3Q2HA

Adamts1 in complex with n-hydroxyformamide inhibitors of adam-ts4
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
296
structure length
284
Chain Sequence
SHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPTCSTLWCTGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKLVP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords A disintegrin and metalloproteinase with thrombospondin moti
total genus 91
structure length 284
sequence length 296
chains with identical sequence B
ec nomenclature ec 3.4.24.-:
pdb deposition date 2010-12-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01421 Reprolysin Reprolysin (M12B) family zinc metalloprotease
A PF17771 ADAM_CR_2 ADAM cysteine-rich domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 3q2hA01
4J4MA 4DD8A 3KECA 830CA 5I43A 2FV5A 3KEJA 3CKIA 1MMQA 2N8RA 2W15A 1AF0A 1K7QA 3DNGA 3KMCA 4HMAA 4XM6A 3DSLA 3TS4A 1SLNA 2XS4A 1YQYA 4GR0A 3K7LA 4FVLA 4FXYP 1KAPP 2K9CA 1Q3AA 4PKVA 5I12A 1R55A 1K7GA 2E3XA 2WO9A 1Y93A 3RTSA 2X7MA 2PJTA 1PWQA 1GO8P 2QPJA 5L79A 4JP4A 5H8XA 4DF9A 2JIHA 1ATLA 1OMJA 2Y6CA 2CKIA 2L0RA 1BUVM 456CA 4JPAA 3TSKA 1DTHA 3LE9A 4Q1LA 1CXVA 1KUKA 3KMEA 4L63A 2W12A 3BA0A 4H84A 2DW2A 3F15A 1YP1A 4H76A 1JK3A 1O0TA 1IABA 3HDAP 3LUNA 2X3BA 1BZSA 1GKCA 2Y6DA 3ZUKA 4FU4A 1MNCA 2OY2A 3USNA 3DWBA 3LUMA 3LIKA 4ILWD 3F1AA 3EHXA 1D8MA 1JJ9A 3B2ZA 1CGEA 1HV5A 4AUOA 1ZP5A 1SATA 1AYKA 1EB6A 1XFZA 1BQQM 1OM7A 4AIGA 4I03A 4PKUA 1L6JA 4A7BA 1EAKA 2K2GA 3L0VA 4GUYA 1OM6A 4DPEA 4CTHA 1IAEA 3HY7A 1BM6A 1ASTA 2OXZA 1G4KA 1ZTQA 2WO8A 1OO9A 2OXWA 1FM1A 2DDYA 1R1JA 3VI1A 4H30A 3DL1A 1UMSA 2I47A 4WKEA 3LMCA 3B8ZA 4L19A 5D3CA 3LIRA 1HFSA 3HB2P 1CAQA 4IJOA 4G9LA 1XFXA 2D1NA 1IACA 1GE6A 3UVCA 1A86A 4JIJA 1XFYA 1UTZA 2MLRA 4XM7A 2JT5A 5L7FA 1JAOA 3OHLA 1G05A 4HX3A 1K7IA 3ZXHA 3HY9A 2RJQA 1IADA 1QICA 4JA1A 4AYKA 5I3MA 3HDBA 5D2BA 1SMPA 1CK7A 3P24A 3LEAA 5D1UA 1OS9A 4GF1A 2JNPA 1XUDA 1PWUA 1WNIA 2OZRA 1XFVA 1FBLA 5B5OA 1USNA 1S4BP 5D1TA 4XBHA 4H2EA 1HTDA 1IAAA 2KRJA 5LABA 1CGFA 1BQOA 1D7XA 3L0TA 3MA2A 2W0DA 1OS2A 3U1RA 3NX7A 5CUHA 3O64A 1ZS0A 1BSWA 3EDHA 3V96B 3E8RA 4IUWA 5CZMA 5D7WA 4GWMA 2JSDA 3P1VA 2OVZA 1JAQA 1C3IA 1GO7P 3KHIA 1QIBA 4PKWA 1KUFA 1R1IA 4PKSA 5CXAA 4H82A 1QJIA 1IAGA 3VTGA 2YIGA 5I4OA 1ROSA 1G9KA 2EROA 1PWWA 1Y0VA 1SRPA 2AYKA 4DV8A 1O0QA 4XM8A 1MMRA 2ERPA 1QIAA 3GBOA 3WV1A 1ZXCA 1KBCA 4JQGA 2A8HA 3HBVP 1G12A 2XS3A 1KUIA 2POJA 4QKZA 1Z3JA 1HFCA 4ON1A 3TVCA 1CGLA 2W13A 2YB9A 3EHYA 1R1HA 2ERQA 3F16A 1BKCI 1Y8JA 3B92A 1SU3A 2MLSA 3LJGA 3LKAA 1ZVXA 3LGPA 1SLMA 1A85A 1RMZA 3AYUA 4WF6A 3TT4A 3G42A 4PKRA 2FV9A 1UMTA 3EWJA 2O36A 3N2UA 3KWVC 2Z2DA 3EDGA 4A3WA 4H1QA 1BKCE 3I7GA 1I73A 1G49A 1H71P 1JH1A 1QJJA 3LJZA 2O3EA 3LILA 1B8YA 1C7KA 1XUCA 1ZXVA 1UEAA 3AYKA 2DW0A 1JIWP 1JKYA 2W14A 1MMPA 4PKQA 2J0TA 5D1SA 4GR8A 4GR3A 3KRYA 2OY4A 3LJTA 4G0DA 1BUDA 3OHOA 3AIGA 3RTTA 1YOUA 2OXUA 4XCTA 2JT6A 2RJPA 966CA 4I35A 1C8TA 1ND1A 1BIWA 5BOYA 5I2ZA 4H3XA 1DMTA 4WKIA 2CLTA 1YCMA 3EDZA 1XFWA 2X3AA 3HBUP 2SRTA 2E2DA 1D8FA 1JAPA 2WOAA 1RM8A 3Q2GA 3LQBA 1EUBA 3LK8A 3N2VA 4WZVA 3DPEA 4AXQA 2MZEA 1PWVA 2HU6A 1GKDA 3HYGA 3F18A 3F19A 1XFUA 2DW1A 2MZHA 3Q2HA 3ELMA 4WK7A 4GWNA 4ZR5A 1OM8A 2OI0A 3LQ0A 3KEKA 2OW1A 4FXQA 3ZVSA 2OVXA 5BOTA 4GQLA 1I76A 2V4BA 3K7NA 1KUGA 3G5CA 1MMBA 1QUAA 2USNA 1R54A 1UTTA 1JIZA 2MZIA 2DDFA 1J7NA 3O2XA 4H49A 4L6TA 3I7IA 1I1IP 1PWPA 4EFSA 1CIZA 4IN9A 1BKCA 3DPFA 1GE7A 2OW9A 2OW0A 1GE5A 2TCLA 1HOVA 1B3DA 5I0LA 5B5PA 5BPAA 2J83A 2X3CA 2AIGP 4PKTA 3SHIA 1FLSA 3EDIA 1KUHA 5JMYA 1AKLA 4R3VA 1GXDA 3F17A 1D5JA 3WV3A 2OW2A 1CQRA 1JANA 1HY7A 1XURA 2D1OA 3WV2A
chains in the Genus database with same CATH superfamily
4J4MA 4DD8A 3KECA 830CA 5I43A 2FV5A 3KEJA 3CKIA 1MMQA 2N8RA 2W15A 1AF0A 1K7QA 3DNGA 3KMCA 4HMAA 4XM6A 3DSLA 3TS4A 1SLNA 2XS4A 1YQYA 4GR0A 3K7LA 4FVLA 4FXYP 1KAPP 2K9CA 1Q3AA 4PKVA 5I12A 1R55A 1K7GA 2E3XA 2WO9A 1Y93A 3RTSA 2X7MA 2PJTA 1PWQA 1GO8P 2QPJA 5L79A 4JP4A 5H8XA 4DF9A 2JIHA 1ATLA 1OMJA 2Y6CA 2CKIA 2L0RA 1BUVM 456CA 4JPAA 3TSKA 1DTHA 3LE9A 4Q1LA 1CXVA 1KUKA 3KMEA 4L63A 2W12A 3BA0A 4H84A 2DW2A 3F15A 1YP1A 4H76A 1JK3A 1O0TA 1IABA 3HDAP 3LUNA 2X3BA 1BZSA 1GKCA 2Y6DA 3ZUKA 4FU4A 1MNCA 2OY2A 3USNA 3DWBA 3LUMA 3LIKA 4ILWD 3F1AA 3EHXA 1D8MA 1JJ9A 3B2ZA 1CGEA 1HV5A 4AUOA 1ZP5A 1SATA 1AYKA 1EB6A 1XFZA 1BQQM 1OM7A 4AIGA 4I03A 4PKUA 1L6JA 4A7BA 1EAKA 2K2GA 3L0VA 4GUYA 1OM6A 4DPEA 4CTHA 1IAEA 3HY7A 1BM6A 1ASTA 2OXZA 1G4KA 1ZTQA 2WO8A 1OO9A 2OXWA 1FM1A 2DDYA 1R1JA 4L7AA 3VI1A 4H30A 3DL1A 1UMSA 2I47A 4WKEA 3LMCA 3B8ZA 4L19A 5D3CA 3LIRA 1HFSA 3HB2P 1CAQA 4IJOA 4G9LA 1XFXA 2D1NA 1IACA 1GE6A 3UVCA 3DTIA 1A86A 4JIJA 1XFYA 1UTZA 2MLRA 4XM7A 2JT5A 5L7FA 1JAOA 3OHLA 1G05A 4HX3A 1K7IA 3ZXHA 3HY9A 2RJQA 1IADA 1QICA 4JA1A 4AYKA 5I3MA 3HDBA 5D2BA 1SMPA 1CK7A 3P24A 3LEAA 5D1UA 1OS9A 4GF1A 2JNPA 1XUDA 1PWUA 1WNIA 2OZRA 1XFVA 1FBLA 5B5OA 1USNA 1S4BP 5D1TA 4XBHA 4H2EA 1HTDA 1IAAA 2KRJA 5LABA 1CGFA 1BQOA 1D7XA 3L0TA 3MA2A 2W0DA 1OS2A 3U1RA 3NX7A 5CUHA 3O64A 1ZS0A 1BSWA 3EDHA 3V96B 3E8RA 4IUWA 5CZMA 5D7WA 4GWMA 2JSDA 3P1VA 2OVZA 1JAQA 1C3IA 1GO7P 3KHIA 1QIBA 4PKWA 1KUFA 1R1IA 4PKSA 5CXAA 3DTEA 4H82A 1QJIA 1IAGA 3VTGA 2YIGA 5I4OA 1ROSA 1G9KA 2EROA 1PWWA 1Y0VA 1SRPA 2AYKA 4DV8A 1O0QA 4XM8A 1MMRA 2ERPA 2YUFA 1QIAA 3GBOA 3WV1A 1ZXCA 1KBCA 4JQGA 2A8HA 3HBVP 1G12A 2XS3A 1KUIA 2POJA 4QKZA 1Z3JA 1HFCA 4ON1A 3TVCA 1CGLA 2W13A 2YB9A 3EHYA 1R1HA 2ERQA 3F16A 1BKCI 1Y8JA 3B92A 1SU3A 2MLSA 3LJGA 3LKAA 1ZVXA 3LGPA 1SLMA 1A85A 1RMZA 3AYUA 4WF6A 3TT4A 3G42A 4PKRA 2FV9A 1UMTA 3EWJA 2O36A 3N2UA 3KWVC 2Z2DA 3EDGA 1XM5A 1TVIA 4A3WA 4H1QA 1BKCE 3I7GA 1I73A 1G49A 1H71P 1JH1A 1QJJA 3LJZA 2O3EA 3LILA 1B8YA 1C7KA 1XUCA 1ZXVA 1UEAA 3AYKA 2DW0A 1JIWP 1JKYA 2W14A 1MMPA 4PKQA 2J0TA 5D1SA 4GR8A 4GR3A 3KRYA 2OY4A 3LJTA 4G0DA 1BUDA 3OHOA 3AIGA 3RTTA 1YOUA 2OXUA 4XCTA 2JT6A 2RJPA 966CA 4I35A 1C8TA 1ND1A 1BIWA 5BOYA 5I2ZA 4H3XA 1DMTA 4WKIA 2CLTA 1YCMA 3EDZA 1XFWA 2X3AA 3HBUP 2SRTA 2E2DA 1D8FA 1JAPA 3DTKA 1OZ9A 2WOAA 1RM8A 3Q2GA 3LQBA 1EUBA 3LK8A 3N2VA 4WZVA 3DPEA 4AXQA 2MZEA 1PWVA 2HU6A 1GKDA 3HYGA 3F18A 3F19A 1XFUA 2DW1A 2MZHA 3Q2HA 3ELMA 4WK7A 4GWNA 4ZR5A 1OM8A 2OI0A 3LQ0A 3KEKA 2OW1A 4FXQA 3ZVSA 2OVXA 5BOTA 4GQLA 1I76A 2V4BA 3K7NA 1KUGA 3G5CA 1MMBA 1QUAA 2USNA 1R54A 1UTTA 1JIZA 2MZIA 2DDFA 1J7NA 3O2XA 4H49A 4L6TA 3I7IA 1I1IP 1PWPA 4EFSA 1CIZA 4IN9A 1BKCA 3DPFA 1GE7A 2OW9A 2OW0A 1GE5A 2TCLA 1HOVA 1B3DA 5I0LA 5B5PA 5BPAA 2J83A 2X3CA 2AIGP 4PKTA 3SHIA 1FLSA 3EDIA 1KUHA 5JMYA 1AKLA 4R3VA 1GXDA 3F17A 1D5JA 1XAXA 3WV3A 2OW2A 1CQRA 1JANA 1HY7A 1XURA 2D1OA 3WV2A
chains in the Genus database with same CATH topology
4J4MA 4DD8A 3KECA 830CA 5I43A 2FV5A 3KEJA 3CKIA 1MMQA 2N8RA 2W15A 1AF0A 1K7QA 3DNGA 3KMCA 4HMAA 4XM6A 3DSLA 3TS4A 1SLNA 2XS4A 1YQYA 4GR0A 3K7LA 4FVLA 4FXYP 1KAPP 2K9CA 1Q3AA 4PKVA 5I12A 1R55A 1K7GA 2E3XA 2WO9A 1Y93A 3RTSA 2X7MA 2PJTA 1PWQA 1GO8P 2QPJA 5L79A 4JP4A 5H8XA 4DF9A 2JIHA 1ATLA 1OMJA 2Y6CA 2CKIA 2L0RA 1BUVM 456CA 4JPAA 3TSKA 1DTHA 3LE9A 4Q1LA 1CXVA 1KUKA 3KMEA 4L63A 2W12A 3BA0A 4H84A 2DW2A 3F15A 1YP1A 4H76A 1JK3A 1O0TA 1IABA 3HDAP 3LUNA 2X3BA 1BZSA 1GKCA 2Y6DA 3ZUKA 4FU4A 1MNCA 2OY2A 3USNA 3DWBA 3LUMA 3LIKA 4ILWD 3F1AA 3EHXA 1D8MA 1JJ9A 3B2ZA 1CGEA 1HV5A 4AUOA 1ZP5A 1SATA 1AYKA 1EB6A 1XFZA 1BQQM 1OM7A 4AIGA 4I03A 4PKUA 1L6JA 4A7BA 1EAKA 2K2GA 3L0VA 4GUYA 1OM6A 4DPEA 4CTHA 1IAEA 3HY7A 1BM6A 1ASTA 2OXZA 1G4KA 1ZTQA 2WO8A 1OO9A 2OXWA 1FM1A 2DDYA 1R1JA 4L7AA 3VI1A 4H30A 3DL1A 1UMSA 2I47A 4WKEA 3LMCA 3B8ZA 4L19A 5D3CA 3LIRA 1HFSA 3HB2P 1CAQA 4IJOA 4G9LA 1XFXA 2D1NA 1IACA 1GE6A 3UVCA 3DTIA 1A86A 4JIJA 1XFYA 1UTZA 2MLRA 4XM7A 2JT5A 5L7FA 1JAOA 3OHLA 1G05A 4HX3A 1K7IA 3ZXHA 3HY9A 2RJQA 1IADA 1QICA 4JA1A 4AYKA 5I3MA 3HDBA 5D2BA 1SMPA 1CK7A 3P24A 3LEAA 5D1UA 1OS9A 4GF1A 2JNPA 1XUDA 1PWUA 1WNIA 2OZRA 1XFVA 1FBLA 5B5OA 1USNA 1S4BP 5D1TA 4XBHA 4H2EA 1HTDA 1IAAA 2KRJA 5LABA 1CGFA 1BQOA 1D7XA 3L0TA 3MA2A 2W0DA 1OS2A 3U1RA 3NX7A 5CUHA 3O64A 1ZS0A 1BSWA 3EDHA 3V96B 3E8RA 4IUWA 5CZMA 5D7WA 4GWMA 2JSDA 3P1VA 2OVZA 1JAQA 1C3IA 1GO7P 3KHIA 1QIBA 4PKWA 1KUFA 1R1IA 4PKSA 5CXAA 3DTEA 4H82A 1QJIA 1IAGA 3VTGA 2YIGA 5I4OA 1ROSA 1G9KA 2EROA 1PWWA 1Y0VA 1SRPA 2AYKA 4DV8A 1O0QA 4XM8A 1MMRA 2ERPA 2YUFA 1QIAA 3GBOA 3WV1A 1ZXCA 1KBCA 4JQGA 2A8HA 3HBVP 1G12A 2XS3A 1KUIA 2POJA 4QKZA 1Z3JA 1HFCA 4ON1A 3TVCA 1CGLA 2W13A 2YB9A 3EHYA 1R1HA 2ERQA 3F16A 1BKCI 1Y8JA 3B92A 1SU3A 2MLSA 3LJGA 3LKAA 1ZVXA 3LGPA 1SLMA 1A85A 1RMZA 3AYUA 4WF6A 3TT4A 3G42A 4PKRA 2FV9A 1UMTA 3EWJA 2O36A 3N2UA 3KWVC 2Z2DA 3EDGA 4A3WA 4H1QA 1BKCE 3I7GA 1I73A 1G49A 1H71P 1JH1A 1QJJA 3LJZA 2O3EA 3LILA 1B8YA 1C7KA 1XUCA 1ZXVA 1UEAA 3AYKA 2DW0A 1JIWP 1JKYA 2W14A 1MMPA 4PKQA 2J0TA 5D1SA 4GR8A 4GR3A 3KRYA 2OY4A 3LJTA 4G0DA 1BUDA 3OHOA 3AIGA 3RTTA 1YOUA 2OXUA 4XCTA 2JT6A 2RJPA 966CA 4I35A 1C8TA 1ND1A 1BIWA 5BOYA 5I2ZA 4H3XA 1DMTA 4WKIA 2CLTA 1YCMA 3EDZA 1XFWA 2X3AA 3HBUP 2SRTA 2E2DA 1D8FA 1JAPA 3DTKA 2WOAA 1RM8A 3Q2GA 3LQBA 1EUBA 3LK8A 3N2VA 4WZVA 3DPEA 4AXQA 2MZEA 1PWVA 2HU6A 1GKDA 3HYGA 3F18A 3F19A 1XFUA 2DW1A 2MZHA 3Q2HA 3ELMA 4WK7A 4GWNA 4ZR5A 1OM8A 2OI0A 3LQ0A 3KEKA 2OW1A 4FXQA 3ZVSA 2OVXA 5BOTA 4GQLA 1I76A 2V4BA 3K7NA 1KUGA 3G5CA 1MMBA 1QUAA 2USNA 1R54A 1UTTA 1JIZA 2MZIA 2DDFA 1J7NA 3O2XA 4H49A 4L6TA 3I7IA 1I1IP 1PWPA 4EFSA 1CIZA 4IN9A 1BKCA 3DPFA 1GE7A 2OW9A 2OW0A 1GE5A 2TCLA 1HOVA 1B3DA 5I0LA 5B5PA 5BPAA 2J83A 2X3CA 2AIGP 4PKTA 3SHIA 1FLSA 3EDIA 1KUHA 5JMYA 1AKLA 4R3VA 1GXDA 3F17A 1D5JA 3WV3A 2OW2A 1CQRA 1JANA 1HY7A 1XURA 2D1OA 3WV2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J4M A;  4DD8 A;  3KEC A;  830C A;  5I43 A;  2FV5 A;  3KEJ A;  3CKI A;  1MMQ A;  2N8R A;  2W15 A;  1AF0 A;  1K7Q A;  3DNG A;  3KMC A;  4HMA A;  4XM6 A;  3DSL A;  3TS4 A;  1SLN A;  2XS4 A;  1YQY A;  4GR0 A;  3K7L A;  4FVL A;  4FXY P;  1KAP P;  2K9C A;  1Q3A A;  4PKV A;  5I12 A;  1R55 A;  1K7G A;  2E3X A;  2WO9 A;  1Y93 A;  3RTS A;  2X7M A;  2PJT A;  1PWQ A;  1GO8 P;  2QPJ A;  5L79 A;  4JP4 A;  5H8X A;  4DF9 A;  2JIH A;  1ATL A;  1OMJ A;  2Y6C A;  2CKI A;  2L0R A;  1BUV M;  456C A;  4JPA A;  3TSK A;  1DTH A;  3LE9 A;  4Q1L A;  1CXV A;  1KUK A;  3KME A;  4L63 A;  2W12 A;  3BA0 A;  4H84 A;  2DW2 A;  3F15 A;  1YP1 A;  4H76 A;  1JK3 A;  1O0T A;  1IAB A;  3HDA P;  3LUN A;  2X3B A;  1BZS A;  1GKC A;  2Y6D A;  3ZUK A;  4FU4 A;  1MNC A;  2OY2 A;  3USN A;  3DWB A;  3LUM A;  3LIK A;  4ILW D;  3F1A A;  3EHX A;  1D8M A;  1JJ9 A;  3B2Z A;  1CGE A;  1HV5 A;  4AUO A;  1ZP5 A;  1SAT A;  1AYK A;  1EB6 A;  1XFZ A;  1BQQ M;  1OM7 A;  4AIG A;  4I03 A;  4PKU A;  1L6J A;  4A7B A;  1EAK A;  2K2G A;  3L0V A;  4GUY A;  1OM6 A;  4DPE A;  4CTH A;  1IAE A;  3HY7 A;  1BM6 A;  1AST A;  2OXZ A;  1G4K A;  1ZTQ A;  2WO8 A;  1OO9 A;  2OXW A;  1FM1 A;  2DDY A;  1R1J A;  3VI1 A;  4H30 A;  3DL1 A;  1UMS A;  2I47 A;  4WKE A;  3LMC A;  3B8Z A;  4L19 A;  5D3C A;  3LIR A;  1HFS A;  3HB2 P;  1CAQ A;  4IJO A;  4G9L A;  1XFX A;  2D1N A;  1IAC A;  1GE6 A;  3UVC A;  1A86 A;  4JIJ A;  1XFY A;  1UTZ A;  2MLR A;  4XM7 A;  2JT5 A;  5L7F A;  1JAO A;  3OHL A;  1G05 A;  4HX3 A;  1K7I A;  3ZXH A;  3HY9 A;  2RJQ A;  1IAD A;  1QIC A;  4JA1 A;  4AYK A;  5I3M A;  3HDB A;  5D2B A;  1SMP A;  1CK7 A;  3P24 A;  3LEA A;  5D1U A;  1OS9 A;  4GF1 A;  2JNP A;  1XUD A;  1PWU A;  1WNI A;  2OZR A;  1XFV A;  1FBL A;  5B5O A;  1USN A;  1S4B P;  5D1T A;  4XBH A;  4H2E A;  1HTD A;  1IAA A;  2KRJ A;  5LAB A;  1CGF A;  1BQO A;  1D7X A;  3L0T A;  3MA2 A;  2W0D A;  1OS2 A;  3U1R A;  3NX7 A;  5CUH A;  3O64 A;  1ZS0 A;  1BSW A;  3EDH A;  3V96 B;  3E8R A;  4IUW A;  5CZM A;  5D7W A;  4GWM A;  2JSD A;  3P1V A;  2OVZ A;  1JAQ A;  1C3I A;  1GO7 P;  3KHI A;  1QIB A;  4PKW A;  1KUF A;  1R1I A;  4PKS A;  5CXA A;  4H82 A;  1QJI A;  1IAG A;  3VTG A;  2YIG A;  5I4O A;  1ROS A;  1G9K A;  2ERO A;  1PWW A;  1Y0V A;  1SRP A;  2AYK A;  4DV8 A;  1O0Q A;  4XM8 A;  1MMR A;  2ERP A;  1QIA A;  3GBO A;  3WV1 A;  1ZXC A;  1KBC A;  4JQG A;  2A8H A;  3HBV P;  1G12 A;  2XS3 A;  1KUI A;  2POJ A;  4QKZ A;  1Z3J A;  1HFC A;  4ON1 A;  3TVC A;  1CGL A;  2W13 A;  2YB9 A;  3EHY A;  1R1H A;  2ERQ A;  3F16 A;  1BKC I;  1Y8J A;  3B92 A;  1SU3 A;  2MLS A;  3LJG A;  3LKA A;  1ZVX A;  3LGP A;  1SLM A;  1A85 A;  1RMZ A;  3AYU A;  4WF6 A;  3TT4 A;  3G42 A;  4PKR A;  2FV9 A;  1UMT A;  3EWJ A;  2O36 A;  3N2U A;  3KWV C;  2Z2D A;  3EDG A;  4A3W A;  4H1Q A;  1BKC E;  3I7G A;  1I73 A;  1G49 A;  1H71 P;  1JH1 A;  1QJJ A;  3LJZ A;  2O3E A;  3LIL A;  1B8Y A;  1C7K A;  1XUC A;  1ZXV A;  1UEA A;  3AYK A;  2DW0 A;  1JIW P;  1JKY A;  2W14 A;  1MMP A;  4PKQ A;  2J0T A;  5D1S A;  4GR8 A;  4GR3 A;  3KRY A;  2OY4 A;  3LJT A;  4G0D A;  1BUD A;  3OHO A;  3AIG A;  3RTT A;  1YOU A;  2OXU A;  4XCT A;  2JT6 A;  2RJP A;  966C A;  4I35 A;  1C8T A;  1ND1 A;  1BIW A;  5BOY A;  5I2Z A;  4H3X A;  1DMT A;  4WKI A;  2CLT A;  1YCM A;  3EDZ A;  1XFW A;  2X3A A;  3HBU P;  2SRT A;  2E2D A;  1D8F A;  1JAP A;  2WOA A;  1RM8 A;  3Q2G A;  3LQB A;  1EUB A;  3LK8 A;  3N2V A;  4WZV A;  3DPE A;  4AXQ A;  2MZE A;  1PWV A;  2HU6 A;  1GKD A;  3HYG A;  3F18 A;  3F19 A;  1XFU A;  2DW1 A;  2MZH A;  3Q2H A;  3ELM A;  4WK7 A;  4GWN A;  4ZR5 A;  1OM8 A;  2OI0 A;  3LQ0 A;  3KEK A;  2OW1 A;  4FXQ A;  3ZVS A;  2OVX A;  5BOT A;  4GQL A;  1I76 A;  2V4B A;  3K7N A;  1KUG A;  3G5C A;  1MMB A;  1QUA A;  2USN A;  1R54 A;  1UTT A;  1JIZ A;  2MZI A;  2DDF A;  1J7N A;  3O2X A;  4H49 A;  4L6T A;  3I7I A;  1I1I P;  1PWP A;  4EFS A;  1CIZ A;  4IN9 A;  1BKC A;  3DPF A;  1GE7 A;  2OW9 A;  2OW0 A;  1GE5 A;  2TCL A;  1HOV A;  1B3D A;  5I0L A;  5B5P A;  5BPA A;  2J83 A;  2X3C A;  2AIG P;  4PKT A;  3SHI A;  1FLS A;  3EDI A;  1KUH A;  5JMY A;  1AKL A;  4R3V A;  1GXD A;  3F17 A;  1D5J A;  3WV3 A;  2OW2 A;  1CQR A;  1JAN A;  1HY7 A;  1XUR A;  2D1O A;  3WV2 A; 
#chains in the Genus database with same CATH topology
 4J4M A;  4DD8 A;  3KEC A;  830C A;  5I43 A;  2FV5 A;  3KEJ A;  3CKI A;  1MMQ A;  2N8R A;  2W15 A;  1AF0 A;  1K7Q A;  3DNG A;  3KMC A;  4HMA A;  4XM6 A;  3DSL A;  3TS4 A;  1SLN A;  2XS4 A;  1YQY A;  4GR0 A;  3K7L A;  4FVL A;  4FXY P;  1KAP P;  2K9C A;  1Q3A A;  4PKV A;  5I12 A;  1R55 A;  1K7G A;  2E3X A;  2WO9 A;  1Y93 A;  3RTS A;  2X7M A;  2PJT A;  1PWQ A;  1GO8 P;  2QPJ A;  5L79 A;  4JP4 A;  5H8X A;  4DF9 A;  2JIH A;  1ATL A;  1OMJ A;  2Y6C A;  2CKI A;  2L0R A;  1BUV M;  456C A;  4JPA A;  3TSK A;  1DTH A;  3LE9 A;  4Q1L A;  1CXV A;  1KUK A;  3KME A;  4L63 A;  2W12 A;  3BA0 A;  4H84 A;  2DW2 A;  3F15 A;  1YP1 A;  4H76 A;  1JK3 A;  1O0T A;  1IAB A;  3HDA P;  3LUN A;  2X3B A;  1BZS A;  1GKC A;  2Y6D A;  3ZUK A;  4FU4 A;  1MNC A;  2OY2 A;  3USN A;  3DWB A;  3LUM A;  3LIK A;  4ILW D;  3F1A A;  3EHX A;  1D8M A;  1JJ9 A;  3B2Z A;  1CGE A;  1HV5 A;  4AUO A;  1ZP5 A;  1SAT A;  1AYK A;  1EB6 A;  1XFZ A;  1BQQ M;  1OM7 A;  4AIG A;  4I03 A;  4PKU A;  1L6J A;  4A7B A;  1EAK A;  2K2G A;  3L0V A;  4GUY A;  1OM6 A;  4DPE A;  4CTH A;  1IAE A;  3HY7 A;  1BM6 A;  1AST A;  2OXZ A;  1G4K A;  1ZTQ A;  2WO8 A;  1OO9 A;  2OXW A;  1FM1 A;  2DDY A;  1R1J A;  4L7A A;  3VI1 A;  4H30 A;  3DL1 A;  1UMS A;  2I47 A;  4WKE A;  3LMC A;  3B8Z A;  4L19 A;  5D3C A;  3LIR A;  1HFS A;  3HB2 P;  1CAQ A;  4IJO A;  4G9L A;  1XFX A;  2D1N A;  1IAC A;  1GE6 A;  3UVC A;  3DTI A;  1A86 A;  4JIJ A;  1XFY A;  1UTZ A;  2MLR A;  4XM7 A;  2JT5 A;  5L7F A;  1JAO A;  3OHL A;  1G05 A;  4HX3 A;  1K7I A;  3ZXH A;  3HY9 A;  2RJQ A;  1IAD A;  1QIC A;  4JA1 A;  4AYK A;  5I3M A;  3HDB A;  5D2B A;  1SMP A;  1CK7 A;  3P24 A;  3LEA A;  5D1U A;  1OS9 A;  4GF1 A;  2JNP A;  1XUD A;  1PWU A;  1WNI A;  2OZR A;  1XFV A;  1FBL A;  5B5O A;  1USN A;  1S4B P;  5D1T A;  4XBH A;  4H2E A;  1HTD A;  1IAA A;  2KRJ A;  5LAB A;  1CGF A;  1BQO A;  1D7X A;  3L0T A;  3MA2 A;  2W0D A;  1OS2 A;  3U1R A;  3NX7 A;  5CUH A;  3O64 A;  1ZS0 A;  1BSW A;  3EDH A;  3V96 B;  3E8R A;  4IUW A;  5CZM A;  5D7W A;  4GWM A;  2JSD A;  3P1V A;  2OVZ A;  1JAQ A;  1C3I A;  1GO7 P;  3KHI A;  1QIB A;  4PKW A;  1KUF A;  1R1I A;  4PKS A;  5CXA A;  3DTE A;  4H82 A;  1QJI A;  1IAG A;  3VTG A;  2YIG A;  5I4O A;  1ROS A;  1G9K A;  2ERO A;  1PWW A;  1Y0V A;  1SRP A;  2AYK A;  4DV8 A;  1O0Q A;  4XM8 A;  1MMR A;  2ERP A;  2YUF A;  1QIA A;  3GBO A;  3WV1 A;  1ZXC A;  1KBC A;  4JQG A;  2A8H A;  3HBV P;  1G12 A;  2XS3 A;  1KUI A;  2POJ A;  4QKZ A;  1Z3J A;  1HFC A;  4ON1 A;  3TVC A;  1CGL A;  2W13 A;  2YB9 A;  3EHY A;  1R1H A;  2ERQ A;  3F16 A;  1BKC I;  1Y8J A;  3B92 A;  1SU3 A;  2MLS A;  3LJG A;  3LKA A;  1ZVX A;  3LGP A;  1SLM A;  1A85 A;  1RMZ A;  3AYU A;  4WF6 A;  3TT4 A;  3G42 A;  4PKR A;  2FV9 A;  1UMT A;  3EWJ A;  2O36 A;  3N2U A;  3KWV C;  2Z2D A;  3EDG A;  1XM5 A;  1TVI A;  4A3W A;  4H1Q A;  1BKC E;  3I7G A;  1I73 A;  1G49 A;  1H71 P;  1JH1 A;  1QJJ A;  3LJZ A;  2O3E A;  3LIL A;  1B8Y A;  1C7K A;  1XUC A;  1ZXV A;  1UEA A;  3AYK A;  2DW0 A;  1JIW P;  1JKY A;  2W14 A;  1MMP A;  4PKQ A;  2J0T A;  5D1S A;  4GR8 A;  4GR3 A;  3KRY A;  2OY4 A;  3LJT A;  4G0D A;  1BUD A;  3OHO A;  3AIG A;  3RTT A;  1YOU A;  2OXU A;  4XCT A;  2JT6 A;  2RJP A;  966C A;  4I35 A;  1C8T A;  1ND1 A;  1BIW A;  5BOY A;  5I2Z A;  4H3X A;  1DMT A;  4WKI A;  2CLT A;  1YCM A;  3EDZ A;  1XFW A;  2X3A A;  3HBU P;  2SRT A;  2E2D A;  1D8F A;  1JAP A;  3DTK A;  1OZ9 A;  2WOA A;  1RM8 A;  3Q2G A;  3LQB A;  1EUB A;  3LK8 A;  3N2V A;  4WZV A;  3DPE A;  4AXQ A;  2MZE A;  1PWV A;  2HU6 A;  1GKD A;  3HYG A;  3F18 A;  3F19 A;  1XFU A;  2DW1 A;  2MZH A;  3Q2H A;  3ELM A;  4WK7 A;  4GWN A;  4ZR5 A;  1OM8 A;  2OI0 A;  3LQ0 A;  3KEK A;  2OW1 A;  4FXQ A;  3ZVS A;  2OVX A;  5BOT A;  4GQL A;  1I76 A;  2V4B A;  3K7N A;  1KUG A;  3G5C A;  1MMB A;  1QUA A;  2USN A;  1R54 A;  1UTT A;  1JIZ A;  2MZI A;  2DDF A;  1J7N A;  3O2X A;  4H49 A;  4L6T A;  3I7I A;  1I1I P;  1PWP A;  4EFS A;  1CIZ A;  4IN9 A;  1BKC A;  3DPF A;  1GE7 A;  2OW9 A;  2OW0 A;  1GE5 A;  2TCL A;  1HOV A;  1B3D A;  5I0L A;  5B5P A;  5BPA A;  2J83 A;  2X3C A;  2AIG P;  4PKT A;  3SHI A;  1FLS A;  3EDI A;  1KUH A;  5JMY A;  1AKL A;  4R3V A;  1GXD A;  3F17 A;  1D5J A;  1XAX A;  3WV3 A;  2OW2 A;  1CQR A;  1JAN A;  1HY7 A;  1XUR A;  2D1O A;  3WV2 A; 
#chains in the Genus database with same CATH homology
 4J4M A;  4DD8 A;  3KEC A;  830C A;  5I43 A;  2FV5 A;  3KEJ A;  3CKI A;  1MMQ A;  2N8R A;  2W15 A;  1AF0 A;  1K7Q A;  3DNG A;  3KMC A;  4HMA A;  4XM6 A;  3DSL A;  3TS4 A;  1SLN A;  2XS4 A;  1YQY A;  4GR0 A;  3K7L A;  4FVL A;  4FXY P;  1KAP P;  2K9C A;  1Q3A A;  4PKV A;  5I12 A;  1R55 A;  1K7G A;  2E3X A;  2WO9 A;  1Y93 A;  3RTS A;  2X7M A;  2PJT A;  1PWQ A;  1GO8 P;  2QPJ A;  5L79 A;  4JP4 A;  5H8X A;  4DF9 A;  2JIH A;  1ATL A;  1OMJ A;  2Y6C A;  2CKI A;  2L0R A;  1BUV M;  456C A;  4JPA A;  3TSK A;  1DTH A;  3LE9 A;  4Q1L A;  1CXV A;  1KUK A;  3KME A;  4L63 A;  2W12 A;  3BA0 A;  4H84 A;  2DW2 A;  3F15 A;  1YP1 A;  4H76 A;  1JK3 A;  1O0T A;  1IAB A;  3HDA P;  3LUN A;  2X3B A;  1BZS A;  1GKC A;  2Y6D A;  3ZUK A;  4FU4 A;  1MNC A;  2OY2 A;  3USN A;  3DWB A;  3LUM A;  3LIK A;  4ILW D;  3F1A A;  3EHX A;  1D8M A;  1JJ9 A;  3B2Z A;  1CGE A;  1HV5 A;  4AUO A;  1ZP5 A;  1SAT A;  1AYK A;  1EB6 A;  1XFZ A;  1BQQ M;  1OM7 A;  4AIG A;  4I03 A;  4PKU A;  1L6J A;  4A7B A;  1EAK A;  2K2G A;  3L0V A;  4GUY A;  1OM6 A;  4DPE A;  4CTH A;  1IAE A;  3HY7 A;  1BM6 A;  1AST A;  2OXZ A;  1G4K A;  1ZTQ A;  2WO8 A;  1OO9 A;  2OXW A;  1FM1 A;  2DDY A;  1R1J A;  4L7A A;  3VI1 A;  4H30 A;  3DL1 A;  1UMS A;  2I47 A;  4WKE A;  3LMC A;  3B8Z A;  4L19 A;  5D3C A;  3LIR A;  1HFS A;  3HB2 P;  1CAQ A;  4IJO A;  4G9L A;  1XFX A;  2D1N A;  1IAC A;  1GE6 A;  3UVC A;  3DTI A;  1A86 A;  4JIJ A;  1XFY A;  1UTZ A;  2MLR A;  4XM7 A;  2JT5 A;  5L7F A;  1JAO A;  3OHL A;  1G05 A;  4HX3 A;  1K7I A;  3ZXH A;  3HY9 A;  2RJQ A;  1IAD A;  1QIC A;  4JA1 A;  4AYK A;  5I3M A;  3HDB A;  5D2B A;  1SMP A;  1CK7 A;  3P24 A;  3LEA A;  5D1U A;  1OS9 A;  4GF1 A;  2JNP A;  1XUD A;  1PWU A;  1WNI A;  2OZR A;  1XFV A;  1FBL A;  5B5O A;  1USN A;  1S4B P;  5D1T A;  4XBH A;  4H2E A;  1HTD A;  1IAA A;  2KRJ A;  5LAB A;  1CGF A;  1BQO A;  1D7X A;  3L0T A;  3MA2 A;  2W0D A;  1OS2 A;  3U1R A;  3NX7 A;  5CUH A;  3O64 A;  1ZS0 A;  1BSW A;  3EDH A;  3V96 B;  3E8R A;  4IUW A;  5CZM A;  5D7W A;  4GWM A;  2JSD A;  3P1V A;  2OVZ A;  1JAQ A;  1C3I A;  1GO7 P;  3KHI A;  1QIB A;  4PKW A;  1KUF A;  1R1I A;  4PKS A;  5CXA A;  3DTE A;  4H82 A;  1QJI A;  1IAG A;  3VTG A;  2YIG A;  5I4O A;  1ROS A;  1G9K A;  2ERO A;  1PWW A;  1Y0V A;  1SRP A;  2AYK A;  4DV8 A;  1O0Q A;  4XM8 A;  1MMR A;  2ERP A;  2YUF A;  1QIA A;  3GBO A;  3WV1 A;  1ZXC A;  1KBC A;  4JQG A;  2A8H A;  3HBV P;  1G12 A;  2XS3 A;  1KUI A;  2POJ A;  4QKZ A;  1Z3J A;  1HFC A;  4ON1 A;  3TVC A;  1CGL A;  2W13 A;  2YB9 A;  3EHY A;  1R1H A;  2ERQ A;  3F16 A;  1BKC I;  1Y8J A;  3B92 A;  1SU3 A;  2MLS A;  3LJG A;  3LKA A;  1ZVX A;  3LGP A;  1SLM A;  1A85 A;  1RMZ A;  3AYU A;  4WF6 A;  3TT4 A;  3G42 A;  4PKR A;  2FV9 A;  1UMT A;  3EWJ A;  2O36 A;  3N2U A;  3KWV C;  2Z2D A;  3EDG A;  4A3W A;  4H1Q A;  1BKC E;  3I7G A;  1I73 A;  1G49 A;  1H71 P;  1JH1 A;  1QJJ A;  3LJZ A;  2O3E A;  3LIL A;  1B8Y A;  1C7K A;  1XUC A;  1ZXV A;  1UEA A;  3AYK A;  2DW0 A;  1JIW P;  1JKY A;  2W14 A;  1MMP A;  4PKQ A;  2J0T A;  5D1S A;  4GR8 A;  4GR3 A;  3KRY A;  2OY4 A;  3LJT A;  4G0D A;  1BUD A;  3OHO A;  3AIG A;  3RTT A;  1YOU A;  2OXU A;  4XCT A;  2JT6 A;  2RJP A;  966C A;  4I35 A;  1C8T A;  1ND1 A;  1BIW A;  5BOY A;  5I2Z A;  4H3X A;  1DMT A;  4WKI A;  2CLT A;  1YCM A;  3EDZ A;  1XFW A;  2X3A A;  3HBU P;  2SRT A;  2E2D A;  1D8F A;  1JAP A;  3DTK A;  2WOA A;  1RM8 A;  3Q2G A;  3LQB A;  1EUB A;  3LK8 A;  3N2V A;  4WZV A;  3DPE A;  4AXQ A;  2MZE A;  1PWV A;  2HU6 A;  1GKD A;  3HYG A;  3F18 A;  3F19 A;  1XFU A;  2DW1 A;  2MZH A;  3Q2H A;  3ELM A;  4WK7 A;  4GWN A;  4ZR5 A;  1OM8 A;  2OI0 A;  3LQ0 A;  3KEK A;  2OW1 A;  4FXQ A;  3ZVS A;  2OVX A;  5BOT A;  4GQL A;  1I76 A;  2V4B A;  3K7N A;  1KUG A;  3G5C A;  1MMB A;  1QUA A;  2USN A;  1R54 A;  1UTT A;  1JIZ A;  2MZI A;  2DDF A;  1J7N A;  3O2X A;  4H49 A;  4L6T A;  3I7I A;  1I1I P;  1PWP A;  4EFS A;  1CIZ A;  4IN9 A;  1BKC A;  3DPF A;  1GE7 A;  2OW9 A;  2OW0 A;  1GE5 A;  2TCL A;  1HOV A;  1B3D A;  5I0L A;  5B5P A;  5BPA A;  2J83 A;  2X3C A;  2AIG P;  4PKT A;  3SHI A;  1FLS A;  3EDI A;  1KUH A;  5JMY A;  1AKL A;  4R3V A;  1GXD A;  3F17 A;  1D5J A;  3WV3 A;  2OW2 A;  1CQR A;  1JAN A;  1HY7 A;  1XUR A;  2D1O A;  3WV2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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