3P3EA

Crystal structure of the pseudomonas aeruginosa lpxc/lpc-009 complex
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
297
structure length
297
Chain Sequence
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYM
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.
pubmed doi rcsb
source organism Pseudomonas aeruginosa
molecule tags Hydrolase
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 83
structure length 297
sequence length 297
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2010-10-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 3p3eA01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 3p3eA02
3U1YA 2IERA 4ISAA 4FW6A 4LCHA 5DRPA 5DRRA 4U3DA 3NZKA 3P3EA 2JT2A 1P42A 4OZEA 4FW5A 4IS9A 1YHCA 4FW4A 2O3ZA 4MQYA 1XXEA 5DROA 4J3DA 4LCGA 3PS3A 1YH8A 4OKGA 3P3CA 4LCFA 3P76A 3P3GA 2J65A 3PS1A 2IESA 2GO4A 4MDTA 4FW7A 3UHMA 4FW3A 3PS2A 5DRQA 4U3BA 2GO3A 2VESA
chains in the Genus database with same CATH superfamily
4X64I 1Z0BA 2WNRA 1N32E 1N34E 3P3EA 1XMQI 1RR9A 2UUBI 3M7NG 3B8HA 5FLXQ 5LL6R 4FW5A 4OX9I 4LF7I 2C38A 3M6AA 2UUAI 4DR1E 1IBKE 4B3SI 3PYDA 1N36I 4JI2I 2E5LE 1VISA 1R6MA 4DV3I 2IESA 2WP8A 1ZXNA 4NXMI 3UHMA 4JYAI 2PNZB 2Z5BB 3J80C 1UEKA 4U3DA 3T1HE 2PNLA 4DV3E 3ZKDA 1S16A 1OYSA 1XNRI 4LFCI 5K36C 3Q6MA 4NXME 1PVGA 1KKHA 3J7AM 5K36F 4IZKB 4LF8I 1Y4SA 3M85D 2WNRB 4JI2E 2AJ4A 4BA2A 3P3GA 1IBKI 3PS1A 1DARA 1NHIA 1UDSA 2XEXA 3T1YI 4B3TE 5JEAD 4MYTA 4WUBA 2UUCE 2O1TA 3NZKA 1ZXMA 2VQFI 3WU6A 2CVEA 3ZZUA 4WUCA 4PU9A 3PYEA 5FWKA 1ZM4A 3LNUA 1IBLE 1Z0WA 4LF4I 4UT4A 1FI4A 5C0XC 1NZ0A 2Z5BA 5K36E 4HXZA 5GMEA 4OKGA 1H72C 3ZZ0A 5C0XF 4JI3E 4DV6I 4DPTA 4MU1A 3L7ZB 3JAMQ 2GO3A 4NXNE 1D6TA 1N34I 1I94I 2UUAE 4JI5E 3V5RA 2PNZA 1E3PA 2WW4A 2UXBE 4FWDA 4JG4A 5BR8E 1N0UA 4DV5E 1XNQI 4KHPE 4AIMA 3L7ZA 4JV5E 2BM1A 2X7IA 2Q2EB 4DPXA 5LMUI 5LMNE 4DR4I 4X66E 4FW7A 4I3HA 1ZM2A 1PIEA 4M1KA 4GQUA 4IZJB 2V2QA 4DPUA 3OTOE 3K17A 4LF8E 2BR2A 4DU7A 4DV1I 4FW9A 4NXNI 1Z5AA 1UDQA 4LFCE 1HNWI 4BA1B 1Z5CA 5A2QC 1E3HA 1B63A 2O3ZA 4YHHE 4MQYA 1HNZI 3GCMA 4LF5I 4K0KE 1OYPA 5K36A 4LCFA 1N33I 2VF3A 1HNWE 2GO4A 4YHHI 4U3BA 2VESA 1NHJA 2ZM6I 4IZJA 1R6LA 1UDOA 5C0XD 2UXBI 4R1FA 4OO1D 1RHYA 1VI7A 2CG9A 2HFSA 4DR1I 4B3SE 4X64E 2O1VA 4XTJA 4JV5I 2BR2B 3QT8A 4B3RE 4IFDA 4DPWA 2UXCI 2R3VA 2HHHI 2PO1B 5DNLA 2J7KA 4GKJE 2WP8B 4DR5E 1I94E 4LOMA 5K36B 4JI8E 4JI3I 3H4LA 4X62E 1HK7A 1ELOA 2NN6D 2BA0G 2CGEA 5C0XA 1N36E 2NN6C 2DEJA 4X65E 1IBME 4IFDC 4DUYI 2PNMA 4DR3I 2BA1D 2EFGA 4JI6E 4JI0I 5DRQA 4Z7YA 3J81C 3HJCA 1RREA 2UXDE 4ISAA 4YY3I 3PRYA 4JI4E 4QNKA 5DNXA 4IZJD 1FJGI 1K47A 3WU3A 1ZM3A 2AE8A 4JI6I 4DR6E 4LF9I 1N33E 2JEBB 5C0XB 3H1CA 4DU8A 4LFAI 1OJ4A 5ELWA 2JEAA 1S4EA 2PO2B 4MYUA 1MX0A 4DV4I 1KIJA 1FWKA 5IT9Q 4UTGA 5A2QQ 1Y4UA 4X66I 5EKWA 2JT2A 5LMUE 1XHKA 1Y5YA 1HNXI 4IZKA 4GKJI 4JI4I 1Y60A 4URLA 2UU9I 4DR7I 1B62A 1EA6A 2BM0A 2HK2A 1FKAE 4LFBI 3WU5A 4DR6I 4K0KI 2V2VA 4J3DA 4BA2B 1FJGE 2NN6A 3P3CA 4LPFA 5FLXC 3GONA 3LPSA 2CZ9A 4JI0E 2HKEA 2NN6E 2F4VE 1Y6ZA 4X62I 3HULA 2F1DA 2JE6A 2PO2A 5JEAC 1H74A 4AQYE 3PYGA 2JEAB 2DEIA 2OI2A 5JEAF 3PYFA 2V8PA 4FW4A 2C39A 2IOQA 4DV7E 2GQ0A 4IFDB 1HNZE 4DXLA 2NN6B 1HR0I 3CDIA 4HACA 2J65A 4LFBE 5GMDA 4DR5I 4MDTA 1UDNA 5L3JA 4MU4A 4AIDA 4JI5I 2IERA 4FW6A 3U1KA 2F4VI 2O1WA 4JI7I 2C39B 2A2CA 2E1RA 4B3ME 2UUCI 2PO0B 3B82A 4LFAE 1J5EE 4PRXA 3GLLA 4IS9A 3QT6A 4JI1I 3QT5A 2HFUA 4LF9E 4ED4A 1MU5A 4BA1A 1OYRA 3J7AG 4GKKI 4DR2E 2JE6B 3PS3A 1H7SA 1YH8A 1XNRE 2HKJA 1Z0VA 4DR7E 3P76A 2ZBKB 1U2RA 1USUA 1HNXE 2PO1A 2UXDI 4FW3A 4DV2E 4DR2I 4GKKE 5DRPA 2X36A 2NPFA 4DR3E 1NHHA 2C38B 3M7ND 5K36D 3DD6A 3HKMA 4DV4E 4B3MI 2LJPA 1KVKA 2IOPA 4IFDD 3J81Q 2A2DA 4JI1E 3JAMC 4P52A 3QT7A 4Z7CA 3K1JA 1EI1A 2Z5CA 2V34A 3OTOI 4LF7E 3M85G 2O1UA 5IWAE 4LCHA 2VQFE 3D4JA 3CDJA 4FN5A 4P7AA 2Z5EA 4B3RI 2UXCE 4DV7I 1Z0CA 2PO0A 5C0XE 1FWLA 4YY3E 3ZKBA 4DV5I 2BV3A 5DROA 2JEBA 1Z0TA 2V2ZA 4HACB 4DUYE 4OX9E 2BA1G 1Z5BA 3CWVA 4NBQA 2ZM6E 1FNMA 2R42A 4JI7E 4LF4E 1N32I 4QNJA 4DV6E 4WUDA 1MG7A 4EMDA 1P42A 4JI8I 4KQVA 4LF6E 4DPYA 1BKNA 1N0VC 1Z0GA 4DV2I 4JYAE 4OO1B 1Z59A 2Z5CB 4MU3A 3J80Q 2C37A 3ZM7A 2C37B 3B78A 4B3TI 4LCGA 1A6FA 2E5LI 4LF5E 3Q6NA 1Z0EA 2HHHE 4HYMA 4DV0I 4IFDE 4N3OA 4DV0E 3ZZTA 5DRRA 5LMNI 4DR4E 3LTOA 5JEAB 1H73A 4FWHA 2VQEI 1H7UA 4IFDF 1XXEA 2GS8A 2NN6F 5IT9C 3Q1QA 1USVA 4USKA 1ZM9A 3KRNA 3T1HI 4FWGA 2ZITA 1IBMI 3V2UC 4DUZE 5EL9A 4MU0A 2BA0D 3U1YA 4HY1A 5BR8I 4DV1E 4OO1E 4OZEA 4X65I 4ZVIA 1J5EI 4OO1C 1PKPA 4DUZI 1YHCA 1IBLI 2HK3A 4AM3A 5JEAE 4OO1A 3GMEA 3K85A 4RPFA 1XMOE 3WU4A 1XNQE 2UUBE 4USMA 1XMQE 1KTVA 4OO1F 3B4TA 1HR0E 3P06A 5JEAA 2VQEE 1WUUA 5IWAI 2UU9E 4AQYI 4LF6I 4PRVA 1QZRA 3T1YE 3PS2A 1XMOI 3F0NA 4KHPI
chains in the Genus database with same CATH topology
3U1YA 2IERA 4ISAA 4FW6A 4LCHA 5DRPA 5DRRA 4U3DA 3NZKA 3P3EA 2JT2A 1P42A 4OZEA 4FW5A 4IS9A 1YHCA 4FW4A 2O3ZA 4MQYA 1XXEA 5DROA 4J3DA 4LCGA 3PS3A 1YH8A 4OKGA 3P3CA 4LCFA 3P76A 3P3GA 2J65A 3PS1A 2IESA 2GO4A 4MDTA 4FW7A 3UHMA 4FW3A 3PS2A 5DRQA 4U3BA 2GO3A 2VESA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3U1Y A;  2IER A;  4ISA A;  4FW6 A;  4LCH A;  5DRP A;  5DRR A;  4U3D A;  3NZK A;  3P3E A;  2JT2 A;  1P42 A;  4OZE A;  4FW5 A;  4IS9 A;  1YHC A;  4FW4 A;  2O3Z A;  4MQY A;  1XXE A;  5DRO A;  4J3D A;  4LCG A;  3PS3 A;  1YH8 A;  4OKG A;  3P3C A;  4LCF A;  3P76 A;  3P3G A;  2J65 A;  3PS1 A;  2IES A;  2GO4 A;  4MDT A;  4FW7 A;  3UHM A;  4FW3 A;  3PS2 A;  5DRQ A;  4U3B A;  2GO3 A;  2VES A; 
#chains in the Genus database with same CATH topology
 4X64 I;  1Z0B A;  2WNR A;  1N32 E;  1N34 E;  3P3E A;  1XMQ I;  1RR9 A;  2UUB I;  3M7N G;  3B8H A;  5FLX Q;  5LL6 R;  4FW5 A;  4OX9 I;  4LF7 I;  2C38 A;  3M6A A;  2UUA I;  4DR1 E;  1IBK E;  4B3S I;  3PYD A;  1N36 I;  4JI2 I;  2E5L E;  1VIS A;  1R6M A;  4DV3 I;  2IES A;  2WP8 A;  1ZXN A;  4NXM I;  3UHM A;  4JYA I;  2PNZ B;  2Z5B B;  3J80 C;  1UEK A;  4U3D A;  3T1H E;  2PNL A;  4DV3 E;  3ZKD A;  1S16 A;  1OYS A;  1XNR I;  4LFC I;  5K36 C;  3Q6M A;  4NXM E;  1PVG A;  1KKH A;  3J7A M;  5K36 F;  4IZK B;  4LF8 I;  1Y4S A;  3M85 D;  2WNR B;  4JI2 E;  2AJ4 A;  4BA2 A;  3P3G A;  1IBK I;  3PS1 A;  1DAR A;  1NHI A;  1UDS A;  2XEX A;  3T1Y I;  4B3T E;  5JEA D;  4MYT A;  4WUB A;  2UUC E;  2O1T A;  3NZK A;  1ZXM A;  2VQF I;  3WU6 A;  2CVE A;  3ZZU A;  4WUC A;  4PU9 A;  3PYE A;  5FWK A;  1ZM4 A;  3LNU A;  1IBL E;  1Z0W A;  4LF4 I;  4UT4 A;  1FI4 A;  5C0X C;  1NZ0 A;  2Z5B A;  5K36 E;  4HXZ A;  5GME A;  4OKG A;  1H72 C;  3ZZ0 A;  5C0X F;  4JI3 E;  4DV6 I;  4DPT A;  4MU1 A;  3L7Z B;  3JAM Q;  2GO3 A;  4NXN E;  1D6T A;  1N34 I;  1I94 I;  2UUA E;  4JI5 E;  3V5R A;  2PNZ A;  1E3P A;  2WW4 A;  2UXB E;  4FWD A;  4JG4 A;  5BR8 E;  1N0U A;  4DV5 E;  1XNQ I;  4KHP E;  4AIM A;  3L7Z A;  4JV5 E;  2BM1 A;  2X7I A;  2Q2E B;  4DPX A;  5LMU I;  5LMN E;  4DR4 I;  4X66 E;  4FW7 A;  4I3H A;  1ZM2 A;  1PIE A;  4M1K A;  4GQU A;  4IZJ B;  2V2Q A;  4DPU A;  3OTO E;  3K17 A;  4LF8 E;  2BR2 A;  4DU7 A;  4DV1 I;  4FW9 A;  4NXN I;  1Z5A A;  1UDQ A;  4LFC E;  1HNW I;  4BA1 B;  1Z5C A;  5A2Q C;  1E3H A;  1B63 A;  2O3Z A;  4YHH E;  4MQY A;  1HNZ I;  3GCM A;  4LF5 I;  4K0K E;  1OYP A;  5K36 A;  4LCF A;  1N33 I;  2VF3 A;  1HNW E;  2GO4 A;  4YHH I;  4U3B A;  2VES A;  1NHJ A;  2ZM6 I;  4IZJ A;  1R6L A;  1UDO A;  5C0X D;  2UXB I;  4R1F A;  4OO1 D;  1RHY A;  1VI7 A;  2CG9 A;  2HFS A;  4DR1 I;  4B3S E;  4X64 E;  2O1V A;  4XTJ A;  4JV5 I;  2BR2 B;  3QT8 A;  4B3R E;  4IFD A;  4DPW A;  2UXC I;  2R3V A;  2HHH I;  2PO1 B;  5DNL A;  2J7K A;  4GKJ E;  2WP8 B;  4DR5 E;  1I94 E;  4LOM A;  5K36 B;  4JI8 E;  4JI3 I;  3H4L A;  4X62 E;  1HK7 A;  1ELO A;  2NN6 D;  2BA0 G;  2CGE A;  5C0X A;  1N36 E;  2NN6 C;  2DEJ A;  4X65 E;  1IBM E;  4IFD C;  4DUY I;  2PNM A;  4DR3 I;  2BA1 D;  2EFG A;  4JI6 E;  4JI0 I;  5DRQ A;  4Z7Y A;  3J81 C;  3HJC A;  1RRE A;  2UXD E;  4ISA A;  4YY3 I;  3PRY A;  4JI4 E;  4QNK A;  5DNX A;  4IZJ D;  1FJG I;  1K47 A;  3WU3 A;  1ZM3 A;  2AE8 A;  4JI6 I;  4DR6 E;  4LF9 I;  1N33 E;  2JEB B;  5C0X B;  3H1C A;  4DU8 A;  4LFA I;  1OJ4 A;  5ELW A;  2JEA A;  1S4E A;  2PO2 B;  4MYU A;  1MX0 A;  4DV4 I;  1KIJ A;  1FWK A;  5IT9 Q;  4UTG A;  5A2Q Q;  1Y4U A;  4X66 I;  5EKW A;  2JT2 A;  5LMU E;  1XHK A;  1Y5Y A;  1HNX I;  4IZK A;  4GKJ I;  4JI4 I;  1Y60 A;  4URL A;  2UU9 I;  4DR7 I;  1B62 A;  1EA6 A;  2BM0 A;  2HK2 A;  1FKA E;  4LFB I;  3WU5 A;  4DR6 I;  4K0K I;  2V2V A;  4J3D A;  4BA2 B;  1FJG E;  2NN6 A;  3P3C A;  4LPF A;  5FLX C;  3GON A;  3LPS A;  2CZ9 A;  4JI0 E;  2HKE A;  2NN6 E;  2F4V E;  1Y6Z A;  4X62 I;  3HUL A;  2F1D A;  2JE6 A;  2PO2 A;  5JEA C;  1H74 A;  4AQY E;  3PYG A;  2JEA B;  2DEI A;  2OI2 A;  5JEA F;  3PYF A;  2V8P A;  4FW4 A;  2C39 A;  2IOQ A;  4DV7 E;  2GQ0 A;  4IFD B;  1HNZ E;  4DXL A;  2NN6 B;  1HR0 I;  3CDI A;  4HAC A;  2J65 A;  4LFB E;  5GMD A;  4DR5 I;  4MDT A;  1UDN A;  5L3J A;  4MU4 A;  4AID A;  4JI5 I;  2IER A;  4FW6 A;  3U1K A;  2F4V I;  2O1W A;  4JI7 I;  2C39 B;  2A2C A;  2E1R A;  4B3M E;  2UUC I;  2PO0 B;  3B82 A;  4LFA E;  1J5E E;  4PRX A;  3GLL A;  4IS9 A;  3QT6 A;  4JI1 I;  3QT5 A;  2HFU A;  4LF9 E;  4ED4 A;  1MU5 A;  4BA1 A;  1OYR A;  3J7A G;  4GKK I;  4DR2 E;  2JE6 B;  3PS3 A;  1H7S A;  1YH8 A;  1XNR E;  2HKJ A;  1Z0V A;  4DR7 E;  3P76 A;  2ZBK B;  1U2R A;  1USU A;  1HNX E;  2PO1 A;  2UXD I;  4FW3 A;  4DV2 E;  4DR2 I;  4GKK E;  5DRP A;  2X36 A;  2NPF A;  4DR3 E;  1NHH A;  2C38 B;  3M7N D;  5K36 D;  3DD6 A;  3HKM A;  4DV4 E;  4B3M I;  2LJP A;  1KVK A;  2IOP A;  4IFD D;  3J81 Q;  2A2D A;  4JI1 E;  3JAM C;  4P52 A;  3QT7 A;  4Z7C A;  3K1J A;  1EI1 A;  2Z5C A;  2V34 A;  3OTO I;  4LF7 E;  3M85 G;  2O1U A;  5IWA E;  4LCH A;  2VQF E;  3D4J A;  3CDJ A;  4FN5 A;  4P7A A;  2Z5E A;  4B3R I;  2UXC E;  4DV7 I;  1Z0C A;  2PO0 A;  5C0X E;  1FWL A;  4YY3 E;  3ZKB A;  4DV5 I;  2BV3 A;  5DRO A;  2JEB A;  1Z0T A;  2V2Z A;  4HAC B;  4DUY E;  4OX9 E;  2BA1 G;  1Z5B A;  3CWV A;  4NBQ A;  2ZM6 E;  1FNM A;  2R42 A;  4JI7 E;  4LF4 E;  1N32 I;  4QNJ A;  4DV6 E;  4WUD A;  1MG7 A;  4EMD A;  1P42 A;  4JI8 I;  4KQV A;  4LF6 E;  4DPY A;  1BKN A;  1N0V C;  1Z0G A;  4DV2 I;  4JYA E;  4OO1 B;  1Z59 A;  2Z5C B;  4MU3 A;  3J80 Q;  2C37 A;  3ZM7 A;  2C37 B;  3B78 A;  4B3T I;  4LCG A;  1A6F A;  2E5L I;  4LF5 E;  3Q6N A;  1Z0E A;  2HHH E;  4HYM A;  4DV0 I;  4IFD E;  4N3O A;  4DV0 E;  3ZZT A;  5DRR A;  5LMN I;  4DR4 E;  3LTO A;  5JEA B;  1H73 A;  4FWH A;  2VQE I;  1H7U A;  4IFD F;  1XXE A;  2GS8 A;  2NN6 F;  5IT9 C;  3Q1Q A;  1USV A;  4USK A;  1ZM9 A;  3KRN A;  3T1H I;  4FWG A;  2ZIT A;  1IBM I;  3V2U C;  4DUZ E;  5EL9 A;  4MU0 A;  2BA0 D;  3U1Y A;  4HY1 A;  5BR8 I;  4DV1 E;  4OO1 E;  4OZE A;  4X65 I;  4ZVI A;  1J5E I;  4OO1 C;  1PKP A;  4DUZ I;  1YHC A;  1IBL I;  2HK3 A;  4AM3 A;  5JEA E;  4OO1 A;  3GME A;  3K85 A;  4RPF A;  1XMO E;  3WU4 A;  1XNQ E;  2UUB E;  4USM A;  1XMQ E;  1KTV A;  4OO1 F;  3B4T A;  1HR0 E;  3P06 A;  5JEA A;  2VQE E;  1WUU A;  5IWA I;  2UU9 E;  4AQY I;  4LF6 I;  4PRV A;  1QZR A;  3T1Y E;  3PS2 A;  1XMO I;  3F0N A;  4KHP I; 
#chains in the Genus database with same CATH homology
 3U1Y A;  2IER A;  4ISA A;  4FW6 A;  4LCH A;  5DRP A;  5DRR A;  4U3D A;  3NZK A;  3P3E A;  2JT2 A;  1P42 A;  4OZE A;  4FW5 A;  4IS9 A;  1YHC A;  4FW4 A;  2O3Z A;  4MQY A;  1XXE A;  5DRO A;  4J3D A;  4LCG A;  3PS3 A;  1YH8 A;  4OKG A;  3P3C A;  4LCF A;  3P76 A;  3P3G A;  2J65 A;  3PS1 A;  2IES A;  2GO4 A;  4MDT A;  4FW7 A;  3UHM A;  4FW3 A;  3PS2 A;  5DRQ A;  4U3B A;  2GO3 A;  2VES A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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