3MZ4A

Crystal structure of d101l mn2+ hdac8 complexed with m344
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
365
structure length
355
Chain Sequence
b'LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEYGLGYLCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Histone deacetylase 8
publication title Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 126
structure length 355
sequence length 365
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2010-05-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 3mz4A00
1W22A 5FCWA 1T67A 5A2SA 5EENA 5EEFA 5EEKA 5EFHA 5EF8A 4CQFA 2VQQA 5IWGA 5G10A 5EFGA 3EW8A 3EZPA 2VQJA 2GH6A 5THUA 4QA7A 3C0YA 5DC6A 3MZ3A 3SFFA 3C10A 1T69A 1ZZ1A 4QA6A 5EFNA 4RN2A 5DC7A 3F07A 4BZ6A 3MAXA 4QA4A 4ZURA 5EFBD 5D1DA 5DC8A 2VCGA 4ZUNA 3Q9FA 4QA1A 4ZUQA 4BKXB 5THVA 4BZ9A 4CBTA 5D1BA 1T64A 5G0GA 5G12A 3C0ZA 4QA3A 3SFHA 1VKGA 5IX0A 4BZ5A 5G0XA 5JI5A 3EZTA 5EEIA 5D1CA 5ICNB 5BWZA 4QA5A 3RQDA 2V5WA 2V5XA 3MZ4A 5G17A 4CBYA 4BZ8A 1ZZ0A 3Q9CA 4QA2A 5G0JA 3ZNRA 1C3SA 4RN0A 5THTA 1C3PA 2VQWG 3EWFA 1C3RA 5G0IA 4LY1A 5G1BA 5LI3A 5EF7A 5EFJD 1ZZ3A 4QA0A 3Q9BA 4ZUOA 3MZ7A 2VQMA 5G1AA 5G11A 5G1CA 4LXZA 2VQOA 3MENA 3MZ6A 5DC5A 3F06A 3Q9EA 4A69A 3F0RA 5EFKB 4RN1A 5G13A 4ZUMA 5EEMA 5THSA 3ZNSA 5G3WA 5FUEA 4BZ7A 5G0YA 5G0HA 2VQVA 4ZUPA
chains in the Genus database with same CATH superfamily
1W22A 2A0MA 5FCWA 5RLAA 1HQXA 1T67A 5A2SA 1CEVA 1T4PA 4MYKA 5EENA 5EEKA 1XFKA 1TBJA 3CEVA 4Q42A 4RHLA 4HXQA 5EFHA 1WOHA 4MYNA 5EF8A 4CQFA 2VQQA 5IWGA 5G10A 1WOIA 5EFGA 3EW8A 1RLAA 3EZPA 1TBLA 1T5GA 2VQJA 3E9BA 1HQ5A 2GH6A 5THUA 1D3VA 5HJAA 4IE3A 3PZLA 4QA7A 3C0YA 5DC6A 3MZ3A 4RHJA 3E8QA 3SFFA 3C10A 1WOGA 1T69A 1ZZ1A 4HZEA 4IE2A 4QA6A 4RN2A 5EFNA 2AEBA 5DC7A 3F07A 1GQ6A 4IU5A 4BZ6A 3MAXA 1P8NA 4RHQA 1P8OA 4QA4A 4ZURA 5EFBD 4ITYA 5D1DA 5DC8A 1P8SA 2VCGA 3E6KA 3LHLA 3E6VA 4IU0A 4ZUNA 2RLAA 3Q9FA 4Q3SA 4QA1A 2PLLA 4GSZA 3F80A 4MYFA 4MXRA 4BKXB 4CEVA 4ZUQA 5THVA 4BZ9A 4CBTA 5D1BA 1T64A 5G0GA 2CEVA 5G12A 3C0ZA 2PHAA 4Q3TA 3SKKA 4QA3A 3RLAA 1HQFA 2EIVA 4FCKA 3SFHA 3M1RA 4Q3VA 1VKGA 5IX0A 4BZ5A 5G0XA 2EF5A 5JI5A 4GWCA 1HQHA 3EZTA 5EEFA 1PQ3A 1TA1A 5HJ9A 3LP4A 4IU1A 5EEIA 4I06A 1P8QA 1ZPGA 5D1CA 5BWZA 5ICNB 1T5FA 4QA5A 4IXVA 1GQ7A 3RQDA 4GWDA 2V5WA 2V5XA 3MZ4A 5G17A 4G3HA 4BZ8A 4CBYA 4IXUA 3SJTA 1ZZ0A 2ZAVA 3Q9CA 4QA2A 5CEVA 3TF3A 5G0JA 3GN0A 3ZNRA 1HQGA 1C3SA 3SL1A 4RN0A 3THEA 2PHOA 5THTA 1C3PA 1T4SA 2VQWG 3GMZA 4Q3QA 3EWFA 1C3RA 5G0IA 4FCIA 4Q3RC 1TBHA 4LY1A 4RHIA 5EF7A 4RLAA 5G1BA 5LI3A 5EFJD 1ZZ3A 4IU4A 4QA0A 3THJA 4DZ4A 3NIPA 3THHA 3Q9BA 1R1OA 4ZUOA 2VQMA 3DJ8A 3MZ7A 4GSMA 3SL0A 4HWWA 1P8MA 5G1AA 5G11A 3LP7A 1T4TA 3NIQA 4Q40A 4Q41A 5G1CA 4LXZA 2VQOA 3MENA 3MZ6A 2EF4A 5DC5A 3F06A 3Q9EA 4GSVA 4A69A 1ZPEA 3F0RA 1WVAA 5EFKB 4RN1A 5G13A 3MFVA 4Q3RA 4ZUMA 5EEMA 5THSA 1WVBA 3MJLA 4Q3PA 3ZNSA 3KV2A 3E8ZA 1P8PA 3MFWA 5G3WA 1T4RA 3NIOA 4MYLA 5FUEA 4BZ7A 4RHKA 3MMRA 1P8RA 3TH7A 4RHMA 5G0YA 5G0HA 2VQVA 4ZUPA 4Q3UA 4IE1A
chains in the Genus database with same CATH topology
1W22A 5FCWA 1T67A 5A2SA 5EENA 5EEFA 5EEKA 5EFHA 5EF8A 4CQFA 2VQQA 5IWGA 5G10A 5EFGA 3EW8A 3EZPA 2VQJA 2GH6A 5THUA 4QA7A 3C0YA 5DC6A 3MZ3A 3SFFA 3C10A 1T69A 1ZZ1A 4QA6A 5EFNA 4RN2A 5DC7A 3F07A 4BZ6A 3MAXA 4QA4A 4ZURA 5EFBD 5D1DA 5DC8A 2VCGA 4ZUNA 3Q9FA 4QA1A 4ZUQA 4BKXB 5THVA 4BZ9A 4CBTA 5D1BA 1T64A 5G0GA 5G12A 3C0ZA 4QA3A 3SFHA 1VKGA 5IX0A 4BZ5A 5G0XA 5JI5A 3EZTA 5EEIA 5D1CA 5ICNB 5BWZA 4QA5A 3RQDA 2V5WA 2V5XA 3MZ4A 5G17A 4CBYA 4BZ8A 1ZZ0A 3Q9CA 4QA2A 5G0JA 3ZNRA 1C3SA 4RN0A 5THTA 1C3PA 2VQWG 3EWFA 1C3RA 5G0IA 4LY1A 5G1BA 5LI3A 5EF7A 5EFJD 1ZZ3A 4QA0A 3Q9BA 4ZUOA 3MZ7A 2VQMA 5G1AA 5G11A 5G1CA 4LXZA 2VQOA 3MENA 3MZ6A 5DC5A 3F06A 3Q9EA 4A69A 3F0RA 5EFKB 4RN1A 5G13A 4ZUMA 5EEMA 5THSA 3ZNSA 5G3WA 5FUEA 4BZ7A 5G0YA 5G0HA 2VQVA 4ZUPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1W22 A;  5FCW A;  1T67 A;  5A2S A;  5EEN A;  5EEF A;  5EEK A;  5EFH A;  5EF8 A;  4CQF A;  2VQQ A;  5IWG A;  5G10 A;  5EFG A;  3EW8 A;  3EZP A;  2VQJ A;  2GH6 A;  5THU A;  4QA7 A;  3C0Y A;  5DC6 A;  3MZ3 A;  3SFF A;  3C10 A;  1T69 A;  1ZZ1 A;  4QA6 A;  5EFN A;  4RN2 A;  5DC7 A;  3F07 A;  4BZ6 A;  3MAX A;  4QA4 A;  4ZUR A;  5EFB D;  5D1D A;  5DC8 A;  2VCG A;  4ZUN A;  3Q9F A;  4QA1 A;  4ZUQ A;  4BKX B;  5THV A;  4BZ9 A;  4CBT A;  5D1B A;  1T64 A;  5G0G A;  5G12 A;  3C0Z A;  4QA3 A;  3SFH A;  1VKG A;  5IX0 A;  4BZ5 A;  5G0X A;  5JI5 A;  3EZT A;  5EEI A;  5D1C A;  5ICN B;  5BWZ A;  4QA5 A;  3RQD A;  2V5W A;  2V5X A;  3MZ4 A;  5G17 A;  4CBY A;  4BZ8 A;  1ZZ0 A;  3Q9C A;  4QA2 A;  5G0J A;  3ZNR A;  1C3S A;  4RN0 A;  5THT A;  1C3P A;  2VQW G;  3EWF A;  1C3R A;  5G0I A;  4LY1 A;  5G1B A;  5LI3 A;  5EF7 A;  5EFJ D;  1ZZ3 A;  4QA0 A;  3Q9B A;  4ZUO A;  3MZ7 A;  2VQM A;  5G1A A;  5G11 A;  5G1C A;  4LXZ A;  2VQO A;  3MEN A;  3MZ6 A;  5DC5 A;  3F06 A;  3Q9E A;  4A69 A;  3F0R A;  5EFK B;  4RN1 A;  5G13 A;  4ZUM A;  5EEM A;  5THS A;  3ZNS A;  5G3W A;  5FUE A;  4BZ7 A;  5G0Y A;  5G0H A;  2VQV A;  4ZUP A; 
#chains in the Genus database with same CATH topology
 1W22 A;  2A0M A;  5FCW A;  5RLA A;  1HQX A;  1T67 A;  5A2S A;  1CEV A;  1T4P A;  4MYK A;  5EEN A;  5EEK A;  1XFK A;  1TBJ A;  3CEV A;  4Q42 A;  4RHL A;  4HXQ A;  5EFH A;  1WOH A;  4MYN A;  5EF8 A;  4CQF A;  2VQQ A;  5IWG A;  5G10 A;  1WOI A;  5EFG A;  3EW8 A;  1RLA A;  3EZP A;  1TBL A;  1T5G A;  2VQJ A;  3E9B A;  1HQ5 A;  2GH6 A;  5THU A;  1D3V A;  5HJA A;  4IE3 A;  3PZL A;  4QA7 A;  3C0Y A;  5DC6 A;  3MZ3 A;  4RHJ A;  3E8Q A;  3SFF A;  3C10 A;  1WOG A;  1T69 A;  1ZZ1 A;  4HZE A;  4IE2 A;  4QA6 A;  4RN2 A;  5EFN A;  2AEB A;  5DC7 A;  3F07 A;  1GQ6 A;  4IU5 A;  4BZ6 A;  3MAX A;  1P8N A;  4RHQ A;  1P8O A;  4QA4 A;  4ZUR A;  5EFB D;  4ITY A;  5D1D A;  5DC8 A;  1P8S A;  2VCG A;  3E6K A;  3LHL A;  3E6V A;  4IU0 A;  4ZUN A;  2RLA A;  3Q9F A;  4Q3S A;  4QA1 A;  2PLL A;  4GSZ A;  3F80 A;  4MYF A;  4MXR A;  4BKX B;  4CEV A;  4ZUQ A;  5THV A;  4BZ9 A;  4CBT A;  5D1B A;  1T64 A;  5G0G A;  2CEV A;  5G12 A;  3C0Z A;  2PHA A;  4Q3T A;  3SKK A;  4QA3 A;  3RLA A;  1HQF A;  2EIV A;  4FCK A;  3SFH A;  3M1R A;  4Q3V A;  1VKG A;  5IX0 A;  4BZ5 A;  5G0X A;  2EF5 A;  5JI5 A;  4GWC A;  1HQH A;  3EZT A;  5EEF A;  1PQ3 A;  1TA1 A;  5HJ9 A;  3LP4 A;  4IU1 A;  5EEI A;  4I06 A;  1P8Q A;  1ZPG A;  5D1C A;  5BWZ A;  5ICN B;  1T5F A;  4QA5 A;  4IXV A;  1GQ7 A;  3RQD A;  4GWD A;  2V5W A;  2V5X A;  3MZ4 A;  5G17 A;  4G3H A;  4BZ8 A;  4CBY A;  4IXU A;  3SJT A;  1ZZ0 A;  2ZAV A;  3Q9C A;  4QA2 A;  5CEV A;  3TF3 A;  5G0J A;  3GN0 A;  3ZNR A;  1HQG A;  1C3S A;  3SL1 A;  4RN0 A;  3THE A;  2PHO A;  5THT A;  1C3P A;  1T4S A;  2VQW G;  3GMZ A;  4Q3Q A;  3EWF A;  1C3R A;  5G0I A;  4FCI A;  4Q3R C;  1TBH A;  4LY1 A;  4RHI A;  5EF7 A;  4RLA A;  5G1B A;  5LI3 A;  5EFJ D;  1ZZ3 A;  4IU4 A;  4QA0 A;  3THJ A;  4DZ4 A;  3NIP A;  3THH A;  3Q9B A;  1R1O A;  4ZUO A;  2VQM A;  3DJ8 A;  3MZ7 A;  4GSM A;  3SL0 A;  4HWW A;  1P8M A;  5G1A A;  5G11 A;  3LP7 A;  1T4T A;  3NIQ A;  4Q40 A;  4Q41 A;  5G1C A;  4LXZ A;  2VQO A;  3MEN A;  3MZ6 A;  2EF4 A;  5DC5 A;  3F06 A;  3Q9E A;  4GSV A;  4A69 A;  1ZPE A;  3F0R A;  1WVA A;  5EFK B;  4RN1 A;  5G13 A;  3MFV A;  4Q3R A;  4ZUM A;  5EEM A;  5THS A;  1WVB A;  3MJL A;  4Q3P A;  3ZNS A;  3KV2 A;  3E8Z A;  1P8P A;  3MFW A;  5G3W A;  1T4R A;  3NIO A;  4MYL A;  5FUE A;  4BZ7 A;  4RHK A;  3MMR A;  1P8R A;  3TH7 A;  4RHM A;  5G0Y A;  5G0H A;  2VQV A;  4ZUP A;  4Q3U A;  4IE1 A; 
#chains in the Genus database with same CATH homology
 1W22 A;  5FCW A;  1T67 A;  5A2S A;  5EEN A;  5EEF A;  5EEK A;  5EFH A;  5EF8 A;  4CQF A;  2VQQ A;  5IWG A;  5G10 A;  5EFG A;  3EW8 A;  3EZP A;  2VQJ A;  2GH6 A;  5THU A;  4QA7 A;  3C0Y A;  5DC6 A;  3MZ3 A;  3SFF A;  3C10 A;  1T69 A;  1ZZ1 A;  4QA6 A;  5EFN A;  4RN2 A;  5DC7 A;  3F07 A;  4BZ6 A;  3MAX A;  4QA4 A;  4ZUR A;  5EFB D;  5D1D A;  5DC8 A;  2VCG A;  4ZUN A;  3Q9F A;  4QA1 A;  4ZUQ A;  4BKX B;  5THV A;  4BZ9 A;  4CBT A;  5D1B A;  1T64 A;  5G0G A;  5G12 A;  3C0Z A;  4QA3 A;  3SFH A;  1VKG A;  5IX0 A;  4BZ5 A;  5G0X A;  5JI5 A;  3EZT A;  5EEI A;  5D1C A;  5ICN B;  5BWZ A;  4QA5 A;  3RQD A;  2V5W A;  2V5X A;  3MZ4 A;  5G17 A;  4CBY A;  4BZ8 A;  1ZZ0 A;  3Q9C A;  4QA2 A;  5G0J A;  3ZNR A;  1C3S A;  4RN0 A;  5THT A;  1C3P A;  2VQW G;  3EWF A;  1C3R A;  5G0I A;  4LY1 A;  5G1B A;  5LI3 A;  5EF7 A;  5EFJ D;  1ZZ3 A;  4QA0 A;  3Q9B A;  4ZUO A;  3MZ7 A;  2VQM A;  5G1A A;  5G11 A;  5G1C A;  4LXZ A;  2VQO A;  3MEN A;  3MZ6 A;  5DC5 A;  3F06 A;  3Q9E A;  4A69 A;  3F0R A;  5EFK B;  4RN1 A;  5G13 A;  4ZUM A;  5EEM A;  5THS A;  3ZNS A;  5G3W A;  5FUE A;  4BZ7 A;  5G0Y A;  5G0H A;  2VQV A;  4ZUP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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