3QW8A

Crystal structure of the protease domain of botulinum neurotoxin serotype a with a peptide inhibitor crgc
Total Genus 138
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
138
sequence length
422
structure length
422
Chain Sequence
PFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Botulinum neurotoxin type A
publication title Peptide inhibitors of botulinum neurotoxin serotype A: design, inhibition, cocrystal structures, structure-activity relationship and pharmacophore modeling.
pubmed doi rcsb
source organism Clostridium botulinum
total genus 138
structure length 422
sequence length 422
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2011-02-27
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 3qw8A00
4HEVA 3BOOA 1ZL5A 1T3AA 4J1LA 3QW6A 3QW5A 2IMCA 1G9AA 3DS9A 2IMBA 1S0DA 3VUOA 1S0FA 1ZKXA 3QIZA 1F82A 3QJ0A 3ZURA 1EPWA 1ZB7A 2A8AA 3QIYA 5BQMA 1E1HA 2NYYA 2G7KA 3DSEA 3ZUQA 2G7NA 4KTXA 1G9BA 1ZN3A 3BONA 2A97A 2ISHA 3QIXA 3DEBA 3C8AA 3DDAA 3D3XA 1G9CA 2NP0A 3FIEA 1YVGA 4ELCA 1XTGA 2NZ9A 1Z7HA 1G9DA 2G7QA 3QW7A 4ZJXA 3NF3A 3DDBA 1T3CA 1XTFA 2IMAA 3C8BA 3QW8A 3C89A 4KS6A 3V0AB 3ZUSA 3BTAA 2FPQA 3BWIA 3C88A 2XHLA 2ETFA 2ILPA 1I1EA 4EL4A 2W2DA 3V0AA 1S0EA 3V0BB 3FIIA 3K3QB 5BQNA 1S0GA 1ZKWA 1F31A 2G7PA 4EJ5A 1S0CA 3BOKA 4ZKTB 2ISEA 1ZL6A 1S0BA 4KUFA 2ISGA 3FFZA 3V0BA 2QN0A
chains in the Genus database with same CATH superfamily
4HEVA 3BOOA 1ZL5A 1T3AA 4J1LA 3QW6A 2EJQA 3QW5A 2IMCA 1G9AA 3E11A 3DS9A 2IMBA 1S0DA 3VUOA 1S0FA 1ZKXA 3QIZA 1F82A 3QJ0A 3ZURA 1EPWA 1ZB7A 2A8AA 3QIYA 5BQMA 1E1HA 2NYYA 2G7KA 3DSEA 3ZUQA 2G7NA 4KTXA 1G9BA 1ZN3A 3BONA 2A97A 2ISHA 3QIXA 3DEBA 3C8AA 3DDAA 3CQBA 3D3XA 1G9CA 2NP0A 3FIEA 1YVGA 4ELCA 1XTGA 2NZ9A 1Z7HA 1G9DA 2G7QA 3QW7A 4ZJXA 3NF3A 3DDBA 1T3CA 1XTFA 2IMAA 3C8BA 3QW8A 3C89A 4KS6A 3V0AB 2YPTA 4JIXA 3ZUSA 3BTAA 2FPQA 3BWIA 3C88A 2XHLA 2ETFA 2ILPA 1I1EA 4EL4A 4IL3A 2W2DA 3V0AA 1S0EA 3V0BB 3FIIA 3K3QB 5BQNA 1S0GA 1ZKWA 1F31A 2G7PA 4AW6A 4EJ5A 1S0CA 3BOKA 4ZKTB 2ISEA 1ZL6A 1S0BA 4KUFA 4QHFA 2ISGA 4JIUA 3FFZA 3V0BA 2QN0A
chains in the Genus database with same CATH topology
4HEVA 3BOOA 1ZL5A 1T3AA 4J1LA 3QW6A 3QW5A 2IMCA 1G9AA 3DS9A 2IMBA 1S0DA 3VUOA 1S0FA 1ZKXA 3QIZA 1F82A 3QJ0A 3ZURA 1EPWA 1ZB7A 2A8AA 3QIYA 5BQMA 1E1HA 2NYYA 2G7KA 3DSEA 3ZUQA 2G7NA 4KTXA 1G9BA 1ZN3A 3BONA 2A97A 2ISHA 3QIXA 3DEBA 3C8AA 3DDAA 3D3XA 1G9CA 2NP0A 3FIEA 1YVGA 4ELCA 1XTGA 2NZ9A 1Z7HA 1G9DA 2G7QA 3QW7A 4ZJXA 3NF3A 3DDBA 1T3CA 1XTFA 2IMAA 3C8BA 3QW8A 3C89A 4KS6A 3V0AB 3ZUSA 3BTAA 2FPQA 3BWIA 3C88A 2XHLA 2ETFA 2ILPA 1I1EA 4EL4A 2W2DA 3V0AA 1S0EA 3V0BB 3FIIA 3K3QB 5BQNA 1S0GA 1ZKWA 1F31A 2G7PA 4EJ5A 1S0CA 3BOKA 4ZKTB 2ISEA 1ZL6A 1S0BA 4KUFA 2ISGA 3FFZA 3V0BA 2QN0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HEV A;  3BOO A;  1ZL5 A;  1T3A A;  4J1L A;  3QW6 A;  3QW5 A;  2IMC A;  1G9A A;  3DS9 A;  2IMB A;  1S0D A;  3VUO A;  1S0F A;  1ZKX A;  3QIZ A;  1F82 A;  3QJ0 A;  3ZUR A;  1EPW A;  1ZB7 A;  2A8A A;  3QIY A;  5BQM A;  1E1H A;  2NYY A;  2G7K A;  3DSE A;  3ZUQ A;  2G7N A;  4KTX A;  1G9B A;  1ZN3 A;  3BON A;  2A97 A;  2ISH A;  3QIX A;  3DEB A;  3C8A A;  3DDA A;  3D3X A;  1G9C A;  2NP0 A;  3FIE A;  1YVG A;  4ELC A;  1XTG A;  2NZ9 A;  1Z7H A;  1G9D A;  2G7Q A;  3QW7 A;  4ZJX A;  3NF3 A;  3DDB A;  1T3C A;  1XTF A;  2IMA A;  3C8B A;  3QW8 A;  3C89 A;  4KS6 A;  3V0A B;  3ZUS A;  3BTA A;  2FPQ A;  3BWI A;  3C88 A;  2XHL A;  2ETF A;  2ILP A;  1I1E A;  4EL4 A;  2W2D A;  3V0A A;  1S0E A;  3V0B B;  3FII A;  3K3Q B;  5BQN A;  1S0G A;  1ZKW A;  1F31 A;  2G7P A;  4EJ5 A;  1S0C A;  3BOK A;  4ZKT B;  2ISE A;  1ZL6 A;  1S0B A;  4KUF A;  2ISG A;  3FFZ A;  3V0B A;  2QN0 A; 
#chains in the Genus database with same CATH topology
 4HEV A;  3BOO A;  1ZL5 A;  1T3A A;  4J1L A;  3QW6 A;  2EJQ A;  3QW5 A;  2IMC A;  1G9A A;  3E11 A;  3DS9 A;  2IMB A;  1S0D A;  3VUO A;  1S0F A;  1ZKX A;  3QIZ A;  1F82 A;  3QJ0 A;  3ZUR A;  1EPW A;  1ZB7 A;  2A8A A;  3QIY A;  5BQM A;  1E1H A;  2NYY A;  2G7K A;  3DSE A;  3ZUQ A;  2G7N A;  4KTX A;  1G9B A;  1ZN3 A;  3BON A;  2A97 A;  2ISH A;  3QIX A;  3DEB A;  3C8A A;  3DDA A;  3CQB A;  3D3X A;  1G9C A;  2NP0 A;  3FIE A;  1YVG A;  4ELC A;  1XTG A;  2NZ9 A;  1Z7H A;  1G9D A;  2G7Q A;  3QW7 A;  4ZJX A;  3NF3 A;  3DDB A;  1T3C A;  1XTF A;  2IMA A;  3C8B A;  3QW8 A;  3C89 A;  4KS6 A;  3V0A B;  2YPT A;  4JIX A;  3ZUS A;  3BTA A;  2FPQ A;  3BWI A;  3C88 A;  2XHL A;  2ETF A;  2ILP A;  1I1E A;  4EL4 A;  4IL3 A;  2W2D A;  3V0A A;  1S0E A;  3V0B B;  3FII A;  3K3Q B;  5BQN A;  1S0G A;  1ZKW A;  1F31 A;  2G7P A;  4AW6 A;  4EJ5 A;  1S0C A;  3BOK A;  4ZKT B;  2ISE A;  1ZL6 A;  1S0B A;  4KUF A;  4QHF A;  2ISG A;  4JIU A;  3FFZ A;  3V0B A;  2QN0 A; 
#chains in the Genus database with same CATH homology
 4HEV A;  3BOO A;  1ZL5 A;  1T3A A;  4J1L A;  3QW6 A;  3QW5 A;  2IMC A;  1G9A A;  3DS9 A;  2IMB A;  1S0D A;  3VUO A;  1S0F A;  1ZKX A;  3QIZ A;  1F82 A;  3QJ0 A;  3ZUR A;  1EPW A;  1ZB7 A;  2A8A A;  3QIY A;  5BQM A;  1E1H A;  2NYY A;  2G7K A;  3DSE A;  3ZUQ A;  2G7N A;  4KTX A;  1G9B A;  1ZN3 A;  3BON A;  2A97 A;  2ISH A;  3QIX A;  3DEB A;  3C8A A;  3DDA A;  3D3X A;  1G9C A;  2NP0 A;  3FIE A;  1YVG A;  4ELC A;  1XTG A;  2NZ9 A;  1Z7H A;  1G9D A;  2G7Q A;  3QW7 A;  4ZJX A;  3NF3 A;  3DDB A;  1T3C A;  1XTF A;  2IMA A;  3C8B A;  3QW8 A;  3C89 A;  4KS6 A;  3V0A B;  3ZUS A;  3BTA A;  2FPQ A;  3BWI A;  3C88 A;  2XHL A;  2ETF A;  2ILP A;  1I1E A;  4EL4 A;  2W2D A;  3V0A A;  1S0E A;  3V0B B;  3FII A;  3K3Q B;  5BQN A;  1S0G A;  1ZKW A;  1F31 A;  2G7P A;  4EJ5 A;  1S0C A;  3BOK A;  4ZKT B;  2ISE A;  1ZL6 A;  1S0B A;  4KUF A;  2ISG A;  3FFZ A;  3V0B A;  2QN0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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