3NR8A

Crystal structure of human ship2
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
310
structure length
293
Chain Sequence
DMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNDISLRFTHLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVGVTS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2
total genus 91
structure length 293
sequence length 310
chains with identical sequence B
ec nomenclature ec 3.1.3.86: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase.
pdb deposition date 2010-06-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 3nr8A00
4GEWA 2ISIA 3NGNA 4L1YA 4PUQA 2JC4A 1DE8A 1ZWXA 5DFJA 1DNKA 3I48A 5DV2A 5CFGA 1I9YA 2O3HA 4FPVA 4CMNA 1VYBA 3NR8A 4GZ2A 3W2XA 4LNDA 4CMLA 1YJHA 2A42B 4QHEA 3G4TA 5DG0A 5DFHA 2DDSA 3MPRA 3G38A 3CJCD 5J3ZA 1SI6X 3FZIA 3L1WA 1AKOA 3G91A 3MTCA 3DNIA 5INQA 3G3CA 3NGQA 1DEWA 2O3CA 3I41A 4B5GA 3G6SA 4A9CA 3G00A 3G3YA 5INOA 4RUWA 5J3SA 5HT2A 2D1KB 3U8UA 3N9VA 3G8VA 4F1RA 4GZ0A 5A7JA 4B5FA 2A3ZB 3K55A 3G1KA 3W3DB 3G2CA 5A7IA 5DV4A 2V0RA 5INKA 5J3PA 4IEMA 4JG3A 1HD7A 1SR4B 2DDRA 2F1NA 3I5VA 4GYZA 5J42A 1Y21A 3WCXA 2JC5A 5EWTA 4B5IA 3TEBA 2A41B 4GZ1A 5J8NA 1I9ZA 4L21A 4B5HA 1NTFA 1DE9A 3G0RA 2VOAA 4F1HB 4AWNA 5INPA 1ATND 1BIXA 5DFFA 1WDUA 5INMA 4QHDA 4K6LF 4B5MA 1E9NA 4F1HA 2V0SA 3G2DA 4QH9A 3W2YA 2DNJA 4L20A 3I46A 5INNA 4L1ZA 4B5JA 2XSWA 4FVAA 5INLA 2EI9A 2F2FB 2DDTA 2J63A 2IMQX 2A40B 5CFEA 4C1RA 2UYRX 3GA6A 4F1IA 5DFIA 3G0AA 3NGOA
chains in the Genus database with same CATH superfamily
4GEWA 2ISIA 3NGNA 4L1YA 4PUQA 2JC4A 1DE8A 1ZWXA 5DFJA 1DNKA 3I48A 5DV2A 5CFGA 1I9YA 2O3HA 4FPVA 4CMNA 1VYBA 3NR8A 4GZ2A 3W2XA 4LNDA 4CMLA 1YJHA 2A42B 4QHEA 3G4TA 5DG0A 5DFHA 2DDSA 3MPRA 3G38A 3CJCD 5J3ZA 1SI6X 3FZIA 3L1WA 1AKOA 3G91A 3MTCA 3DNIA 5INQA 3G3CA 3NGQA 1DEWA 2O3CA 3I41A 4B5GA 3G6SA 4A9CA 3G00A 3G3YA 5INOA 4RUWA 5J3SA 5HT2A 2D1KB 3U8UA 3N9VA 3G8VA 4F1RA 4GZ0A 5A7JA 4B5FA 2A3ZB 3K55A 3G1KA 3W3DB 3G2CA 5A7IA 5DV4A 2V0RA 5INKA 5J3PA 4IEMA 4JG3A 1HD7A 1SR4B 2DDRA 2F1NA 3I5VA 4GYZA 5J42A 1Y21A 3WCXA 2JC5A 5EWTA 4B5IA 3TEBA 2A41B 4GZ1A 5J8NA 1I9ZA 4L21A 4B5HA 1NTFA 1DE9A 3G0RA 2VOAA 4F1HB 4AWNA 5INPA 1ATND 1BIXA 5DFFA 1WDUA 5INMA 4QHDA 4K6LF 4B5MA 1E9NA 4F1HA 2V0SA 3G2DA 4QH9A 3W2YA 2DNJA 4L20A 3I46A 5INNA 4L1ZA 4B5JA 2XSWA 4FVAA 5INLA 2EI9A 2F2FB 2DDTA 2J63A 2IMQX 2A40B 5CFEA 4C1RA 2UYRX 3GA6A 4F1IA 5DFIA 3G0AA 3NGOA
chains in the Genus database with same CATH topology
4GEWA 2ISIA 3NGNA 4L1YA 4PUQA 2JC4A 1DE8A 1ZWXA 5DFJA 1DNKA 3I48A 5DV2A 5CFGA 1I9YA 2O3HA 4FPVA 4CMNA 1VYBA 3NR8A 4GZ2A 3W2XA 4LNDA 4CMLA 1YJHA 2A42B 4QHEA 3G4TA 5DG0A 5DFHA 2DDSA 3MPRA 3G38A 3CJCD 5J3ZA 1SI6X 3FZIA 3L1WA 1AKOA 3G91A 3MTCA 3DNIA 5INQA 3G3CA 3NGQA 1DEWA 2O3CA 3I41A 4B5GA 3G6SA 4A9CA 3G00A 3G3YA 5INOA 4RUWA 5J3SA 5HT2A 2D1KB 3U8UA 3N9VA 3G8VA 4F1RA 4GZ0A 5A7JA 4B5FA 2A3ZB 3K55A 3G1KA 3W3DB 3G2CA 5A7IA 5DV4A 2V0RA 5INKA 5J3PA 4IEMA 4JG3A 1HD7A 1SR4B 2DDRA 2F1NA 3I5VA 4GYZA 5J42A 1Y21A 3WCXA 2JC5A 5EWTA 4B5IA 3TEBA 2A41B 4GZ1A 5J8NA 1I9ZA 4L21A 4B5HA 1NTFA 1DE9A 3G0RA 2VOAA 4F1HB 4AWNA 5INPA 1ATND 1BIXA 5DFFA 1WDUA 5INMA 4QHDA 4K6LF 4B5MA 1E9NA 4F1HA 2V0SA 3G2DA 4QH9A 3W2YA 2DNJA 4L20A 3I46A 5INNA 4L1ZA 4B5JA 2XSWA 4FVAA 5INLA 2EI9A 2F2FB 2DDTA 2J63A 2IMQX 2A40B 5CFEA 4C1RA 2UYRX 3GA6A 4F1IA 5DFIA 3G0AA 3NGOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GEW A;  2ISI A;  3NGN A;  4L1Y A;  4PUQ A;  2JC4 A;  1DE8 A;  1ZWX A;  5DFJ A;  1DNK A;  3I48 A;  5DV2 A;  5CFG A;  1I9Y A;  2O3H A;  4FPV A;  4CMN A;  1VYB A;  3NR8 A;  4GZ2 A;  3W2X A;  4LND A;  4CML A;  1YJH A;  2A42 B;  4QHE A;  3G4T A;  5DG0 A;  5DFH A;  2DDS A;  3MPR A;  3G38 A;  3CJC D;  5J3Z A;  1SI6 X;  3FZI A;  3L1W A;  1AKO A;  3G91 A;  3MTC A;  3DNI A;  5INQ A;  3G3C A;  3NGQ A;  1DEW A;  2O3C A;  3I41 A;  4B5G A;  3G6S A;  4A9C A;  3G00 A;  3G3Y A;  5INO A;  4RUW A;  5J3S A;  5HT2 A;  2D1K B;  3U8U A;  3N9V A;  3G8V A;  4F1R A;  4GZ0 A;  5A7J A;  4B5F A;  2A3Z B;  3K55 A;  3G1K A;  3W3D B;  3G2C A;  5A7I A;  5DV4 A;  2V0R A;  5INK A;  5J3P A;  4IEM A;  4JG3 A;  1HD7 A;  1SR4 B;  2DDR A;  2F1N A;  3I5V A;  4GYZ A;  5J42 A;  1Y21 A;  3WCX A;  2JC5 A;  5EWT A;  4B5I A;  3TEB A;  2A41 B;  4GZ1 A;  5J8N A;  1I9Z A;  4L21 A;  4B5H A;  1NTF A;  1DE9 A;  3G0R A;  2VOA A;  4F1H B;  4AWN A;  5INP A;  1ATN D;  1BIX A;  5DFF A;  1WDU A;  5INM A;  4QHD A;  4K6L F;  4B5M A;  1E9N A;  4F1H A;  2V0S A;  3G2D A;  4QH9 A;  3W2Y A;  2DNJ A;  4L20 A;  3I46 A;  5INN A;  4L1Z A;  4B5J A;  2XSW A;  4FVA A;  5INL A;  2EI9 A;  2F2F B;  2DDT A;  2J63 A;  2IMQ X;  2A40 B;  5CFE A;  4C1R A;  2UYR X;  3GA6 A;  4F1I A;  5DFI A;  3G0A A;  3NGO A; 
#chains in the Genus database with same CATH topology
 4GEW A;  2ISI A;  3NGN A;  4L1Y A;  4PUQ A;  2JC4 A;  1DE8 A;  1ZWX A;  5DFJ A;  1DNK A;  3I48 A;  5DV2 A;  5CFG A;  1I9Y A;  2O3H A;  4FPV A;  4CMN A;  1VYB A;  3NR8 A;  4GZ2 A;  3W2X A;  4LND A;  4CML A;  1YJH A;  2A42 B;  4QHE A;  3G4T A;  5DG0 A;  5DFH A;  2DDS A;  3MPR A;  3G38 A;  3CJC D;  5J3Z A;  1SI6 X;  3FZI A;  3L1W A;  1AKO A;  3G91 A;  3MTC A;  3DNI A;  5INQ A;  3G3C A;  3NGQ A;  1DEW A;  2O3C A;  3I41 A;  4B5G A;  3G6S A;  4A9C A;  3G00 A;  3G3Y A;  5INO A;  4RUW A;  5J3S A;  5HT2 A;  2D1K B;  3U8U A;  3N9V A;  3G8V A;  4F1R A;  4GZ0 A;  5A7J A;  4B5F A;  2A3Z B;  3K55 A;  3G1K A;  3W3D B;  3G2C A;  5A7I A;  5DV4 A;  2V0R A;  5INK A;  5J3P A;  4IEM A;  4JG3 A;  1HD7 A;  1SR4 B;  2DDR A;  2F1N A;  3I5V A;  4GYZ A;  5J42 A;  1Y21 A;  3WCX A;  2JC5 A;  5EWT A;  4B5I A;  3TEB A;  2A41 B;  4GZ1 A;  5J8N A;  1I9Z A;  4L21 A;  4B5H A;  1NTF A;  1DE9 A;  3G0R A;  2VOA A;  4F1H B;  4AWN A;  5INP A;  1ATN D;  1BIX A;  5DFF A;  1WDU A;  5INM A;  4QHD A;  4K6L F;  4B5M A;  1E9N A;  4F1H A;  2V0S A;  3G2D A;  4QH9 A;  3W2Y A;  2DNJ A;  4L20 A;  3I46 A;  5INN A;  4L1Z A;  4B5J A;  2XSW A;  4FVA A;  5INL A;  2EI9 A;  2F2F B;  2DDT A;  2J63 A;  2IMQ X;  2A40 B;  5CFE A;  4C1R A;  2UYR X;  3GA6 A;  4F1I A;  5DFI A;  3G0A A;  3NGO A; 
#chains in the Genus database with same CATH homology
 4GEW A;  2ISI A;  3NGN A;  4L1Y A;  4PUQ A;  2JC4 A;  1DE8 A;  1ZWX A;  5DFJ A;  1DNK A;  3I48 A;  5DV2 A;  5CFG A;  1I9Y A;  2O3H A;  4FPV A;  4CMN A;  1VYB A;  3NR8 A;  4GZ2 A;  3W2X A;  4LND A;  4CML A;  1YJH A;  2A42 B;  4QHE A;  3G4T A;  5DG0 A;  5DFH A;  2DDS A;  3MPR A;  3G38 A;  3CJC D;  5J3Z A;  1SI6 X;  3FZI A;  3L1W A;  1AKO A;  3G91 A;  3MTC A;  3DNI A;  5INQ A;  3G3C A;  3NGQ A;  1DEW A;  2O3C A;  3I41 A;  4B5G A;  3G6S A;  4A9C A;  3G00 A;  3G3Y A;  5INO A;  4RUW A;  5J3S A;  5HT2 A;  2D1K B;  3U8U A;  3N9V A;  3G8V A;  4F1R A;  4GZ0 A;  5A7J A;  4B5F A;  2A3Z B;  3K55 A;  3G1K A;  3W3D B;  3G2C A;  5A7I A;  5DV4 A;  2V0R A;  5INK A;  5J3P A;  4IEM A;  4JG3 A;  1HD7 A;  1SR4 B;  2DDR A;  2F1N A;  3I5V A;  4GYZ A;  5J42 A;  1Y21 A;  3WCX A;  2JC5 A;  5EWT A;  4B5I A;  3TEB A;  2A41 B;  4GZ1 A;  5J8N A;  1I9Z A;  4L21 A;  4B5H A;  1NTF A;  1DE9 A;  3G0R A;  2VOA A;  4F1H B;  4AWN A;  5INP A;  1ATN D;  1BIX A;  5DFF A;  1WDU A;  5INM A;  4QHD A;  4K6L F;  4B5M A;  1E9N A;  4F1H A;  2V0S A;  3G2D A;  4QH9 A;  3W2Y A;  2DNJ A;  4L20 A;  3I46 A;  5INN A;  4L1Z A;  4B5J A;  2XSW A;  4FVA A;  5INL A;  2EI9 A;  2F2F B;  2DDT A;  2J63 A;  2IMQ X;  2A40 B;  5CFE A;  4C1R A;  2UYR X;  3GA6 A;  4F1I A;  5DFI A;  3G0A A;  3NGO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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