3MZ3A

Crystal structure of co2+ hdac8 complexed with m344
Total Genus 116
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
116
sequence length
364
structure length
357
Chain Sequence
LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Histone deacetylase 8
publication title Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 116
structure length 357
sequence length 364
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2010-05-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 3mz3A00
4QA1A 4RN0A 5D1DA 1W22A 5G17A 4LY1A 5IX0A 2V5WA 5G13A 3MZ4A 2VQMA 4ZUNA 4BZ9A 3C0ZA 3C0YA 5G3WA 3RQDA 4ZUMA 5THUA 4QA2A 4QA7A 5EFNA 5G11A 4BZ6A 3SFFA 1ZZ1A 4RN2A 1T64A 5ICNB 4QA4A 5DC5A 5EEIA 5G0IA 4QA6A 4QA5A 1ZZ3A 2VQJA 3Q9BA 5THSA 5FCWA 1C3PA 5D1BA 4ZUPA 5A2SA 5BWZA 3EW8A 3EZPA 5EFKB 5D1CA 4ZURA 5G0YA 3Q9EA 2V5XA 2VQQA 4A69A 4RN1A 4CBYA 3MENA 1C3RA 5EENA 5G1AA 1ZZ0A 5G10A 3MZ7A 5LI3A 2VQOA 4QA3A 4QA0A 5IWGA 5DC7A 5G12A 5G0GA 2VQVA 5EFGA 2VQWG 2VCGA 5FUEA 5G0HA 4BZ8A 3MAXA 5DC6A 5EFJD 4ZUOA 5G1CA 4BKXB 5EF7A 3Q9FA 3EWFA 3C10A 4BZ5A 5G0XA 5EEFA 5EEMA 1T67A 3F07A 5THVA 3F0RA 1T69A 3SFHA 5EFBD 4LXZA 1VKGA 4CBTA 4BZ7A 3MZ6A 1C3SA 4CQFA 2GH6A 5DC8A 5EF8A 4ZUQA 3Q9CA 5G1BA 5EFHA 3ZNSA 3ZNRA 5JI5A 3F06A 5G0JA 3MZ3A 5THTA 3EZTA 5EEKA
chains in the Genus database with same CATH superfamily
1R1OA 1HQXA 4RHKA 1HQGA 4I06A 4QA1A 1P8PA 4Q3VA 4RN0A 5D1DA 1W22A 1P8OA 5G17A 3E6KA 4LY1A 1P8NA 5IX0A 4Q3SA 2V5WA 1T4TA 2RLAA 5G13A 3MZ4A 2VQMA 4ZUNA 4BZ9A 4RHJA 3C0ZA 3C0YA 4Q41A 1TA1A 2EIVA 4MYLA 4GSMA 1CEVA 3SL1A 5G3WA 5JI5A 1D3VA 4RHQA 4ZUMA 3RQDA 5THUA 4QA2A 4IU1A 3E9BA 4QA7A 5EFNA 5G11A 4BZ6A 3SFFA 4Q3RA 4IXUA 3MFVA 1ZZ1A 3NIOA 1GQ7A 1P8RA 4RN2A 3SKKA 3GN0A 3RLAA 1T64A 5ICNB 2ZAVA 1HQ5A 1WOIA 3GMZA 2PHOA 3M1RA 4QA4A 1P8QA 3MFWA 5DC5A 3MJLA 4MXRA 4QA6A 4QA5A 1P8SA 5EEIA 1ZZ3A 2VQJA 3NIQA 2EF5A 4MYFA 3Q9BA 5THSA 5FCWA 1C3PA 4GSVA 5CEVA 2CEVA 5D1BA 4ZUPA 1WVAA 5A2SA 1HQHA 1ZPEA 5BWZA 3EW8A 4IE1A 3EZPA 5EFKB 5D1CA 5HJ9A 3MMRA 3KV2A 3LP4A 4ZURA 5G0YA 3Q9EA 2V5XA 2PHAA 1T5FA 2VQQA 1PQ3A 4A69A 4FCIA 1WVBA 4G3HA 4RN1A 4CBYA 3MENA 1C3RA 4IU0A 5EENA 3THJA 4ITYA 5G1AA 4DZ4A 1ZZ0A 5G10A 3MZ7A 5LI3A 2VQOA 4QA3A 4QA0A 5IWGA 4IU5A 4Q3QA 3E8QA 3LHLA 5DC7A 5G12A 3THHA 5G0GA 4IU4A 4GSZA 5G0IA 2VQVA 4MYNA 2VQWG 2VCGA 5EFGA 5FUEA 1TBHA 4Q3UA 5G0HA 4BZ8A 3MAXA 5DC6A 5EFJD 3TF3A 2A0MA 4HWWA 4ZUOA 3SL0A 3SJTA 4IE3A 5EEKA 1HQFA 1T4PA 1T5GA 5G1CA 3THEA 4BKXB 5EF7A 3DJ8A 3Q9FA 4HXQA 5HJAA 3EWFA 1GQ6A 3C10A 4BZ5A 4Q40A 1P8MA 1WOHA 5EEFA 5G0XA 4GWDA 1ZPGA 5EEMA 1T67A 3F07A 5THVA 3E8ZA 3F0RA 1T4RA 1T69A 3SFHA 5EFBD 3NIPA 4HZEA 4IE2A 4LXZA 1VKGA 3F80A 4Q42A 4CBTA 4BZ7A 2EF4A 3MZ6A 2PLLA 4GWCA 1C3SA 2AEBA 1T4SA 3LP7A 4CQFA 1RLAA 1WOGA 3PZLA 3E6VA 2GH6A 1TBLA 4FCKA 5DC8A 1TBJA 5EF8A 4RHLA 4Q3PA 4RHIA 1XFKA 4ZUQA 4Q3RC 4RHMA 4Q3TA 3Q9CA 5G1BA 4IXVA 3CEVA 4RLAA 5EFHA 3F06A 5G0JA 3ZNSA 3MZ3A 3TH7A 3ZNRA 5THTA 4CEVA 3EZTA 5RLAA 4MYKA
chains in the Genus database with same CATH topology
4QA1A 4RN0A 5D1DA 1W22A 5G17A 4LY1A 5IX0A 2V5WA 5G13A 3MZ4A 2VQMA 4ZUNA 4BZ9A 3C0ZA 3C0YA 5G3WA 3RQDA 4ZUMA 5THUA 4QA2A 4QA7A 5EFNA 5G11A 4BZ6A 3SFFA 1ZZ1A 4RN2A 1T64A 5ICNB 4QA4A 5DC5A 5EEIA 5G0IA 4QA6A 4QA5A 1ZZ3A 2VQJA 3Q9BA 5THSA 5FCWA 1C3PA 5D1BA 4ZUPA 5A2SA 5BWZA 3EW8A 3EZPA 5EFKB 5D1CA 4ZURA 5G0YA 3Q9EA 2V5XA 2VQQA 4A69A 4RN1A 4CBYA 3MENA 1C3RA 5EENA 5G1AA 1ZZ0A 5G10A 3MZ7A 5LI3A 2VQOA 4QA3A 4QA0A 5IWGA 5DC7A 5G12A 5G0GA 2VQVA 5EFGA 2VQWG 2VCGA 5FUEA 5G0HA 4BZ8A 3MAXA 5DC6A 5EFJD 4ZUOA 5G1CA 4BKXB 5EF7A 3Q9FA 3EWFA 3C10A 4BZ5A 5G0XA 5EEFA 5EEMA 1T67A 3F07A 5THVA 3F0RA 1T69A 3SFHA 5EFBD 4LXZA 1VKGA 4CBTA 4BZ7A 3MZ6A 1C3SA 4CQFA 2GH6A 5DC8A 5EF8A 4ZUQA 3Q9CA 5G1BA 5EFHA 3ZNSA 3ZNRA 5JI5A 3F06A 5G0JA 3MZ3A 5THTA 3EZTA 5EEKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4QA1 A;  4RN0 A;  5D1D A;  1W22 A;  5G17 A;  4LY1 A;  5IX0 A;  2V5W A;  5G13 A;  3MZ4 A;  2VQM A;  4ZUN A;  4BZ9 A;  3C0Z A;  3C0Y A;  5G3W A;  3RQD A;  4ZUM A;  5THU A;  4QA2 A;  4QA7 A;  5EFN A;  5G11 A;  4BZ6 A;  3SFF A;  1ZZ1 A;  4RN2 A;  1T64 A;  5ICN B;  4QA4 A;  5DC5 A;  5EEI A;  5G0I A;  4QA6 A;  4QA5 A;  1ZZ3 A;  2VQJ A;  3Q9B A;  5THS A;  5FCW A;  1C3P A;  5D1B A;  4ZUP A;  5A2S A;  5BWZ A;  3EW8 A;  3EZP A;  5EFK B;  5D1C A;  4ZUR A;  5G0Y A;  3Q9E A;  2V5X A;  2VQQ A;  4A69 A;  4RN1 A;  4CBY A;  3MEN A;  1C3R A;  5EEN A;  5G1A A;  1ZZ0 A;  5G10 A;  3MZ7 A;  5LI3 A;  2VQO A;  4QA3 A;  4QA0 A;  5IWG A;  5DC7 A;  5G12 A;  5G0G A;  2VQV A;  5EFG A;  2VQW G;  2VCG A;  5FUE A;  5G0H A;  4BZ8 A;  3MAX A;  5DC6 A;  5EFJ D;  4ZUO A;  5G1C A;  4BKX B;  5EF7 A;  3Q9F A;  3EWF A;  3C10 A;  4BZ5 A;  5G0X A;  5EEF A;  5EEM A;  1T67 A;  3F07 A;  5THV A;  3F0R A;  1T69 A;  3SFH A;  5EFB D;  4LXZ A;  1VKG A;  4CBT A;  4BZ7 A;  3MZ6 A;  1C3S A;  4CQF A;  2GH6 A;  5DC8 A;  5EF8 A;  4ZUQ A;  3Q9C A;  5G1B A;  5EFH A;  3ZNS A;  3ZNR A;  5JI5 A;  3F06 A;  5G0J A;  3MZ3 A;  5THT A;  3EZT A;  5EEK A; 
#chains in the Genus database with same CATH topology
 1R1O A;  1HQX A;  4RHK A;  1HQG A;  4I06 A;  4QA1 A;  1P8P A;  4Q3V A;  4RN0 A;  5D1D A;  1W22 A;  1P8O A;  5G17 A;  3E6K A;  4LY1 A;  1P8N A;  5IX0 A;  4Q3S A;  2V5W A;  1T4T A;  2RLA A;  5G13 A;  3MZ4 A;  2VQM A;  4ZUN A;  4BZ9 A;  4RHJ A;  3C0Z A;  3C0Y A;  4Q41 A;  1TA1 A;  2EIV A;  4MYL A;  4GSM A;  1CEV A;  3SL1 A;  5G3W A;  5JI5 A;  1D3V A;  4RHQ A;  4ZUM A;  3RQD A;  5THU A;  4QA2 A;  4IU1 A;  3E9B A;  4QA7 A;  5EFN A;  5G11 A;  4BZ6 A;  3SFF A;  4Q3R A;  4IXU A;  3MFV A;  1ZZ1 A;  3NIO A;  1GQ7 A;  1P8R A;  4RN2 A;  3SKK A;  3GN0 A;  3RLA A;  1T64 A;  5ICN B;  2ZAV A;  1HQ5 A;  1WOI A;  3GMZ A;  2PHO A;  3M1R A;  4QA4 A;  1P8Q A;  3MFW A;  5DC5 A;  3MJL A;  4MXR A;  4QA6 A;  4QA5 A;  1P8S A;  5EEI A;  1ZZ3 A;  2VQJ A;  3NIQ A;  2EF5 A;  4MYF A;  3Q9B A;  5THS A;  5FCW A;  1C3P A;  4GSV A;  5CEV A;  2CEV A;  5D1B A;  4ZUP A;  1WVA A;  5A2S A;  1HQH A;  1ZPE A;  5BWZ A;  3EW8 A;  4IE1 A;  3EZP A;  5EFK B;  5D1C A;  5HJ9 A;  3MMR A;  3KV2 A;  3LP4 A;  4ZUR A;  5G0Y A;  3Q9E A;  2V5X A;  2PHA A;  1T5F A;  2VQQ A;  1PQ3 A;  4A69 A;  4FCI A;  1WVB A;  4G3H A;  4RN1 A;  4CBY A;  3MEN A;  1C3R A;  4IU0 A;  5EEN A;  3THJ A;  4ITY A;  5G1A A;  4DZ4 A;  1ZZ0 A;  5G10 A;  3MZ7 A;  5LI3 A;  2VQO A;  4QA3 A;  4QA0 A;  5IWG A;  4IU5 A;  4Q3Q A;  3E8Q A;  3LHL A;  5DC7 A;  5G12 A;  3THH A;  5G0G A;  4IU4 A;  4GSZ A;  5G0I A;  2VQV A;  4MYN A;  2VQW G;  2VCG A;  5EFG A;  5FUE A;  1TBH A;  4Q3U A;  5G0H A;  4BZ8 A;  3MAX A;  5DC6 A;  5EFJ D;  3TF3 A;  2A0M A;  4HWW A;  4ZUO A;  3SL0 A;  3SJT A;  4IE3 A;  5EEK A;  1HQF A;  1T4P A;  1T5G A;  5G1C A;  3THE A;  4BKX B;  5EF7 A;  3DJ8 A;  3Q9F A;  4HXQ A;  5HJA A;  3EWF A;  1GQ6 A;  3C10 A;  4BZ5 A;  4Q40 A;  1P8M A;  1WOH A;  5EEF A;  5G0X A;  4GWD A;  1ZPG A;  5EEM A;  1T67 A;  3F07 A;  5THV A;  3E8Z A;  3F0R A;  1T4R A;  1T69 A;  3SFH A;  5EFB D;  3NIP A;  4HZE A;  4IE2 A;  4LXZ A;  1VKG A;  3F80 A;  4Q42 A;  4CBT A;  4BZ7 A;  2EF4 A;  3MZ6 A;  2PLL A;  4GWC A;  1C3S A;  2AEB A;  1T4S A;  3LP7 A;  4CQF A;  1RLA A;  1WOG A;  3PZL A;  3E6V A;  2GH6 A;  1TBL A;  4FCK A;  5DC8 A;  1TBJ A;  5EF8 A;  4RHL A;  4Q3P A;  4RHI A;  1XFK A;  4ZUQ A;  4Q3R C;  4RHM A;  4Q3T A;  3Q9C A;  5G1B A;  4IXV A;  3CEV A;  4RLA A;  5EFH A;  3F06 A;  5G0J A;  3ZNS A;  3MZ3 A;  3TH7 A;  3ZNR A;  5THT A;  4CEV A;  3EZT A;  5RLA A;  4MYK A; 
#chains in the Genus database with same CATH homology
 4QA1 A;  4RN0 A;  5D1D A;  1W22 A;  5G17 A;  4LY1 A;  5IX0 A;  2V5W A;  5G13 A;  3MZ4 A;  2VQM A;  4ZUN A;  4BZ9 A;  3C0Z A;  3C0Y A;  5G3W A;  3RQD A;  4ZUM A;  5THU A;  4QA2 A;  4QA7 A;  5EFN A;  5G11 A;  4BZ6 A;  3SFF A;  1ZZ1 A;  4RN2 A;  1T64 A;  5ICN B;  4QA4 A;  5DC5 A;  5EEI A;  5G0I A;  4QA6 A;  4QA5 A;  1ZZ3 A;  2VQJ A;  3Q9B A;  5THS A;  5FCW A;  1C3P A;  5D1B A;  4ZUP A;  5A2S A;  5BWZ A;  3EW8 A;  3EZP A;  5EFK B;  5D1C A;  4ZUR A;  5G0Y A;  3Q9E A;  2V5X A;  2VQQ A;  4A69 A;  4RN1 A;  4CBY A;  3MEN A;  1C3R A;  5EEN A;  5G1A A;  1ZZ0 A;  5G10 A;  3MZ7 A;  5LI3 A;  2VQO A;  4QA3 A;  4QA0 A;  5IWG A;  5DC7 A;  5G12 A;  5G0G A;  2VQV A;  5EFG A;  2VQW G;  2VCG A;  5FUE A;  5G0H A;  4BZ8 A;  3MAX A;  5DC6 A;  5EFJ D;  4ZUO A;  5G1C A;  4BKX B;  5EF7 A;  3Q9F A;  3EWF A;  3C10 A;  4BZ5 A;  5G0X A;  5EEF A;  5EEM A;  1T67 A;  3F07 A;  5THV A;  3F0R A;  1T69 A;  3SFH A;  5EFB D;  4LXZ A;  1VKG A;  4CBT A;  4BZ7 A;  3MZ6 A;  1C3S A;  4CQF A;  2GH6 A;  5DC8 A;  5EF8 A;  4ZUQ A;  3Q9C A;  5G1B A;  5EFH A;  3ZNS A;  3ZNR A;  5JI5 A;  3F06 A;  5G0J A;  3MZ3 A;  5THT A;  3EZT A;  5EEK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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