3NVWC

Crystal structure of bovine xanthine oxidase in complex with guanine
Total Genus 263
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
263
sequence length
756
structure length
756
Chain Sequence
b'DTVGRPLPHLAAAMQASGEAVYCDDIPRYENELFLRLVTSTRAHAKIKSIDVSEAQKVPGFVCFLSADDIPGSNETGLFNDETVFAKDTVTCVGHIIGAVVADTPEHAERAAHVVKVTYEDLPAIITIEDAIKNNSFYGSELKIEKGDLKKGFSEADNVVSGELYIGGQDHFYLETHCTIAIPKGEEGEMELFVSTQNAMKTQSFVAKMLGVPVNRILVRVKRMGGGFGGKETRSTLVSVAVALAAYKTGHPVRCMLDRNEDMLITGGRHPFLARYKVGFMKTGTIVALEVDHYSNAGNSRDLSHSIMERALFHMDNCYKIPNIRGTGRLCKTNLSSNTAFRGFGGPQALFIAENWMSEVAVTCGLPAEEVRWKNMYKEGDLTHFNQRLEGFSVPRCWDECLKSSQYYARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALIHVYTDGSVLVSHGGTEMGQGLHTKMVQVASKALKIPISKIYISETSTNTVPNSSPTAASVSTDIYGQAVYEACQTILKRLEPFKKKNPDGSWEDWVMAAYQDRVSLSTTGFYRTPNLGYSFETNSGNAFHYFTYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPTEFRVSLLRDCPNKKAIYASKAVGEPPLFLGASVFFAIKDAIRAARAQHTNNNTKELFRLDSPATPEKIRNACVDKFTTLCVTGAPGNCK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Xanthine dehydrogenase/oxidase
publication title Substrate orientation and specificity in xanthine oxidase: crystal structures of the enzyme in complex with indole-3-acetaldehyde and guanine.
pubmed doi rcsb
molecule tags Oxidoreductase
total genus 263
structure length 756
sequence length 756
chains with identical sequence L
ec nomenclature ec 1.17.1.4: Xanthine dehydrogenase.
pdb deposition date 2010-07-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01315 Ald_Xan_dh_C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
C PF02738 Ald_Xan_dh_C2 Molybdopterin-binding domain of aldehyde dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3nvwC02
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3nvwC05
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3nvwC04
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3nvwC03
3.90.1170.50 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead 3nvwC01
1N62B 3NVYC 1FFVB 3FC4A 3ETRC 1N5XA 1FFUB 3AMZA 2W54B 1N5WB 3HRDB 1FIQC 1DGJA 1SIJA 4C7ZA 1ZXIB 1VLBA 3EUB4 2W3RB 4USAA 4US8A 3SR6C 3FAHA 1N63B 1VDVA 2E3TA 4ZOHA 1RM6A 3L4PA 1N61B 3NVWC 3NRZC 3NS1C 1SB3A 1V97A 1N60B 1FO4A 3B9JC 3AN1A 2W55B 4US9A 3HRDA 3AM9A 3NVZC 4C7YA 1JROB 1WYGA 1JRPB 2W3SB 4C80A 3NVVC
chains in the Genus database with same CATH superfamily
3CXCH 2Q5WE 5JVHJ 3PIOJ 2OMDA 1N5XA 2B7QA 1FFUB 3HRDB 1VQ9H 5H1SO 4IOCJ 2DSJA 3C2OA 1QPOA 1FMAE 2E3TA 3C2EA 1YTKA 1M1KJ 2PA2A 2QIEA 1YTDA 2I14A 5AN9F 1BRWA 2ZJQJ 3NVWC 2WK6A 5DM7J 3CC2H 1VQ8H 3NRZC 1VQPH 1NVJA 3VMMA 4I9AA 3B9JC 3AN1A 4WFBJ 4US9A 3HRDA 2B7PA 5HL7J 3CF5J 3TQVA 1JRPB 5JVGJ 4GA4A 1Q86J 5HUOA 3RPFA 1VQNH 3CCSH 1WKIA 1YJ9H 3FC4A 3I55H 1Q81J 4XR5A 2WP4A 4KWWA 4AP8A 1VQOH 2W54B 1YIJH 1VQ6H 1QVGH 1DGJA 3CCUH 1ZXIB 1VLBA 2OTLH 4GA6A 4USAA 3CCVH 1OTPA 3C2VA 1N63B 4X46A 4ZOHA 4WCEJ 5AYYA 3CMAH 1Y69K 1S72H 3CC7H 1VQ4H 1V97A 4YYYA 1N60B 3CCJH 1W2BH 3G71H 1QPQA 2W55B 3WO0A 2ZJPJ 1K73J 1YITH 1QVFH 3AM9A 1Q82J 5GAHN 3GNNA 1QPRA 1YJWH 4C80A 1O4UA 3NVVC 3CC4H 1QPNA 5HULA 1N62B 4EADA 1YTEA 5GADN 4EAFA 4WF9J 5MPOC 2QEXH 3CCRH 3CCQH 1KQSH 3CPWH 1AZYA 5HUPA 1FIQC 1SIJA 1UOUA 3G6EH 1JJ2H 3EUB4 4KWVA 5DM6J 2QA4H 3SR6C 3FAHA 3PIPJ 1N8RJ 4UY8M 1VDVA 2WK5A 3OW2H 3L4PA 1N61B 3CMEH 2OTJH 1K9MJ 3C2RA 3WO1A 3NS1C 1SB3A 3PAJA 4IO9J 1VQ7H 1VQLH 3CCMH 2ZJRJ 5GAEN 3BIIE 3NVZC 1JROB 1WYGA 3CD6H 3H5QA 2TPTA 5MLCO 3J7ZM 3I56H 1VQ5H 3L0GA 3WNZA 3NVYC 1FFVB 3ETRC 1NVIE 1NJIJ 1K8AJ 3AMZA 1N5WB 1X1OA 3G4SH 4IOAJ 4C7ZA 5AYZA 1M90J 2I1OA 2W3RB 1FM0E 4LHMA 4US8A 4WFAJ 1YHQH 1YJNH 4GA5A 4YEKA 1KC8J 1VQMH 1RM6A 3C2FA 3CCEH 4WFNJ 1Q7YJ 5GAGN 5EP8A 1YI2H 3DLLJ 2J0FA 5EY3A 1FO4A 1T3QB 5AYXA 1VQKH 4C7YA 1QAPA 1KD1J 2W3SB 2B7NA 2JBMA 4U67J 3CCLH
chains in the Genus database with same CATH topology
1N62B 3NVYC 1FFVB 3FC4A 3ETRC 1N5XA 1FFUB 3AMZA 2W54B 1N5WB 3HRDB 1FIQC 1DGJA 1SIJA 4C7ZA 1ZXIB 1VLBA 3EUB4 2W3RB 4USAA 4US8A 3SR6C 3FAHA 1N63B 1VDVA 2E3TA 4ZOHA 1RM6A 3L4PA 1N61B 3NVWC 3NRZC 3NS1C 1SB3A 1V97A 1N60B 1FO4A 3B9JC 3AN1A 2W55B 4US9A 3HRDA 3AM9A 3NVZC 4C7YA 1JROB 1WYGA 1JRPB 2W3SB 4C80A 3NVVC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1N62 B;  3NVY C;  1FFV B;  3FC4 A;  3ETR C;  1N5X A;  1FFU B;  3AMZ A;  2W54 B;  1N5W B;  3HRD B;  1FIQ C;  1DGJ A;  1SIJ A;  4C7Z A;  1ZXI B;  1VLB A;  3EUB 4;  2W3R B;  4USA A;  4US8 A;  3SR6 C;  3FAH A;  1N63 B;  1VDV A;  2E3T A;  4ZOH A;  1RM6 A;  3L4P A;  1N61 B;  3NVW C;  3NRZ C;  3NS1 C;  1SB3 A;  1V97 A;  1N60 B;  1FO4 A;  3B9J C;  3AN1 A;  2W55 B;  4US9 A;  3HRD A;  3AM9 A;  3NVZ C;  4C7Y A;  1JRO B;  1WYG A;  1JRP B;  2W3S B;  4C80 A;  3NVV C; 
#chains in the Genus database with same CATH topology
 3CXC H;  2Q5W E;  5JVH J;  3PIO J;  2OMD A;  1N5X A;  2B7Q A;  1FFU B;  3HRD B;  1VQ9 H;  5H1S O;  4IOC J;  2DSJ A;  3C2O A;  1QPO A;  1FMA E;  2E3T A;  3C2E A;  1YTK A;  1M1K J;  2PA2 A;  2QIE A;  1YTD A;  2I14 A;  5AN9 F;  1BRW A;  2ZJQ J;  3NVW C;  2WK6 A;  5DM7 J;  3CC2 H;  1VQ8 H;  3NRZ C;  1VQP H;  1NVJ A;  3VMM A;  4I9A A;  3B9J C;  3AN1 A;  4WFB J;  4US9 A;  3HRD A;  2B7P A;  5HL7 J;  3CF5 J;  3TQV A;  1JRP B;  5JVG J;  4GA4 A;  1Q86 J;  5HUO A;  3RPF A;  1VQN H;  3CCS H;  1WKI A;  1YJ9 H;  3FC4 A;  3I55 H;  1Q81 J;  4XR5 A;  2WP4 A;  4KWW A;  4AP8 A;  1VQO H;  2W54 B;  1YIJ H;  1VQ6 H;  1QVG H;  1DGJ A;  3CCU H;  1ZXI B;  1VLB A;  2OTL H;  4GA6 A;  4USA A;  3CCV H;  1OTP A;  3C2V A;  1N63 B;  4X46 A;  4ZOH A;  4WCE J;  5AYY A;  3CMA H;  1Y69 K;  1S72 H;  3CC7 H;  1VQ4 H;  1V97 A;  4YYY A;  1N60 B;  3CCJ H;  1W2B H;  3G71 H;  1QPQ A;  2W55 B;  3WO0 A;  2ZJP J;  1K73 J;  1YIT H;  1QVF H;  3AM9 A;  1Q82 J;  5GAH N;  3GNN A;  1QPR A;  1YJW H;  4C80 A;  1O4U A;  3NVV C;  3CC4 H;  1QPN A;  5HUL A;  1N62 B;  4EAD A;  1YTE A;  5GAD N;  4EAF A;  4WF9 J;  5MPO C;  2QEX H;  3CCR H;  3CCQ H;  1KQS H;  3CPW H;  1AZY A;  5HUP A;  1FIQ C;  1SIJ A;  1UOU A;  3G6E H;  1JJ2 H;  3EUB 4;  4KWV A;  5DM6 J;  2QA4 H;  3SR6 C;  3FAH A;  3PIP J;  1N8R J;  4UY8 M;  1VDV A;  2WK5 A;  3OW2 H;  3L4P A;  1N61 B;  3CME H;  2OTJ H;  1K9M J;  3C2R A;  3WO1 A;  3NS1 C;  1SB3 A;  3PAJ A;  4IO9 J;  1VQ7 H;  1VQL H;  3CCM H;  2ZJR J;  5GAE N;  3BII E;  3NVZ C;  1JRO B;  1WYG A;  3CD6 H;  3H5Q A;  2TPT A;  5MLC O;  3J7Z M;  3I56 H;  1VQ5 H;  3L0G A;  3WNZ A;  3NVY C;  1FFV B;  3ETR C;  1NVI E;  1NJI J;  1K8A J;  3AMZ A;  1N5W B;  1X1O A;  3G4S H;  4IOA J;  4C7Z A;  5AYZ A;  1M90 J;  2I1O A;  2W3R B;  1FM0 E;  4LHM A;  4US8 A;  4WFA J;  1YHQ H;  1YJN H;  4GA5 A;  4YEK A;  1KC8 J;  1VQM H;  1RM6 A;  3C2F A;  3CCE H;  4WFN J;  1Q7Y J;  5GAG N;  5EP8 A;  1YI2 H;  3DLL J;  2J0F A;  5EY3 A;  1FO4 A;  1T3Q B;  5AYX A;  1VQK H;  4C7Y A;  1QAP A;  1KD1 J;  2W3S B;  2B7N A;  2JBM A;  4U67 J;  3CCL H; 
#chains in the Genus database with same CATH homology
 1N62 B;  3NVY C;  1FFV B;  3FC4 A;  3ETR C;  1N5X A;  1FFU B;  3AMZ A;  2W54 B;  1N5W B;  3HRD B;  1FIQ C;  1DGJ A;  1SIJ A;  4C7Z A;  1ZXI B;  1VLB A;  3EUB 4;  2W3R B;  4USA A;  4US8 A;  3SR6 C;  3FAH A;  1N63 B;  1VDV A;  2E3T A;  4ZOH A;  1RM6 A;  3L4P A;  1N61 B;  3NVW C;  3NRZ C;  3NS1 C;  1SB3 A;  1V97 A;  1N60 B;  1FO4 A;  3B9J C;  3AN1 A;  2W55 B;  4US9 A;  3HRD A;  3AM9 A;  3NVZ C;  4C7Y A;  1JRO B;  1WYG A;  1JRP B;  2W3S B;  4C80 A;  3NVV C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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