3P8EA

Crystal structure of human dimethylarginine dimethylaminohydrolase-1 (ddah-1) covalently bound with n5-(1-iminopentyl)-l-ornithine
Total Genus 90
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
90
sequence length
274
structure length
272
Chain Sequence
AFGRATHAVVRALPESLGQHALRSGEEVDVARAERQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTCCSVLINKK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
publication title Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1.
pubmed doi rcsb
source organism Homo sapiens
total genus 90
structure length 272
sequence length 274
chains with identical sequence B
ec nomenclature ec 3.5.3.18: Dimethylargininase.
pdb deposition date 2010-10-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02274 Amidinotransf Amidinotransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.75.10.10 Alpha Beta 5-stranded Propeller L-arginine/glycine Amidinotransferase; Chain A L-arginine/glycine Amidinotransferase; Chain A 3p8eA00
1S9RA 4N2DA 2CI5A 4N2MA 5AK7A 2JAJA 1RXXA 4N2AA 2ACIA 2DEXX 4X8CA 2A9GA 6JDWA 2CMUA 4X8GA 4BOFA 1JDXA 4N2IA 2CI6A 3I4AA 3APMA 4JDWA 3HVMA 2JDWA 4N2CA 4YTGA 4YTBA 4N2BA 2CI1A 4N20A 5JDWA 1VKPA 1G61A 3H7CX 1H70A 4N2GA 3B1TA 1WD9A 3RHYA 2CI4A 3P8EA 4N2HA 1WDAA 1WD8A 8JDWA 4DKTA 2AAFA 3B1UA 4N24A 4E4JA 4N22A 4YT9A 3P8PA 4N2FA 1ZBRA 4N26A 2ABRA 3APNA 2CI3A 4N25A 7JDWA 1G62A 1XKNA 3H7KA 3JDWA 5M3QA 2JDXA 2CI7A 2Q3UA 2JERA 2DW5A 1LXYA 2JAIA 2DEYX 4N2EA 4N2LA 9JDWA 4N28A 1BWDA 3I2EA 3BPBA 2DEWX 4N2KA 5AK8A 5AN9I 2EWOA 2C6ZA 1JDWA 4N2NA 5HP5A
chains in the Genus database with same CATH superfamily
1S9RA 4N2DA 2CI5A 4N2MA 5AK7A 2JAJA 1RXXA 4N2AA 2ACIA 2DEXX 4X8CA 2A9GA 6JDWA 2CMUA 4X8GA 4BOFA 1JDXA 4N2IA 2CI6A 3I4AA 3APMA 4JDWA 3HVMA 2JDWA 4N2CA 4YTGA 4YTBA 4N2BA 2CI1A 4N20A 5JDWA 1VKPA 1G61A 3H7CX 1YNFA 1H70A 4N2GA 3B1TA 1WD9A 3RHYA 2CI4A 3P8EA 4N2HA 1WDAA 1WD8A 8JDWA 4DKTA 2AAFA 3B1UA 4N24A 4E4JA 4N22A 4YT9A 3P8PA 4N2FA 1ZBRA 4N26A 2ABRA 3APNA 2CI3A 4N25A 7JDWA 1G62A 1XKNA 3H7KA 3JDWA 5M3QA 2JDXA 2CI7A 2Q3UA 2JERA 2DW5A 1LXYA 2JAIA 2DEYX 4N2EA 4N2LA 9JDWA 4N28A 1YNHA 1BWDA 3I2EA 3BPBA 2DEWX 4N2KA 5AK8A 5AN9I 2EWOA 2C6ZA 1JDWA 1YNIA 4N2NA 5HP5A
chains in the Genus database with same CATH topology
1S9RA 4N2DA 2CI5A 4N2MA 5AK7A 2JAJA 1RXXA 4N2AA 2ACIA 2DEXX 4X8CA 2A9GA 6JDWA 2CMUA 4X8GA 4BOFA 1JDXA 4N2IA 2CI6A 3I4AA 3APMA 4JDWA 3HVMA 2JDWA 4N2CA 4YTGA 4YTBA 4N2BA 2CI1A 4N20A 5JDWA 1VKPA 1G61A 3H7CX 1H70A 4N2GA 3B1TA 1WD9A 3RHYA 2CI4A 3P8EA 4N2HA 1WDAA 1WD8A 8JDWA 4DKTA 2AAFA 3B1UA 4N24A 4E4JA 4N22A 4YT9A 3P8PA 4N2FA 1ZBRA 4N26A 2ABRA 3APNA 2CI3A 4N25A 7JDWA 1G62A 1XKNA 3H7KA 3JDWA 5M3QA 2JDXA 2CI7A 2Q3UA 2JERA 2DW5A 1LXYA 2JAIA 2DEYX 4N2EA 4N2LA 9JDWA 4N28A 1BWDA 3I2EA 3BPBA 2DEWX 4N2KA 5AK8A 5AN9I 2EWOA 2C6ZA 1JDWA 4N2NA 5HP5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1S9R A;  4N2D A;  2CI5 A;  4N2M A;  5AK7 A;  2JAJ A;  1RXX A;  4N2A A;  2ACI A;  2DEX X;  4X8C A;  2A9G A;  6JDW A;  2CMU A;  4X8G A;  4BOF A;  1JDX A;  4N2I A;  2CI6 A;  3I4A A;  3APM A;  4JDW A;  3HVM A;  2JDW A;  4N2C A;  4YTG A;  4YTB A;  4N2B A;  2CI1 A;  4N20 A;  5JDW A;  1VKP A;  1G61 A;  3H7C X;  1H70 A;  4N2G A;  3B1T A;  1WD9 A;  3RHY A;  2CI4 A;  3P8E A;  4N2H A;  1WDA A;  1WD8 A;  8JDW A;  4DKT A;  2AAF A;  3B1U A;  4N24 A;  4E4J A;  4N22 A;  4YT9 A;  3P8P A;  4N2F A;  1ZBR A;  4N26 A;  2ABR A;  3APN A;  2CI3 A;  4N25 A;  7JDW A;  1G62 A;  1XKN A;  3H7K A;  3JDW A;  5M3Q A;  2JDX A;  2CI7 A;  2Q3U A;  2JER A;  2DW5 A;  1LXY A;  2JAI A;  2DEY X;  4N2E A;  4N2L A;  9JDW A;  4N28 A;  1BWD A;  3I2E A;  3BPB A;  2DEW X;  4N2K A;  5AK8 A;  5AN9 I;  2EWO A;  2C6Z A;  1JDW A;  4N2N A;  5HP5 A; 
#chains in the Genus database with same CATH topology
 1S9R A;  4N2D A;  2CI5 A;  4N2M A;  5AK7 A;  2JAJ A;  1RXX A;  4N2A A;  2ACI A;  2DEX X;  4X8C A;  2A9G A;  6JDW A;  2CMU A;  4X8G A;  4BOF A;  1JDX A;  4N2I A;  2CI6 A;  3I4A A;  3APM A;  4JDW A;  3HVM A;  2JDW A;  4N2C A;  4YTG A;  4YTB A;  4N2B A;  2CI1 A;  4N20 A;  5JDW A;  1VKP A;  1G61 A;  3H7C X;  1YNF A;  1H70 A;  4N2G A;  3B1T A;  1WD9 A;  3RHY A;  2CI4 A;  3P8E A;  4N2H A;  1WDA A;  1WD8 A;  8JDW A;  4DKT A;  2AAF A;  3B1U A;  4N24 A;  4E4J A;  4N22 A;  4YT9 A;  3P8P A;  4N2F A;  1ZBR A;  4N26 A;  2ABR A;  3APN A;  2CI3 A;  4N25 A;  7JDW A;  1G62 A;  1XKN A;  3H7K A;  3JDW A;  5M3Q A;  2JDX A;  2CI7 A;  2Q3U A;  2JER A;  2DW5 A;  1LXY A;  2JAI A;  2DEY X;  4N2E A;  4N2L A;  9JDW A;  4N28 A;  1YNH A;  1BWD A;  3I2E A;  3BPB A;  2DEW X;  4N2K A;  5AK8 A;  5AN9 I;  2EWO A;  2C6Z A;  1JDW A;  1YNI A;  4N2N A;  5HP5 A; 
#chains in the Genus database with same CATH homology
 1S9R A;  4N2D A;  2CI5 A;  4N2M A;  5AK7 A;  2JAJ A;  1RXX A;  4N2A A;  2ACI A;  2DEX X;  4X8C A;  2A9G A;  6JDW A;  2CMU A;  4X8G A;  4BOF A;  1JDX A;  4N2I A;  2CI6 A;  3I4A A;  3APM A;  4JDW A;  3HVM A;  2JDW A;  4N2C A;  4YTG A;  4YTB A;  4N2B A;  2CI1 A;  4N20 A;  5JDW A;  1VKP A;  1G61 A;  3H7C X;  1H70 A;  4N2G A;  3B1T A;  1WD9 A;  3RHY A;  2CI4 A;  3P8E A;  4N2H A;  1WDA A;  1WD8 A;  8JDW A;  4DKT A;  2AAF A;  3B1U A;  4N24 A;  4E4J A;  4N22 A;  4YT9 A;  3P8P A;  4N2F A;  1ZBR A;  4N26 A;  2ABR A;  3APN A;  2CI3 A;  4N25 A;  7JDW A;  1G62 A;  1XKN A;  3H7K A;  3JDW A;  5M3Q A;  2JDX A;  2CI7 A;  2Q3U A;  2JER A;  2DW5 A;  1LXY A;  2JAI A;  2DEY X;  4N2E A;  4N2L A;  9JDW A;  4N28 A;  1BWD A;  3I2E A;  3BPB A;  2DEW X;  4N2K A;  5AK8 A;  5AN9 I;  2EWO A;  2C6Z A;  1JDW A;  4N2N A;  5HP5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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