3QBPA

Crystal structure of fumarase fum from mycobacterium marinum
Total Genus 175
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
175
sequence length
447
structure length
441
Chain Sequence
RVPAKALWRAQTQRAVENFPISGRGLERAQIRALGLLKGACAQVNMDLGLLAPEKAEAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAGANGVAVHPNDDVNMSQSSNDTFPTATHIAATEAAVSHLIPALEILQDALATKALEWQSVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRATLPRLGELAIGGTAVGTGLNAPEGFGVKVVSVLVSQTGLPQLRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLMPGKVNPVLPEAVTQVAAQVIGNDAAVAWGGANGAFELNVYIPMMARNILESFTLLTNVSKLFAQRCIAGLTANAEHLRELAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDKLSLEELDRRLDVLAMAKVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Fumarase Fum
publication title Increasing the structural coverage of tuberculosis drug targets.
pubmed doi rcsb
source organism Mycobacterium marinum
molecule tags Lyase
total genus 175
structure length 441
sequence length 447
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2011-01-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 3qbpA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3qbpA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3qbpA02
3C8TA 2O7DA 1HY1A 1XWOA 4ADMA 1T6PA 4ADLA 4NLEA 5F92A 1C3UA 3BHGA 1U16A 3RD8A 2FUSA 4CQ5A 3UNVA 3KDYA 4C6GA 2YIIA 2E9FA 5EYTA 4MX2A 2PTSA 2X75A 5F91A 4V2RA 1TJVA 4FFXA 1TJUA 2PTRA 3R6YA 1GK3A 1VDKA 2J91A 2NYFA 4BAAA 4EFCA 5EYVA 1KQ7A 2QVEA 3CZOA 4BABA 1TJWA 1K7WA 2O7FA 1TJ7A 2O7BA 2PTQA 5D6BA 3R6VA 1JSWA 1FUQA 3GTDA 3OCEA 4NSLA 5HW2A 1U15A 2VD6A 3KDZA 1RE5A 2O6YA 1GKMA 4APBA 1YISA 1DOFA 1Y2MA 1FURA 2O7EA 4C5UA 2QGAB 1YFMA 1GKJA 2RJSA 1W27A 1Q5NA 2NYNA 4V2QA 1FUPA 3NO9A 2PFMA 4C5SA 3RRPA 1HY0A 1K62A 3R6QA 2O78A 1GK2A 4APAA 1C3CA 1EB4A 4HGVA 3E04A 2RJRA 4EEIA 4FLCA 1I0AA 1DCNA 1J3UA 1AUWA 3OCFA 4C5RA 3GZHA 1FUOA 3TV2A 2OHYA 1T6JA 1YFEA 2HVGA 3NZ4A 1B8FA 3QBPA
chains in the Genus database with same CATH superfamily
4IQJM 1XLYA 3C8TA 2O7DA 1HY1A 1XWOA 2VL7A 4ADMA 1T6PA 4ADLA 4NLEA 5F92A 1C3UA 3BHGA 1U16A 3RD8A 1Z4KA 2FUSA 4CQ5A 3UNVA 3KDYA 3CRW1 4C6GA 1Z4PX 2YIIA 2E9FA 4L6CA 5EYTA 4L57A 5H8WA 4MX2A 2PTSA 2X75A 5F91A 4V2RA 1IW7D 4YIKA 1TJVA 1U0LA 4MUMA 1Q91A 4FFXA 1TJUA 2PTRA 3R6YA 1XMCA 1Q92A 1GK3A 1VDKA 2J91A 2NYFA 4BAAA 4EFCA 4E88A 4NFLA 2D28C 2JAWA 1Z4QA 5EYVA 4L6AA 1KQ7A 2FENA 2QVEA 3CZOA 1Z4LA 4BABA 1TJWA 2JAOA 1K7WA 2O7FA 1TJ7A 2O7BA 2PTQA 5D6BA 1XL7A 3R6VA 1JSWA 4A15A 1FUQA 3GTDA 3OCEA 2JAUA 3CI0K 4NSLA 5HW2A 1U15A 2I7DA 2VD6A 3KDZA 1RE5A 2O6YA 1GKMA 4APBA 1YISA 1DOFA 3U19A 1XMDA 5M0JA 2JARA 3F4RA 3BWVA 1Z4JA 2YV5A 1Y2MA 1FURA 2O7EA 4C5UA 1Z4MA 2QGAB 1YFMA 4YIHA 1GKJA 3F4SA 2RJSA 1W27A 2FELA 2D27A 1Q5NA 2NYNA 4V2QA 3F4TA 1FUPA 2VSFA 3NO9A 2PFMA 4C5SA 5M0IA 3RRPA 1HY0A 1K62A 4MWOA 3R6QA 2O78A 4APAA 1GK2A 1C3CA 4WNLA 1EB4A 4HGVA 1MH9A 3E04A 2RJRA 3CRVA 1XL8A 4EEIA 4FLCA 1I0AA 1DCNA 1T9HA 1J3UA 1AUWA 2RCNA 3OCFA 4C5RA 3GZHA 3U13A 1FUOA 1Z4IA 3TV2A 2OHYA 1T6JA 1YFEA 2HVGA 3NZ4A 1B8FA 3QBPA
chains in the Genus database with same CATH topology
3C8TA 2O7DA 1HY1A 1XWOA 4ADMA 1T6PA 4ADLA 4NLEA 5F92A 1C3UA 3BHGA 1U16A 3RD8A 2FUSA 4CQ5A 3UNVA 3KDYA 4C6GA 2YIIA 2E9FA 5EYTA 4MX2A 2PTSA 2X75A 5F91A 4V2RA 1TJVA 4FFXA 1TJUA 2PTRA 3R6YA 1GK3A 1VDKA 2J91A 2NYFA 4BAAA 4EFCA 5EYVA 1KQ7A 2QVEA 3CZOA 4BABA 1TJWA 1K7WA 2O7FA 1TJ7A 2O7BA 2PTQA 5D6BA 3R6VA 1JSWA 1FUQA 3GTDA 3OCEA 4NSLA 5HW2A 1U15A 2VD6A 3KDZA 1RE5A 2O6YA 1GKMA 4APBA 1YISA 1DOFA 1Y2MA 1FURA 2O7EA 4C5UA 2QGAB 1YFMA 1GKJA 2RJSA 1W27A 1Q5NA 2NYNA 4V2QA 1FUPA 3NO9A 2PFMA 4C5SA 3RRPA 1HY0A 1K62A 3R6QA 2O78A 1GK2A 4APAA 1C3CA 1EB4A 4HGVA 3E04A 2RJRA 4EEIA 4FLCA 1I0AA 1DCNA 1J3UA 1AUWA 3OCFA 4C5RA 3GZHA 1FUOA 3TV2A 2OHYA 1T6JA 1YFEA 2HVGA 3NZ4A 1B8FA 3QBPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3C8T A;  2O7D A;  1HY1 A;  1XWO A;  4ADM A;  1T6P A;  4ADL A;  4NLE A;  5F92 A;  1C3U A;  3BHG A;  1U16 A;  3RD8 A;  2FUS A;  4CQ5 A;  3UNV A;  3KDY A;  4C6G A;  2YII A;  2E9F A;  5EYT A;  4MX2 A;  2PTS A;  2X75 A;  5F91 A;  4V2R A;  1TJV A;  4FFX A;  1TJU A;  2PTR A;  3R6Y A;  1GK3 A;  1VDK A;  2J91 A;  2NYF A;  4BAA A;  4EFC A;  5EYV A;  1KQ7 A;  2QVE A;  3CZO A;  4BAB A;  1TJW A;  1K7W A;  2O7F A;  1TJ7 A;  2O7B A;  2PTQ A;  5D6B A;  3R6V A;  1JSW A;  1FUQ A;  3GTD A;  3OCE A;  4NSL A;  5HW2 A;  1U15 A;  2VD6 A;  3KDZ A;  1RE5 A;  2O6Y A;  1GKM A;  4APB A;  1YIS A;  1DOF A;  1Y2M A;  1FUR A;  2O7E A;  4C5U A;  2QGA B;  1YFM A;  1GKJ A;  2RJS A;  1W27 A;  1Q5N A;  2NYN A;  4V2Q A;  1FUP A;  3NO9 A;  2PFM A;  4C5S A;  3RRP A;  1HY0 A;  1K62 A;  3R6Q A;  2O78 A;  1GK2 A;  4APA A;  1C3C A;  1EB4 A;  4HGV A;  3E04 A;  2RJR A;  4EEI A;  4FLC A;  1I0A A;  1DCN A;  1J3U A;  1AUW A;  3OCF A;  4C5R A;  3GZH A;  1FUO A;  3TV2 A;  2OHY A;  1T6J A;  1YFE A;  2HVG A;  3NZ4 A;  1B8F A;  3QBP A; 
#chains in the Genus database with same CATH topology
 4IQJ M;  1XLY A;  3C8T A;  2O7D A;  1HY1 A;  1XWO A;  2VL7 A;  4ADM A;  1T6P A;  4ADL A;  4NLE A;  5F92 A;  1C3U A;  3BHG A;  1U16 A;  3RD8 A;  1Z4K A;  2FUS A;  4CQ5 A;  3UNV A;  3KDY A;  3CRW 1;  4C6G A;  1Z4P X;  2YII A;  2E9F A;  4L6C A;  5EYT A;  4L57 A;  5H8W A;  4MX2 A;  2PTS A;  2X75 A;  5F91 A;  4V2R A;  1IW7 D;  4YIK A;  1TJV A;  1U0L A;  4MUM A;  1Q91 A;  4FFX A;  1TJU A;  2PTR A;  3R6Y A;  1XMC A;  1Q92 A;  1GK3 A;  1VDK A;  2J91 A;  2NYF A;  4BAA A;  4EFC A;  4E88 A;  4NFL A;  2D28 C;  2JAW A;  1Z4Q A;  5EYV A;  4L6A A;  1KQ7 A;  2FEN A;  2QVE A;  3CZO A;  1Z4L A;  4BAB A;  1TJW A;  2JAO A;  1K7W A;  2O7F A;  1TJ7 A;  2O7B A;  2PTQ A;  5D6B A;  1XL7 A;  3R6V A;  1JSW A;  4A15 A;  1FUQ A;  3GTD A;  3OCE A;  2JAU A;  3CI0 K;  4NSL A;  5HW2 A;  1U15 A;  2I7D A;  2VD6 A;  3KDZ A;  1RE5 A;  2O6Y A;  1GKM A;  4APB A;  1YIS A;  1DOF A;  3U19 A;  1XMD A;  5M0J A;  2JAR A;  3F4R A;  3BWV A;  1Z4J A;  2YV5 A;  1Y2M A;  1FUR A;  2O7E A;  4C5U A;  1Z4M A;  2QGA B;  1YFM A;  4YIH A;  1GKJ A;  3F4S A;  2RJS A;  1W27 A;  2FEL A;  2D27 A;  1Q5N A;  2NYN A;  4V2Q A;  3F4T A;  1FUP A;  2VSF A;  3NO9 A;  2PFM A;  4C5S A;  5M0I A;  3RRP A;  1HY0 A;  1K62 A;  4MWO A;  3R6Q A;  2O78 A;  4APA A;  1GK2 A;  1C3C A;  4WNL A;  1EB4 A;  4HGV A;  1MH9 A;  3E04 A;  2RJR A;  3CRV A;  1XL8 A;  4EEI A;  4FLC A;  1I0A A;  1DCN A;  1T9H A;  1J3U A;  1AUW A;  2RCN A;  3OCF A;  4C5R A;  3GZH A;  3U13 A;  1FUO A;  1Z4I A;  3TV2 A;  2OHY A;  1T6J A;  1YFE A;  2HVG A;  3NZ4 A;  1B8F A;  3QBP A; 
#chains in the Genus database with same CATH homology
 3C8T A;  2O7D A;  1HY1 A;  1XWO A;  4ADM A;  1T6P A;  4ADL A;  4NLE A;  5F92 A;  1C3U A;  3BHG A;  1U16 A;  3RD8 A;  2FUS A;  4CQ5 A;  3UNV A;  3KDY A;  4C6G A;  2YII A;  2E9F A;  5EYT A;  4MX2 A;  2PTS A;  2X75 A;  5F91 A;  4V2R A;  1TJV A;  4FFX A;  1TJU A;  2PTR A;  3R6Y A;  1GK3 A;  1VDK A;  2J91 A;  2NYF A;  4BAA A;  4EFC A;  5EYV A;  1KQ7 A;  2QVE A;  3CZO A;  4BAB A;  1TJW A;  1K7W A;  2O7F A;  1TJ7 A;  2O7B A;  2PTQ A;  5D6B A;  3R6V A;  1JSW A;  1FUQ A;  3GTD A;  3OCE A;  4NSL A;  5HW2 A;  1U15 A;  2VD6 A;  3KDZ A;  1RE5 A;  2O6Y A;  1GKM A;  4APB A;  1YIS A;  1DOF A;  1Y2M A;  1FUR A;  2O7E A;  4C5U A;  2QGA B;  1YFM A;  1GKJ A;  2RJS A;  1W27 A;  1Q5N A;  2NYN A;  4V2Q A;  1FUP A;  3NO9 A;  2PFM A;  4C5S A;  3RRP A;  1HY0 A;  1K62 A;  3R6Q A;  2O78 A;  1GK2 A;  4APA A;  1C3C A;  1EB4 A;  4HGV A;  3E04 A;  2RJR A;  4EEI A;  4FLC A;  1I0A A;  1DCN A;  1J3U A;  1AUW A;  3OCF A;  4C5R A;  3GZH A;  1FUO A;  3TV2 A;  2OHY A;  1T6J A;  1YFE A;  2HVG A;  3NZ4 A;  1B8F A;  3QBP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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