3PQBA

The crystal structure of pregilvocarcin in complex with gilr, an oxidoreductase that catalyzes the terminal step of gilvocarcin biosynthesis
Total Genus 165
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
165
sequence length
492
structure length
492
Chain Sequence
PFTVGREDPRYIELSHSDNHRFVVEPEEFFLPATPDDVVASLQKAVTEGRGVACRSGGHCGQDFVGTPRRDLVLDLHNLHAIGPAADGAGVRVGSGATVDQVQKALFRRWNAALPLGACSAVGMGGLVAGGGYGPLSRQLGLVVDHLHAVEVAVVDESRTVRLVTARADDTGDLGELFWAHTGGGGGNFGVVTAYEFRSPEHLATEPVGLPRAAGRLHVQKVVFPWAMIDETSFVTVMRRFFEWHERHSEPGSPESSLFATFFVNHVSSGVLQLMVQQDADVDPEGEILARFVASLTEGTGVVGIPRGGVMSWLTGTRYMSQADCGDVMGARSASKSAYHRAAPTDEQLSVLHRHLHADHPGQASYVMFNSYGGEINRRGPSDAAVPQRDSVVKSSWFSAWQDAELDELHLGWLRGLYEEFFAGTGGVPVTGGRTDGCYINYPDADLLDPARNRSGEPWHHLYYKDNYARLRSAKRAWDPLNTFHHSMSIGL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title The Crystal Structure and Mechanism of an Unusual Oxidoreductase, GilR, Involved in Gilvocarcin V Biosynthesis.
pubmed doi rcsb
source organism Streptomyces griseoflavus
molecule tags Oxidoreductase
molecule keywords Putative oxidoreductase
total genus 165
structure length 492
sequence length 492
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2010-11-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01565 FAD_binding_4 FAD binding domain
A PF08031 BBE Berberine and berberine like
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.465.40 Alpha Beta 2-Layer Sandwich Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 3pqbA01
3.40.462.20 Alpha Beta 3-Layer(aba) Sandwich Vanillyl-alcohol Oxidase; Chain A, domain 3 Vanillyl-alcohol Oxidase; Chain A, domain 3 3pqbA02
3POPA 3TSJA 3W8ZA 3RJAA 4PVJA 4PVEA 5L6FA 3TSHA 3W8WA 3GSYA 2Y4GA 2Y08A 4XLOA 4EC3A 5K8EA 2BVFA 2Y3SA 1ZR6A 3RJ8A 4PWBA 5D79A 3FW8A 4PZFA 3D2JA 3FW7A 2AXRA 2BVGA 2BVHA 3HSUA 4PVKA 4PWCA 2IPIA 2UUVA 4UD8A 3W8XA 4DNSA 2Y3RA 2WDWA 2UUUA 5I1VA 4PVHA 3FWAA 3FW9A 5L6GA 3VTEA 3D2DA 3PQBA 3D2HA 5I1WA 5AWVA
chains in the Genus database with same CATH superfamily
5FXEA 3JS8A 4HG0A 1N63C 2R2ZA 5HQXA 2W3SA 4ZOHB 1N62C 2Y08A 1N60C 5K8EA 2Y3SA 1E8HA 2RK5A 3RJ8A 1FO4A 5D79A 1N61C 4BC9A 1ZXIC 2AXRA 2VAOA 4PVKA 1JRPA 2VFUA 1SB3B 1E8GA 1N5XA 3BW7A 4UD8A 1QLTA 1FFUC 3I99A 5HHZA 3FWAA 5L6GA 3C0PA 3VTEA 3S1CA 3D2DA 3AM9A 1DIQA 3PQBA 1MBBA 3D2HA 2O3GA 2E3TA 5I1WA 1W1JA 1FFVC 3POPA 3W8ZA 4ML8A 3GSYA 2QKNA 1W1LA 2MBRA 4BBYA 2Y4GA 4XLOA 2VFRA 1W1KA 2BVFA 4EC3A 1N5WC 5G5GB 1AHZA 1F0XA 1JROA 3FW8A 3NVYB 4PZFA 4OALA 3AN1A 5AE3A 4JB1A 2BVGA 2YVSA 3HSUA 2VFSA 2PLSA 1T3QC 2I0KA 2QPMA 3DQ0A 2WDWA 3HRDC 5AE2A 2UUUA 3KJMA 5I1VA 1I19A 1MBTA 1W1SA 2GQTA 4BC7A 2R8DA 1WYGA 3SR6B 2Q4WA 3NVWB 1W1MA 3DEDA 1E8FA 3TSJA 3RJAA 3NVVB 1UXYA 2W54A 5L6FA 3TSHA 1V97A 1W1QA 5ADZA 1RM6B 1W1RA 3AMZA 5FXFA 2W55A 3S1FA 4MLAA 1AHVA 2NQWA 1HSKA 1FIQB 2BVHA 2PLIA 3ETRB 3TX1A 5HMRA 3EUB3 2P3HA 3NVZB 2IPIA 2UUVA 3W8XA 4DNSA 2Y3RA 3B9JB 3S1DA 4O95A 5AE1A 3FW9A 4PYTA 2P4PA 5FXPA 4PVEA 3NS1B 5AWVA 5G5HB 4BCAA 4PVJA 2Q85A 2OAIA 5FXDA 3W8WA 1WVEA 1AHUA 1W1OA 4JAYA 1ZR6A 2GQUA 2VFTA 2EXRA 4PWBA 2VFVA 3LLBA 1VDVA 3D2JA 1WVFA 3FW7A 2W3RA 4PWCA 3LAEA 3NRZB 1QLUA 1E0YA 4PVHA 2P13A 3PM9A 1DIIA 3S1EA 1VAOA 1DZNA
chains in the Genus database with same CATH topology
5FXEA 3JS8A 4HG0A 1N63C 2R2ZA 5HQXA 2W3SA 4ZOHB 1N62C 2Y08A 1N60C 5K8EA 2Y3SA 1E8HA 2RK5A 3RJ8A 1FO4A 5D79A 1N61C 4BC9A 1ZXIC 2AXRA 2VAOA 4PVKA 1JRPA 2VFUA 1SB3B 1E8GA 1N5XA 3BW7A 4UD8A 1QLTA 1FFUC 3I99A 5HHZA 3FWAA 5L6GA 3C0PA 3VTEA 3S1CA 3D2DA 3AM9A 1DIQA 3PQBA 1MBBA 3D2HA 2O3GA 2E3TA 5I1WA 1W1JA 1FFVC 3POPA 3W8ZA 4ML8A 3GSYA 2QKNA 1W1LA 2MBRA 4BBYA 2Y4GA 4XLOA 2VFRA 1W1KA 2BVFA 4EC3A 1N5WC 5G5GB 1AHZA 1F0XA 1JROA 3FW8A 3NVYB 4PZFA 4OALA 3AN1A 5AE3A 4JB1A 2BVGA 2YVSA 3HSUA 2VFSA 2PLSA 1T3QC 2I0KA 2QPMA 3DQ0A 2WDWA 3HRDC 5AE2A 2UUUA 3KJMA 5I1VA 1I19A 1MBTA 1W1SA 2GQTA 4BC7A 2R8DA 1WYGA 3SR6B 2Q4WA 3NVWB 1W1MA 3DEDA 1E8FA 3TSJA 3RJAA 3NVVB 1UXYA 2W54A 5L6FA 3TSHA 1V97A 1W1QA 5ADZA 1RM6B 1W1RA 3AMZA 5FXFA 2W55A 3S1FA 4MLAA 1AHVA 2NQWA 1HSKA 1FIQB 2BVHA 2PLIA 3ETRB 3TX1A 5HMRA 3EUB3 2P3HA 3NVZB 2IPIA 2UUVA 3W8XA 4DNSA 2Y3RA 3B9JB 3S1DA 4O95A 5AE1A 3FW9A 4PYTA 2P4PA 5FXPA 4PVEA 3NS1B 5AWVA 5G5HB 4BCAA 4PVJA 2Q85A 2OAIA 5FXDA 3W8WA 1WVEA 1AHUA 1W1OA 4JAYA 1ZR6A 2GQUA 2VFTA 2EXRA 4PWBA 2VFVA 3LLBA 1VDVA 3D2JA 1WVFA 3FW7A 2W3RA 4PWCA 3LAEA 3NRZB 1QLUA 1E0YA 4PVHA 2P13A 3PM9A 1DIIA 3S1EA 1VAOA 1DZNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3POP A;  3TSJ A;  3W8Z A;  3RJA A;  4PVJ A;  4PVE A;  5L6F A;  3TSH A;  3W8W A;  3GSY A;  2Y4G A;  2Y08 A;  4XLO A;  4EC3 A;  5K8E A;  2BVF A;  2Y3S A;  1ZR6 A;  3RJ8 A;  4PWB A;  5D79 A;  3FW8 A;  4PZF A;  3D2J A;  3FW7 A;  2AXR A;  2BVG A;  2BVH A;  3HSU A;  4PVK A;  4PWC A;  2IPI A;  2UUV A;  4UD8 A;  3W8X A;  4DNS A;  2Y3R A;  2WDW A;  2UUU A;  5I1V A;  4PVH A;  3FWA A;  3FW9 A;  5L6G A;  3VTE A;  3D2D A;  3PQB A;  3D2H A;  5I1W A;  5AWV A; 
#chains in the Genus database with same CATH topology
 5FXE A;  3JS8 A;  4HG0 A;  1N63 C;  2R2Z A;  5HQX A;  2W3S A;  4ZOH B;  1N62 C;  2Y08 A;  1N60 C;  5K8E A;  2Y3S A;  1E8H A;  2RK5 A;  3RJ8 A;  1FO4 A;  5D79 A;  1N61 C;  4BC9 A;  1ZXI C;  2AXR A;  2VAO A;  4PVK A;  1JRP A;  2VFU A;  1SB3 B;  1E8G A;  1N5X A;  3BW7 A;  4UD8 A;  1QLT A;  1FFU C;  3I99 A;  5HHZ A;  3FWA A;  5L6G A;  3C0P A;  3VTE A;  3S1C A;  3D2D A;  3AM9 A;  1DIQ A;  3PQB A;  1MBB A;  3D2H A;  2O3G A;  2E3T A;  5I1W A;  1W1J A;  1FFV C;  3POP A;  3W8Z A;  4ML8 A;  3GSY A;  2QKN A;  1W1L A;  2MBR A;  4BBY A;  2Y4G A;  4XLO A;  2VFR A;  1W1K A;  2BVF A;  4EC3 A;  1N5W C;  5G5G B;  1AHZ A;  1F0X A;  1JRO A;  3FW8 A;  3NVY B;  4PZF A;  4OAL A;  3AN1 A;  5AE3 A;  4JB1 A;  2BVG A;  2YVS A;  3HSU A;  2VFS A;  2PLS A;  1T3Q C;  2I0K A;  2QPM A;  3DQ0 A;  2WDW A;  3HRD C;  5AE2 A;  2UUU A;  3KJM A;  5I1V A;  1I19 A;  1MBT A;  1W1S A;  2GQT A;  4BC7 A;  2R8D A;  1WYG A;  3SR6 B;  2Q4W A;  3NVW B;  1W1M A;  3DED A;  1E8F A;  3TSJ A;  3RJA A;  3NVV B;  1UXY A;  2W54 A;  5L6F A;  3TSH A;  1V97 A;  1W1Q A;  5ADZ A;  1RM6 B;  1W1R A;  3AMZ A;  5FXF A;  2W55 A;  3S1F A;  4MLA A;  1AHV A;  2NQW A;  1HSK A;  1FIQ B;  2BVH A;  2PLI A;  3ETR B;  3TX1 A;  5HMR A;  3EUB 3;  2P3H A;  3NVZ B;  2IPI A;  2UUV A;  3W8X A;  4DNS A;  2Y3R A;  3B9J B;  3S1D A;  4O95 A;  5AE1 A;  3FW9 A;  4PYT A;  2P4P A;  5FXP A;  4PVE A;  3NS1 B;  5AWV A;  5G5H B;  4BCA A;  4PVJ A;  2Q85 A;  2OAI A;  5FXD A;  3W8W A;  1WVE A;  1AHU A;  1W1O A;  4JAY A;  1ZR6 A;  2GQU A;  2VFT A;  2EXR A;  4PWB A;  2VFV A;  3LLB A;  1VDV A;  3D2J A;  1WVF A;  3FW7 A;  2W3R A;  4PWC A;  3LAE A;  3NRZ B;  1QLU A;  1E0Y A;  4PVH A;  2P13 A;  3PM9 A;  1DII A;  3S1E A;  1VAO A;  1DZN A; 
#chains in the Genus database with same CATH homology
 5FXE A;  3JS8 A;  4HG0 A;  1N63 C;  2R2Z A;  5HQX A;  2W3S A;  4ZOH B;  1N62 C;  2Y08 A;  1N60 C;  5K8E A;  2Y3S A;  1E8H A;  2RK5 A;  3RJ8 A;  1FO4 A;  5D79 A;  1N61 C;  4BC9 A;  1ZXI C;  2AXR A;  2VAO A;  4PVK A;  1JRP A;  2VFU A;  1SB3 B;  1E8G A;  1N5X A;  3BW7 A;  4UD8 A;  1QLT A;  1FFU C;  3I99 A;  5HHZ A;  3FWA A;  5L6G A;  3C0P A;  3VTE A;  3S1C A;  3D2D A;  3AM9 A;  1DIQ A;  3PQB A;  1MBB A;  3D2H A;  2O3G A;  2E3T A;  5I1W A;  1W1J A;  1FFV C;  3POP A;  3W8Z A;  4ML8 A;  3GSY A;  2QKN A;  1W1L A;  2MBR A;  4BBY A;  2Y4G A;  4XLO A;  2VFR A;  1W1K A;  2BVF A;  4EC3 A;  1N5W C;  5G5G B;  1AHZ A;  1F0X A;  1JRO A;  3FW8 A;  3NVY B;  4PZF A;  4OAL A;  3AN1 A;  5AE3 A;  4JB1 A;  2BVG A;  2YVS A;  3HSU A;  2VFS A;  2PLS A;  1T3Q C;  2I0K A;  2QPM A;  3DQ0 A;  2WDW A;  3HRD C;  5AE2 A;  2UUU A;  3KJM A;  5I1V A;  1I19 A;  1MBT A;  1W1S A;  2GQT A;  4BC7 A;  2R8D A;  1WYG A;  3SR6 B;  2Q4W A;  3NVW B;  1W1M A;  3DED A;  1E8F A;  3TSJ A;  3RJA A;  3NVV B;  1UXY A;  2W54 A;  5L6F A;  3TSH A;  1V97 A;  1W1Q A;  5ADZ A;  1RM6 B;  1W1R A;  3AMZ A;  5FXF A;  2W55 A;  3S1F A;  4MLA A;  1AHV A;  2NQW A;  1HSK A;  1FIQ B;  2BVH A;  2PLI A;  3ETR B;  3TX1 A;  5HMR A;  3EUB 3;  2P3H A;  3NVZ B;  2IPI A;  2UUV A;  3W8X A;  4DNS A;  2Y3R A;  3B9J B;  3S1D A;  4O95 A;  5AE1 A;  3FW9 A;  4PYT A;  2P4P A;  5FXP A;  4PVE A;  3NS1 B;  5AWV A;  5G5H B;  4BCA A;  4PVJ A;  2Q85 A;  2OAI A;  5FXD A;  3W8W A;  1WVE A;  1AHU A;  1W1O A;  4JAY A;  1ZR6 A;  2GQU A;  2VFT A;  2EXR A;  4PWB A;  2VFV A;  3LLB A;  1VDV A;  3D2J A;  1WVF A;  3FW7 A;  2W3R A;  4PWC A;  3LAE A;  3NRZ B;  1QLU A;  1E0Y A;  4PVH A;  2P13 A;  3PM9 A;  1DII A;  3S1E A;  1VAO A;  1DZN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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