3PS3A

Crystal structure of the escherichia coli lpxc/lpc-053 complex
Total Genus 82
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
82
sequence length
300
structure length
300
Chain Sequence
MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold.
pubmed doi rcsb
source organism Escherichia coli ihe3034
molecule tags Hydrolase/antibiotic
molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
total genus 82
structure length 300
sequence length 300
ec nomenclature ec 3.5.1.-:
pdb deposition date 2010-11-30
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 3ps3A01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 3ps3A02
4FW6A 1YHCA 3PS3A 1XXEA 2IERA 2O3ZA 3P3EA 3P76A 4J3DA 2IESA 4U3BA 4LCFA 4FW4A 4U3DA 5DRQA 4FW7A 3PS2A 4MQYA 2JT2A 5DRRA 3P3CA 5DROA 4OKGA 4OZEA 1P42A 2VESA 4LCGA 4MDTA 2GO4A 2GO3A 3PS1A 4FW3A 4FW5A 4LCHA 4ISAA 3NZKA 2J65A 3U1YA 5DRPA 4IS9A 3UHMA 1YH8A 3P3GA
chains in the Genus database with same CATH superfamily
2Z5BA 4B3SE 5L3JA 4JI1I 5A2QQ 4B3ME 4DV0I 3LTOA 1Z5BA 3P3EA 4J3DA 4OO1A 4MYUA 4AIMA 1FWLA 1HNXE 3ZZ0A 4FW7A 4LF9I 4LF5E 2UUBI 4DV7I 4DR6I 4HYMA 1ZM9A 1Z0WA 1RHYA 4QNKA 4P52A 4JI0E 2XEXA 2IOPA 2C37A 3PYGA 1RREA 4HACA 4OO1D 4DPYA 3H1CA 2UXBE 3D4JA 4JI4I 2HK3A 4YHHE 2UXDE 1YHCA 2PO2A 4LOMA 4KHPI 4X62I 1J5EE 1HNZI 1ZM2A 2NN6B 1NHIA 4JI6E 2JEBA 5IT9Q 4KHPE 5K36B 1FI4A 4LPFA 1IBMI 3QT7A 1Z5AA 1FKAE 4GKKE 1OJ4A 4LF9E 5JEAB 5C0XE 1XHKA 4JI2I 5K36E 4DPXA 4HY1A 2F1DA 2WP8A 3PS3A 5IWAE 1BKNA 2E1RA 2WW4A 3CWVA 4IZKB 5DRQA 3GMEA 3B4TA 4DPTA 4LFBI 5A2QC 4B3RI 1N32I 5LMNI 1B63A 4KQVA 2V2VA 4R1FA 2O1VA 2C37B 1Z59A 4LCGA 3U1YA 2UU9I 2PNLA 2PNZA 2OI2A 5DNLA 4DPUA 1Y6ZA 4NXME 4WUDA 2E5LI 3WU3A 5JEAD 1MG7A 2VQEE 2V34A 1H74A 3P3CA 3K17A 3JAMQ 1IBLE 2V8PA 5IWAI 4DUYE 1ELOA 1IBME 5K36F 3M85G 2CGEA 2LJPA 4MU0A 1NHJA 5ELWA 4BA1A 4QNJA 4DV6E 5LMUI 4B3MI 1A6FA 4JI1E 2C38A 2PO0A 3T1YE 5K36A 4YY3I 5JEAA 4RPFA 1U2RA 4LCFA 4OO1B 4HXZA 2PO1B 3LPSA 3QT5A 2GQ0A 2GS8A 4IFDD 2X7IA 1UDOA 1ZXNA 1P42A 4LF7E 1N33E 4X65I 4JI0I 3PS1A 2UUCI 4MYTA 2CVEA 3J80C 4DV2E 1IBKE 4IS9A 2A2CA 2PO1A 1Y5YA 3J80Q 1H72C 4ZVIA 1R6MA 1HNWI 3WU5A 3GLLA 2PNZB 4DV2I 1B62A 4USMA 4I3HA 4DR7I 1WUUA 4U3DA 1OYPA 2VQFI 5DROA 2C39A 4DR4E 4OZEA 2AE8A 4DR1E 4LF6E 2ZBKB 1FJGE 4YY3E 3Q6MA 4DV1E 4FW5A 4FW3A 4LCHA 1XMQI 4JI3E 2BR2B 4OX9E 1ZM3A 5DRPA 1EA6A 3OTOE 4PU9A 4EMDA 3HJCA 3HKMA 4AIDA 4X64I 2NPFA 4X65E 1Z0GA 3T1YI 1EI1A 1N36E 1Z0VA 1UDSA 2NN6E 3CDJA 1D6TA 2NN6F 1N32E 2HKEA 4NXNI 4B3SI 5K36C 2JEBB 4LF7I 3KRNA 4JI8E 4DV3E 4JYAI 2Z5CB 4DR1I 4LF4I 5JEAF 3J7AM 4OO1F 1XXEA 4JV5E 4DPWA 1XMQE 2ZITA 2F4VI 1KIJA 2DEIA 5DRRA 3CDIA 4JI4E 4K0KI 4BA2B 1HK7A 5FLXC 4HACB 4DUYI 4LF6I 4JI2E 4DR5I 1Y4SA 4DU7A 5EL9A 3P06A 4DXLA 2EFGA 3PYFA 4IZJA 2HHHE 3PYDA 2R3VA 1E3PA 4AQYI 1Z0EA 4USKA 4DR5E 2BA1D 4BA1B 4Z7YA 4FW9A 4MU1A 1PVGA 2ZM6E 3LNUA 4IFDF 1S16A 2BA0G 1FWKA 1XNRE 1UDNA 3ZKBA 1N36I 4OO1E 4JI7I 1K47A 2PO2B 1FNMA 1USUA 1Z5CA 4DV5E 3M7NG 4GKJE 5FWKA 2UXCI 2VF3A 3M85D 3DD6A 2HKJA 4ED4A 2HFUA 3HULA 4IFDC 4DV4I 3J81C 4JI6I 3ZZTA 4LF8E 3J7AG 5LL6R 5GMDA 2E5LE 4LFAE 1OYRA 1UDQA 3QT6A 2VQEI 1H7SA 5FLXQ 2JT2A 3M6AA 4P7AA 4OO1C 2BM1A 1PKPA 2O1UA 5EKWA 1NZ0A 2BR2A 3GCMA 4DR2E 2VESA 1KKHA 4MDTA 3Q1QA 4FWGA 3F0NA 2O1TA 3WU4A 4N3OA 3OTOI 5LMUE 1XNQE 4IFDE 3P3GA 4NBQA 4AM3A 1RR9A 3QT8A 1N34I 2UXCE 1XMOI 1E3HA 3PYEA 2BV3A 5C0XD 2UXBI 5BR8E 2UUBE 4LFCI 1DARA 5C0XC 2GO3A 4DUZI 4LFCE 2WP8B 4JYAE 3UHMA 4JI5I 4JI8I 4NXMI 1YH8A 3ZZUA 4LF4E 4DUZE 4PRVA 2Z5CA 4FWDA 1N33I 4LF8I 4JV5I 2UU9E 4WUBA 4IZJD 2J7KA 4FW4A 1Z0CA 1QZRA 4MQYA 3T1HE 4K0KE 1FJGI 4OKGA 4B3TI 1I94E 1XMOE 2NN6A 2GO4A 2WNRA 2Z5BB 1VISA 4XTJA 2X36A 4LFBE 2AJ4A 4UT4A 3ZKDA 3GONA 3U1KA 2IESA 1MX0A 3K1JA 4LF5I 2ZM6I 4OX9I 1HNXI 2WNRB 1XNRI 1H73A 1NHHA 1Z0TA 3PRYA 1Y4UA 4DV5I 4GKJI 1ZM4A 4X64E 2DEJA 5BR8I 2PNMA 2UUAI 4WUCA 4DV3I 2JEAB 4DU8A 4DR3I 2CZ9A 1HR0E 4BA2A 4DR7E 4URLA 2BM0A 2UXDI 2BA1G 2V2ZA 1IBLI 2UUCE 4NXNE 1MU5A 2CG9A 5C0XA 2VQFE 1Y60A 4DR4I 1HR0I 3Q6NA 2BA0D 4GQUA 1HNZE 3PS2A 4MU4A 3M7ND 5K36D 1Z0BA 2Z5EA 4X66E 3T1HI 1USVA 2V2QA 4GKKI 4DR2I 3ZM7A 4IZJB 1I94I 3B8HA 2F4VE 2C39B 2HFSA 4AQYE 2C38B 2PO0B 4DV0E 2JE6B 1N34E 4IFDB 4JI3I 4FWHA 2O3ZA 3P76A 3B78A 1H7UA 4U3BA 3H4LA 4DR3E 4DV7E 1N0VC 3L7ZA 4DR6E 4JI7E 3J81Q 4B3RE 4PRXA 4Z7CA 4MU3A 5GMEA 4M1KA 3WU6A 2O1WA 4IZKA 5LMNE 2IOQA 4JG4A 2HK2A 4ISAA 2NN6D 2J65A 3V5RA 2UUAE 1N0UA 2JE6A 2Q2EB 2R42A 3L7ZB 5JEAE 4YHHI 4JI5E 5JEAC 3JAMC 1IBKI 4LFAI 4FW6A 1J5EI 1KVKA 2IERA 2NN6C 1VI7A 4IFDA 1HNWE 3B82A 3V2UC 1KTVA 1R6LA 2JEAA 5DNXA 4DV4E 4UTGA 1ZXMA 1UEKA 1PIEA 4B3TE 2HHHI 5IT9C 4X62E 4X66I 2A2DA 1XNQI 3NZKA 5C0XB 4DV1I 1OYSA 1S4EA 4DV6I 3K85A 5C0XF 4FN5A
chains in the Genus database with same CATH topology
4FW6A 1YHCA 3PS3A 1XXEA 2IERA 2O3ZA 3P3EA 3P76A 4J3DA 2IESA 4U3BA 4LCFA 4FW4A 4U3DA 5DRQA 4FW7A 3PS2A 4MQYA 2JT2A 5DRRA 3P3CA 5DROA 4OKGA 4OZEA 1P42A 2VESA 4LCGA 4MDTA 2GO4A 2GO3A 3PS1A 4FW3A 4FW5A 4LCHA 4ISAA 3NZKA 2J65A 3U1YA 5DRPA 4IS9A 3UHMA 1YH8A 3P3GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FW6 A;  1YHC A;  3PS3 A;  1XXE A;  2IER A;  2O3Z A;  3P3E A;  3P76 A;  4J3D A;  2IES A;  4U3B A;  4LCF A;  4FW4 A;  4U3D A;  5DRQ A;  4FW7 A;  3PS2 A;  4MQY A;  2JT2 A;  5DRR A;  3P3C A;  5DRO A;  4OKG A;  4OZE A;  1P42 A;  2VES A;  4LCG A;  4MDT A;  2GO4 A;  2GO3 A;  3PS1 A;  4FW3 A;  4FW5 A;  4LCH A;  4ISA A;  3NZK A;  2J65 A;  3U1Y A;  5DRP A;  4IS9 A;  3UHM A;  1YH8 A;  3P3G A; 
#chains in the Genus database with same CATH topology
 2Z5B A;  4B3S E;  5L3J A;  4JI1 I;  5A2Q Q;  4B3M E;  4DV0 I;  3LTO A;  1Z5B A;  3P3E A;  4J3D A;  4OO1 A;  4MYU A;  4AIM A;  1FWL A;  1HNX E;  3ZZ0 A;  4FW7 A;  4LF9 I;  4LF5 E;  2UUB I;  4DV7 I;  4DR6 I;  4HYM A;  1ZM9 A;  1Z0W A;  1RHY A;  4QNK A;  4P52 A;  4JI0 E;  2XEX A;  2IOP A;  2C37 A;  3PYG A;  1RRE A;  4HAC A;  4OO1 D;  4DPY A;  3H1C A;  2UXB E;  3D4J A;  4JI4 I;  2HK3 A;  4YHH E;  2UXD E;  1YHC A;  2PO2 A;  4LOM A;  4KHP I;  4X62 I;  1J5E E;  1HNZ I;  1ZM2 A;  2NN6 B;  1NHI A;  4JI6 E;  2JEB A;  5IT9 Q;  4KHP E;  5K36 B;  1FI4 A;  4LPF A;  1IBM I;  3QT7 A;  1Z5A A;  1FKA E;  4GKK E;  1OJ4 A;  4LF9 E;  5JEA B;  5C0X E;  1XHK A;  4JI2 I;  5K36 E;  4DPX A;  4HY1 A;  2F1D A;  2WP8 A;  3PS3 A;  5IWA E;  1BKN A;  2E1R A;  2WW4 A;  3CWV A;  4IZK B;  5DRQ A;  3GME A;  3B4T A;  4DPT A;  4LFB I;  5A2Q C;  4B3R I;  1N32 I;  5LMN I;  1B63 A;  4KQV A;  2V2V A;  4R1F A;  2O1V A;  2C37 B;  1Z59 A;  4LCG A;  3U1Y A;  2UU9 I;  2PNL A;  2PNZ A;  2OI2 A;  5DNL A;  4DPU A;  1Y6Z A;  4NXM E;  4WUD A;  2E5L I;  3WU3 A;  5JEA D;  1MG7 A;  2VQE E;  2V34 A;  1H74 A;  3P3C A;  3K17 A;  3JAM Q;  1IBL E;  2V8P A;  5IWA I;  4DUY E;  1ELO A;  1IBM E;  5K36 F;  3M85 G;  2CGE A;  2LJP A;  4MU0 A;  1NHJ A;  5ELW A;  4BA1 A;  4QNJ A;  4DV6 E;  5LMU I;  4B3M I;  1A6F A;  4JI1 E;  2C38 A;  2PO0 A;  3T1Y E;  5K36 A;  4YY3 I;  5JEA A;  4RPF A;  1U2R A;  4LCF A;  4OO1 B;  4HXZ A;  2PO1 B;  3LPS A;  3QT5 A;  2GQ0 A;  2GS8 A;  4IFD D;  2X7I A;  1UDO A;  1ZXN A;  1P42 A;  4LF7 E;  1N33 E;  4X65 I;  4JI0 I;  3PS1 A;  2UUC I;  4MYT A;  2CVE A;  3J80 C;  4DV2 E;  1IBK E;  4IS9 A;  2A2C A;  2PO1 A;  1Y5Y A;  3J80 Q;  1H72 C;  4ZVI A;  1R6M A;  1HNW I;  3WU5 A;  3GLL A;  2PNZ B;  4DV2 I;  1B62 A;  4USM A;  4I3H A;  4DR7 I;  1WUU A;  4U3D A;  1OYP A;  2VQF I;  5DRO A;  2C39 A;  4DR4 E;  4OZE A;  2AE8 A;  4DR1 E;  4LF6 E;  2ZBK B;  1FJG E;  4YY3 E;  3Q6M A;  4DV1 E;  4FW5 A;  4FW3 A;  4LCH A;  1XMQ I;  4JI3 E;  2BR2 B;  4OX9 E;  1ZM3 A;  5DRP A;  1EA6 A;  3OTO E;  4PU9 A;  4EMD A;  3HJC A;  3HKM A;  4AID A;  4X64 I;  2NPF A;  4X65 E;  1Z0G A;  3T1Y I;  1EI1 A;  1N36 E;  1Z0V A;  1UDS A;  2NN6 E;  3CDJ A;  1D6T A;  2NN6 F;  1N32 E;  2HKE A;  4NXN I;  4B3S I;  5K36 C;  2JEB B;  4LF7 I;  3KRN A;  4JI8 E;  4DV3 E;  4JYA I;  2Z5C B;  4DR1 I;  4LF4 I;  5JEA F;  3J7A M;  4OO1 F;  1XXE A;  4JV5 E;  4DPW A;  1XMQ E;  2ZIT A;  2F4V I;  1KIJ A;  2DEI A;  5DRR A;  3CDI A;  4JI4 E;  4K0K I;  4BA2 B;  1HK7 A;  5FLX C;  4HAC B;  4DUY I;  4LF6 I;  4JI2 E;  4DR5 I;  1Y4S A;  4DU7 A;  5EL9 A;  3P06 A;  4DXL A;  2EFG A;  3PYF A;  4IZJ A;  2HHH E;  3PYD A;  2R3V A;  1E3P A;  4AQY I;  1Z0E A;  4USK A;  4DR5 E;  2BA1 D;  4BA1 B;  4Z7Y A;  4FW9 A;  4MU1 A;  1PVG A;  2ZM6 E;  3LNU A;  4IFD F;  1S16 A;  2BA0 G;  1FWK A;  1XNR E;  1UDN A;  3ZKB A;  1N36 I;  4OO1 E;  4JI7 I;  1K47 A;  2PO2 B;  1FNM A;  1USU A;  1Z5C A;  4DV5 E;  3M7N G;  4GKJ E;  5FWK A;  2UXC I;  2VF3 A;  3M85 D;  3DD6 A;  2HKJ A;  4ED4 A;  2HFU A;  3HUL A;  4IFD C;  4DV4 I;  3J81 C;  4JI6 I;  3ZZT A;  4LF8 E;  3J7A G;  5LL6 R;  5GMD A;  2E5L E;  4LFA E;  1OYR A;  1UDQ A;  3QT6 A;  2VQE I;  1H7S A;  5FLX Q;  2JT2 A;  3M6A A;  4P7A A;  4OO1 C;  2BM1 A;  1PKP A;  2O1U A;  5EKW A;  1NZ0 A;  2BR2 A;  3GCM A;  4DR2 E;  2VES A;  1KKH A;  4MDT A;  3Q1Q A;  4FWG A;  3F0N A;  2O1T A;  3WU4 A;  4N3O A;  3OTO I;  5LMU E;  1XNQ E;  4IFD E;  3P3G A;  4NBQ A;  4AM3 A;  1RR9 A;  3QT8 A;  1N34 I;  2UXC E;  1XMO I;  1E3H A;  3PYE A;  2BV3 A;  5C0X D;  2UXB I;  5BR8 E;  2UUB E;  4LFC I;  1DAR A;  5C0X C;  2GO3 A;  4DUZ I;  4LFC E;  2WP8 B;  4JYA E;  3UHM A;  4JI5 I;  4JI8 I;  4NXM I;  1YH8 A;  3ZZU A;  4LF4 E;  4DUZ E;  4PRV A;  2Z5C A;  4FWD A;  1N33 I;  4LF8 I;  4JV5 I;  2UU9 E;  4WUB A;  4IZJ D;  2J7K A;  4FW4 A;  1Z0C A;  1QZR A;  4MQY A;  3T1H E;  4K0K E;  1FJG I;  4OKG A;  4B3T I;  1I94 E;  1XMO E;  2NN6 A;  2GO4 A;  2WNR A;  2Z5B B;  1VIS A;  4XTJ A;  2X36 A;  4LFB E;  2AJ4 A;  4UT4 A;  3ZKD A;  3GON A;  3U1K A;  2IES A;  1MX0 A;  3K1J A;  4LF5 I;  2ZM6 I;  4OX9 I;  1HNX I;  2WNR B;  1XNR I;  1H73 A;  1NHH A;  1Z0T A;  3PRY A;  1Y4U A;  4DV5 I;  4GKJ I;  1ZM4 A;  4X64 E;  2DEJ A;  5BR8 I;  2PNM A;  2UUA I;  4WUC A;  4DV3 I;  2JEA B;  4DU8 A;  4DR3 I;  2CZ9 A;  1HR0 E;  4BA2 A;  4DR7 E;  4URL A;  2BM0 A;  2UXD I;  2BA1 G;  2V2Z A;  1IBL I;  2UUC E;  4NXN E;  1MU5 A;  2CG9 A;  5C0X A;  2VQF E;  1Y60 A;  4DR4 I;  1HR0 I;  3Q6N A;  2BA0 D;  4GQU A;  1HNZ E;  3PS2 A;  4MU4 A;  3M7N D;  5K36 D;  1Z0B A;  2Z5E A;  4X66 E;  3T1H I;  1USV A;  2V2Q A;  4GKK I;  4DR2 I;  3ZM7 A;  4IZJ B;  1I94 I;  3B8H A;  2F4V E;  2C39 B;  2HFS A;  4AQY E;  2C38 B;  2PO0 B;  4DV0 E;  2JE6 B;  1N34 E;  4IFD B;  4JI3 I;  4FWH A;  2O3Z A;  3P76 A;  3B78 A;  1H7U A;  4U3B A;  3H4L A;  4DR3 E;  4DV7 E;  1N0V C;  3L7Z A;  4DR6 E;  4JI7 E;  3J81 Q;  4B3R E;  4PRX A;  4Z7C A;  4MU3 A;  5GME A;  4M1K A;  3WU6 A;  2O1W A;  4IZK A;  5LMN E;  2IOQ A;  4JG4 A;  2HK2 A;  4ISA A;  2NN6 D;  2J65 A;  3V5R A;  2UUA E;  1N0U A;  2JE6 A;  2Q2E B;  2R42 A;  3L7Z B;  5JEA E;  4YHH I;  4JI5 E;  5JEA C;  3JAM C;  1IBK I;  4LFA I;  4FW6 A;  1J5E I;  1KVK A;  2IER A;  2NN6 C;  1VI7 A;  4IFD A;  1HNW E;  3B82 A;  3V2U C;  1KTV A;  1R6L A;  2JEA A;  5DNX A;  4DV4 E;  4UTG A;  1ZXM A;  1UEK A;  1PIE A;  4B3T E;  2HHH I;  5IT9 C;  4X62 E;  4X66 I;  2A2D A;  1XNQ I;  3NZK A;  5C0X B;  4DV1 I;  1OYS A;  1S4E A;  4DV6 I;  3K85 A;  5C0X F;  4FN5 A; 
#chains in the Genus database with same CATH homology
 4FW6 A;  1YHC A;  3PS3 A;  1XXE A;  2IER A;  2O3Z A;  3P3E A;  3P76 A;  4J3D A;  2IES A;  4U3B A;  4LCF A;  4FW4 A;  4U3D A;  5DRQ A;  4FW7 A;  3PS2 A;  4MQY A;  2JT2 A;  5DRR A;  3P3C A;  5DRO A;  4OKG A;  4OZE A;  1P42 A;  2VES A;  4LCG A;  4MDT A;  2GO4 A;  2GO3 A;  3PS1 A;  4FW3 A;  4FW5 A;  4LCH A;  4ISA A;  3NZK A;  2J65 A;  3U1Y A;  5DRP A;  4IS9 A;  3UHM A;  1YH8 A;  3P3G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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