3NWYA

Structure and allosteric regulation of the uridine monophosphate kinase from mycobacterium tuberculosis
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
235
structure length
227
Chain Sequence
LSGYSRVLLKLGGEMFGGGQVGLDPDVVAQVARQIADVVRGGVQIAVVIGGGNFAQLQQLGMERTRSDYMGMLGTVMNSLALQDFLEKEGIVTRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIGADVVLMAKAVDGVFAEPEAELLTAVSHREVLDRGLRVADATAFSLCMDNGMPILVFNLLTDGNIARAVRGEKIGTLVTT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation.
pubmed doi rcsb
molecule tags Transferase
source organism Mycobacterium tuberculosis
molecule keywords Uridylate kinase
total genus 73
structure length 227
sequence length 235
chains with identical sequence B, C, D, E, F
ec nomenclature ec 2.7.4.22: UMP kinase.
pdb deposition date 2010-07-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00696 AA_kinase Amino acid kinase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1160.10 Alpha Beta 3-Layer(aba) Sandwich Carbamate kinase Acetylglutamate kinase-like 3nwyA00
4AXSA 3L76A 3QUNA 3C1NA 3AAWA 3WWMA 2J4LA 2J0XA 4NDOA 1OHAA 2V5HA 4NDQB 3D2PA 2J5TA 2JI5A 3C1MA 2OGXB 3QURA 3LL5A 3D40A 3ZZGA 2W21A 3K4YA 2BNFA 2VA1A 3C20A 2J4JA 3LL9A 2OGXA 4NDPB 4A7XA 2BNEA 3LKKA 2J5VA 3AB2A 3K4OA 3QVHA 4F6TB 1YBDA 2BNDA 3ZZHA 1GS5A 3EK5A 4Q1TA 2E9YA 2JJ4A 3ZZFA 4F6TA 4NDRB 4NDQA 3QUOA 3K52A 2RD5A 4OLCA 2AP9A 2IJ9A 2BUFA 4NDRA 1Z9DA 2BTYA 2J4KA 2V4YA 3K56A 3NWYA 2R8VA 4NDPA 2X2WA 2J0WA 3AB4A 2HMFA 2WE5A 3WWNA 3B8GA 2WXBA 4A7WA 3L86A 2WE4A 2CDQA 2JJXA 3QVFA 3D41A 3ZZIA 1OH9A 2BRIA 4JZ8A 4JZ7A 1OHBA 4I49A 3D2MA 3S6KA 3EK6A 4USJA 2AKOA 4KZTA 4AB7A 3T7BA 2R98A 4JZ9A 2BMUA 3U6UA 1B7BA 3S6GA 1E19A 3TVIA 3S6HA 3KZFA 1GSJA 2BRXA 2A1FA 4NDOB
chains in the Genus database with same CATH superfamily
4AXSA 3L76A 3QUNA 3C1NA 3AAWA 3WWMA 2J4LA 2J0XA 4NDOA 1OHAA 2V5HA 4NDQB 3D2PA 2J5TA 2JI5A 3C1MA 2OGXB 3QURA 3LL5A 3D40A 3ZZGA 2W21A 3K4YA 2BNFA 2VA1A 3C20A 2J4JA 3LL9A 2OGXA 4NDPB 4A7XA 2BNEA 3LKKA 2J5VA 3AB2A 3K4OA 3QVHA 4F6TB 1YBDA 2BNDA 3ZZHA 1GS5A 3EK5A 4Q1TA 2E9YA 2JJ4A 3ZZFA 4F6TA 4NDRB 4NDQA 3QUOA 3K52A 2RD5A 4OLCA 2AP9A 2IJ9A 2BUFA 4NDRA 1Z9DA 2BTYA 2J4KA 2V4YA 3K56A 3NWYA 2R8VA 4NDPA 2X2WA 2J0WA 3AB4A 2HMFA 2WE5A 3WWNA 3B8GA 2WXBA 4A7WA 3L86A 2WE4A 2CDQA 2JJXA 3QVFA 3D41A 3ZZIA 1OH9A 2BRIA 4JZ8A 4JZ7A 1OHBA 4I49A 3D2MA 3S6KA 3EK6A 4USJA 2AKOA 4KZTA 4AB7A 3T7BA 2R98A 4JZ9A 2BMUA 3U6UA 1B7BA 3S6GA 1E19A 3TVIA 3S6HA 3KZFA 1GSJA 2BRXA 2A1FA 4NDOB
chains in the Genus database with same CATH topology
4AXSA 3L76A 3QUNA 3C1NA 3AAWA 3WWMA 2J4LA 2J0XA 4NDOA 1OHAA 2V5HA 4NDQB 3D2PA 2J5TA 2JI5A 3C1MA 2OGXB 3QURA 3LL5A 3D40A 3ZZGA 2W21A 3K4YA 2BNFA 2VA1A 3C20A 2J4JA 3LL9A 2OGXA 4NDPB 4A7XA 2BNEA 3LKKA 2J5VA 3AB2A 3K4OA 3QVHA 4F6TB 1YBDA 2BNDA 3ZZHA 1GS5A 3EK5A 4Q1TA 2E9YA 2JJ4A 3ZZFA 4F6TA 4NDRB 4NDQA 3QUOA 3K52A 2RD5A 4OLCA 2AP9A 2IJ9A 2BUFA 4NDRA 1Z9DA 2BTYA 2J4KA 2V4YA 3K56A 3NWYA 2R8VA 4NDPA 2X2WA 2J0WA 3AB4A 2HMFA 2WE5A 3WWNA 3B8GA 2WXBA 4A7WA 3L86A 2WE4A 2CDQA 2JJXA 3QVFA 3D41A 3ZZIA 1OH9A 2BRIA 4JZ8A 4JZ7A 1OHBA 4I49A 3D2MA 3S6KA 3EK6A 4USJA 2AKOA 4KZTA 4AB7A 3T7BA 2R98A 4JZ9A 2BMUA 3U6UA 1B7BA 3S6GA 1E19A 3TVIA 3S6HA 3KZFA 1GSJA 2BRXA 2A1FA 4NDOB
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4AXS A;  3L76 A;  3QUN A;  3C1N A;  3AAW A;  3WWM A;  2J4L A;  2J0X A;  4NDO A;  1OHA A;  2V5H A;  4NDQ B;  3D2P A;  2J5T A;  2JI5 A;  3C1M A;  2OGX B;  3QUR A;  3LL5 A;  3D40 A;  3ZZG A;  2W21 A;  3K4Y A;  2BNF A;  2VA1 A;  3C20 A;  2J4J A;  3LL9 A;  2OGX A;  4NDP B;  4A7X A;  2BNE A;  3LKK A;  2J5V A;  3AB2 A;  3K4O A;  3QVH A;  4F6T B;  1YBD A;  2BND A;  3ZZH A;  1GS5 A;  3EK5 A;  4Q1T A;  2E9Y A;  2JJ4 A;  3ZZF A;  4F6T A;  4NDR B;  4NDQ A;  3QUO A;  3K52 A;  2RD5 A;  4OLC A;  2AP9 A;  2IJ9 A;  2BUF A;  4NDR A;  1Z9D A;  2BTY A;  2J4K A;  2V4Y A;  3K56 A;  3NWY A;  2R8V A;  4NDP A;  2X2W A;  2J0W A;  3AB4 A;  2HMF A;  2WE5 A;  3WWN A;  3B8G A;  2WXB A;  4A7W A;  3L86 A;  2WE4 A;  2CDQ A;  2JJX A;  3QVF A;  3D41 A;  3ZZI A;  1OH9 A;  2BRI A;  4JZ8 A;  4JZ7 A;  1OHB A;  4I49 A;  3D2M A;  3S6K A;  3EK6 A;  4USJ A;  2AKO A;  4KZT A;  4AB7 A;  3T7B A;  2R98 A;  4JZ9 A;  2BMU A;  3U6U A;  1B7B A;  3S6G A;  1E19 A;  3TVI A;  3S6H A;  3KZF A;  1GSJ A;  2BRX A;  2A1F A;  4NDO B; 
#chains in the Genus database with same CATH topology
 4AXS A;  3L76 A;  3QUN A;  3C1N A;  3AAW A;  3WWM A;  2J4L A;  2J0X A;  4NDO A;  1OHA A;  2V5H A;  4NDQ B;  3D2P A;  2J5T A;  2JI5 A;  3C1M A;  2OGX B;  3QUR A;  3LL5 A;  3D40 A;  3ZZG A;  2W21 A;  3K4Y A;  2BNF A;  2VA1 A;  3C20 A;  2J4J A;  3LL9 A;  2OGX A;  4NDP B;  4A7X A;  2BNE A;  3LKK A;  2J5V A;  3AB2 A;  3K4O A;  3QVH A;  4F6T B;  1YBD A;  2BND A;  3ZZH A;  1GS5 A;  3EK5 A;  4Q1T A;  2E9Y A;  2JJ4 A;  3ZZF A;  4F6T A;  4NDR B;  4NDQ A;  3QUO A;  3K52 A;  2RD5 A;  4OLC A;  2AP9 A;  2IJ9 A;  2BUF A;  4NDR A;  1Z9D A;  2BTY A;  2J4K A;  2V4Y A;  3K56 A;  3NWY A;  2R8V A;  4NDP A;  2X2W A;  2J0W A;  3AB4 A;  2HMF A;  2WE5 A;  3WWN A;  3B8G A;  2WXB A;  4A7W A;  3L86 A;  2WE4 A;  2CDQ A;  2JJX A;  3QVF A;  3D41 A;  3ZZI A;  1OH9 A;  2BRI A;  4JZ8 A;  4JZ7 A;  1OHB A;  4I49 A;  3D2M A;  3S6K A;  3EK6 A;  4USJ A;  2AKO A;  4KZT A;  4AB7 A;  3T7B A;  2R98 A;  4JZ9 A;  2BMU A;  3U6U A;  1B7B A;  3S6G A;  1E19 A;  3TVI A;  3S6H A;  3KZF A;  1GSJ A;  2BRX A;  2A1F A;  4NDO B; 
#chains in the Genus database with same CATH homology
 4AXS A;  3L76 A;  3QUN A;  3C1N A;  3AAW A;  3WWM A;  2J4L A;  2J0X A;  4NDO A;  1OHA A;  2V5H A;  4NDQ B;  3D2P A;  2J5T A;  2JI5 A;  3C1M A;  2OGX B;  3QUR A;  3LL5 A;  3D40 A;  3ZZG A;  2W21 A;  3K4Y A;  2BNF A;  2VA1 A;  3C20 A;  2J4J A;  3LL9 A;  2OGX A;  4NDP B;  4A7X A;  2BNE A;  3LKK A;  2J5V A;  3AB2 A;  3K4O A;  3QVH A;  4F6T B;  1YBD A;  2BND A;  3ZZH A;  1GS5 A;  3EK5 A;  4Q1T A;  2E9Y A;  2JJ4 A;  3ZZF A;  4F6T A;  4NDR B;  4NDQ A;  3QUO A;  3K52 A;  2RD5 A;  4OLC A;  2AP9 A;  2IJ9 A;  2BUF A;  4NDR A;  1Z9D A;  2BTY A;  2J4K A;  2V4Y A;  3K56 A;  3NWY A;  2R8V A;  4NDP A;  2X2W A;  2J0W A;  3AB4 A;  2HMF A;  2WE5 A;  3WWN A;  3B8G A;  2WXB A;  4A7W A;  3L86 A;  2WE4 A;  2CDQ A;  2JJX A;  3QVF A;  3D41 A;  3ZZI A;  1OH9 A;  2BRI A;  4JZ8 A;  4JZ7 A;  1OHB A;  4I49 A;  3D2M A;  3S6K A;  3EK6 A;  4USJ A;  2AKO A;  4KZT A;  4AB7 A;  3T7B A;  2R98 A;  4JZ9 A;  2BMU A;  3U6U A;  1B7B A;  3S6G A;  1E19 A;  3TVI A;  3S6H A;  3KZF A;  1GSJ A;  2BRX A;  2A1F A;  4NDO B;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
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