3MOPG

The ternary death domain complex of myd88, irak4, and irak2
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
107
structure length
107
Chain Sequence
MGPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPLE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.
pubmed doi rcsb
molecule tags Signaling protein, immune system
source organism Homo sapiens
molecule keywords Myeloid differentiation primary response protein MyD88
total genus 27
structure length 107
sequence length 107
chains with identical sequence H, I, J
ec nomenclature ec 2.7.11.1: Non-specific serine/threonine protein kinase.
pdb deposition date 2010-04-23
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 3mopG00
1A1WA 2IB1A 2B1WA 4N1JA 2LWEA 1E41A 4E9MA 2NAQA 4F42A 4P4HA 2L9MA 2YQFA 2A5YB 2DBDA 4IZAB 3YGSC 4IZ5E 2N7ZA 4NQKA 1CY5A 4F44A 3T6PA 2F1SA 1PN5A 3LQQA 2KM6A 1FADA 3YGSP 4ZBWA 2OF5A 2YGSA 2P1HA 2MPCA 1E3YA 2N97A 2LWDA 2N83A 4I16A 1A1ZA 1YGOA 3J63A 1WH4A 2O71A 2MN4A 2YVIA 2BBZA 2OF5H 4P4HI 1N3KA 1D2ZB 1Z6TA 2MB9A 2M5VA 2YU0A 2KN6A 2N1FA 1WMGA 2D96A 1DGNA 4EWIA 2A9IA 2HM2Q 3J6JA 2DO9A 4DWNA 2MS7A 3CRDA 2MS8A 3QF2A 4M9XA 1UCPA 2G7RA 4N1KA 2DBGA 2BBRA 2DBFA 1WXPA 2NSNA 4O6XA 1ICHA 1D2ZA 4M9ZA 3MOPG 2GF5A 4UZ0A 4A2WA 2L6AA 3KATA 4D8OA 4JUPA 2DBHA 2NZ7A 4M9SA 3MOPA 1CWWA 4O9LA 1C15A 3EZQB 4A2QA 4RHWE 1NGRA 4RHWA 1DDFA 3CL3A 4FH0A 2N80A 4LWDA 4IZ7B 3MOPK 4O9FA 4N1LA 4JQWA 3LQRA 2VGQA 4QOBA 2LS7A 4O7QA 3EZQA 2N00A
chains in the Genus database with same CATH superfamily
1A1WA 2IB1A 2B1WA 4N1JA 2LWEA 1E41A 4E9MA 2NAQA 4F42A 4P4HA 2L9MA 2YQFA 2A5YB 2DBDA 4IZAB 3YGSC 4IZ5E 2N7ZA 4NQKA 1CY5A 4F44A 3T6PA 2F1SA 2XV9A 1PN5A 3LQQA 2KM6A 1FADA 3YGSP 4ZBWA 2OF5A 2YGSA 2P1HA 2MPCA 1E3YA 2N97A 2LWDA 2N83A 4I16A 1A1ZA 1YGOA 3J63A 1WH4A 2O71A 2MN4A 2YVIA 2BBZA 2OF5H 4P4HI 1N3KA 1D2ZB 2MJMA 1Z6TA 2MB9A 2M5VA 2YU0A 2KN6A 2N1FA 1WMGA 2D96A 1DGNA 4EWIA 2A9IA 2HM2Q 3J6JA 2DO9A 4DWNA 2MS7A 3CRDA 2MS8A 3QF2A 4M9XA 1UCPA 2G7RA 4N1KA 2DBGA 2BBRA 2DBFA 1WXPA 2NSNA 4O6XA 1ICHA 1D2ZA 4M9ZA 3MOPG 2GF5A 4UZ0A 4A2WA 2L6AA 3KATA 4D8OA 4JUPA 2DBHA 2NZ7A 4M9SA 3MOPA 1CWWA 4O9LA 1C15A 3EZQB 4A2QA 4RHWE 1NGRA 4RHWA 1DDFA 3CL3A 4FH0A 2N80A 4LWDA 4IZ7B 3MOPK 4O9FA 4N1LA 4JQWA 3LQRA 2VGQA 4QOBA 2LS7A 4O7QA 3EZQA 2N00A
chains in the Genus database with same CATH topology
1A1WA 2IB1A 2B1WA 4N1JA 2LWEA 1E41A 4E9MA 2NAQA 4F42A 4P4HA 2L9MA 2YQFA 2A5YB 2DBDA 4IZAB 3YGSC 4IZ5E 2N7ZA 4NQKA 1CY5A 4F44A 3T6PA 2F1SA 2XV9A 1PN5A 3LQQA 2KM6A 1FADA 3YGSP 4ZBWA 2OF5A 2YGSA 2P1HA 2MPCA 1E3YA 2N97A 2LWDA 2N83A 4I16A 1A1ZA 1YGOA 3J63A 1WH4A 2O71A 2MN4A 2YVIA 2BBZA 2OF5H 4P4HI 1N3KA 1D2ZB 2MJMA 1Z6TA 2MB9A 2M5VA 2YU0A 2KN6A 2N1FA 1WMGA 2D96A 1DGNA 4EWIA 2A9IA 2HM2Q 3J6JA 2DO9A 4DWNA 2MS7A 3CRDA 2MS8A 3QF2A 4M9XA 1UCPA 2G7RA 4N1KA 2DBGA 2BBRA 2DBFA 1WXPA 2NSNA 4O6XA 1ICHA 1D2ZA 4M9ZA 3MOPG 2GF5A 4UZ0A 4A2WA 2L6AA 3KATA 4D8OA 4JUPA 2DBHA 2NZ7A 4M9SA 3MOPA 1CWWA 4O9LA 1C15A 3EZQB 4A2QA 4RHWE 1NGRA 4RHWA 1DDFA 3CL3A 4FH0A 2N80A 4LWDA 4IZ7B 3MOPK 4O9FA 4N1LA 4JQWA 3LQRA 2VGQA 4QOBA 2LS7A 4O7QA 3EZQA 2N00A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1A1W A;  2IB1 A;  2B1W A;  4N1J A;  2LWE A;  1E41 A;  4E9M A;  2NAQ A;  4F42 A;  4P4H A;  2L9M A;  2YQF A;  2A5Y B;  2DBD A;  4IZA B;  3YGS C;  4IZ5 E;  2N7Z A;  4NQK A;  1CY5 A;  4F44 A;  3T6P A;  2F1S A;  1PN5 A;  3LQQ A;  2KM6 A;  1FAD A;  3YGS P;  4ZBW A;  2OF5 A;  2YGS A;  2P1H A;  2MPC A;  1E3Y A;  2N97 A;  2LWD A;  2N83 A;  4I16 A;  1A1Z A;  1YGO A;  3J63 A;  1WH4 A;  2O71 A;  2MN4 A;  2YVI A;  2BBZ A;  2OF5 H;  4P4H I;  1N3K A;  1D2Z B;  1Z6T A;  2MB9 A;  2M5V A;  2YU0 A;  2KN6 A;  2N1F A;  1WMG A;  2D96 A;  1DGN A;  4EWI A;  2A9I A;  2HM2 Q;  3J6J A;  2DO9 A;  4DWN A;  2MS7 A;  3CRD A;  2MS8 A;  3QF2 A;  4M9X A;  1UCP A;  2G7R A;  4N1K A;  2DBG A;  2BBR A;  2DBF A;  1WXP A;  2NSN A;  4O6X A;  1ICH A;  1D2Z A;  4M9Z A;  3MOP G;  2GF5 A;  4UZ0 A;  4A2W A;  2L6A A;  3KAT A;  4D8O A;  4JUP A;  2DBH A;  2NZ7 A;  4M9S A;  3MOP A;  1CWW A;  4O9L A;  1C15 A;  3EZQ B;  4A2Q A;  4RHW E;  1NGR A;  4RHW A;  1DDF A;  3CL3 A;  4FH0 A;  2N80 A;  4LWD A;  4IZ7 B;  3MOP K;  4O9F A;  4N1L A;  4JQW A;  3LQR A;  2VGQ A;  4QOB A;  2LS7 A;  4O7Q A;  3EZQ A;  2N00 A; 
#chains in the Genus database with same CATH topology
 1A1W A;  2IB1 A;  2B1W A;  4N1J A;  2LWE A;  1E41 A;  4E9M A;  2NAQ A;  4F42 A;  4P4H A;  2L9M A;  2YQF A;  2A5Y B;  2DBD A;  4IZA B;  3YGS C;  4IZ5 E;  2N7Z A;  4NQK A;  1CY5 A;  4F44 A;  3T6P A;  2F1S A;  2XV9 A;  1PN5 A;  3LQQ A;  2KM6 A;  1FAD A;  3YGS P;  4ZBW A;  2OF5 A;  2YGS A;  2P1H A;  2MPC A;  1E3Y A;  2N97 A;  2LWD A;  2N83 A;  4I16 A;  1A1Z A;  1YGO A;  3J63 A;  1WH4 A;  2O71 A;  2MN4 A;  2YVI A;  2BBZ A;  2OF5 H;  4P4H I;  1N3K A;  1D2Z B;  2MJM A;  1Z6T A;  2MB9 A;  2M5V A;  2YU0 A;  2KN6 A;  2N1F A;  1WMG A;  2D96 A;  1DGN A;  4EWI A;  2A9I A;  2HM2 Q;  3J6J A;  2DO9 A;  4DWN A;  2MS7 A;  3CRD A;  2MS8 A;  3QF2 A;  4M9X A;  1UCP A;  2G7R A;  4N1K A;  2DBG A;  2BBR A;  2DBF A;  1WXP A;  2NSN A;  4O6X A;  1ICH A;  1D2Z A;  4M9Z A;  3MOP G;  2GF5 A;  4UZ0 A;  4A2W A;  2L6A A;  3KAT A;  4D8O A;  4JUP A;  2DBH A;  2NZ7 A;  4M9S A;  3MOP A;  1CWW A;  4O9L A;  1C15 A;  3EZQ B;  4A2Q A;  4RHW E;  1NGR A;  4RHW A;  1DDF A;  3CL3 A;  4FH0 A;  2N80 A;  4LWD A;  4IZ7 B;  3MOP K;  4O9F A;  4N1L A;  4JQW A;  3LQR A;  2VGQ A;  4QOB A;  2LS7 A;  4O7Q A;  3EZQ A;  2N00 A; 
#chains in the Genus database with same CATH homology
 1A1W A;  2IB1 A;  2B1W A;  4N1J A;  2LWE A;  1E41 A;  4E9M A;  2NAQ A;  4F42 A;  4P4H A;  2L9M A;  2YQF A;  2A5Y B;  2DBD A;  4IZA B;  3YGS C;  4IZ5 E;  2N7Z A;  4NQK A;  1CY5 A;  4F44 A;  3T6P A;  2F1S A;  2XV9 A;  1PN5 A;  3LQQ A;  2KM6 A;  1FAD A;  3YGS P;  4ZBW A;  2OF5 A;  2YGS A;  2P1H A;  2MPC A;  1E3Y A;  2N97 A;  2LWD A;  2N83 A;  4I16 A;  1A1Z A;  1YGO A;  3J63 A;  1WH4 A;  2O71 A;  2MN4 A;  2YVI A;  2BBZ A;  2OF5 H;  4P4H I;  1N3K A;  1D2Z B;  2MJM A;  1Z6T A;  2MB9 A;  2M5V A;  2YU0 A;  2KN6 A;  2N1F A;  1WMG A;  2D96 A;  1DGN A;  4EWI A;  2A9I A;  2HM2 Q;  3J6J A;  2DO9 A;  4DWN A;  2MS7 A;  3CRD A;  2MS8 A;  3QF2 A;  4M9X A;  1UCP A;  2G7R A;  4N1K A;  2DBG A;  2BBR A;  2DBF A;  1WXP A;  2NSN A;  4O6X A;  1ICH A;  1D2Z A;  4M9Z A;  3MOP G;  2GF5 A;  4UZ0 A;  4A2W A;  2L6A A;  3KAT A;  4D8O A;  4JUP A;  2DBH A;  2NZ7 A;  4M9S A;  3MOP A;  1CWW A;  4O9L A;  1C15 A;  3EZQ B;  4A2Q A;  4RHW E;  1NGR A;  4RHW A;  1DDF A;  3CL3 A;  4FH0 A;  2N80 A;  4LWD A;  4IZ7 B;  3MOP K;  4O9F A;  4N1L A;  4JQW A;  3LQR A;  2VGQ A;  4QOB A;  2LS7 A;  4O7Q A;  3EZQ A;  2N00 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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