3MX6A

Crystal structure of methionine aminopeptidase from rickettsia prowazekii bound to methionine
Total Genus 80
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
80
sequence length
257
structure length
257
Chain Sequence
IKIHTEKDFIKMRAAGKLAAETLDFITDHVKPNVTTNSLNDLCHNFITSHNAIPAPLNYKGFPKSICTSINHVVCHGIPNDKPLKNGDIVNIDVTVILDGWYGDTSRMYYVGDVAIKPKRLIQVTYDAMMKGIEVVRPGAKLGDIGYAIQSYAEKHNYSVVRDYTGHGIGRVFHDKPSILNYGRNGTGLTLKEGMFFTVEPMINAGNYDTILSKLDGWTVTTRDKSLSAQFEHTIGVTKDGFEIFTLSPKKLDYPPY
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
molecule tags Hydrolase
source organism Rickettsia prowazekii
total genus 80
structure length 257
sequence length 257
chains with identical sequence B
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2010-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 3mx6A00
1QXYA 5CE6A 3TAVA 2BHAA 4IKRA 1C22A 1M35A 3BIQA 1WL9A 1N51A 2Q95A 4S01A 1KQ0A 5CDEA 1WN1A 4U6ZA 1O0XA 2GZ5A 1KQ9A 2EVOA 2Q93A 4IDYA 2Q8KA 1C24A 2Q92A 3IU8A 1R5GA 1CHMA 4U6CA 2BWSA 2HOWA 2GG3A 3MX6A 2NQ6A 3PKBA 1R5HA 2B3LA 4A6WA 2BWWA 2GG9A 4Z7MA 1A16A 2V3XA 2EVMA 2GG0A 5JHUA 4RZZA 4A6VA 2P9AA 4U71A 3IU9A 3CB5A 4IU6A 2BHBA 4PNCA 4U6EA 1BN5A 2V3YA 3FMRA 2EA4A 1JAWA 4ZWOA 4MATA 1QXZA 3MATA 1BOAA 1WLRA 1XNZA 4U6WA 5D6FA 2GTXA 2OAZA 4S2TP 1YJ3A 4JUQA 4KM3A 1WY2A 2GG7A 2BHDA 3Q6DA 3L24A 1XGNA 2GU5A 1WL6A 2BWVA 2GG8A 1MATA 1XGSA 3FMQA 4S00A 4U1BA 3CB6A 2BWUA 2G6PA 3IG4A 3FM3A 2B3HA 3IU7A 4R60A 1W7VA 5FCFA 1C21A 4U73A 2GG2A 1YVMA 2BWTA 4ZWPA 3RVAA 2OKNA 5CLSA 1R58A 5D6EA 2P99A 3BITA 4IKSA 2V6CA 3PKAA 3BIPA 5JI6A 1C27A 5CIKA 2V3ZA 1PV9A 3RORA 2GU4A 3MR1A 4IECA 4FO7A 4U70A 2DFIA 1C23A 2Q96A 5E5BA 1XGOA 4FKCA 3D27A 3L7GA 2BB7A 1WBQA 1B6AA 2EVCA 1YW8A 4OOKA 3PKDA 2GGBA 1QXWA 1YW9A 4U69A 4IKTA 1XGMA 5FCHA 4FUKA 4HXXA 3S6BA 2BHCA 2BWXA 2GA2A 4IPAA 2P98A 3CTZA 1Y1NA 4FLLA 4FO8A 4EGEA 2IW2A 2BH3A 5JFRA 2GG5A 5CDLA 2ADUA 2B3KA 2GU7A 4PV4A 4RZYA 3PKEA 1W2MA 1YW7A 2BN7A 4U76A 4B28A 1KP0A 2MATA 4FLKA 2NQ7A 5CDVA 3PKCA 4ZWUA 1WKMA 2EA2A 2GGCA 4FLJA 1B59A 2GU6A 4U6JA 2BWYA 3TB5A 4IKUA 4U75A 4RGZ1 4S2RP 4QR8A 4ZNGA 4FLIA 5CNXA 1QZYA 2Q94A 2ZSGA 4IF7A
chains in the Genus database with same CATH superfamily
1QXYA 5CE6A 3TAVA 2BHAA 4IKRA 1C22A 1M35A 3BIQA 1WL9A 1N51A 2Q95A 4S01A 1KQ0A 5CDEA 1WN1A 4U6ZA 1O0XA 2GZ5A 1KQ9A 2EVOA 2Q93A 4IDYA 2Q8KA 1C24A 2Q92A 3IU8A 1R5GA 1CHMA 4U6CA 2BWSA 2HOWA 2GG3A 3MX6A 2NQ6A 3PKBA 1R5HA 2B3LA 4A6WA 2BWWA 2GG9A 4Z7MA 1A16A 2V3XA 2EVMA 2GG0A 5JHUA 4RZZA 4A6VA 2P9AA 4U71A 3IU9A 3CB5A 4IU6A 2BHBA 4PNCA 4U6EA 1BN5A 2V3YA 3FMRA 2EA4A 1JAWA 4ZWOA 4MATA 1QXZA 3MATA 1BOAA 1WLRA 1XNZA 4U6WA 5D6FA 2GTXA 2OAZA 4S2TP 1YJ3A 4JUQA 4KM3A 1WY2A 2GG7A 2BHDA 3Q6DA 3L24A 1XGNA 2GU5A 1WL6A 2BWVA 2GG8A 1MATA 1XGSA 3FMQA 4S00A 4U1BA 3CB6A 2BWUA 2G6PA 3IG4A 3FM3A 2B3HA 3IU7A 4R60A 1W7VA 5FCFA 1C21A 4U73A 2GG2A 1YVMA 2BWTA 4ZWPA 3RVAA 2OKNA 5CLSA 1R58A 5D6EA 2P99A 3BITA 4IKSA 2V6CA 3PKAA 3BIPA 5JI6A 1C27A 5CIKA 2V3ZA 1PV9A 3RORA 2GU4A 3MR1A 4IECA 4FO7A 4U70A 2DFIA 1C23A 2Q96A 5E5BA 1XGOA 4FKCA 3D27A 3L7GA 2BB7A 1WBQA 1B6AA 2EVCA 1YW8A 4OOKA 3PKDA 2GGBA 1QXWA 1YW9A 4U69A 4IKTA 1XGMA 5FCHA 4FUKA 4HXXA 3S6BA 2BHCA 2BWXA 2GA2A 4IPAA 2P98A 3CTZA 1Y1NA 4FLLA 4FO8A 4EGEA 2IW2A 2BH3A 5JFRA 2GG5A 5CDLA 2ADUA 2B3KA 2GU7A 4PV4A 4RZYA 3PKEA 1W2MA 1YW7A 2BN7A 4U76A 4B28A 1KP0A 2MATA 4FLKA 2NQ7A 5CDVA 3PKCA 4ZWUA 1WKMA 2EA2A 2GGCA 4FLJA 1B59A 2GU6A 4U6JA 2BWYA 3TB5A 4IKUA 4U75A 4RGZ1 4S2RP 4QR8A 4ZNGA 4FLIA 5CNXA 1QZYA 2Q94A 2ZSGA 4IF7A
chains in the Genus database with same CATH topology
1QXYA 5CE6A 3TAVA 2BHAA 4IKRA 1C22A 1M35A 3BIQA 1WL9A 1N51A 2Q95A 4S01A 1KQ0A 5CDEA 1WN1A 4U6ZA 1O0XA 2GZ5A 1KQ9A 2EVOA 2Q93A 4IDYA 2Q8KA 1C24A 2Q92A 3IU8A 1R5GA 1CHMA 4U6CA 2BWSA 2HOWA 2GG3A 3MX6A 2NQ6A 3PKBA 1R5HA 2B3LA 4A6WA 2BWWA 2GG9A 4Z7MA 1A16A 2V3XA 2EVMA 2GG0A 5JHUA 4RZZA 4A6VA 2P9AA 4U71A 3IU9A 3CB5A 4IU6A 2BHBA 4PNCA 4U6EA 1BN5A 2V3YA 3FMRA 2EA4A 1JAWA 4ZWOA 4MATA 1QXZA 3MATA 1BOAA 1WLRA 1XNZA 4U6WA 5D6FA 2GTXA 2OAZA 4S2TP 1YJ3A 4JUQA 4KM3A 1WY2A 2GG7A 2BHDA 3Q6DA 3L24A 1XGNA 2GU5A 1WL6A 2BWVA 2GG8A 1MATA 1XGSA 3FMQA 4S00A 4U1BA 3CB6A 2BWUA 2G6PA 3IG4A 3FM3A 2B3HA 3IU7A 4R60A 1W7VA 5FCFA 1C21A 4U73A 2GG2A 1YVMA 2BWTA 4ZWPA 3RVAA 2OKNA 5CLSA 1R58A 5D6EA 2P99A 3BITA 4IKSA 2V6CA 3PKAA 3BIPA 5JI6A 1C27A 5CIKA 2V3ZA 1PV9A 3RORA 2GU4A 3MR1A 4IECA 4FO7A 4U70A 2DFIA 1C23A 2Q96A 5E5BA 1XGOA 4FKCA 3D27A 3L7GA 2BB7A 1WBQA 1B6AA 2EVCA 1YW8A 4OOKA 3PKDA 2GGBA 1QXWA 1YW9A 4U69A 4IKTA 1XGMA 5FCHA 4FUKA 4HXXA 3S6BA 2BHCA 2BWXA 2GA2A 4IPAA 2P98A 3CTZA 1Y1NA 4FLLA 4FO8A 4EGEA 2IW2A 2BH3A 5JFRA 2GG5A 5CDLA 2ADUA 2B3KA 2GU7A 4PV4A 4RZYA 3PKEA 1W2MA 1YW7A 2BN7A 4U76A 4B28A 1KP0A 2MATA 4FLKA 2NQ7A 5CDVA 3PKCA 4ZWUA 1WKMA 2EA2A 2GGCA 4FLJA 1B59A 2GU6A 4U6JA 2BWYA 3TB5A 4IKUA 4U75A 4RGZ1 4S2RP 4QR8A 4ZNGA 4FLIA 5CNXA 1QZYA 2Q94A 2ZSGA 4IF7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1QXY A;  5CE6 A;  3TAV A;  2BHA A;  4IKR A;  1C22 A;  1M35 A;  3BIQ A;  1WL9 A;  1N51 A;  2Q95 A;  4S01 A;  1KQ0 A;  5CDE A;  1WN1 A;  4U6Z A;  1O0X A;  2GZ5 A;  1KQ9 A;  2EVO A;  2Q93 A;  4IDY A;  2Q8K A;  1C24 A;  2Q92 A;  3IU8 A;  1R5G A;  1CHM A;  4U6C A;  2BWS A;  2HOW A;  2GG3 A;  3MX6 A;  2NQ6 A;  3PKB A;  1R5H A;  2B3L A;  4A6W A;  2BWW A;  2GG9 A;  4Z7M A;  1A16 A;  2V3X A;  2EVM A;  2GG0 A;  5JHU A;  4RZZ A;  4A6V A;  2P9A A;  4U71 A;  3IU9 A;  3CB5 A;  4IU6 A;  2BHB A;  4PNC A;  4U6E A;  1BN5 A;  2V3Y A;  3FMR A;  2EA4 A;  1JAW A;  4ZWO A;  4MAT A;  1QXZ A;  3MAT A;  1BOA A;  1WLR A;  1XNZ A;  4U6W A;  5D6F A;  2GTX A;  2OAZ A;  4S2T P;  1YJ3 A;  4JUQ A;  4KM3 A;  1WY2 A;  2GG7 A;  2BHD A;  3Q6D A;  3L24 A;  1XGN A;  2GU5 A;  1WL6 A;  2BWV A;  2GG8 A;  1MAT A;  1XGS A;  3FMQ A;  4S00 A;  4U1B A;  3CB6 A;  2BWU A;  2G6P A;  3IG4 A;  3FM3 A;  2B3H A;  3IU7 A;  4R60 A;  1W7V A;  5FCF A;  1C21 A;  4U73 A;  2GG2 A;  1YVM A;  2BWT A;  4ZWP A;  3RVA A;  2OKN A;  5CLS A;  1R58 A;  5D6E A;  2P99 A;  3BIT A;  4IKS A;  2V6C A;  3PKA A;  3BIP A;  5JI6 A;  1C27 A;  5CIK A;  2V3Z A;  1PV9 A;  3ROR A;  2GU4 A;  3MR1 A;  4IEC A;  4FO7 A;  4U70 A;  2DFI A;  1C23 A;  2Q96 A;  5E5B A;  1XGO A;  4FKC A;  3D27 A;  3L7G A;  2BB7 A;  1WBQ A;  1B6A A;  2EVC A;  1YW8 A;  4OOK A;  3PKD A;  2GGB A;  1QXW A;  1YW9 A;  4U69 A;  4IKT A;  1XGM A;  5FCH A;  4FUK A;  4HXX A;  3S6B A;  2BHC A;  2BWX A;  2GA2 A;  4IPA A;  2P98 A;  3CTZ A;  1Y1N A;  4FLL A;  4FO8 A;  4EGE A;  2IW2 A;  2BH3 A;  5JFR A;  2GG5 A;  5CDL A;  2ADU A;  2B3K A;  2GU7 A;  4PV4 A;  4RZY A;  3PKE A;  1W2M A;  1YW7 A;  2BN7 A;  4U76 A;  4B28 A;  1KP0 A;  2MAT A;  4FLK A;  2NQ7 A;  5CDV A;  3PKC A;  4ZWU A;  1WKM A;  2EA2 A;  2GGC A;  4FLJ A;  1B59 A;  2GU6 A;  4U6J A;  2BWY A;  3TB5 A;  4IKU A;  4U75 A;  4RGZ 1;  4S2R P;  4QR8 A;  4ZNG A;  4FLI A;  5CNX A;  1QZY A;  2Q94 A;  2ZSG A;  4IF7 A; 
#chains in the Genus database with same CATH topology
 1QXY A;  5CE6 A;  3TAV A;  2BHA A;  4IKR A;  1C22 A;  1M35 A;  3BIQ A;  1WL9 A;  1N51 A;  2Q95 A;  4S01 A;  1KQ0 A;  5CDE A;  1WN1 A;  4U6Z A;  1O0X A;  2GZ5 A;  1KQ9 A;  2EVO A;  2Q93 A;  4IDY A;  2Q8K A;  1C24 A;  2Q92 A;  3IU8 A;  1R5G A;  1CHM A;  4U6C A;  2BWS A;  2HOW A;  2GG3 A;  3MX6 A;  2NQ6 A;  3PKB A;  1R5H A;  2B3L A;  4A6W A;  2BWW A;  2GG9 A;  4Z7M A;  1A16 A;  2V3X A;  2EVM A;  2GG0 A;  5JHU A;  4RZZ A;  4A6V A;  2P9A A;  4U71 A;  3IU9 A;  3CB5 A;  4IU6 A;  2BHB A;  4PNC A;  4U6E A;  1BN5 A;  2V3Y A;  3FMR A;  2EA4 A;  1JAW A;  4ZWO A;  4MAT A;  1QXZ A;  3MAT A;  1BOA A;  1WLR A;  1XNZ A;  4U6W A;  5D6F A;  2GTX A;  2OAZ A;  4S2T P;  1YJ3 A;  4JUQ A;  4KM3 A;  1WY2 A;  2GG7 A;  2BHD A;  3Q6D A;  3L24 A;  1XGN A;  2GU5 A;  1WL6 A;  2BWV A;  2GG8 A;  1MAT A;  1XGS A;  3FMQ A;  4S00 A;  4U1B A;  3CB6 A;  2BWU A;  2G6P A;  3IG4 A;  3FM3 A;  2B3H A;  3IU7 A;  4R60 A;  1W7V A;  5FCF A;  1C21 A;  4U73 A;  2GG2 A;  1YVM A;  2BWT A;  4ZWP A;  3RVA A;  2OKN A;  5CLS A;  1R58 A;  5D6E A;  2P99 A;  3BIT A;  4IKS A;  2V6C A;  3PKA A;  3BIP A;  5JI6 A;  1C27 A;  5CIK A;  2V3Z A;  1PV9 A;  3ROR A;  2GU4 A;  3MR1 A;  4IEC A;  4FO7 A;  4U70 A;  2DFI A;  1C23 A;  2Q96 A;  5E5B A;  1XGO A;  4FKC A;  3D27 A;  3L7G A;  2BB7 A;  1WBQ A;  1B6A A;  2EVC A;  1YW8 A;  4OOK A;  3PKD A;  2GGB A;  1QXW A;  1YW9 A;  4U69 A;  4IKT A;  1XGM A;  5FCH A;  4FUK A;  4HXX A;  3S6B A;  2BHC A;  2BWX A;  2GA2 A;  4IPA A;  2P98 A;  3CTZ A;  1Y1N A;  4FLL A;  4FO8 A;  4EGE A;  2IW2 A;  2BH3 A;  5JFR A;  2GG5 A;  5CDL A;  2ADU A;  2B3K A;  2GU7 A;  4PV4 A;  4RZY A;  3PKE A;  1W2M A;  1YW7 A;  2BN7 A;  4U76 A;  4B28 A;  1KP0 A;  2MAT A;  4FLK A;  2NQ7 A;  5CDV A;  3PKC A;  4ZWU A;  1WKM A;  2EA2 A;  2GGC A;  4FLJ A;  1B59 A;  2GU6 A;  4U6J A;  2BWY A;  3TB5 A;  4IKU A;  4U75 A;  4RGZ 1;  4S2R P;  4QR8 A;  4ZNG A;  4FLI A;  5CNX A;  1QZY A;  2Q94 A;  2ZSG A;  4IF7 A; 
#chains in the Genus database with same CATH homology
 1QXY A;  5CE6 A;  3TAV A;  2BHA A;  4IKR A;  1C22 A;  1M35 A;  3BIQ A;  1WL9 A;  1N51 A;  2Q95 A;  4S01 A;  1KQ0 A;  5CDE A;  1WN1 A;  4U6Z A;  1O0X A;  2GZ5 A;  1KQ9 A;  2EVO A;  2Q93 A;  4IDY A;  2Q8K A;  1C24 A;  2Q92 A;  3IU8 A;  1R5G A;  1CHM A;  4U6C A;  2BWS A;  2HOW A;  2GG3 A;  3MX6 A;  2NQ6 A;  3PKB A;  1R5H A;  2B3L A;  4A6W A;  2BWW A;  2GG9 A;  4Z7M A;  1A16 A;  2V3X A;  2EVM A;  2GG0 A;  5JHU A;  4RZZ A;  4A6V A;  2P9A A;  4U71 A;  3IU9 A;  3CB5 A;  4IU6 A;  2BHB A;  4PNC A;  4U6E A;  1BN5 A;  2V3Y A;  3FMR A;  2EA4 A;  1JAW A;  4ZWO A;  4MAT A;  1QXZ A;  3MAT A;  1BOA A;  1WLR A;  1XNZ A;  4U6W A;  5D6F A;  2GTX A;  2OAZ A;  4S2T P;  1YJ3 A;  4JUQ A;  4KM3 A;  1WY2 A;  2GG7 A;  2BHD A;  3Q6D A;  3L24 A;  1XGN A;  2GU5 A;  1WL6 A;  2BWV A;  2GG8 A;  1MAT A;  1XGS A;  3FMQ A;  4S00 A;  4U1B A;  3CB6 A;  2BWU A;  2G6P A;  3IG4 A;  3FM3 A;  2B3H A;  3IU7 A;  4R60 A;  1W7V A;  5FCF A;  1C21 A;  4U73 A;  2GG2 A;  1YVM A;  2BWT A;  4ZWP A;  3RVA A;  2OKN A;  5CLS A;  1R58 A;  5D6E A;  2P99 A;  3BIT A;  4IKS A;  2V6C A;  3PKA A;  3BIP A;  5JI6 A;  1C27 A;  5CIK A;  2V3Z A;  1PV9 A;  3ROR A;  2GU4 A;  3MR1 A;  4IEC A;  4FO7 A;  4U70 A;  2DFI A;  1C23 A;  2Q96 A;  5E5B A;  1XGO A;  4FKC A;  3D27 A;  3L7G A;  2BB7 A;  1WBQ A;  1B6A A;  2EVC A;  1YW8 A;  4OOK A;  3PKD A;  2GGB A;  1QXW A;  1YW9 A;  4U69 A;  4IKT A;  1XGM A;  5FCH A;  4FUK A;  4HXX A;  3S6B A;  2BHC A;  2BWX A;  2GA2 A;  4IPA A;  2P98 A;  3CTZ A;  1Y1N A;  4FLL A;  4FO8 A;  4EGE A;  2IW2 A;  2BH3 A;  5JFR A;  2GG5 A;  5CDL A;  2ADU A;  2B3K A;  2GU7 A;  4PV4 A;  4RZY A;  3PKE A;  1W2M A;  1YW7 A;  2BN7 A;  4U76 A;  4B28 A;  1KP0 A;  2MAT A;  4FLK A;  2NQ7 A;  5CDV A;  3PKC A;  4ZWU A;  1WKM A;  2EA2 A;  2GGC A;  4FLJ A;  1B59 A;  2GU6 A;  4U6J A;  2BWY A;  3TB5 A;  4IKU A;  4U75 A;  4RGZ 1;  4S2R P;  4QR8 A;  4ZNG A;  4FLI A;  5CNX A;  1QZY A;  2Q94 A;  2ZSG A;  4IF7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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