3MK1A

Refinement of placental alkaline phosphatase complexed with nitrophenyl
Total Genus 180
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
180
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase, placental type
total genus 180
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2010-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3mk1A00
1O99A 3B5QA 1HJKA 1K7HA 3KD8A 5GRRA 3BDGB 4LQYA 5DLVA 2W5QA 3SZYA 1Y6VA 3UN3A 1KHLA 2VQRA 4UOOA 5L0BA 1N2KA 3M7VA 1AUKA 3M8ZA 1KHNA 4LRCA 3M8YA 4UOPA 3E2DA 4MHXA 1ANIA 3Q3QA 1KHKA 1URAA 4UPKA 3T01A 2W5TA 4NWXA 4ZG9A 4FDJA 1O98A 3TX0A 2GSOA 3NKNA 3UO0A 3DYCA 5IJQA 3IGZB 5EGHA 3T00A 4ZG7A 3DPCA 1EI6A 2RH6A 5TJ3A 1ALJA 1AJCA 5L0EA 1E33P 3OT9A 1EQJA 1ELXA 5KXAA 4CXUA 4CYRA 5INHA 4CYSA 1FSUA 4GTXA 4MY4A 5DLTA 2ZKTA 4UPHA 4KJGA 5EGEA 3WBHA 2IFYA 2GLQA 1ELYA 4MIVA 3UN2A 3IGYB 2XR9A 1B8JA 4CXKA 2D1GA 4LRAA 2G9YA 1ALKA 1EW9A 3NVLA 1ZEBA 2GA3A 1AJDA 1KH5A 2W5RA 4LR8A 1URBA 5LRMA 1ALIA 2W5VA 2X98A 1SHNA 1KHJA 4GTYA 2GSNA 1EW2A 5HRTA 3A52A 3MK2A 1E2SP 4ZG6A 4LRDA 3NKPA 1HDHA 3NKRA 4GTZA 3MK1A 4KJDA 5GOVA 1ZEDA 4YR1A 4CXSA 3UNYA 3WAWA 4B56A 1ED8A 4KAYA 1ALHA 3BDFA 4NWJA 3SZZA 4KAVA 4LRFA 2W5SA 1SHQA 5IJSA 2W5WA 3NKQA 2QZUA 2ANHA 3NKMA 1P49A 4ZGAA 5C66A 4LR7A 1ELZA 1Y7AA 1ANJA 1E1ZP 4LRBA 5LRNA 1E3CP 1KH9A 3M8WA 4UORA 3LXQA 2W8DA 3WAVA 2W8SA 1HQAA 3ED4A 1EJJA 3TWZA 3TG0A 2W5XA 1AJAA 2GSUA 3T02A 4LR9A 4UPLA 4UPIA 1AJBA 1KH4A 5LQQA 4KM4A 5K4PA 5L0KA 2IUCB 4LR2A 5AJ9A 4TN0A 5DLWA 4GTWA 1ED9A 3UN5A 3WAXA 5LIAA 1ZEFA 3BDGA 4FDIA 1EW8A 1N2LA 2IUCA 4LREA 4N7TA 1KH7A 2XRGA 3IDDA 3NKOA 3BDHA 3MK0A 3WAYA 3CMRA 4QAXA
chains in the Genus database with same CATH superfamily
1O99A 3B5QA 1HJKA 1K7HA 3KD8A 5GRRA 3BDGB 4LQYA 5DLVA 2W5QA 3SZYA 1Y6VA 3UN3A 1KHLA 2VQRA 4UOOA 5L0BA 1N2KA 3M7VA 1AUKA 3M8ZA 1KHNA 4LRCA 3M8YA 4UOPA 3E2DA 4MHXA 1ANIA 3Q3QA 1KHKA 1URAA 4UPKA 3T01A 2W5TA 4NWXA 4ZG9A 4FDJA 1O98A 3TX0A 2GSOA 3NKNA 3UO0A 3DYCA 5IJQA 3IGZB 5EGHA 3T00A 4ZG7A 3DPCA 1EI6A 2RH6A 5TJ3A 1ALJA 1AJCA 5L0EA 1E33P 3OT9A 1EQJA 1ELXA 5KXAA 4CXUA 4CYRA 5INHA 4CYSA 1FSUA 4GTXA 4MY4A 5DLTA 2ZKTA 4UPHA 4KJGA 5EGEA 3WBHA 2IFYA 2GLQA 1ELYA 4MIVA 3UN2A 3IGYB 2XR9A 1B8JA 4CXKA 2D1GA 4LRAA 2G9YA 1ALKA 1EW9A 3NVLA 1ZEBA 2GA3A 1AJDA 1KH5A 2W5RA 4LR8A 1URBA 5LRMA 1ALIA 2W5VA 2X98A 1SHNA 1KHJA 4GTYA 2GSNA 1EW2A 5HRTA 3A52A 3MK2A 1E2SP 4ZG6A 4LRDA 3NKPA 1HDHA 3NKRA 4GTZA 3MK1A 4KJDA 5GOVA 1ZEDA 4YR1A 4CXSA 3UNYA 3WAWA 4B56A 1ED8A 4KAYA 1ALHA 3BDFA 4NWJA 3SZZA 4KAVA 4LRFA 2W5SA 1SHQA 5IJSA 2W5WA 3NKQA 2QZUA 2ANHA 3NKMA 1P49A 4ZGAA 5C66A 4LR7A 1ELZA 1Y7AA 1ANJA 1E1ZP 4LRBA 5LRNA 1E3CP 1KH9A 3M8WA 4UORA 3LXQA 2W8DA 3WAVA 2W8SA 1HQAA 3ED4A 1EJJA 3TWZA 3TG0A 2W5XA 1AJAA 2GSUA 3T02A 4LR9A 4UPLA 4UPIA 1AJBA 1KH4A 5LQQA 4KM4A 5K4PA 5L0KA 2IUCB 4LR2A 5AJ9A 4TN0A 5DLWA 4GTWA 1ED9A 3UN5A 3WAXA 5LIAA 1ZEFA 3BDGA 4FDIA 1EW8A 1N2LA 2IUCA 4LREA 4N7TA 1KH7A 2XRGA 3IDDA 3NKOA 3BDHA 3MK0A 3WAYA 3CMRA 4QAXA
chains in the Genus database with same CATH topology
1O99A 3B5QA 1HJKA 1K7HA 3KD8A 5GRRA 3BDGB 4LQYA 5DLVA 2W5QA 3SZYA 1Y6VA 3UN3A 1KHLA 2VQRA 4UOOA 5L0BA 1N2KA 3M7VA 1AUKA 3M8ZA 1KHNA 4LRCA 3M8YA 4UOPA 3E2DA 4MHXA 1ANIA 3Q3QA 1KHKA 1URAA 4UPKA 3T01A 2W5TA 4NWXA 4ZG9A 4FDJA 1O98A 3TX0A 2GSOA 3NKNA 3UO0A 3DYCA 5IJQA 3IGZB 5EGHA 3T00A 4ZG7A 3DPCA 1EI6A 2RH6A 5TJ3A 1ALJA 1AJCA 5L0EA 1E33P 3OT9A 1EQJA 1ELXA 5KXAA 4CXUA 4CYRA 5INHA 4CYSA 1FSUA 4GTXA 4MY4A 5DLTA 2ZKTA 4UPHA 4KJGA 5EGEA 3WBHA 2IFYA 2GLQA 1ELYA 4MIVA 3UN2A 3IGYB 2XR9A 1B8JA 4CXKA 2D1GA 4LRAA 2G9YA 1ALKA 1EW9A 3NVLA 1ZEBA 2GA3A 1AJDA 1KH5A 2W5RA 4LR8A 1URBA 5LRMA 1ALIA 2W5VA 2X98A 1SHNA 1KHJA 4GTYA 2GSNA 1EW2A 5HRTA 3A52A 3MK2A 1E2SP 4ZG6A 4LRDA 3NKPA 1HDHA 3NKRA 4GTZA 3MK1A 4KJDA 5GOVA 1ZEDA 4YR1A 4CXSA 3UNYA 3WAWA 4B56A 1ED8A 4KAYA 1ALHA 3BDFA 4NWJA 3SZZA 4KAVA 4LRFA 2W5SA 1SHQA 5IJSA 2W5WA 3NKQA 2QZUA 2ANHA 3NKMA 1P49A 4ZGAA 5C66A 4LR7A 1ELZA 1Y7AA 1ANJA 1E1ZP 4LRBA 5LRNA 1E3CP 1KH9A 3M8WA 4UORA 3LXQA 2W8DA 3WAVA 2W8SA 1HQAA 3ED4A 1EJJA 3TWZA 3TG0A 2W5XA 1AJAA 2GSUA 3T02A 4LR9A 4UPLA 4UPIA 1AJBA 1KH4A 5LQQA 4KM4A 5K4PA 5L0KA 2IUCB 4LR2A 5AJ9A 4TN0A 5DLWA 4GTWA 1ED9A 3UN5A 3WAXA 5LIAA 1ZEFA 3BDGA 4FDIA 1EW8A 1N2LA 2IUCA 4LREA 4N7TA 1KH7A 2XRGA 3IDDA 3NKOA 3BDHA 3MK0A 3WAYA 3CMRA 4QAXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1O99 A;  3B5Q A;  1HJK A;  1K7H A;  3KD8 A;  5GRR A;  3BDG B;  4LQY A;  5DLV A;  2W5Q A;  3SZY A;  1Y6V A;  3UN3 A;  1KHL A;  2VQR A;  4UOO A;  5L0B A;  1N2K A;  3M7V A;  1AUK A;  3M8Z A;  1KHN A;  4LRC A;  3M8Y A;  4UOP A;  3E2D A;  4MHX A;  1ANI A;  3Q3Q A;  1KHK A;  1URA A;  4UPK A;  3T01 A;  2W5T A;  4NWX A;  4ZG9 A;  4FDJ A;  1O98 A;  3TX0 A;  2GSO A;  3NKN A;  3UO0 A;  3DYC A;  5IJQ A;  3IGZ B;  5EGH A;  3T00 A;  4ZG7 A;  3DPC A;  1EI6 A;  2RH6 A;  5TJ3 A;  1ALJ A;  1AJC A;  5L0E A;  1E33 P;  3OT9 A;  1EQJ A;  1ELX A;  5KXA A;  4CXU A;  4CYR A;  5INH A;  4CYS A;  1FSU A;  4GTX A;  4MY4 A;  5DLT A;  2ZKT A;  4UPH A;  4KJG A;  5EGE A;  3WBH A;  2IFY A;  2GLQ A;  1ELY A;  4MIV A;  3UN2 A;  3IGY B;  2XR9 A;  1B8J A;  4CXK A;  2D1G A;  4LRA A;  2G9Y A;  1ALK A;  1EW9 A;  3NVL A;  1ZEB A;  2GA3 A;  1AJD A;  1KH5 A;  2W5R A;  4LR8 A;  1URB A;  5LRM A;  1ALI A;  2W5V A;  2X98 A;  1SHN A;  1KHJ A;  4GTY A;  2GSN A;  1EW2 A;  5HRT A;  3A52 A;  3MK2 A;  1E2S P;  4ZG6 A;  4LRD A;  3NKP A;  1HDH A;  3NKR A;  4GTZ A;  3MK1 A;  4KJD A;  5GOV A;  1ZED A;  4YR1 A;  4CXS A;  3UNY A;  3WAW A;  4B56 A;  1ED8 A;  4KAY A;  1ALH A;  3BDF A;  4NWJ A;  3SZZ A;  4KAV A;  4LRF A;  2W5S A;  1SHQ A;  5IJS A;  2W5W A;  3NKQ A;  2QZU A;  2ANH A;  3NKM A;  1P49 A;  4ZGA A;  5C66 A;  4LR7 A;  1ELZ A;  1Y7A A;  1ANJ A;  1E1Z P;  4LRB A;  5LRN A;  1E3C P;  1KH9 A;  3M8W A;  4UOR A;  3LXQ A;  2W8D A;  3WAV A;  2W8S A;  1HQA A;  3ED4 A;  1EJJ A;  3TWZ A;  3TG0 A;  2W5X A;  1AJA A;  2GSU A;  3T02 A;  4LR9 A;  4UPL A;  4UPI A;  1AJB A;  1KH4 A;  5LQQ A;  4KM4 A;  5K4P A;  5L0K A;  2IUC B;  4LR2 A;  5AJ9 A;  4TN0 A;  5DLW A;  4GTW A;  1ED9 A;  3UN5 A;  3WAX A;  5LIA A;  1ZEF A;  3BDG A;  4FDI A;  1EW8 A;  1N2L A;  2IUC A;  4LRE A;  4N7T A;  1KH7 A;  2XRG A;  3IDD A;  3NKO A;  3BDH A;  3MK0 A;  3WAY A;  3CMR A;  4QAX A; 
#chains in the Genus database with same CATH topology
 1O99 A;  3B5Q A;  1HJK A;  1K7H A;  3KD8 A;  5GRR A;  3BDG B;  4LQY A;  5DLV A;  2W5Q A;  3SZY A;  1Y6V A;  3UN3 A;  1KHL A;  2VQR A;  4UOO A;  5L0B A;  1N2K A;  3M7V A;  1AUK A;  3M8Z A;  1KHN A;  4LRC A;  3M8Y A;  4UOP A;  3E2D A;  4MHX A;  1ANI A;  3Q3Q A;  1KHK A;  1URA A;  4UPK A;  3T01 A;  2W5T A;  4NWX A;  4ZG9 A;  4FDJ A;  1O98 A;  3TX0 A;  2GSO A;  3NKN A;  3UO0 A;  3DYC A;  5IJQ A;  3IGZ B;  5EGH A;  3T00 A;  4ZG7 A;  3DPC A;  1EI6 A;  2RH6 A;  5TJ3 A;  1ALJ A;  1AJC A;  5L0E A;  1E33 P;  3OT9 A;  1EQJ A;  1ELX A;  5KXA A;  4CXU A;  4CYR A;  5INH A;  4CYS A;  1FSU A;  4GTX A;  4MY4 A;  5DLT A;  2ZKT A;  4UPH A;  4KJG A;  5EGE A;  3WBH A;  2IFY A;  2GLQ A;  1ELY A;  4MIV A;  3UN2 A;  3IGY B;  2XR9 A;  1B8J A;  4CXK A;  2D1G A;  4LRA A;  2G9Y A;  1ALK A;  1EW9 A;  3NVL A;  1ZEB A;  2GA3 A;  1AJD A;  1KH5 A;  2W5R A;  4LR8 A;  1URB A;  5LRM A;  1ALI A;  2W5V A;  2X98 A;  1SHN A;  1KHJ A;  4GTY A;  2GSN A;  1EW2 A;  5HRT A;  3A52 A;  3MK2 A;  1E2S P;  4ZG6 A;  4LRD A;  3NKP A;  1HDH A;  3NKR A;  4GTZ A;  3MK1 A;  4KJD A;  5GOV A;  1ZED A;  4YR1 A;  4CXS A;  3UNY A;  3WAW A;  4B56 A;  1ED8 A;  4KAY A;  1ALH A;  3BDF A;  4NWJ A;  3SZZ A;  4KAV A;  4LRF A;  2W5S A;  1SHQ A;  5IJS A;  2W5W A;  3NKQ A;  2QZU A;  2ANH A;  3NKM A;  1P49 A;  4ZGA A;  5C66 A;  4LR7 A;  1ELZ A;  1Y7A A;  1ANJ A;  1E1Z P;  4LRB A;  5LRN A;  1E3C P;  1KH9 A;  3M8W A;  4UOR A;  3LXQ A;  2W8D A;  3WAV A;  2W8S A;  1HQA A;  3ED4 A;  1EJJ A;  3TWZ A;  3TG0 A;  2W5X A;  1AJA A;  2GSU A;  3T02 A;  4LR9 A;  4UPL A;  4UPI A;  1AJB A;  1KH4 A;  5LQQ A;  4KM4 A;  5K4P A;  5L0K A;  2IUC B;  4LR2 A;  5AJ9 A;  4TN0 A;  5DLW A;  4GTW A;  1ED9 A;  3UN5 A;  3WAX A;  5LIA A;  1ZEF A;  3BDG A;  4FDI A;  1EW8 A;  1N2L A;  2IUC A;  4LRE A;  4N7T A;  1KH7 A;  2XRG A;  3IDD A;  3NKO A;  3BDH A;  3MK0 A;  3WAY A;  3CMR A;  4QAX A; 
#chains in the Genus database with same CATH homology
 1O99 A;  3B5Q A;  1HJK A;  1K7H A;  3KD8 A;  5GRR A;  3BDG B;  4LQY A;  5DLV A;  2W5Q A;  3SZY A;  1Y6V A;  3UN3 A;  1KHL A;  2VQR A;  4UOO A;  5L0B A;  1N2K A;  3M7V A;  1AUK A;  3M8Z A;  1KHN A;  4LRC A;  3M8Y A;  4UOP A;  3E2D A;  4MHX A;  1ANI A;  3Q3Q A;  1KHK A;  1URA A;  4UPK A;  3T01 A;  2W5T A;  4NWX A;  4ZG9 A;  4FDJ A;  1O98 A;  3TX0 A;  2GSO A;  3NKN A;  3UO0 A;  3DYC A;  5IJQ A;  3IGZ B;  5EGH A;  3T00 A;  4ZG7 A;  3DPC A;  1EI6 A;  2RH6 A;  5TJ3 A;  1ALJ A;  1AJC A;  5L0E A;  1E33 P;  3OT9 A;  1EQJ A;  1ELX A;  5KXA A;  4CXU A;  4CYR A;  5INH A;  4CYS A;  1FSU A;  4GTX A;  4MY4 A;  5DLT A;  2ZKT A;  4UPH A;  4KJG A;  5EGE A;  3WBH A;  2IFY A;  2GLQ A;  1ELY A;  4MIV A;  3UN2 A;  3IGY B;  2XR9 A;  1B8J A;  4CXK A;  2D1G A;  4LRA A;  2G9Y A;  1ALK A;  1EW9 A;  3NVL A;  1ZEB A;  2GA3 A;  1AJD A;  1KH5 A;  2W5R A;  4LR8 A;  1URB A;  5LRM A;  1ALI A;  2W5V A;  2X98 A;  1SHN A;  1KHJ A;  4GTY A;  2GSN A;  1EW2 A;  5HRT A;  3A52 A;  3MK2 A;  1E2S P;  4ZG6 A;  4LRD A;  3NKP A;  1HDH A;  3NKR A;  4GTZ A;  3MK1 A;  4KJD A;  5GOV A;  1ZED A;  4YR1 A;  4CXS A;  3UNY A;  3WAW A;  4B56 A;  1ED8 A;  4KAY A;  1ALH A;  3BDF A;  4NWJ A;  3SZZ A;  4KAV A;  4LRF A;  2W5S A;  1SHQ A;  5IJS A;  2W5W A;  3NKQ A;  2QZU A;  2ANH A;  3NKM A;  1P49 A;  4ZGA A;  5C66 A;  4LR7 A;  1ELZ A;  1Y7A A;  1ANJ A;  1E1Z P;  4LRB A;  5LRN A;  1E3C P;  1KH9 A;  3M8W A;  4UOR A;  3LXQ A;  2W8D A;  3WAV A;  2W8S A;  1HQA A;  3ED4 A;  1EJJ A;  3TWZ A;  3TG0 A;  2W5X A;  1AJA A;  2GSU A;  3T02 A;  4LR9 A;  4UPL A;  4UPI A;  1AJB A;  1KH4 A;  5LQQ A;  4KM4 A;  5K4P A;  5L0K A;  2IUC B;  4LR2 A;  5AJ9 A;  4TN0 A;  5DLW A;  4GTW A;  1ED9 A;  3UN5 A;  3WAX A;  5LIA A;  1ZEF A;  3BDG A;  4FDI A;  1EW8 A;  1N2L A;  2IUC A;  4LRE A;  4N7T A;  1KH7 A;  2XRG A;  3IDD A;  3NKO A;  3BDH A;  3MK0 A;  3WAY A;  3CMR A;  4QAX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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