3MK1A

Refinement of placental alkaline phosphatase complexed with nitrophenyl
Total Genus 180
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
180
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase, placental type
publication title Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
pubmed doi rcsb
molecule tags Hydrolase
total genus 180
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2010-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3mk1A00
1EI6A 1HDHA 5LQQA 1KHLA 1ALIA 3BDGB 3IDDA 5K4PA 1B8JA 4CYRA 2W8DA 1EW8A 1EW9A 3NKNA 3M8WA 2W5TA 4GTWA 1KH7A 3MK1A 1SHNA 5LRMA 1URAA 4UORA 4N7TA 4GTXA 2GLQA 3NKRA 1FSUA 4CYSA 3LXQA 3WBHA 1URBA 4LQYA 1E2SP 2GSUA 3B5QA 2GSOA 1AUKA 4CXUA 2W5WA 5GOVA 1ZEBA 2G9YA 1ZEFA 1E1ZP 1HJKA 4UPLA 3BDGA 3UN5A 1ANJA 1SHQA 2QZUA 4ZG7A 1AJAA 1KHKA 2W5QA 3UNYA 1ALJA 2X98A 4LRCA 4UOPA 1ANIA 4MHXA 4KAVA 1KH9A 4TN0A 3UO0A 5INHA 1E3CP 2IUCB 3NKOA 5EGEA 3DYCA 3KD8A 3A52A 4GTYA 1ED8A 4B56A 3NKPA 2IFYA 3BDHA 4ZG6A 3NKMA 3WAVA 3T00A 3DPCA 3UN3A 5L0KA 4FDJA 3OT9A 3CMRA 1HQAA 5C66A 1AJDA 4LREA 3M8YA 3WAYA 3IGZB 4UPIA 4LRBA 3TG0A 4UPHA 1KHJA 4LR2A 1N2KA 3BDFA 4LR9A 1KH5A 3MK0A 1ELXA 5DLVA 2ANHA 3M8ZA 1ZEDA 4LR7A 1AJCA 3WAXA 2VQRA 2W5XA 1O99A 5LRNA 4KAYA 4FDIA 5GRRA 3UN2A 5LIAA 1Y7AA 4LRDA 3M7VA 1P49A 2W5SA 5L0BA 4NWJA 1K7HA 5DLTA 2XRGA 3NVLA 4YR1A 4UPKA 3E2DA 2IUCA 1EW2A 1N2LA 2W5VA 4MY4A 1ELYA 5AJ9A 2GA3A 4MIVA 2W5RA 5EGHA 3MK2A 5IJSA 4ZG9A 1ALHA 4ZGAA 1EJJA 2W8SA 1ELZA 4KM4A 2D1GA 1KHNA 4QAXA 4CXSA 3SZYA 3T01A 5HRTA 4KJGA 4UOOA 5L0EA 3NKQA 4GTZA 5KXAA 3ED4A 4KJDA 2GSNA 1ED9A 1KH4A 5DLWA 4LRFA 3TX0A 5IJQA 3T02A 1AJBA 1Y6VA 3IGYB 3WAWA 4LR8A 4CXKA 3SZZA 4LRAA 4NWXA 1ALKA 2ZKTA 1O98A 5TJ3A 2RH6A 2XR9A 3TWZA 1EQJA 1E33P 3Q3QA
chains in the Genus database with same CATH superfamily
1EI6A 1HDHA 5LQQA 1KHLA 1ALIA 3BDGB 3IDDA 5K4PA 1B8JA 4CYRA 2W8DA 1EW8A 1EW9A 3NKNA 3M8WA 2W5TA 4GTWA 1KH7A 3MK1A 1SHNA 5LRMA 1URAA 4UORA 4N7TA 4GTXA 2GLQA 3NKRA 1FSUA 4CYSA 3LXQA 3WBHA 1URBA 4LQYA 1E2SP 2GSUA 3B5QA 2GSOA 1AUKA 4CXUA 2W5WA 5GOVA 1ZEBA 2G9YA 1ZEFA 1E1ZP 1HJKA 4UPLA 3BDGA 3UN5A 1ANJA 1SHQA 2QZUA 4ZG7A 1AJAA 1KHKA 2W5QA 3UNYA 1ALJA 2X98A 4LRCA 4UOPA 1ANIA 4MHXA 4KAVA 1KH9A 4TN0A 3UO0A 5INHA 1E3CP 2IUCB 3NKOA 5EGEA 3DYCA 3KD8A 3A52A 4GTYA 1ED8A 4B56A 3NKPA 2IFYA 3BDHA 4ZG6A 3NKMA 3WAVA 3T00A 3DPCA 3UN3A 5L0KA 4FDJA 3OT9A 3CMRA 1HQAA 5C66A 1AJDA 4LREA 3M8YA 3WAYA 3IGZB 4UPIA 4LRBA 3TG0A 4UPHA 1KHJA 4LR2A 1N2KA 3BDFA 4LR9A 1KH5A 3MK0A 1ELXA 5DLVA 2ANHA 3M8ZA 1ZEDA 4LR7A 1AJCA 3WAXA 2VQRA 2W5XA 1O99A 5LRNA 4KAYA 4FDIA 5GRRA 3UN2A 5LIAA 1Y7AA 4LRDA 3M7VA 1P49A 2W5SA 5L0BA 4NWJA 1K7HA 5DLTA 2XRGA 3NVLA 4YR1A 4UPKA 3E2DA 2IUCA 1EW2A 1N2LA 2W5VA 4MY4A 1ELYA 5AJ9A 2GA3A 4MIVA 2W5RA 5EGHA 3MK2A 5IJSA 4ZG9A 1ALHA 4ZGAA 1EJJA 2W8SA 1ELZA 4KM4A 2D1GA 1KHNA 4QAXA 4CXSA 3SZYA 3T01A 5HRTA 4KJGA 4UOOA 5L0EA 3NKQA 4GTZA 5KXAA 3ED4A 4KJDA 2GSNA 1ED9A 1KH4A 5DLWA 4LRFA 3TX0A 5IJQA 3T02A 1AJBA 1Y6VA 3IGYB 3WAWA 4LR8A 4CXKA 3SZZA 4LRAA 4NWXA 1ALKA 2ZKTA 1O98A 5TJ3A 2RH6A 2XR9A 3TWZA 1EQJA 1E33P 3Q3QA
chains in the Genus database with same CATH topology
1EI6A 1HDHA 5LQQA 1KHLA 1ALIA 3BDGB 3IDDA 5K4PA 1B8JA 4CYRA 2W8DA 1EW8A 1EW9A 3NKNA 3M8WA 2W5TA 4GTWA 1KH7A 3MK1A 1SHNA 5LRMA 1URAA 4UORA 4N7TA 4GTXA 2GLQA 3NKRA 1FSUA 4CYSA 3LXQA 3WBHA 1URBA 4LQYA 1E2SP 2GSUA 3B5QA 2GSOA 1AUKA 4CXUA 2W5WA 5GOVA 1ZEBA 2G9YA 1ZEFA 1E1ZP 1HJKA 4UPLA 3BDGA 3UN5A 1ANJA 1SHQA 2QZUA 4ZG7A 1AJAA 1KHKA 2W5QA 3UNYA 1ALJA 2X98A 4LRCA 4UOPA 1ANIA 4MHXA 4KAVA 1KH9A 4TN0A 3UO0A 5INHA 1E3CP 2IUCB 3NKOA 5EGEA 3DYCA 3KD8A 3A52A 4GTYA 1ED8A 4B56A 3NKPA 2IFYA 3BDHA 4ZG6A 3NKMA 3WAVA 3T00A 3DPCA 3UN3A 5L0KA 4FDJA 3OT9A 3CMRA 1HQAA 5C66A 1AJDA 4LREA 3M8YA 3WAYA 3IGZB 4UPIA 4LRBA 3TG0A 4UPHA 1KHJA 4LR2A 1N2KA 3BDFA 4LR9A 1KH5A 3MK0A 1ELXA 5DLVA 2ANHA 3M8ZA 1ZEDA 4LR7A 1AJCA 3WAXA 2VQRA 2W5XA 1O99A 5LRNA 4KAYA 4FDIA 5GRRA 3UN2A 5LIAA 1Y7AA 4LRDA 3M7VA 1P49A 2W5SA 5L0BA 4NWJA 1K7HA 5DLTA 2XRGA 3NVLA 4YR1A 4UPKA 3E2DA 2IUCA 1EW2A 1N2LA 2W5VA 4MY4A 1ELYA 5AJ9A 2GA3A 4MIVA 2W5RA 5EGHA 3MK2A 5IJSA 4ZG9A 1ALHA 4ZGAA 1EJJA 2W8SA 1ELZA 4KM4A 2D1GA 1KHNA 4QAXA 4CXSA 3SZYA 3T01A 5HRTA 4KJGA 4UOOA 5L0EA 3NKQA 4GTZA 5KXAA 3ED4A 4KJDA 2GSNA 1ED9A 1KH4A 5DLWA 4LRFA 3TX0A 5IJQA 3T02A 1AJBA 1Y6VA 3IGYB 3WAWA 4LR8A 4CXKA 3SZZA 4LRAA 4NWXA 1ALKA 2ZKTA 1O98A 5TJ3A 2RH6A 2XR9A 3TWZA 1EQJA 1E33P 3Q3QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EI6 A;  1HDH A;  5LQQ A;  1KHL A;  1ALI A;  3BDG B;  3IDD A;  5K4P A;  1B8J A;  4CYR A;  2W8D A;  1EW8 A;  1EW9 A;  3NKN A;  3M8W A;  2W5T A;  4GTW A;  1KH7 A;  3MK1 A;  1SHN A;  5LRM A;  1URA A;  4UOR A;  4N7T A;  4GTX A;  2GLQ A;  3NKR A;  1FSU A;  4CYS A;  3LXQ A;  3WBH A;  1URB A;  4LQY A;  1E2S P;  2GSU A;  3B5Q A;  2GSO A;  1AUK A;  4CXU A;  2W5W A;  5GOV A;  1ZEB A;  2G9Y A;  1ZEF A;  1E1Z P;  1HJK A;  4UPL A;  3BDG A;  3UN5 A;  1ANJ A;  1SHQ A;  2QZU A;  4ZG7 A;  1AJA A;  1KHK A;  2W5Q A;  3UNY A;  1ALJ A;  2X98 A;  4LRC A;  4UOP A;  1ANI A;  4MHX A;  4KAV A;  1KH9 A;  4TN0 A;  3UO0 A;  5INH A;  1E3C P;  2IUC B;  3NKO A;  5EGE A;  3DYC A;  3KD8 A;  3A52 A;  4GTY A;  1ED8 A;  4B56 A;  3NKP A;  2IFY A;  3BDH A;  4ZG6 A;  3NKM A;  3WAV A;  3T00 A;  3DPC A;  3UN3 A;  5L0K A;  4FDJ A;  3OT9 A;  3CMR A;  1HQA A;  5C66 A;  1AJD A;  4LRE A;  3M8Y A;  3WAY A;  3IGZ B;  4UPI A;  4LRB A;  3TG0 A;  4UPH A;  1KHJ A;  4LR2 A;  1N2K A;  3BDF A;  4LR9 A;  1KH5 A;  3MK0 A;  1ELX A;  5DLV A;  2ANH A;  3M8Z A;  1ZED A;  4LR7 A;  1AJC A;  3WAX A;  2VQR A;  2W5X A;  1O99 A;  5LRN A;  4KAY A;  4FDI A;  5GRR A;  3UN2 A;  5LIA A;  1Y7A A;  4LRD A;  3M7V A;  1P49 A;  2W5S A;  5L0B A;  4NWJ A;  1K7H A;  5DLT A;  2XRG A;  3NVL A;  4YR1 A;  4UPK A;  3E2D A;  2IUC A;  1EW2 A;  1N2L A;  2W5V A;  4MY4 A;  1ELY A;  5AJ9 A;  2GA3 A;  4MIV A;  2W5R A;  5EGH A;  3MK2 A;  5IJS A;  4ZG9 A;  1ALH A;  4ZGA A;  1EJJ A;  2W8S A;  1ELZ A;  4KM4 A;  2D1G A;  1KHN A;  4QAX A;  4CXS A;  3SZY A;  3T01 A;  5HRT A;  4KJG A;  4UOO A;  5L0E A;  3NKQ A;  4GTZ A;  5KXA A;  3ED4 A;  4KJD A;  2GSN A;  1ED9 A;  1KH4 A;  5DLW A;  4LRF A;  3TX0 A;  5IJQ A;  3T02 A;  1AJB A;  1Y6V A;  3IGY B;  3WAW A;  4LR8 A;  4CXK A;  3SZZ A;  4LRA A;  4NWX A;  1ALK A;  2ZKT A;  1O98 A;  5TJ3 A;  2RH6 A;  2XR9 A;  3TWZ A;  1EQJ A;  1E33 P;  3Q3Q A; 
#chains in the Genus database with same CATH topology
 1EI6 A;  1HDH A;  5LQQ A;  1KHL A;  1ALI A;  3BDG B;  3IDD A;  5K4P A;  1B8J A;  4CYR A;  2W8D A;  1EW8 A;  1EW9 A;  3NKN A;  3M8W A;  2W5T A;  4GTW A;  1KH7 A;  3MK1 A;  1SHN A;  5LRM A;  1URA A;  4UOR A;  4N7T A;  4GTX A;  2GLQ A;  3NKR A;  1FSU A;  4CYS A;  3LXQ A;  3WBH A;  1URB A;  4LQY A;  1E2S P;  2GSU A;  3B5Q A;  2GSO A;  1AUK A;  4CXU A;  2W5W A;  5GOV A;  1ZEB A;  2G9Y A;  1ZEF A;  1E1Z P;  1HJK A;  4UPL A;  3BDG A;  3UN5 A;  1ANJ A;  1SHQ A;  2QZU A;  4ZG7 A;  1AJA A;  1KHK A;  2W5Q A;  3UNY A;  1ALJ A;  2X98 A;  4LRC A;  4UOP A;  1ANI A;  4MHX A;  4KAV A;  1KH9 A;  4TN0 A;  3UO0 A;  5INH A;  1E3C P;  2IUC B;  3NKO A;  5EGE A;  3DYC A;  3KD8 A;  3A52 A;  4GTY A;  1ED8 A;  4B56 A;  3NKP A;  2IFY A;  3BDH A;  4ZG6 A;  3NKM A;  3WAV A;  3T00 A;  3DPC A;  3UN3 A;  5L0K A;  4FDJ A;  3OT9 A;  3CMR A;  1HQA A;  5C66 A;  1AJD A;  4LRE A;  3M8Y A;  3WAY A;  3IGZ B;  4UPI A;  4LRB A;  3TG0 A;  4UPH A;  1KHJ A;  4LR2 A;  1N2K A;  3BDF A;  4LR9 A;  1KH5 A;  3MK0 A;  1ELX A;  5DLV A;  2ANH A;  3M8Z A;  1ZED A;  4LR7 A;  1AJC A;  3WAX A;  2VQR A;  2W5X A;  1O99 A;  5LRN A;  4KAY A;  4FDI A;  5GRR A;  3UN2 A;  5LIA A;  1Y7A A;  4LRD A;  3M7V A;  1P49 A;  2W5S A;  5L0B A;  4NWJ A;  1K7H A;  5DLT A;  2XRG A;  3NVL A;  4YR1 A;  4UPK A;  3E2D A;  2IUC A;  1EW2 A;  1N2L A;  2W5V A;  4MY4 A;  1ELY A;  5AJ9 A;  2GA3 A;  4MIV A;  2W5R A;  5EGH A;  3MK2 A;  5IJS A;  4ZG9 A;  1ALH A;  4ZGA A;  1EJJ A;  2W8S A;  1ELZ A;  4KM4 A;  2D1G A;  1KHN A;  4QAX A;  4CXS A;  3SZY A;  3T01 A;  5HRT A;  4KJG A;  4UOO A;  5L0E A;  3NKQ A;  4GTZ A;  5KXA A;  3ED4 A;  4KJD A;  2GSN A;  1ED9 A;  1KH4 A;  5DLW A;  4LRF A;  3TX0 A;  5IJQ A;  3T02 A;  1AJB A;  1Y6V A;  3IGY B;  3WAW A;  4LR8 A;  4CXK A;  3SZZ A;  4LRA A;  4NWX A;  1ALK A;  2ZKT A;  1O98 A;  5TJ3 A;  2RH6 A;  2XR9 A;  3TWZ A;  1EQJ A;  1E33 P;  3Q3Q A; 
#chains in the Genus database with same CATH homology
 1EI6 A;  1HDH A;  5LQQ A;  1KHL A;  1ALI A;  3BDG B;  3IDD A;  5K4P A;  1B8J A;  4CYR A;  2W8D A;  1EW8 A;  1EW9 A;  3NKN A;  3M8W A;  2W5T A;  4GTW A;  1KH7 A;  3MK1 A;  1SHN A;  5LRM A;  1URA A;  4UOR A;  4N7T A;  4GTX A;  2GLQ A;  3NKR A;  1FSU A;  4CYS A;  3LXQ A;  3WBH A;  1URB A;  4LQY A;  1E2S P;  2GSU A;  3B5Q A;  2GSO A;  1AUK A;  4CXU A;  2W5W A;  5GOV A;  1ZEB A;  2G9Y A;  1ZEF A;  1E1Z P;  1HJK A;  4UPL A;  3BDG A;  3UN5 A;  1ANJ A;  1SHQ A;  2QZU A;  4ZG7 A;  1AJA A;  1KHK A;  2W5Q A;  3UNY A;  1ALJ A;  2X98 A;  4LRC A;  4UOP A;  1ANI A;  4MHX A;  4KAV A;  1KH9 A;  4TN0 A;  3UO0 A;  5INH A;  1E3C P;  2IUC B;  3NKO A;  5EGE A;  3DYC A;  3KD8 A;  3A52 A;  4GTY A;  1ED8 A;  4B56 A;  3NKP A;  2IFY A;  3BDH A;  4ZG6 A;  3NKM A;  3WAV A;  3T00 A;  3DPC A;  3UN3 A;  5L0K A;  4FDJ A;  3OT9 A;  3CMR A;  1HQA A;  5C66 A;  1AJD A;  4LRE A;  3M8Y A;  3WAY A;  3IGZ B;  4UPI A;  4LRB A;  3TG0 A;  4UPH A;  1KHJ A;  4LR2 A;  1N2K A;  3BDF A;  4LR9 A;  1KH5 A;  3MK0 A;  1ELX A;  5DLV A;  2ANH A;  3M8Z A;  1ZED A;  4LR7 A;  1AJC A;  3WAX A;  2VQR A;  2W5X A;  1O99 A;  5LRN A;  4KAY A;  4FDI A;  5GRR A;  3UN2 A;  5LIA A;  1Y7A A;  4LRD A;  3M7V A;  1P49 A;  2W5S A;  5L0B A;  4NWJ A;  1K7H A;  5DLT A;  2XRG A;  3NVL A;  4YR1 A;  4UPK A;  3E2D A;  2IUC A;  1EW2 A;  1N2L A;  2W5V A;  4MY4 A;  1ELY A;  5AJ9 A;  2GA3 A;  4MIV A;  2W5R A;  5EGH A;  3MK2 A;  5IJS A;  4ZG9 A;  1ALH A;  4ZGA A;  1EJJ A;  2W8S A;  1ELZ A;  4KM4 A;  2D1G A;  1KHN A;  4QAX A;  4CXS A;  3SZY A;  3T01 A;  5HRT A;  4KJG A;  4UOO A;  5L0E A;  3NKQ A;  4GTZ A;  5KXA A;  3ED4 A;  4KJD A;  2GSN A;  1ED9 A;  1KH4 A;  5DLW A;  4LRF A;  3TX0 A;  5IJQ A;  3T02 A;  1AJB A;  1Y6V A;  3IGY B;  3WAW A;  4LR8 A;  4CXK A;  3SZZ A;  4LRA A;  4NWX A;  1ALK A;  2ZKT A;  1O98 A;  5TJ3 A;  2RH6 A;  2XR9 A;  3TWZ A;  1EQJ A;  1E33 P;  3Q3Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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