3MR1A

Crystal structure of methionine aminopeptidase from rickettsia prowazekii
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
249
structure length
249
Chain Sequence
SMIKIHTEKDFIKMRAAGKLAAETLDFITDHVKPNVTTNSLNDLCHNFITSHNAIPAPLNYKGFPKSICTSINHVVCHGIPNDKPLKNGDIVNIDVTVILDGWYGDTSRMYYVGDVAIKPKRLIQVTYDAMMKGIEVVRPGAKLGDIGYAIQSYAEKHNYSVVRDYTGHGIGRVFHDKPSILNYGRNGTGLTLKEGMFFTVEPMINAGNYDTILSKLDGWTVTTRDKSLSAQFEHTIGVTKDGFEIFTL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.
pubmed doi rcsb
molecule tags Hydrolase
source organism Rickettsia prowazekii
molecule keywords Methionine aminopeptidase
total genus 79
structure length 249
sequence length 249
chains with identical sequence B, C, D
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2010-04-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 3mr1A00
4RGZ1 3MATA 4U70A 2GGBA 4U76A 3IU8A 2Q8KA 2DFIA 2B3HA 5JHUA 5CNXA 4U6EA 4Z7MA 2EVMA 3D27A 3PKAA 1B6AA 2IW2A 2BWXA 4S2TP 3MR1A 4PNCA 4ZWPA 3PKEA 2GG7A 4IDYA 1C27A 2NQ6A 2GU4A 3CB5A 2GU6A 3FMRA 4U6ZA 5D6EA 2BWTA 1XGMA 1C21A 2GGCA 2HOWA 3IU9A 3MX6A 2BHBA 4A6WA 2EVCA 2Q92A 4S2RP 1WLRA 1O0XA 1KQ9A 1W2MA 3BITA 4FO8A 2B3KA 4IKSA 5CDVA 3S6BA 1WL9A 1WL6A 4U71A 1QXZA 2BN7A 5E5BA 4HXXA 2BWWA 1BOAA 1QXYA 2G6PA 4FO7A 4FLLA 3TB5A 4PV4A 3FMQA 4IPAA 1M35A 2P9AA 5D6FA 1B59A 4FUKA 4U73A 4QR8A 2BHDA 1KQ0A 1QXWA 1YJ3A 2Q94A 4IECA 4ZNGA 4IKRA 2MATA 4FKCA 4MATA 2OKNA 5CLSA 1BN5A 1C23A 2BWSA 3L7GA 4FLIA 2ZSGA 4IKTA 4U1BA 4U6CA 4EGEA 2GA2A 2BHCA 2P99A 2ADUA 1A16A 2BH3A 1MATA 2GG5A 1YW9A 2B3LA 1C22A 4RZYA 1C24A 2BB7A 2GG3A 4S01A 1WN1A 4RZZA 2Q96A 2EA2A 2V3YA 2Q95A 1YVMA 3IU7A 4ZWOA 3RORA 5CDEA 4U6JA 3CB6A 4A6VA 5JFRA 2V3ZA 5FCHA 4JUQA 2NQ7A 2GG8A 3IG4A 3L24A 4B28A 5JI6A 3BIQA 4U6WA 2BWVA 1KP0A 3PKDA 5CDLA 5CIKA 2GG0A 4U69A 2Q93A 1PV9A 2EVOA 2GG2A 1YW8A 1Y1NA 3BIPA 4FLKA 2V3XA 3CTZA 1WKMA 2OAZA 2EA4A 1WBQA 3TAVA 3RVAA 1W7VA 2GU5A 3FM3A 1CHMA 4ZWUA 5FCFA 4IU6A 2P98A 1XGSA 1WY2A 1YW7A 3Q6DA 4IF7A 1N51A 2BHAA 1R5GA 4KM3A 3PKCA 4S00A 4U75A 2BWYA 2V6CA 1R58A 3PKBA 1QZYA 2GU7A 1XNZA 2GG9A 4OOKA 4R60A 1XGOA 4IKUA 5CE6A 2GTXA 1R5HA 4FLJA 2GZ5A 1JAWA 2BWUA 1XGNA
chains in the Genus database with same CATH superfamily
4RGZ1 3MATA 4U70A 2GGBA 4U76A 3IU8A 2Q8KA 2DFIA 2B3HA 5JHUA 5CNXA 4U6EA 4Z7MA 2EVMA 3D27A 3PKAA 1B6AA 2IW2A 2BWXA 4S2TP 3MR1A 4PNCA 4ZWPA 3PKEA 2GG7A 4IDYA 1C27A 2NQ6A 2GU4A 3CB5A 2GU6A 3FMRA 4U6ZA 5D6EA 2BWTA 1XGMA 1C21A 2GGCA 2HOWA 3IU9A 3MX6A 2BHBA 4A6WA 2EVCA 2Q92A 4S2RP 1WLRA 1O0XA 1KQ9A 1W2MA 3BITA 4FO8A 2B3KA 4IKSA 5CDVA 3S6BA 1WL9A 1WL6A 4U71A 1QXZA 2BN7A 5E5BA 4HXXA 2BWWA 1BOAA 1QXYA 2G6PA 4FO7A 4FLLA 3TB5A 4PV4A 3FMQA 4IPAA 1M35A 2P9AA 5D6FA 1B59A 4FUKA 4U73A 4QR8A 2BHDA 1KQ0A 1QXWA 1YJ3A 2Q94A 4IECA 4ZNGA 4IKRA 2MATA 4FKCA 4MATA 2OKNA 5CLSA 1BN5A 1C23A 2BWSA 3L7GA 4FLIA 2ZSGA 4IKTA 4U1BA 4U6CA 4EGEA 2GA2A 2BHCA 2P99A 2ADUA 1A16A 2BH3A 1MATA 2GG5A 1YW9A 2B3LA 1C22A 4RZYA 1C24A 2BB7A 2GG3A 4S01A 1WN1A 4RZZA 2Q96A 2EA2A 2V3YA 2Q95A 1YVMA 3IU7A 4ZWOA 3RORA 5CDEA 4U6JA 3CB6A 4A6VA 5JFRA 2V3ZA 5FCHA 4JUQA 2NQ7A 2GG8A 3IG4A 3L24A 4B28A 5JI6A 3BIQA 4U6WA 2BWVA 1KP0A 3PKDA 5CDLA 5CIKA 2GG0A 4U69A 2Q93A 1PV9A 2EVOA 2GG2A 1YW8A 1Y1NA 3BIPA 4FLKA 2V3XA 3CTZA 1WKMA 2OAZA 2EA4A 1WBQA 3TAVA 3RVAA 1W7VA 2GU5A 3FM3A 1CHMA 4ZWUA 5FCFA 4IU6A 2P98A 1XGSA 1WY2A 1YW7A 3Q6DA 4IF7A 1N51A 2BHAA 1R5GA 4KM3A 3PKCA 4S00A 4U75A 2BWYA 2V6CA 1R58A 3PKBA 1QZYA 2GU7A 1XNZA 2GG9A 4OOKA 4R60A 1XGOA 4IKUA 5CE6A 2GTXA 1R5HA 4FLJA 2GZ5A 1JAWA 2BWUA 1XGNA
chains in the Genus database with same CATH topology
4RGZ1 3MATA 4U70A 2GGBA 4U76A 3IU8A 2Q8KA 2DFIA 2B3HA 5JHUA 5CNXA 4U6EA 4Z7MA 2EVMA 3D27A 3PKAA 1B6AA 2IW2A 2BWXA 4S2TP 3MR1A 4PNCA 4ZWPA 3PKEA 2GG7A 4IDYA 1C27A 2NQ6A 2GU4A 3CB5A 2GU6A 3FMRA 4U6ZA 5D6EA 2BWTA 1XGMA 1C21A 2GGCA 2HOWA 3IU9A 3MX6A 2BHBA 4A6WA 2EVCA 2Q92A 4S2RP 1WLRA 1O0XA 1KQ9A 1W2MA 3BITA 4FO8A 2B3KA 4IKSA 5CDVA 3S6BA 1WL9A 1WL6A 4U71A 1QXZA 2BN7A 5E5BA 4HXXA 2BWWA 1BOAA 1QXYA 2G6PA 4FO7A 4FLLA 3TB5A 4PV4A 3FMQA 4IPAA 1M35A 2P9AA 5D6FA 1B59A 4FUKA 4U73A 4QR8A 2BHDA 1KQ0A 1QXWA 1YJ3A 2Q94A 4IECA 4ZNGA 4IKRA 2MATA 4FKCA 4MATA 2OKNA 5CLSA 1BN5A 1C23A 2BWSA 3L7GA 4FLIA 2ZSGA 4IKTA 4U1BA 4U6CA 4EGEA 2GA2A 2BHCA 2P99A 2ADUA 1A16A 2BH3A 1MATA 2GG5A 1YW9A 2B3LA 1C22A 4RZYA 1C24A 2BB7A 2GG3A 4S01A 1WN1A 4RZZA 2Q96A 2EA2A 2V3YA 2Q95A 1YVMA 3IU7A 4ZWOA 3RORA 5CDEA 4U6JA 3CB6A 4A6VA 5JFRA 2V3ZA 5FCHA 4JUQA 2NQ7A 2GG8A 3IG4A 3L24A 4B28A 5JI6A 3BIQA 4U6WA 2BWVA 1KP0A 3PKDA 5CDLA 5CIKA 2GG0A 4U69A 2Q93A 1PV9A 2EVOA 2GG2A 1YW8A 1Y1NA 3BIPA 4FLKA 2V3XA 3CTZA 1WKMA 2OAZA 2EA4A 1WBQA 3TAVA 3RVAA 1W7VA 2GU5A 3FM3A 1CHMA 4ZWUA 5FCFA 4IU6A 2P98A 1XGSA 1WY2A 1YW7A 3Q6DA 4IF7A 1N51A 2BHAA 1R5GA 4KM3A 3PKCA 4S00A 4U75A 2BWYA 2V6CA 1R58A 3PKBA 1QZYA 2GU7A 1XNZA 2GG9A 4OOKA 4R60A 1XGOA 4IKUA 5CE6A 2GTXA 1R5HA 4FLJA 2GZ5A 1JAWA 2BWUA 1XGNA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4RGZ 1;  3MAT A;  4U70 A;  2GGB A;  4U76 A;  3IU8 A;  2Q8K A;  2DFI A;  2B3H A;  5JHU A;  5CNX A;  4U6E A;  4Z7M A;  2EVM A;  3D27 A;  3PKA A;  1B6A A;  2IW2 A;  2BWX A;  4S2T P;  3MR1 A;  4PNC A;  4ZWP A;  3PKE A;  2GG7 A;  4IDY A;  1C27 A;  2NQ6 A;  2GU4 A;  3CB5 A;  2GU6 A;  3FMR A;  4U6Z A;  5D6E A;  2BWT A;  1XGM A;  1C21 A;  2GGC A;  2HOW A;  3IU9 A;  3MX6 A;  2BHB A;  4A6W A;  2EVC A;  2Q92 A;  4S2R P;  1WLR A;  1O0X A;  1KQ9 A;  1W2M A;  3BIT A;  4FO8 A;  2B3K A;  4IKS A;  5CDV A;  3S6B A;  1WL9 A;  1WL6 A;  4U71 A;  1QXZ A;  2BN7 A;  5E5B A;  4HXX A;  2BWW A;  1BOA A;  1QXY A;  2G6P A;  4FO7 A;  4FLL A;  3TB5 A;  4PV4 A;  3FMQ A;  4IPA A;  1M35 A;  2P9A A;  5D6F A;  1B59 A;  4FUK A;  4U73 A;  4QR8 A;  2BHD A;  1KQ0 A;  1QXW A;  1YJ3 A;  2Q94 A;  4IEC A;  4ZNG A;  4IKR A;  2MAT A;  4FKC A;  4MAT A;  2OKN A;  5CLS A;  1BN5 A;  1C23 A;  2BWS A;  3L7G A;  4FLI A;  2ZSG A;  4IKT A;  4U1B A;  4U6C A;  4EGE A;  2GA2 A;  2BHC A;  2P99 A;  2ADU A;  1A16 A;  2BH3 A;  1MAT A;  2GG5 A;  1YW9 A;  2B3L A;  1C22 A;  4RZY A;  1C24 A;  2BB7 A;  2GG3 A;  4S01 A;  1WN1 A;  4RZZ A;  2Q96 A;  2EA2 A;  2V3Y A;  2Q95 A;  1YVM A;  3IU7 A;  4ZWO A;  3ROR A;  5CDE A;  4U6J A;  3CB6 A;  4A6V A;  5JFR A;  2V3Z A;  5FCH A;  4JUQ A;  2NQ7 A;  2GG8 A;  3IG4 A;  3L24 A;  4B28 A;  5JI6 A;  3BIQ A;  4U6W A;  2BWV A;  1KP0 A;  3PKD A;  5CDL A;  5CIK A;  2GG0 A;  4U69 A;  2Q93 A;  1PV9 A;  2EVO A;  2GG2 A;  1YW8 A;  1Y1N A;  3BIP A;  4FLK A;  2V3X A;  3CTZ A;  1WKM A;  2OAZ A;  2EA4 A;  1WBQ A;  3TAV A;  3RVA A;  1W7V A;  2GU5 A;  3FM3 A;  1CHM A;  4ZWU A;  5FCF A;  4IU6 A;  2P98 A;  1XGS A;  1WY2 A;  1YW7 A;  3Q6D A;  4IF7 A;  1N51 A;  2BHA A;  1R5G A;  4KM3 A;  3PKC A;  4S00 A;  4U75 A;  2BWY A;  2V6C A;  1R58 A;  3PKB A;  1QZY A;  2GU7 A;  1XNZ A;  2GG9 A;  4OOK A;  4R60 A;  1XGO A;  4IKU A;  5CE6 A;  2GTX A;  1R5H A;  4FLJ A;  2GZ5 A;  1JAW A;  2BWU A;  1XGN A; 
#chains in the Genus database with same CATH topology
 4RGZ 1;  3MAT A;  4U70 A;  2GGB A;  4U76 A;  3IU8 A;  2Q8K A;  2DFI A;  2B3H A;  5JHU A;  5CNX A;  4U6E A;  4Z7M A;  2EVM A;  3D27 A;  3PKA A;  1B6A A;  2IW2 A;  2BWX A;  4S2T P;  3MR1 A;  4PNC A;  4ZWP A;  3PKE A;  2GG7 A;  4IDY A;  1C27 A;  2NQ6 A;  2GU4 A;  3CB5 A;  2GU6 A;  3FMR A;  4U6Z A;  5D6E A;  2BWT A;  1XGM A;  1C21 A;  2GGC A;  2HOW A;  3IU9 A;  3MX6 A;  2BHB A;  4A6W A;  2EVC A;  2Q92 A;  4S2R P;  1WLR A;  1O0X A;  1KQ9 A;  1W2M A;  3BIT A;  4FO8 A;  2B3K A;  4IKS A;  5CDV A;  3S6B A;  1WL9 A;  1WL6 A;  4U71 A;  1QXZ A;  2BN7 A;  5E5B A;  4HXX A;  2BWW A;  1BOA A;  1QXY A;  2G6P A;  4FO7 A;  4FLL A;  3TB5 A;  4PV4 A;  3FMQ A;  4IPA A;  1M35 A;  2P9A A;  5D6F A;  1B59 A;  4FUK A;  4U73 A;  4QR8 A;  2BHD A;  1KQ0 A;  1QXW A;  1YJ3 A;  2Q94 A;  4IEC A;  4ZNG A;  4IKR A;  2MAT A;  4FKC A;  4MAT A;  2OKN A;  5CLS A;  1BN5 A;  1C23 A;  2BWS A;  3L7G A;  4FLI A;  2ZSG A;  4IKT A;  4U1B A;  4U6C A;  4EGE A;  2GA2 A;  2BHC A;  2P99 A;  2ADU A;  1A16 A;  2BH3 A;  1MAT A;  2GG5 A;  1YW9 A;  2B3L A;  1C22 A;  4RZY A;  1C24 A;  2BB7 A;  2GG3 A;  4S01 A;  1WN1 A;  4RZZ A;  2Q96 A;  2EA2 A;  2V3Y A;  2Q95 A;  1YVM A;  3IU7 A;  4ZWO A;  3ROR A;  5CDE A;  4U6J A;  3CB6 A;  4A6V A;  5JFR A;  2V3Z A;  5FCH A;  4JUQ A;  2NQ7 A;  2GG8 A;  3IG4 A;  3L24 A;  4B28 A;  5JI6 A;  3BIQ A;  4U6W A;  2BWV A;  1KP0 A;  3PKD A;  5CDL A;  5CIK A;  2GG0 A;  4U69 A;  2Q93 A;  1PV9 A;  2EVO A;  2GG2 A;  1YW8 A;  1Y1N A;  3BIP A;  4FLK A;  2V3X A;  3CTZ A;  1WKM A;  2OAZ A;  2EA4 A;  1WBQ A;  3TAV A;  3RVA A;  1W7V A;  2GU5 A;  3FM3 A;  1CHM A;  4ZWU A;  5FCF A;  4IU6 A;  2P98 A;  1XGS A;  1WY2 A;  1YW7 A;  3Q6D A;  4IF7 A;  1N51 A;  2BHA A;  1R5G A;  4KM3 A;  3PKC A;  4S00 A;  4U75 A;  2BWY A;  2V6C A;  1R58 A;  3PKB A;  1QZY A;  2GU7 A;  1XNZ A;  2GG9 A;  4OOK A;  4R60 A;  1XGO A;  4IKU A;  5CE6 A;  2GTX A;  1R5H A;  4FLJ A;  2GZ5 A;  1JAW A;  2BWU A;  1XGN A; 
#chains in the Genus database with same CATH homology
 4RGZ 1;  3MAT A;  4U70 A;  2GGB A;  4U76 A;  3IU8 A;  2Q8K A;  2DFI A;  2B3H A;  5JHU A;  5CNX A;  4U6E A;  4Z7M A;  2EVM A;  3D27 A;  3PKA A;  1B6A A;  2IW2 A;  2BWX A;  4S2T P;  3MR1 A;  4PNC A;  4ZWP A;  3PKE A;  2GG7 A;  4IDY A;  1C27 A;  2NQ6 A;  2GU4 A;  3CB5 A;  2GU6 A;  3FMR A;  4U6Z A;  5D6E A;  2BWT A;  1XGM A;  1C21 A;  2GGC A;  2HOW A;  3IU9 A;  3MX6 A;  2BHB A;  4A6W A;  2EVC A;  2Q92 A;  4S2R P;  1WLR A;  1O0X A;  1KQ9 A;  1W2M A;  3BIT A;  4FO8 A;  2B3K A;  4IKS A;  5CDV A;  3S6B A;  1WL9 A;  1WL6 A;  4U71 A;  1QXZ A;  2BN7 A;  5E5B A;  4HXX A;  2BWW A;  1BOA A;  1QXY A;  2G6P A;  4FO7 A;  4FLL A;  3TB5 A;  4PV4 A;  3FMQ A;  4IPA A;  1M35 A;  2P9A A;  5D6F A;  1B59 A;  4FUK A;  4U73 A;  4QR8 A;  2BHD A;  1KQ0 A;  1QXW A;  1YJ3 A;  2Q94 A;  4IEC A;  4ZNG A;  4IKR A;  2MAT A;  4FKC A;  4MAT A;  2OKN A;  5CLS A;  1BN5 A;  1C23 A;  2BWS A;  3L7G A;  4FLI A;  2ZSG A;  4IKT A;  4U1B A;  4U6C A;  4EGE A;  2GA2 A;  2BHC A;  2P99 A;  2ADU A;  1A16 A;  2BH3 A;  1MAT A;  2GG5 A;  1YW9 A;  2B3L A;  1C22 A;  4RZY A;  1C24 A;  2BB7 A;  2GG3 A;  4S01 A;  1WN1 A;  4RZZ A;  2Q96 A;  2EA2 A;  2V3Y A;  2Q95 A;  1YVM A;  3IU7 A;  4ZWO A;  3ROR A;  5CDE A;  4U6J A;  3CB6 A;  4A6V A;  5JFR A;  2V3Z A;  5FCH A;  4JUQ A;  2NQ7 A;  2GG8 A;  3IG4 A;  3L24 A;  4B28 A;  5JI6 A;  3BIQ A;  4U6W A;  2BWV A;  1KP0 A;  3PKD A;  5CDL A;  5CIK A;  2GG0 A;  4U69 A;  2Q93 A;  1PV9 A;  2EVO A;  2GG2 A;  1YW8 A;  1Y1N A;  3BIP A;  4FLK A;  2V3X A;  3CTZ A;  1WKM A;  2OAZ A;  2EA4 A;  1WBQ A;  3TAV A;  3RVA A;  1W7V A;  2GU5 A;  3FM3 A;  1CHM A;  4ZWU A;  5FCF A;  4IU6 A;  2P98 A;  1XGS A;  1WY2 A;  1YW7 A;  3Q6D A;  4IF7 A;  1N51 A;  2BHA A;  1R5G A;  4KM3 A;  3PKC A;  4S00 A;  4U75 A;  2BWY A;  2V6C A;  1R58 A;  3PKB A;  1QZY A;  2GU7 A;  1XNZ A;  2GG9 A;  4OOK A;  4R60 A;  1XGO A;  4IKU A;  5CE6 A;  2GTX A;  1R5H A;  4FLJ A;  2GZ5 A;  1JAW A;  2BWU A;  1XGN A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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