3MASA

Crystal structure of heterodimeric r132h mutant of human cytosolic nadp(+)-dependent isocitrate dehydrogenase in complex with nadp and isocitrate
Total Genus 133
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
133
sequence length
412
structure length
393
Chain Sequence
KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGHHARATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords Isocitrate dehydrogenase [NADP] cytoplasmic
publication title Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H.
pubmed doi rcsb
source organism Homo sapiens
total genus 133
structure length 393
sequence length 412
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2010-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 3masA00
5I96A 3WZXA 5K11A 1PS6A 3VMLA 1DR0A 1IPDA 1XAAA 4XRXA 1PS7A 2AYQA 1OSJA 1IDCA 3TY4A 1ISOA 3LCBC 1AI2A 5GRLB 3VMJA 1W0DA 4XS3A 5J32A 1IDEA 1G2UA 3BLXB 3VL7A 3TSNA 4KZOA 1V5BA 3BLVA 4IWHA 5GRHA 3LXYA 1YCOA 4AJ3A 4L06A 5J33A 1PB1A 4Y1PA 5HN5A 3WZYA 5GREA 2G4OA 2Y3ZA 1R8KA 3MARA 3INMA 2D1CA 3TNGA 1GC9A 1GC8A 6ICDA 3MASB 4JQPA 5HN3A 2QFWA 2DHTA 4UMXA 2QFXA 4AOYA 5DE1A 1XKDA 3FMXX 1CM7A 2UXQA 2E0CA 5GRLA 3U1HA 5GRIB 3U9EA 1IDFA 3BLXA 1P8FA 1CW7A 1WALA 4L04A 4HCXA 1ZORA 4AOUA 4AJBA 1V53A 1XABA 3VL4A 1TYOA 3VKZA 3VL2A 1XACA 3TY3A 2IV0A 5ICDA 2Y41A 1XGVA 1LWDA 3ICDA 1A05A 5K10A 4AJAA 2UXRA 3R8WA 5I95A 2QFYA 4P69C 1HJ6A 1SJSA 2Y42A 3MASA 3VL6A 3MAPA 4AJRA 5HN6A 5L57A 2Y40A 3VMKA 2QFVA 1U7NA 4I3LA 2E5MA 3VL3A 1IDMA 1T0LA 4AJCA 4ICDA 1XADA 5GRFB 4YB4A 1AI3A 3UDUA 3WZWA 1GRPA 3ASJA 4BNPA 4AOVA 7ICDA 4UMYA 1YXOA 1HEXA 1IDDA 1DPZA 1PB3A 4WUOA 5J34A 5LGEA 1GROA 2D4VA 1CNZA 2ZTWA 1OSIA 4F7IA 3UF6A 1IKAA 2HI1A 1VLCA 3BLVB 4L03A 3UDOA 1BL5A 5GRHB 4AJSA 1CW1A 3WZVA 1V94A 1WPWA 4ATYA 5L58A 3AH3A 4XXVA 9ICDA 1DR8A 3DMSA 5GREB 4JA8A 1HQSA 1CW4A 5GRIA 3US8A 5HN4A 4I3KA 1PTMA 1T09A 1X0LA 3FLKA 8ICDA 1VI1A 5GRFA
chains in the Genus database with same CATH superfamily
5I96A 3WZXA 5K11A 1PS6A 3VMLA 1DR0A 1IPDA 1XAAA 4XRXA 1PS7A 2AYQA 1OSJA 1IDCA 3TY4A 1ISOA 3LCBC 1AI2A 5GRLB 3VMJA 1W0DA 4XS3A 5J32A 1IDEA 1G2UA 3BLXB 3VL7A 3TSNA 4KZOA 1V5BA 3BLVA 4IWHA 5GRHA 3LXYA 1YCOA 4AJ3A 4L06A 5J33A 1PB1A 4Y1PA 5HN5A 3WZYA 5GREA 2G4OA 2Y3ZA 1R8KA 3MARA 3INMA 2D1CA 3TNGA 1GC9A 1GC8A 6ICDA 3MASB 4JQPA 5HN3A 2QFWA 2DHTA 4UMXA 2QFXA 4AOYA 5DE1A 1XKDA 3FMXX 1CM7A 2UXQA 2E0CA 5GRLA 3U1HA 5GRIB 3U9EA 1IDFA 3BLXA 1P8FA 1CW7A 1WALA 4L04A 4HCXA 1ZORA 4AOUA 4AJBA 1V53A 1XABA 3VL4A 1TYOA 3VKZA 3VL2A 1XACA 3TY3A 2IV0A 5ICDA 2Y41A 1XGVA 1LWDA 3ICDA 1A05A 5K10A 4AJAA 2UXRA 3R8WA 5I95A 2QFYA 4P69C 1HJ6A 1SJSA 2Y42A 3MASA 3VL6A 3MAPA 4AJRA 5HN6A 5L57A 2Y40A 3VMKA 2QFVA 1U7NA 4I3LA 2E5MA 3VL3A 1IDMA 1T0LA 4AJCA 4ICDA 1XADA 5GRFB 4YB4A 1AI3A 3UDUA 3WZWA 1GRPA 3ASJA 4BNPA 4AOVA 7ICDA 4UMYA 1YXOA 1HEXA 1IDDA 1DPZA 1PB3A 4WUOA 5J34A 5LGEA 1GROA 2D4VA 1CNZA 2ZTWA 1OSIA 4F7IA 3UF6A 1IKAA 2HI1A 1VLCA 3BLVB 4L03A 3UDOA 1BL5A 5GRHB 4AJSA 1CW1A 3WZVA 1V94A 1WPWA 4ATYA 5L58A 3AH3A 4XXVA 9ICDA 1DR8A 3DMSA 5GREB 4JA8A 1HQSA 1CW4A 5GRIA 3US8A 5HN4A 4I3KA 1PTMA 1T09A 1X0LA 3FLKA 8ICDA 1VI1A 5GRFA
chains in the Genus database with same CATH topology
5I96A 3WZXA 5K11A 1PS6A 3VMLA 1DR0A 1IPDA 1XAAA 4XRXA 1PS7A 2AYQA 1OSJA 1IDCA 3TY4A 1ISOA 3LCBC 1AI2A 5GRLB 3VMJA 1W0DA 4XS3A 5J32A 1IDEA 1G2UA 3BLXB 3VL7A 3TSNA 4KZOA 1V5BA 3BLVA 4IWHA 5GRHA 3LXYA 1YCOA 4AJ3A 4L06A 5J33A 1PB1A 4Y1PA 5HN5A 3WZYA 5GREA 2G4OA 2Y3ZA 1R8KA 3MARA 3INMA 2D1CA 3TNGA 1GC9A 1GC8A 6ICDA 3MASB 4JQPA 5HN3A 2QFWA 2DHTA 4UMXA 2QFXA 4AOYA 5DE1A 1XKDA 3FMXX 1CM7A 2UXQA 2E0CA 5GRLA 3U1HA 5GRIB 3U9EA 1IDFA 3BLXA 1P8FA 1CW7A 1WALA 4L04A 4HCXA 1ZORA 4AOUA 4AJBA 1V53A 1XABA 3VL4A 1TYOA 3VKZA 3VL2A 1XACA 3TY3A 2IV0A 5ICDA 2Y41A 1XGVA 1LWDA 3ICDA 1A05A 5K10A 4AJAA 2UXRA 3R8WA 5I95A 2QFYA 4P69C 1HJ6A 1SJSA 2Y42A 3MASA 3VL6A 3MAPA 4AJRA 5HN6A 5L57A 2Y40A 3VMKA 2QFVA 1U7NA 4I3LA 2E5MA 3VL3A 1IDMA 1T0LA 4AJCA 4ICDA 1XADA 5GRFB 4YB4A 1AI3A 3UDUA 3WZWA 1GRPA 3ASJA 4BNPA 4AOVA 7ICDA 4UMYA 1YXOA 1HEXA 1IDDA 1DPZA 1PB3A 4WUOA 5J34A 5LGEA 1GROA 2D4VA 1CNZA 2ZTWA 1OSIA 4F7IA 3UF6A 1IKAA 2HI1A 1VLCA 3BLVB 4L03A 3UDOA 1BL5A 5GRHB 4AJSA 1CW1A 3WZVA 1V94A 1WPWA 4ATYA 5L58A 3AH3A 4XXVA 9ICDA 1DR8A 3DMSA 5GREB 4JA8A 1HQSA 1CW4A 5GRIA 3US8A 5HN4A 4I3KA 1PTMA 1T09A 1X0LA 3FLKA 8ICDA 1VI1A 5GRFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5I96 A;  3WZX A;  5K11 A;  1PS6 A;  3VML A;  1DR0 A;  1IPD A;  1XAA A;  4XRX A;  1PS7 A;  2AYQ A;  1OSJ A;  1IDC A;  3TY4 A;  1ISO A;  3LCB C;  1AI2 A;  5GRL B;  3VMJ A;  1W0D A;  4XS3 A;  5J32 A;  1IDE A;  1G2U A;  3BLX B;  3VL7 A;  3TSN A;  4KZO A;  1V5B A;  3BLV A;  4IWH A;  5GRH A;  3LXY A;  1YCO A;  4AJ3 A;  4L06 A;  5J33 A;  1PB1 A;  4Y1P A;  5HN5 A;  3WZY A;  5GRE A;  2G4O A;  2Y3Z A;  1R8K A;  3MAR A;  3INM A;  2D1C A;  3TNG A;  1GC9 A;  1GC8 A;  6ICD A;  3MAS B;  4JQP A;  5HN3 A;  2QFW A;  2DHT A;  4UMX A;  2QFX A;  4AOY A;  5DE1 A;  1XKD A;  3FMX X;  1CM7 A;  2UXQ A;  2E0C A;  5GRL A;  3U1H A;  5GRI B;  3U9E A;  1IDF A;  3BLX A;  1P8F A;  1CW7 A;  1WAL A;  4L04 A;  4HCX A;  1ZOR A;  4AOU A;  4AJB A;  1V53 A;  1XAB A;  3VL4 A;  1TYO A;  3VKZ A;  3VL2 A;  1XAC A;  3TY3 A;  2IV0 A;  5ICD A;  2Y41 A;  1XGV A;  1LWD A;  3ICD A;  1A05 A;  5K10 A;  4AJA A;  2UXR A;  3R8W A;  5I95 A;  2QFY A;  4P69 C;  1HJ6 A;  1SJS A;  2Y42 A;  3MAS A;  3VL6 A;  3MAP A;  4AJR A;  5HN6 A;  5L57 A;  2Y40 A;  3VMK A;  2QFV A;  1U7N A;  4I3L A;  2E5M A;  3VL3 A;  1IDM A;  1T0L A;  4AJC A;  4ICD A;  1XAD A;  5GRF B;  4YB4 A;  1AI3 A;  3UDU A;  3WZW A;  1GRP A;  3ASJ A;  4BNP A;  4AOV A;  7ICD A;  4UMY A;  1YXO A;  1HEX A;  1IDD A;  1DPZ A;  1PB3 A;  4WUO A;  5J34 A;  5LGE A;  1GRO A;  2D4V A;  1CNZ A;  2ZTW A;  1OSI A;  4F7I A;  3UF6 A;  1IKA A;  2HI1 A;  1VLC A;  3BLV B;  4L03 A;  3UDO A;  1BL5 A;  5GRH B;  4AJS A;  1CW1 A;  3WZV A;  1V94 A;  1WPW A;  4ATY A;  5L58 A;  3AH3 A;  4XXV A;  9ICD A;  1DR8 A;  3DMS A;  5GRE B;  4JA8 A;  1HQS A;  1CW4 A;  5GRI A;  3US8 A;  5HN4 A;  4I3K A;  1PTM A;  1T09 A;  1X0L A;  3FLK A;  8ICD A;  1VI1 A;  5GRF A; 
#chains in the Genus database with same CATH topology
 5I96 A;  3WZX A;  5K11 A;  1PS6 A;  3VML A;  1DR0 A;  1IPD A;  1XAA A;  4XRX A;  1PS7 A;  2AYQ A;  1OSJ A;  1IDC A;  3TY4 A;  1ISO A;  3LCB C;  1AI2 A;  5GRL B;  3VMJ A;  1W0D A;  4XS3 A;  5J32 A;  1IDE A;  1G2U A;  3BLX B;  3VL7 A;  3TSN A;  4KZO A;  1V5B A;  3BLV A;  4IWH A;  5GRH A;  3LXY A;  1YCO A;  4AJ3 A;  4L06 A;  5J33 A;  1PB1 A;  4Y1P A;  5HN5 A;  3WZY A;  5GRE A;  2G4O A;  2Y3Z A;  1R8K A;  3MAR A;  3INM A;  2D1C A;  3TNG A;  1GC9 A;  1GC8 A;  6ICD A;  3MAS B;  4JQP A;  5HN3 A;  2QFW A;  2DHT A;  4UMX A;  2QFX A;  4AOY A;  5DE1 A;  1XKD A;  3FMX X;  1CM7 A;  2UXQ A;  2E0C A;  5GRL A;  3U1H A;  5GRI B;  3U9E A;  1IDF A;  3BLX A;  1P8F A;  1CW7 A;  1WAL A;  4L04 A;  4HCX A;  1ZOR A;  4AOU A;  4AJB A;  1V53 A;  1XAB A;  3VL4 A;  1TYO A;  3VKZ A;  3VL2 A;  1XAC A;  3TY3 A;  2IV0 A;  5ICD A;  2Y41 A;  1XGV A;  1LWD A;  3ICD A;  1A05 A;  5K10 A;  4AJA A;  2UXR A;  3R8W A;  5I95 A;  2QFY A;  4P69 C;  1HJ6 A;  1SJS A;  2Y42 A;  3MAS A;  3VL6 A;  3MAP A;  4AJR A;  5HN6 A;  5L57 A;  2Y40 A;  3VMK A;  2QFV A;  1U7N A;  4I3L A;  2E5M A;  3VL3 A;  1IDM A;  1T0L A;  4AJC A;  4ICD A;  1XAD A;  5GRF B;  4YB4 A;  1AI3 A;  3UDU A;  3WZW A;  1GRP A;  3ASJ A;  4BNP A;  4AOV A;  7ICD A;  4UMY A;  1YXO A;  1HEX A;  1IDD A;  1DPZ A;  1PB3 A;  4WUO A;  5J34 A;  5LGE A;  1GRO A;  2D4V A;  1CNZ A;  2ZTW A;  1OSI A;  4F7I A;  3UF6 A;  1IKA A;  2HI1 A;  1VLC A;  3BLV B;  4L03 A;  3UDO A;  1BL5 A;  5GRH B;  4AJS A;  1CW1 A;  3WZV A;  1V94 A;  1WPW A;  4ATY A;  5L58 A;  3AH3 A;  4XXV A;  9ICD A;  1DR8 A;  3DMS A;  5GRE B;  4JA8 A;  1HQS A;  1CW4 A;  5GRI A;  3US8 A;  5HN4 A;  4I3K A;  1PTM A;  1T09 A;  1X0L A;  3FLK A;  8ICD A;  1VI1 A;  5GRF A; 
#chains in the Genus database with same CATH homology
 5I96 A;  3WZX A;  5K11 A;  1PS6 A;  3VML A;  1DR0 A;  1IPD A;  1XAA A;  4XRX A;  1PS7 A;  2AYQ A;  1OSJ A;  1IDC A;  3TY4 A;  1ISO A;  3LCB C;  1AI2 A;  5GRL B;  3VMJ A;  1W0D A;  4XS3 A;  5J32 A;  1IDE A;  1G2U A;  3BLX B;  3VL7 A;  3TSN A;  4KZO A;  1V5B A;  3BLV A;  4IWH A;  5GRH A;  3LXY A;  1YCO A;  4AJ3 A;  4L06 A;  5J33 A;  1PB1 A;  4Y1P A;  5HN5 A;  3WZY A;  5GRE A;  2G4O A;  2Y3Z A;  1R8K A;  3MAR A;  3INM A;  2D1C A;  3TNG A;  1GC9 A;  1GC8 A;  6ICD A;  3MAS B;  4JQP A;  5HN3 A;  2QFW A;  2DHT A;  4UMX A;  2QFX A;  4AOY A;  5DE1 A;  1XKD A;  3FMX X;  1CM7 A;  2UXQ A;  2E0C A;  5GRL A;  3U1H A;  5GRI B;  3U9E A;  1IDF A;  3BLX A;  1P8F A;  1CW7 A;  1WAL A;  4L04 A;  4HCX A;  1ZOR A;  4AOU A;  4AJB A;  1V53 A;  1XAB A;  3VL4 A;  1TYO A;  3VKZ A;  3VL2 A;  1XAC A;  3TY3 A;  2IV0 A;  5ICD A;  2Y41 A;  1XGV A;  1LWD A;  3ICD A;  1A05 A;  5K10 A;  4AJA A;  2UXR A;  3R8W A;  5I95 A;  2QFY A;  4P69 C;  1HJ6 A;  1SJS A;  2Y42 A;  3MAS A;  3VL6 A;  3MAP A;  4AJR A;  5HN6 A;  5L57 A;  2Y40 A;  3VMK A;  2QFV A;  1U7N A;  4I3L A;  2E5M A;  3VL3 A;  1IDM A;  1T0L A;  4AJC A;  4ICD A;  1XAD A;  5GRF B;  4YB4 A;  1AI3 A;  3UDU A;  3WZW A;  1GRP A;  3ASJ A;  4BNP A;  4AOV A;  7ICD A;  4UMY A;  1YXO A;  1HEX A;  1IDD A;  1DPZ A;  1PB3 A;  4WUO A;  5J34 A;  5LGE A;  1GRO A;  2D4V A;  1CNZ A;  2ZTW A;  1OSI A;  4F7I A;  3UF6 A;  1IKA A;  2HI1 A;  1VLC A;  3BLV B;  4L03 A;  3UDO A;  1BL5 A;  5GRH B;  4AJS A;  1CW1 A;  3WZV A;  1V94 A;  1WPW A;  4ATY A;  5L58 A;  3AH3 A;  4XXV A;  9ICD A;  1DR8 A;  3DMS A;  5GRE B;  4JA8 A;  1HQS A;  1CW4 A;  5GRI A;  3US8 A;  5HN4 A;  4I3K A;  1PTM A;  1T09 A;  1X0L A;  3FLK A;  8ICD A;  1VI1 A;  5GRF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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