 A;  2B63 A;  1I50 A;  4GFQ A;  2F4Q A;  1ISE A;  3MAQ A;  2B9S A;  1IW7 D;  1TWC A;  2A68 D;  1K83 A;  4O26 A;  4Q5G A;  1T8I A;  1IS1 A;  4JLR C;  1EJ9 A;  3IAY A;  3GTM A;  1Q8I A;  1WQG A;  1YNN D;  4IP9 A;  2WB1 A;  4IP8 A;  1WCM A;  4KB2 A;  1TWA A;  3FKI A;  3K58 A;  4NOM A;  1Y69 8;  3M4A A;  2CW0 D;  4KC6 A;  1LPQ A;  2YU9 A;  1RR8 C;  3GTG A;  2VUM A;  1R9T A;  3K5M A;  2R7Z A;  3GTK A;  4FXD A;  2B9S B;  3K57 A;  1K4T A;  3KYL A;  3K5N A;  3LF9 A;  3GTQ A;  3GTO A;  2Y0S A;  2R92 A;  2A6E D;  1NH3 A;  4D3Z A;  2JA7 A;  2JA6 A;  1TWH A;  4QIW A;  4AHC A;  3GTL A;  2NVX A;  2WAQ A;  2E2H A;  1SEU A;  4KAW X;  3H0G A;  5C9H A;  1DD5 A;  2O5J D;  5JSB B;  1A36 A;  4EJ3 A;  1WQH A;  4NOL A;  4AN8 A;  3IGC A;  4H3T A;  1Y1W A;  1R5Z A;  4KDD A;  1ZYR D;  3CQZ A;  1K4S A;  2H7G X;  3GTJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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