3MZ4A

Crystal structure of d101l mn2+ hdac8 complexed with m344
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
365
structure length
355
Chain Sequence
LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEYGLGYLCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Histone deacetylase 8
publication title Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 126
structure length 355
sequence length 365
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2010-05-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 3mz4A00
3EW8A 5G12A 4ZUOA 3MZ6A 3ZNSA 2VCGA 3Q9FA 5EEMA 5EFJD 4RN1A 4BZ8A 2VQQA 5G17A 4ZUQA 1ZZ0A 4CBYA 5EFNA 3Q9EA 4QA5A 5BWZA 1C3RA 5EFGA 1C3PA 5G0JA 1T67A 2GH6A 5EFBD 4QA2A 2VQMA 1VKGA 2VQOA 3EZTA 1ZZ1A 4BKXB 5EENA 3EZPA 5DC6A 4LXZA 3SFHA 5G0GA 3RQDA 4ZUMA 1ZZ3A 4QA0A 5G13A 5G1CA 2V5XA 5DC7A 5IWGA 5THVA 4BZ9A 3SFFA 1W22A 5IX0A 5DC8A 3MZ3A 5EFKB 3F06A 4ZUPA 5G3WA 3MZ7A 4QA3A 1T64A 3C0YA 5D1BA 5G0HA 5EF8A 5G10A 4BZ5A 4CQFA 5DC5A 3EWFA 4RN0A 4BZ7A 3F07A 4QA1A 5FUEA 4LY1A 4A69A 3ZNRA 5G1BA 5THUA 3F0RA 3C10A 3MZ4A 5A2SA 4BZ6A 3Q9CA 5THTA 5LI3A 4QA7A 5G11A 5G1AA 5EFHA 4ZUNA 2VQWG 5G0IA 5FCWA 5EEKA 5JI5A 5THSA 5G0XA 4QA4A 3MENA 4QA6A 4CBTA 5EF7A 1C3SA 4RN2A 4ZURA 2VQJA 1T69A 3Q9BA 5ICNB 2VQVA 3MAXA 3C0ZA 5D1CA 5D1DA 2V5WA 5EEFA 5G0YA 5EEIA
chains in the Genus database with same CATH superfamily
5RLAA 3EW8A 5G12A 4ZUOA 3MZ6A 3ZNSA 2VCGA 2EF4A 1WOGA 2RLAA 5HJAA 4MYKA 1T4TA 3MMRA 1TBJA 3Q9FA 1RLAA 4GSMA 5EEMA 1WVAA 1WOHA 3CEVA 4IXVA 5EFJD 1HQ5A 4RN1A 1P8NA 4BZ8A 1P8OA 2PHOA 4Q42A 4MYLA 3LHLA 3NIQA 2VQQA 5G17A 4ZUQA 3E9BA 1ZZ0A 4CBYA 5EFNA 1T4PA 4Q3VA 1TBLA 3Q9EA 4QA5A 5BWZA 1P8QA 1C3RA 4I06A 2EIVA 3RLAA 3SJTA 4CEVA 5EFGA 2ZAVA 1C3PA 2PLLA 5G0JA 4IE1A 1T67A 2GH6A 1HQGA 5EFBD 1WOIA 1PQ3A 4QA2A 2VQMA 3NIPA 2CEVA 1VKGA 2VQOA 4HWWA 3EZTA 4RHLA 4DZ4A 3LP4A 1ZZ1A 4RHMA 4RHKA 4BKXB 3F80A 1R1OA 4IU5A 5EENA 2AEBA 3EZPA 4LXZA 5DC6A 4RHIA 3SFHA 5G0GA 1T4RA 3RQDA 4ZUMA 4Q41A 4Q40A 1ZZ3A 4QA0A 5G13A 5G1CA 3THEA 5HJ9A 1HQXA 4Q3PA 1P8PA 4IU1A 2V5XA 5DC7A 5IWGA 5D1DA 4HZEA 4HXQA 4G3HA 3LP7A 5THVA 4BZ9A 3KV2A 3SL1A 2PHAA 1T4SA 3SFFA 1TBHA 1HQFA 1W22A 5IX0A 1ZPEA 5DC8A 3M1RA 1P8MA 1ZPGA 3F06A 3GN0A 3MZ3A 1HQHA 4GSVA 3MZ7A 4MYNA 4RHQA 4ZUPA 5G3WA 4QA3A 1T64A 3C0YA 1P8SA 5D1BA 5G0HA 5EF8A 4RLAA 5G10A 5EFKB 1TA1A 1GQ7A 1XFKA 4FCKA 4FCIA 4IE3A 1P8RA 4BZ5A 1T5GA 3TF3A 4CQFA 3MFWA 2A0MA 5DC5A 3EWFA 4RN0A 4Q3QA 4BZ7A 3F07A 4QA1A 3DJ8A 4ITYA 4LY1A 5FUEA 3THJA 4Q3RA 4A69A 3MFVA 3ZNRA 5G1BA 1T5FA 1D3VA 5CEVA 1WVBA 5THUA 3F0RA 4GSZA 3C10A 3MZ4A 5A2SA 4BZ6A 3Q9CA 5THTA 3SL0A 5LI3A 4GWDA 3E8ZA 4Q3RC 4Q3UA 3E6VA 4QA7A 5G11A 4RHJA 4Q3SA 5G1AA 5EFHA 3E8QA 3MJLA 4ZUNA 2VQWG 1CEVA 5G0IA 5FCWA 5EEKA 3E6KA 3SKKA 5JI5A 3NIOA 5G0XA 5THSA 4IU0A 4QA4A 3MENA 4QA6A 3THHA 1GQ6A 4IXUA 4CBTA 5EF7A 1C3SA 4RN2A 4ZURA 4MXRA 2VQJA 1T69A 3Q9BA 2EF5A 3TH7A 5ICNB 2VQVA 3MAXA 3C0ZA 3PZLA 5D1CA 3GMZA 4IU4A 4IE2A 4Q3TA 4MYFA 2V5WA 4GWCA 5EEFA 5G0YA 5EEIA
chains in the Genus database with same CATH topology
3EW8A 5G12A 4ZUOA 3MZ6A 3ZNSA 2VCGA 3Q9FA 5EEMA 5EFJD 4RN1A 4BZ8A 2VQQA 5G17A 4ZUQA 1ZZ0A 4CBYA 5EFNA 3Q9EA 4QA5A 5BWZA 1C3RA 5EFGA 1C3PA 5G0JA 1T67A 2GH6A 5EFBD 4QA2A 2VQMA 1VKGA 2VQOA 3EZTA 1ZZ1A 4BKXB 5EENA 3EZPA 5DC6A 4LXZA 3SFHA 5G0GA 3RQDA 4ZUMA 1ZZ3A 4QA0A 5G13A 5G1CA 2V5XA 5DC7A 5IWGA 5THVA 4BZ9A 3SFFA 1W22A 5IX0A 5DC8A 3MZ3A 5EFKB 3F06A 4ZUPA 5G3WA 3MZ7A 4QA3A 1T64A 3C0YA 5D1BA 5G0HA 5EF8A 5G10A 4BZ5A 4CQFA 5DC5A 3EWFA 4RN0A 4BZ7A 3F07A 4QA1A 5FUEA 4LY1A 4A69A 3ZNRA 5G1BA 5THUA 3F0RA 3C10A 3MZ4A 5A2SA 4BZ6A 3Q9CA 5THTA 5LI3A 4QA7A 5G11A 5G1AA 5EFHA 4ZUNA 2VQWG 5G0IA 5FCWA 5EEKA 5JI5A 5THSA 5G0XA 4QA4A 3MENA 4QA6A 4CBTA 5EF7A 1C3SA 4RN2A 4ZURA 2VQJA 1T69A 3Q9BA 5ICNB 2VQVA 3MAXA 3C0ZA 5D1CA 5D1DA 2V5WA 5EEFA 5G0YA 5EEIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EW8 A;  5G12 A;  4ZUO A;  3MZ6 A;  3ZNS A;  2VCG A;  3Q9F A;  5EEM A;  5EFJ D;  4RN1 A;  4BZ8 A;  2VQQ A;  5G17 A;  4ZUQ A;  1ZZ0 A;  4CBY A;  5EFN A;  3Q9E A;  4QA5 A;  5BWZ A;  1C3R A;  5EFG A;  1C3P A;  5G0J A;  1T67 A;  2GH6 A;  5EFB D;  4QA2 A;  2VQM A;  1VKG A;  2VQO A;  3EZT A;  1ZZ1 A;  4BKX B;  5EEN A;  3EZP A;  5DC6 A;  4LXZ A;  3SFH A;  5G0G A;  3RQD A;  4ZUM A;  1ZZ3 A;  4QA0 A;  5G13 A;  5G1C A;  2V5X A;  5DC7 A;  5IWG A;  5THV A;  4BZ9 A;  3SFF A;  1W22 A;  5IX0 A;  5DC8 A;  3MZ3 A;  5EFK B;  3F06 A;  4ZUP A;  5G3W A;  3MZ7 A;  4QA3 A;  1T64 A;  3C0Y A;  5D1B A;  5G0H A;  5EF8 A;  5G10 A;  4BZ5 A;  4CQF A;  5DC5 A;  3EWF A;  4RN0 A;  4BZ7 A;  3F07 A;  4QA1 A;  5FUE A;  4LY1 A;  4A69 A;  3ZNR A;  5G1B A;  5THU A;  3F0R A;  3C10 A;  3MZ4 A;  5A2S A;  4BZ6 A;  3Q9C A;  5THT A;  5LI3 A;  4QA7 A;  5G11 A;  5G1A A;  5EFH A;  4ZUN A;  2VQW G;  5G0I A;  5FCW A;  5EEK A;  5JI5 A;  5THS A;  5G0X A;  4QA4 A;  3MEN A;  4QA6 A;  4CBT A;  5EF7 A;  1C3S A;  4RN2 A;  4ZUR A;  2VQJ A;  1T69 A;  3Q9B A;  5ICN B;  2VQV A;  3MAX A;  3C0Z A;  5D1C A;  5D1D A;  2V5W A;  5EEF A;  5G0Y A;  5EEI A; 
#chains in the Genus database with same CATH topology
 5RLA A;  3EW8 A;  5G12 A;  4ZUO A;  3MZ6 A;  3ZNS A;  2VCG A;  2EF4 A;  1WOG A;  2RLA A;  5HJA A;  4MYK A;  1T4T A;  3MMR A;  1TBJ A;  3Q9F A;  1RLA A;  4GSM A;  5EEM A;  1WVA A;  1WOH A;  3CEV A;  4IXV A;  5EFJ D;  1HQ5 A;  4RN1 A;  1P8N A;  4BZ8 A;  1P8O A;  2PHO A;  4Q42 A;  4MYL A;  3LHL A;  3NIQ A;  2VQQ A;  5G17 A;  4ZUQ A;  3E9B A;  1ZZ0 A;  4CBY A;  5EFN A;  1T4P A;  4Q3V A;  1TBL A;  3Q9E A;  4QA5 A;  5BWZ A;  1P8Q A;  1C3R A;  4I06 A;  2EIV A;  3RLA A;  3SJT A;  4CEV A;  5EFG A;  2ZAV A;  1C3P A;  2PLL A;  5G0J A;  4IE1 A;  1T67 A;  2GH6 A;  1HQG A;  5EFB D;  1WOI A;  1PQ3 A;  4QA2 A;  2VQM A;  3NIP A;  2CEV A;  1VKG A;  2VQO A;  4HWW A;  3EZT A;  4RHL A;  4DZ4 A;  3LP4 A;  1ZZ1 A;  4RHM A;  4RHK A;  4BKX B;  3F80 A;  1R1O A;  4IU5 A;  5EEN A;  2AEB A;  3EZP A;  4LXZ A;  5DC6 A;  4RHI A;  3SFH A;  5G0G A;  1T4R A;  3RQD A;  4ZUM A;  4Q41 A;  4Q40 A;  1ZZ3 A;  4QA0 A;  5G13 A;  5G1C A;  3THE A;  5HJ9 A;  1HQX A;  4Q3P A;  1P8P A;  4IU1 A;  2V5X A;  5DC7 A;  5IWG A;  5D1D A;  4HZE A;  4HXQ A;  4G3H A;  3LP7 A;  5THV A;  4BZ9 A;  3KV2 A;  3SL1 A;  2PHA A;  1T4S A;  3SFF A;  1TBH A;  1HQF A;  1W22 A;  5IX0 A;  1ZPE A;  5DC8 A;  3M1R A;  1P8M A;  1ZPG A;  3F06 A;  3GN0 A;  3MZ3 A;  1HQH A;  4GSV A;  3MZ7 A;  4MYN A;  4RHQ A;  4ZUP A;  5G3W A;  4QA3 A;  1T64 A;  3C0Y A;  1P8S A;  5D1B A;  5G0H A;  5EF8 A;  4RLA A;  5G10 A;  5EFK B;  1TA1 A;  1GQ7 A;  1XFK A;  4FCK A;  4FCI A;  4IE3 A;  1P8R A;  4BZ5 A;  1T5G A;  3TF3 A;  4CQF A;  3MFW A;  2A0M A;  5DC5 A;  3EWF A;  4RN0 A;  4Q3Q A;  4BZ7 A;  3F07 A;  4QA1 A;  3DJ8 A;  4ITY A;  4LY1 A;  5FUE A;  3THJ A;  4Q3R A;  4A69 A;  3MFV A;  3ZNR A;  5G1B A;  1T5F A;  1D3V A;  5CEV A;  1WVB A;  5THU A;  3F0R A;  4GSZ A;  3C10 A;  3MZ4 A;  5A2S A;  4BZ6 A;  3Q9C A;  5THT A;  3SL0 A;  5LI3 A;  4GWD A;  3E8Z A;  4Q3R C;  4Q3U A;  3E6V A;  4QA7 A;  5G11 A;  4RHJ A;  4Q3S A;  5G1A A;  5EFH A;  3E8Q A;  3MJL A;  4ZUN A;  2VQW G;  1CEV A;  5G0I A;  5FCW A;  5EEK A;  3E6K A;  3SKK A;  5JI5 A;  3NIO A;  5G0X A;  5THS A;  4IU0 A;  4QA4 A;  3MEN A;  4QA6 A;  3THH A;  1GQ6 A;  4IXU A;  4CBT A;  5EF7 A;  1C3S A;  4RN2 A;  4ZUR A;  4MXR A;  2VQJ A;  1T69 A;  3Q9B A;  2EF5 A;  3TH7 A;  5ICN B;  2VQV A;  3MAX A;  3C0Z A;  3PZL A;  5D1C A;  3GMZ A;  4IU4 A;  4IE2 A;  4Q3T A;  4MYF A;  2V5W A;  4GWC A;  5EEF A;  5G0Y A;  5EEI A; 
#chains in the Genus database with same CATH homology
 3EW8 A;  5G12 A;  4ZUO A;  3MZ6 A;  3ZNS A;  2VCG A;  3Q9F A;  5EEM A;  5EFJ D;  4RN1 A;  4BZ8 A;  2VQQ A;  5G17 A;  4ZUQ A;  1ZZ0 A;  4CBY A;  5EFN A;  3Q9E A;  4QA5 A;  5BWZ A;  1C3R A;  5EFG A;  1C3P A;  5G0J A;  1T67 A;  2GH6 A;  5EFB D;  4QA2 A;  2VQM A;  1VKG A;  2VQO A;  3EZT A;  1ZZ1 A;  4BKX B;  5EEN A;  3EZP A;  5DC6 A;  4LXZ A;  3SFH A;  5G0G A;  3RQD A;  4ZUM A;  1ZZ3 A;  4QA0 A;  5G13 A;  5G1C A;  2V5X A;  5DC7 A;  5IWG A;  5THV A;  4BZ9 A;  3SFF A;  1W22 A;  5IX0 A;  5DC8 A;  3MZ3 A;  5EFK B;  3F06 A;  4ZUP A;  5G3W A;  3MZ7 A;  4QA3 A;  1T64 A;  3C0Y A;  5D1B A;  5G0H A;  5EF8 A;  5G10 A;  4BZ5 A;  4CQF A;  5DC5 A;  3EWF A;  4RN0 A;  4BZ7 A;  3F07 A;  4QA1 A;  5FUE A;  4LY1 A;  4A69 A;  3ZNR A;  5G1B A;  5THU A;  3F0R A;  3C10 A;  3MZ4 A;  5A2S A;  4BZ6 A;  3Q9C A;  5THT A;  5LI3 A;  4QA7 A;  5G11 A;  5G1A A;  5EFH A;  4ZUN A;  2VQW G;  5G0I A;  5FCW A;  5EEK A;  5JI5 A;  5THS A;  5G0X A;  4QA4 A;  3MEN A;  4QA6 A;  4CBT A;  5EF7 A;  1C3S A;  4RN2 A;  4ZUR A;  2VQJ A;  1T69 A;  3Q9B A;  5ICN B;  2VQV A;  3MAX A;  3C0Z A;  5D1C A;  5D1D A;  2V5W A;  5EEF A;  5G0Y A;  5EEI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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