3R62A

Structure of complement regulator factor h mutant, t1184r.
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
125
structure length
125
Chain Sequence
GKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWRAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystallographic determination of the disease-associated T1184R variant of the complement Factor H.
rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Complement factor H
total genus 24
structure length 125
sequence length 125
chains with identical sequence B
ec nomenclature
pdb deposition date 2011-03-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 3r62A01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 3r62A02
4J38B 3TVJA 4YNXA 4F4OC 2RKZA 5HYPA 2RLPA 2CG6A 2JGXA 1E8BA 2WIIC 1GKNA 1G4GA 1LY2A 1OK2A 4CSYA 1QGBA 2V8EA 2IZ4A 5HZPB 4K12A 4MUCA 1FBRA 2BZMA 3OEDC 1H2PP 2UWNA 3L89M 1GPZA 1ZJKA 1GKGA 1C1ZA 4B2SA 4LOTA 3ZD1A 2JGWA 2JRAA 4ONTD 1G4FA 3GOVA 1O9AA 4WJG2 2XWBF 4LOSA 2RL0A 3O8EB 4JHSA 2XRBA 2KRIA 5FO8C 1H03P 1OK3A 2B5ID 1OJVA 1OJYA 2IZ3A 1VVDA 2KMSA 3MQLA 4ZH1D 3ZD2A 1HFIA 1OK1A 2XQWC 2MCZA 1HCCA 3KZJA 1E5GA 1NWVA 4AYDA 2G7IA 1TPNA 1OJWA 1H04P 3IX0A 1Z92B 3ZRZA 3SW0X 4FXGG 1PPQA 2LOJA 3NFPI 1VVCA 3KXVA 2XWJI 5HYUB 1GHQB 1QUBA 2W81A 1CKLA 2O39C 5HYTB 3M7PA 4C16A 3INBC 4B2RA 2CG7A 5I0QB 5JPMG 2XRDA 3R62A 1Q3XA 3GXEA 1SRZA 1ELVA 3RJ3D 2YBYA 2EHFA 4IGDA 4AYIA 3ERBA 2RKYA 1TPMA 4AYEA 1TPGA 2RLQA 1QO6A 1E88A 1UOTP 2EC3A 3CALA 1MD7A 3OXUD 1MD8A 1H2QP 1SS2A 2QY0A 1OK9A 1U5MA 4KKDA 2YRAA 2A55A 3IU3I 1HFHA 4PZ5A 4AYMA 2MCYA 2W80A 4A5WB 3EJHA 3T5OA 2ERJA 2CKUA 3OP8A 4DJZA
chains in the Genus database with same CATH superfamily
4J38B 4N7EA 3FGTA 3TVJA 4YNXA 4F4OC 2RKZA 5HYPA 2RLPA 2CG6A 2JGXA 2Y8RA 2WIIC 1E8BA 1RLHA 1G4GA 1LY2A 1OK2A 3CI0J 1QGBA 4CSYA 2V8EA 2IZ4A 4MSLA 5HZPB 4K12A 3WSXA 4MUCA 1FBRA 2BZMA 3OEDC 1H2PP 2UWNA 3L89M 1GPZA 1ZJKA 1GKGA 1C1ZA 3VWOA 4LOTA 4B2SA 3ZD1A 2JGWA 2JRAA 4ONTD 1G4FA 3GOVA 1O9AA 4WJG2 2XWBF 4LOSA 2RL0A 3O8EB 4JHSA 2XRBA 2KRIA 5FO8C 1H03P 1OK3A 2I2LA 4YIZA 2B5ID 1OJVA 1OJYA 2IZ3A 1VVDA 2KMSA 3MQLA 3NJAA 4ZH1D 3ZD2A 1HFIA 5DN4A 1OK1A 2XQWC 4BWCA 2MCZA 1HCCA 3KZJA 2X2ZA 1E5GA 1NWVA 4AYDA 2G7IA 1TPNA 1OJWA 1H04P 2Y8SA 1GKNA 3IX0A 1Z92B 3ZRZA 3F6KA 4PO7A 3SW0X 4FXGG 1PPQA 3WSYA 2LOJA 3NFPI 1VVCA 3ZLDA 3KXVA 2XWJI 5HYUB 1GHQB 1QUBA 2W81A 1CKLA 2O39C 5HYTB 3M7PA 4C16A 3FGRA 3INBC 4B2RA 2CG7A 5I0QB 3ZLEA 5JPMG 2XRDA 3R62A 1Q3XA 3GXEA 1SRZA 1ELVA 2Y8TA 3RJ3D 2YBYA 2EHFA 4IGDA 4AYIA 3ERBA 3K3TA 2RKYA 1TPMA 4AYEA 1TPGA 2RLQA 2ZYCA 1QO6A 1E88A 1UOTP 2EC3A 3CALA 1MD7A 3OXUD 1MD8A 1H2QP 1SS2A 2QY0A 1OK9A 1U5MA 4KKDA 2YRAA 2A55A 3IU3I 1HFHA 4PZ5A 4AYMA 2MCYA 5DN5A 4APLA 2W80A 4A5WB 3EJHA 3T5OA 2ERJA 2CKUA 3OP8A 4DJZA
chains in the Genus database with same CATH topology
4J38B 3TVJA 4YNXA 4F4OC 2RKZA 5HYPA 2RLPA 2CG6A 2JGXA 1E8BA 2WIIC 1GKNA 1G4GA 1LY2A 1OK2A 4CSYA 1QGBA 2V8EA 2IZ4A 5HZPB 4K12A 4MUCA 1FBRA 2BZMA 3OEDC 1H2PP 2UWNA 3L89M 1GPZA 1ZJKA 1GKGA 1C1ZA 4B2SA 4LOTA 3ZD1A 2JGWA 2JRAA 4ONTD 1G4FA 3GOVA 1O9AA 4WJG2 2XWBF 4LOSA 2RL0A 3O8EB 4JHSA 2XRBA 2KRIA 5FO8C 1H03P 1OK3A 2B5ID 1OJVA 1OJYA 2IZ3A 1VVDA 2KMSA 3MQLA 4ZH1D 3ZD2A 1HFIA 1OK1A 2XQWC 2MCZA 1HCCA 3KZJA 1E5GA 1NWVA 4AYDA 2G7IA 1TPNA 1OJWA 1H04P 3IX0A 1Z92B 3ZRZA 3SW0X 4FXGG 1PPQA 2LOJA 3NFPI 1VVCA 3KXVA 2XWJI 5HYUB 1GHQB 1QUBA 2W81A 1CKLA 2O39C 5HYTB 3M7PA 4C16A 3INBC 4B2RA 2CG7A 5I0QB 5JPMG 2XRDA 3R62A 1Q3XA 3GXEA 1SRZA 1ELVA 3RJ3D 2YBYA 2EHFA 4IGDA 4AYIA 3ERBA 2RKYA 1TPMA 4AYEA 1TPGA 2RLQA 1QO6A 1E88A 1UOTP 2EC3A 3CALA 1MD7A 3OXUD 1MD8A 1H2QP 1SS2A 2QY0A 1OK9A 1U5MA 4KKDA 2YRAA 2A55A 3IU3I 1HFHA 4PZ5A 4AYMA 2MCYA 2W80A 4A5WB 3EJHA 3T5OA 2ERJA 2CKUA 3OP8A 4DJZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J38 B;  3TVJ A;  4YNX A;  4F4O C;  2RKZ A;  5HYP A;  2RLP A;  2CG6 A;  2JGX A;  1E8B A;  2WII C;  1GKN A;  1G4G A;  1LY2 A;  1OK2 A;  4CSY A;  1QGB A;  2V8E A;  2IZ4 A;  5HZP B;  4K12 A;  4MUC A;  1FBR A;  2BZM A;  3OED C;  1H2P P;  2UWN A;  3L89 M;  1GPZ A;  1ZJK A;  1GKG A;  1C1Z A;  4B2S A;  4LOT A;  3ZD1 A;  2JGW A;  2JRA A;  4ONT D;  1G4F A;  3GOV A;  1O9A A;  4WJG 2;  2XWB F;  4LOS A;  2RL0 A;  3O8E B;  4JHS A;  2XRB A;  2KRI A;  5FO8 C;  1H03 P;  1OK3 A;  2B5I D;  1OJV A;  1OJY A;  2IZ3 A;  1VVD A;  2KMS A;  3MQL A;  4ZH1 D;  3ZD2 A;  1HFI A;  1OK1 A;  2XQW C;  2MCZ A;  1HCC A;  3KZJ A;  1E5G A;  1NWV A;  4AYD A;  2G7I A;  1TPN A;  1OJW A;  1H04 P;  3IX0 A;  1Z92 B;  3ZRZ A;  3SW0 X;  4FXG G;  1PPQ A;  2LOJ A;  3NFP I;  1VVC A;  3KXV A;  2XWJ I;  5HYU B;  1GHQ B;  1QUB A;  2W81 A;  1CKL A;  2O39 C;  5HYT B;  3M7P A;  4C16 A;  3INB C;  4B2R A;  2CG7 A;  5I0Q B;  5JPM G;  2XRD A;  3R62 A;  1Q3X A;  3GXE A;  1SRZ A;  1ELV A;  3RJ3 D;  2YBY A;  2EHF A;  4IGD A;  4AYI A;  3ERB A;  2RKY A;  1TPM A;  4AYE A;  1TPG A;  2RLQ A;  1QO6 A;  1E88 A;  1UOT P;  2EC3 A;  3CAL A;  1MD7 A;  3OXU D;  1MD8 A;  1H2Q P;  1SS2 A;  2QY0 A;  1OK9 A;  1U5M A;  4KKD A;  2YRA A;  2A55 A;  3IU3 I;  1HFH A;  4PZ5 A;  4AYM A;  2MCY A;  2W80 A;  4A5W B;  3EJH A;  3T5O A;  2ERJ A;  2CKU A;  3OP8 A;  4DJZ A; 
#chains in the Genus database with same CATH topology
 4J38 B;  4N7E A;  3FGT A;  3TVJ A;  4YNX A;  4F4O C;  2RKZ A;  5HYP A;  2RLP A;  2CG6 A;  2JGX A;  2Y8R A;  2WII C;  1E8B A;  1RLH A;  1G4G A;  1LY2 A;  1OK2 A;  3CI0 J;  1QGB A;  4CSY A;  2V8E A;  2IZ4 A;  4MSL A;  5HZP B;  4K12 A;  3WSX A;  4MUC A;  1FBR A;  2BZM A;  3OED C;  1H2P P;  2UWN A;  3L89 M;  1GPZ A;  1ZJK A;  1GKG A;  1C1Z A;  3VWO A;  4LOT A;  4B2S A;  3ZD1 A;  2JGW A;  2JRA A;  4ONT D;  1G4F A;  3GOV A;  1O9A A;  4WJG 2;  2XWB F;  4LOS A;  2RL0 A;  3O8E B;  4JHS A;  2XRB A;  2KRI A;  5FO8 C;  1H03 P;  1OK3 A;  2I2L A;  4YIZ A;  2B5I D;  1OJV A;  1OJY A;  2IZ3 A;  1VVD A;  2KMS A;  3MQL A;  3NJA A;  4ZH1 D;  3ZD2 A;  1HFI A;  5DN4 A;  1OK1 A;  2XQW C;  4BWC A;  2MCZ A;  1HCC A;  3KZJ A;  2X2Z A;  1E5G A;  1NWV A;  4AYD A;  2G7I A;  1TPN A;  1OJW A;  1H04 P;  2Y8S A;  1GKN A;  3IX0 A;  1Z92 B;  3ZRZ A;  3F6K A;  4PO7 A;  3SW0 X;  4FXG G;  1PPQ A;  3WSY A;  2LOJ A;  3NFP I;  1VVC A;  3ZLD A;  3KXV A;  2XWJ I;  5HYU B;  1GHQ B;  1QUB A;  2W81 A;  1CKL A;  2O39 C;  5HYT B;  3M7P A;  4C16 A;  3FGR A;  3INB C;  4B2R A;  2CG7 A;  5I0Q B;  3ZLE A;  5JPM G;  2XRD A;  3R62 A;  1Q3X A;  3GXE A;  1SRZ A;  1ELV A;  2Y8T A;  3RJ3 D;  2YBY A;  2EHF A;  4IGD A;  4AYI A;  3ERB A;  3K3T A;  2RKY A;  1TPM A;  4AYE A;  1TPG A;  2RLQ A;  2ZYC A;  1QO6 A;  1E88 A;  1UOT P;  2EC3 A;  3CAL A;  1MD7 A;  3OXU D;  1MD8 A;  1H2Q P;  1SS2 A;  2QY0 A;  1OK9 A;  1U5M A;  4KKD A;  2YRA A;  2A55 A;  3IU3 I;  1HFH A;  4PZ5 A;  4AYM A;  2MCY A;  5DN5 A;  4APL A;  2W80 A;  4A5W B;  3EJH A;  3T5O A;  2ERJ A;  2CKU A;  3OP8 A;  4DJZ A; 
#chains in the Genus database with same CATH homology
 4J38 B;  3TVJ A;  4YNX A;  4F4O C;  2RKZ A;  5HYP A;  2RLP A;  2CG6 A;  2JGX A;  1E8B A;  2WII C;  1GKN A;  1G4G A;  1LY2 A;  1OK2 A;  4CSY A;  1QGB A;  2V8E A;  2IZ4 A;  5HZP B;  4K12 A;  4MUC A;  1FBR A;  2BZM A;  3OED C;  1H2P P;  2UWN A;  3L89 M;  1GPZ A;  1ZJK A;  1GKG A;  1C1Z A;  4B2S A;  4LOT A;  3ZD1 A;  2JGW A;  2JRA A;  4ONT D;  1G4F A;  3GOV A;  1O9A A;  4WJG 2;  2XWB F;  4LOS A;  2RL0 A;  3O8E B;  4JHS A;  2XRB A;  2KRI A;  5FO8 C;  1H03 P;  1OK3 A;  2B5I D;  1OJV A;  1OJY A;  2IZ3 A;  1VVD A;  2KMS A;  3MQL A;  4ZH1 D;  3ZD2 A;  1HFI A;  1OK1 A;  2XQW C;  2MCZ A;  1HCC A;  3KZJ A;  1E5G A;  1NWV A;  4AYD A;  2G7I A;  1TPN A;  1OJW A;  1H04 P;  3IX0 A;  1Z92 B;  3ZRZ A;  3SW0 X;  4FXG G;  1PPQ A;  2LOJ A;  3NFP I;  1VVC A;  3KXV A;  2XWJ I;  5HYU B;  1GHQ B;  1QUB A;  2W81 A;  1CKL A;  2O39 C;  5HYT B;  3M7P A;  4C16 A;  3INB C;  4B2R A;  2CG7 A;  5I0Q B;  5JPM G;  2XRD A;  3R62 A;  1Q3X A;  3GXE A;  1SRZ A;  1ELV A;  3RJ3 D;  2YBY A;  2EHF A;  4IGD A;  4AYI A;  3ERB A;  2RKY A;  1TPM A;  4AYE A;  1TPG A;  2RLQ A;  1QO6 A;  1E88 A;  1UOT P;  2EC3 A;  3CAL A;  1MD7 A;  3OXU D;  1MD8 A;  1H2Q P;  1SS2 A;  2QY0 A;  1OK9 A;  1U5M A;  4KKD A;  2YRA A;  2A55 A;  3IU3 I;  1HFH A;  4PZ5 A;  4AYM A;  2MCY A;  2W80 A;  4A5W B;  3EJH A;  3T5O A;  2ERJ A;  2CKU A;  3OP8 A;  4DJZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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