3N7RA

Crystal structure of the ectodomain complex of the cgrp receptor, a class-b gpcr, reveals the site of drug antagonism
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
97
structure length
91
Chain Sequence
IQLGVTRNKIMTAQYECYQKIMQDPVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Membrane protein
molecule keywords Calcitonin gene-related peptide type 1 receptor
publication title Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism.
pubmed doi rcsb
source organism Homo sapiens
total genus 24
structure length 91
sequence length 97
chains with identical sequence B
ec nomenclature
pdb deposition date 2010-05-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02793 HRM Hormone receptor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.1240.10 Few Secondary Structures Irregular Hormone receptor fold GPCR, family 2, extracellular hormone receptor domain 3n7rA00
3N7PA 3C59A 4ERSA 2L27A 3AQFB 3N7RA 1U34A 4HJ0A 2JODA 4DLQA 3H3GA 3EHSA 3IOLA 2JNCA 3L2JA 2JNDA 5II0A 2XDGA 4DLOA 3EHTA 3C5TA 3N7SA 3C4MA 2QKHA 3EHUA 4LF3C 4ZGMA
chains in the Genus database with same CATH superfamily
3N7PA 3C59A 4ERSA 2L27A 3AQFB 3N7RA 1U34A 4HJ0A 2JODA 4DLQA 3H3GA 3EHSA 3IOLA 2JNCA 3L2JA 2JNDA 5II0A 2XDGA 4DLOA 3EHTA 3C5TA 3N7SA 3C4MA 2QKHA 3EHUA 4LF3C 4ZGMA
chains in the Genus database with same CATH topology
3N7PA 3C59A 4ERSA 2L27A 3AQFB 3N7RA 1U34A 4HJ0A 2JODA 4DLQA 3H3GA 3EHSA 3IOLA 2JNCA 3L2JA 2JNDA 5II0A 2XDGA 4DLOA 3EHTA 3C5TA 3N7SA 3C4MA 2QKHA 3EHUA 4LF3C 4ZGMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3N7P A;  3C59 A;  4ERS A;  2L27 A;  3AQF B;  3N7R A;  1U34 A;  4HJ0 A;  2JOD A;  4DLQ A;  3H3G A;  3EHS A;  3IOL A;  2JNC A;  3L2J A;  2JND A;  5II0 A;  2XDG A;  4DLO A;  3EHT A;  3C5T A;  3N7S A;  3C4M A;  2QKH A;  3EHU A;  4LF3 C;  4ZGM A; 
#chains in the Genus database with same CATH topology
 3N7P A;  3C59 A;  4ERS A;  2L27 A;  3AQF B;  3N7R A;  1U34 A;  4HJ0 A;  2JOD A;  4DLQ A;  3H3G A;  3EHS A;  3IOL A;  2JNC A;  3L2J A;  2JND A;  5II0 A;  2XDG A;  4DLO A;  3EHT A;  3C5T A;  3N7S A;  3C4M A;  2QKH A;  3EHU A;  4LF3 C;  4ZGM A; 
#chains in the Genus database with same CATH homology
 3N7P A;  3C59 A;  4ERS A;  2L27 A;  3AQF B;  3N7R A;  1U34 A;  4HJ0 A;  2JOD A;  4DLQ A;  3H3G A;  3EHS A;  3IOL A;  2JNC A;  3L2J A;  2JND A;  5II0 A;  2XDG A;  4DLO A;  3EHT A;  3C5T A;  3N7S A;  3C4M A;  2QKH A;  3EHU A;  4LF3 C;  4ZGM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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