3QBPA

Crystal structure of fumarase fum from mycobacterium marinum
Total Genus 175
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
175
sequence length
447
structure length
441
Chain Sequence
RVPAKALWRAQTQRAVENFPISGRGLERAQIRALGLLKGACAQVNMDLGLLAPEKAEAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAGANGVAVHPNDDVNMSQSSNDTFPTATHIAATEAAVSHLIPALEILQDALATKALEWQSVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRATLPRLGELAIGGTAVGTGLNAPEGFGVKVVSVLVSQTGLPQLRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLMPGKVNPVLPEAVTQVAAQVIGNDAAVAWGGANGAFELNVYIPMMARNILESFTLLTNVSKLFAQRCIAGLTANAEHLRELAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDKLSLEELDRRLDVLAMAKVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Increasing the structural coverage of tuberculosis drug targets.
pubmed doi rcsb
source organism Mycobacterium marinum
molecule tags Lyase
molecule keywords Fumarase Fum
total genus 175
structure length 441
sequence length 447
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2011-01-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 3qbpA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3qbpA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3qbpA02
1YFMA 3OCFA 4APAA 1FUOA 1GK3A 3C8TA 2O7EA 4ADLA 3CZOA 5EYVA 3R6QA 1B8FA 3BHGA 4V2QA 1AUWA 2RJSA 3NZ4A 2HVGA 4C6GA 3OCEA 1U16A 3KDZA 2O7FA 1TJ7A 2E9FA 1GKMA 4CQ5A 4EFCA 3R6VA 4APBA 2FUSA 1T6JA 1GKJA 5F91A 1FURA 1W27A 4FFXA 4C5SA 2O7DA 1I0AA 4NLEA 4C5RA 1TJVA 3TV2A 3NO9A 2NYFA 1HY0A 1C3CA 3UNVA 5HW2A 4EEIA 3GZHA 4NSLA 2PTSA 2PTQA 5D6BA 1T6PA 1K62A 3GTDA 1XWOA 1DCNA 2QGAB 1EB4A 1FUPA 3RRPA 3R6YA 2QVEA 1YFEA 4ADMA 1VDKA 1GK2A 4BAAA 1KQ7A 1K7WA 2NYNA 2YIIA 2J91A 1TJUA 1RE5A 4FLCA 2PTRA 2X75A 2O7BA 1Q5NA 1DOFA 4C5UA 2RJRA 2PFMA 2O78A 4V2RA 1JSWA 2OHYA 5EYTA 1U15A 1C3UA 3QBPA 2O6YA 5F92A 3KDYA 4HGVA 1FUQA 1TJWA 3E04A 4BABA 1HY1A 3RD8A 1J3UA 2VD6A 1YISA 1Y2MA 4MX2A
chains in the Genus database with same CATH superfamily
1YFMA 3OCFA 3U13A 4APAA 1FUOA 1GK3A 1XMCA 3C8TA 2O7EA 1Z4IA 4ADLA 3CZOA 5EYVA 3R6QA 1B8FA 3BHGA 4V2QA 1AUWA 2RJSA 3NZ4A 2HVGA 4C6GA 3OCEA 1U16A 3KDZA 1Z4PX 2O7FA 4E88A 5H8WA 1TJ7A 2E9FA 1GKMA 4WNLA 4L6CA 4YIHA 1Z4JA 2FELA 4CQ5A 3CI0K 3F4TA 1Q92A 4EFCA 3R6VA 4APBA 2FUSA 1T6JA 1GKJA 5F91A 1FURA 1W27A 4FFXA 4MUMA 4C5SA 2O7DA 3CRW1 1XL8A 2I7DA 1I0AA 4NLEA 4NFLA 4C5RA 1TJVA 3TV2A 3NO9A 4IQJM 1MH9A 3BWVA 2NYFA 1HY0A 1C3CA 3UNVA 3F4RA 5HW2A 4EEIA 3GZHA 2D27A 4NSLA 2PTSA 4A15A 2PTQA 5D6BA 1Z4QA 1T6PA 1K62A 1Z4KA 2JAWA 4MWOA 1YISA 3GTDA 1XWOA 1DCNA 2QGAB 1EB4A 1FUPA 3RRPA 3R6YA 3F4SA 1U0LA 1XLYA 2QVEA 1YFEA 4ADMA 1VDKA 1GK2A 1IW7D 4BAAA 1XL7A 1KQ7A 2YV5A 1T9HA 2RCNA 2D28C 1K7WA 4L57A 2NYNA 2YIIA 2J91A 1TJUA 1RE5A 4FLCA 2PTRA 2VL7A 5M0IA 3U19A 2X75A 2O7BA 4YIKA 1Q5NA 2JAOA 4L6AA 1DOFA 4C5UA 2RJRA 2PFMA 2O78A 4V2RA 1JSWA 2OHYA 5EYTA 2JARA 1U15A 1C3UA 3QBPA 2O6YA 5F92A 3KDYA 4HGVA 3CRVA 1FUQA 1TJWA 3E04A 4BABA 1HY1A 5M0JA 2JAUA 2VSFA 3RD8A 1J3UA 1Z4MA 2FENA 1Q91A 2VD6A 1Z4LA 1Y2MA 4MX2A 1XMDA
chains in the Genus database with same CATH topology
1YFMA 3OCFA 4APAA 1FUOA 1GK3A 3C8TA 2O7EA 4ADLA 3CZOA 5EYVA 3R6QA 1B8FA 3BHGA 4V2QA 1AUWA 2RJSA 3NZ4A 2HVGA 4C6GA 3OCEA 1U16A 3KDZA 2O7FA 1TJ7A 2E9FA 1GKMA 4CQ5A 4EFCA 3R6VA 4APBA 2FUSA 1T6JA 1GKJA 5F91A 1FURA 1W27A 4FFXA 4C5SA 2O7DA 1I0AA 4NLEA 4C5RA 1TJVA 3TV2A 3NO9A 2NYFA 1HY0A 1C3CA 3UNVA 5HW2A 4EEIA 3GZHA 4NSLA 2PTSA 2PTQA 5D6BA 1T6PA 1K62A 3GTDA 1XWOA 1DCNA 2QGAB 1EB4A 1FUPA 3RRPA 3R6YA 2QVEA 1YFEA 4ADMA 1VDKA 1GK2A 4BAAA 1KQ7A 1K7WA 2NYNA 2YIIA 2J91A 1TJUA 1RE5A 4FLCA 2PTRA 2X75A 2O7BA 1Q5NA 1DOFA 4C5UA 2RJRA 2PFMA 2O78A 4V2RA 1JSWA 2OHYA 5EYTA 1U15A 1C3UA 3QBPA 2O6YA 5F92A 3KDYA 4HGVA 1FUQA 1TJWA 3E04A 4BABA 1HY1A 3RD8A 1J3UA 2VD6A 1YISA 1Y2MA 4MX2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YFM A;  3OCF A;  4APA A;  1FUO A;  1GK3 A;  3C8T A;  2O7E A;  4ADL A;  3CZO A;  5EYV A;  3R6Q A;  1B8F A;  3BHG A;  4V2Q A;  1AUW A;  2RJS A;  3NZ4 A;  2HVG A;  4C6G A;  3OCE A;  1U16 A;  3KDZ A;  2O7F A;  1TJ7 A;  2E9F A;  1GKM A;  4CQ5 A;  4EFC A;  3R6V A;  4APB A;  2FUS A;  1T6J A;  1GKJ A;  5F91 A;  1FUR A;  1W27 A;  4FFX A;  4C5S A;  2O7D A;  1I0A A;  4NLE A;  4C5R A;  1TJV A;  3TV2 A;  3NO9 A;  2NYF A;  1HY0 A;  1C3C A;  3UNV A;  5HW2 A;  4EEI A;  3GZH A;  4NSL A;  2PTS A;  2PTQ A;  5D6B A;  1T6P A;  1K62 A;  3GTD A;  1XWO A;  1DCN A;  2QGA B;  1EB4 A;  1FUP A;  3RRP A;  3R6Y A;  2QVE A;  1YFE A;  4ADM A;  1VDK A;  1GK2 A;  4BAA A;  1KQ7 A;  1K7W A;  2NYN A;  2YII A;  2J91 A;  1TJU A;  1RE5 A;  4FLC A;  2PTR A;  2X75 A;  2O7B A;  1Q5N A;  1DOF A;  4C5U A;  2RJR A;  2PFM A;  2O78 A;  4V2R A;  1JSW A;  2OHY A;  5EYT A;  1U15 A;  1C3U A;  3QBP A;  2O6Y A;  5F92 A;  3KDY A;  4HGV A;  1FUQ A;  1TJW A;  3E04 A;  4BAB A;  1HY1 A;  3RD8 A;  1J3U A;  2VD6 A;  1YIS A;  1Y2M A;  4MX2 A; 
#chains in the Genus database with same CATH topology
 1YFM A;  3OCF A;  3U13 A;  4APA A;  1FUO A;  1GK3 A;  1XMC A;  3C8T A;  2O7E A;  1Z4I A;  4ADL A;  3CZO A;  5EYV A;  3R6Q A;  1B8F A;  3BHG A;  4V2Q A;  1AUW A;  2RJS A;  3NZ4 A;  2HVG A;  4C6G A;  3OCE A;  1U16 A;  3KDZ A;  1Z4P X;  2O7F A;  4E88 A;  5H8W A;  1TJ7 A;  2E9F A;  1GKM A;  4WNL A;  4L6C A;  4YIH A;  1Z4J A;  2FEL A;  4CQ5 A;  3CI0 K;  3F4T A;  1Q92 A;  4EFC A;  3R6V A;  4APB A;  2FUS A;  1T6J A;  1GKJ A;  5F91 A;  1FUR A;  1W27 A;  4FFX A;  4MUM A;  4C5S A;  2O7D A;  3CRW 1;  1XL8 A;  2I7D A;  1I0A A;  4NLE A;  4NFL A;  4C5R A;  1TJV A;  3TV2 A;  3NO9 A;  4IQJ M;  1MH9 A;  3BWV A;  2NYF A;  1HY0 A;  1C3C A;  3UNV A;  3F4R A;  5HW2 A;  4EEI A;  3GZH A;  2D27 A;  4NSL A;  2PTS A;  4A15 A;  2PTQ A;  5D6B A;  1Z4Q A;  1T6P A;  1K62 A;  1Z4K A;  2JAW A;  4MWO A;  1YIS A;  3GTD A;  1XWO A;  1DCN A;  2QGA B;  1EB4 A;  1FUP A;  3RRP A;  3R6Y A;  3F4S A;  1U0L A;  1XLY A;  2QVE A;  1YFE A;  4ADM A;  1VDK A;  1GK2 A;  1IW7 D;  4BAA A;  1XL7 A;  1KQ7 A;  2YV5 A;  1T9H A;  2RCN A;  2D28 C;  1K7W A;  4L57 A;  2NYN A;  2YII A;  2J91 A;  1TJU A;  1RE5 A;  4FLC A;  2PTR A;  2VL7 A;  5M0I A;  3U19 A;  2X75 A;  2O7B A;  4YIK A;  1Q5N A;  2JAO A;  4L6A A;  1DOF A;  4C5U A;  2RJR A;  2PFM A;  2O78 A;  4V2R A;  1JSW A;  2OHY A;  5EYT A;  2JAR A;  1U15 A;  1C3U A;  3QBP A;  2O6Y A;  5F92 A;  3KDY A;  4HGV A;  3CRV A;  1FUQ A;  1TJW A;  3E04 A;  4BAB A;  1HY1 A;  5M0J A;  2JAU A;  2VSF A;  3RD8 A;  1J3U A;  1Z4M A;  2FEN A;  1Q91 A;  2VD6 A;  1Z4L A;  1Y2M A;  4MX2 A;  1XMD A; 
#chains in the Genus database with same CATH homology
 1YFM A;  3OCF A;  4APA A;  1FUO A;  1GK3 A;  3C8T A;  2O7E A;  4ADL A;  3CZO A;  5EYV A;  3R6Q A;  1B8F A;  3BHG A;  4V2Q A;  1AUW A;  2RJS A;  3NZ4 A;  2HVG A;  4C6G A;  3OCE A;  1U16 A;  3KDZ A;  2O7F A;  1TJ7 A;  2E9F A;  1GKM A;  4CQ5 A;  4EFC A;  3R6V A;  4APB A;  2FUS A;  1T6J A;  1GKJ A;  5F91 A;  1FUR A;  1W27 A;  4FFX A;  4C5S A;  2O7D A;  1I0A A;  4NLE A;  4C5R A;  1TJV A;  3TV2 A;  3NO9 A;  2NYF A;  1HY0 A;  1C3C A;  3UNV A;  5HW2 A;  4EEI A;  3GZH A;  4NSL A;  2PTS A;  2PTQ A;  5D6B A;  1T6P A;  1K62 A;  3GTD A;  1XWO A;  1DCN A;  2QGA B;  1EB4 A;  1FUP A;  3RRP A;  3R6Y A;  2QVE A;  1YFE A;  4ADM A;  1VDK A;  1GK2 A;  4BAA A;  1KQ7 A;  1K7W A;  2NYN A;  2YII A;  2J91 A;  1TJU A;  1RE5 A;  4FLC A;  2PTR A;  2X75 A;  2O7B A;  1Q5N A;  1DOF A;  4C5U A;  2RJR A;  2PFM A;  2O78 A;  4V2R A;  1JSW A;  2OHY A;  5EYT A;  1U15 A;  1C3U A;  3QBP A;  2O6Y A;  5F92 A;  3KDY A;  4HGV A;  1FUQ A;  1TJW A;  3E04 A;  4BAB A;  1HY1 A;  3RD8 A;  1J3U A;  2VD6 A;  1YIS A;  1Y2M A;  4MX2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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