3Q1IA

Polo-like kinase i polo-box domain in complex with fmpppmspsm phosphopeptide from tcerg1
Total Genus 73
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
73
sequence length
223
structure length
216
Chain Sequence
CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPRLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Serine/threonine-protein kinase PLK1
total genus 73
structure length 216
sequence length 223
ec nomenclature ec 2.7.11.21: Polo kinase.
pdb deposition date 2010-12-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00659 POLO_box POLO box duplicated region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 3q1iA02
3.30.1120.30 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain POLO box domain 3q1iA01
4RCPA 4XB0A 3P2WA 2N19A 3HIKA 4H5XA 4J7BB 3FVHA 4LKLA 4WHHA 4DFWA 5DNJA 4RS6A 4E9CA 3P36A 4O9WA 3Q1IA 4YYPA 3P2ZA 3P35A 3RQ7A 4WHKA 4HY2A 4O56A 4HABA 1Q4OA 4LKMA 5LHZA 2OJXA 1UMWA 3BZIA 4X9WA 5J19A 2OGQA 4E9DA 4WHLA 5DMSA 4X9RA 4E67A 4HCOA 4O6WA 4X9VA 1Q4KA 3P34A 3P37A 3HIHA 3C5LA 5DMVC 4H71A
chains in the Genus database with same CATH superfamily
4RCPA 1P49A 2N19A 3HIKA 4CYSA 4LKLA 3P36A 3Q1IA 3P35A 1N2LA 5DAYA 4HY2A 4LKMA 5LHZA 3GYWA 3FS3A 4HCOA 3GYVA 3P37A 3KDRA 4FDJA 3P2WA 4J7BB 5DNJA 4RS6A 1E1ZP 3P2ZA 3RQ7A 4CXUA 4WHKA 4N7VA 2OJXA 3BZIA 5J19A 2QZUA 4NKBA 5DMSA 4X9RA 4O6WA 1E33P 3HIHA 3HMJG 4WHHA 1E2TA 4H5XA 3FVHA 4DFWA 2VKZG 4E9CA 4CXKA 4O9WA 1FSUA 1A87A 4NK7A 4N7ZA 1Q4OA 1N2KA 4WHLA 1E2SP 4FDIA 4E67A 4X9VA 3P34A 3C5LA 4H71A 4XB0A 2UV8G 3LXQA 1HDHA 2E50A 3HFDA 3ED4A 1F34B 4YYPA 4CXSA 4O56A 4HABA 1UMWA 2I9ZA 4X9WA 2IA9A 2I9XA 2OGQA 3LM3A 4E9DA 4G7NA 1Q4KA 1F32A 5AJ9A 4CYRA 4N9JA 1AUKA 5DMVC 1E3CP
chains in the Genus database with same CATH topology
4RCPA 4XB0A 3P2WA 2N19A 3HIKA 4H5XA 4J7BB 3FVHA 4LKLA 4WHHA 4DFWA 5DNJA 4RS6A 4E9CA 3P36A 4O9WA 3Q1IA 4YYPA 3P2ZA 3P35A 3RQ7A 4WHKA 4HY2A 4O56A 4HABA 1Q4OA 4LKMA 5LHZA 2OJXA 1UMWA 3BZIA 4X9WA 5J19A 2OGQA 4E9DA 4WHLA 5DMSA 4X9RA 4E67A 4HCOA 4O6WA 4X9VA 1Q4KA 3P34A 3P37A 3HIHA 3C5LA 5DMVC 4H71A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4RCP A;  4XB0 A;  3P2W A;  2N19 A;  3HIK A;  4H5X A;  4J7B B;  3FVH A;  4LKL A;  4WHH A;  4DFW A;  5DNJ A;  4RS6 A;  4E9C A;  3P36 A;  4O9W A;  3Q1I A;  4YYP A;  3P2Z A;  3P35 A;  3RQ7 A;  4WHK A;  4HY2 A;  4O56 A;  4HAB A;  1Q4O A;  4LKM A;  5LHZ A;  2OJX A;  1UMW A;  3BZI A;  4X9W A;  5J19 A;  2OGQ A;  4E9D A;  4WHL A;  5DMS A;  4X9R A;  4E67 A;  4HCO A;  4O6W A;  4X9V A;  1Q4K A;  3P34 A;  3P37 A;  3HIH A;  3C5L A;  5DMV C;  4H71 A; 
#chains in the Genus database with same CATH topology
 4RCP A;  1P49 A;  2N19 A;  3HIK A;  4CYS A;  4LKL A;  3P36 A;  3Q1I A;  3P35 A;  1N2L A;  5DAY A;  4HY2 A;  4LKM A;  5LHZ A;  3GYW A;  3FS3 A;  4HCO A;  3GYV A;  3P37 A;  3KDR A;  4FDJ A;  3P2W A;  4J7B B;  5DNJ A;  4RS6 A;  1E1Z P;  3P2Z A;  3RQ7 A;  4CXU A;  4WHK A;  4N7V A;  2OJX A;  3BZI A;  5J19 A;  2QZU A;  4NKB A;  5DMS A;  4X9R A;  4O6W A;  1E33 P;  3HIH A;  3HMJ G;  4WHH A;  1E2T A;  4H5X A;  3FVH A;  4DFW A;  2VKZ G;  4E9C A;  4CXK A;  4O9W A;  1FSU A;  1A87 A;  4NK7 A;  4N7Z A;  1Q4O A;  1N2K A;  4WHL A;  1E2S P;  4FDI A;  4E67 A;  4X9V A;  3P34 A;  3C5L A;  4H71 A;  4XB0 A;  2UV8 G;  3LXQ A;  1HDH A;  2E50 A;  3HFD A;  3ED4 A;  1F34 B;  4YYP A;  4CXS A;  4O56 A;  4HAB A;  1UMW A;  2I9Z A;  4X9W A;  2IA9 A;  2I9X A;  2OGQ A;  3LM3 A;  4E9D A;  4G7N A;  1Q4K A;  1F32 A;  5AJ9 A;  4CYR A;  4N9J A;  1AUK A;  5DMV C;  1E3C P; 
#chains in the Genus database with same CATH homology
 4RCP A;  4XB0 A;  3P2W A;  2N19 A;  3HIK A;  4H5X A;  4J7B B;  3FVH A;  4LKL A;  4WHH A;  4DFW A;  5DNJ A;  4RS6 A;  4E9C A;  3P36 A;  4O9W A;  3Q1I A;  4YYP A;  3P2Z A;  3P35 A;  3RQ7 A;  4WHK A;  4HY2 A;  4O56 A;  4HAB A;  1Q4O A;  4LKM A;  5LHZ A;  2OJX A;  1UMW A;  3BZI A;  4X9W A;  5J19 A;  2OGQ A;  4E9D A;  4WHL A;  5DMS A;  4X9R A;  4E67 A;  4HCO A;  4O6W A;  4X9V A;  1Q4K A;  3P34 A;  3P37 A;  3HIH A;  3C5L A;  5DMV C;  4H71 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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