3RRPA

Crystal structure of fumarate hydratase fum from mycobacterium abscessus with malate bound
Total Genus 182
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
182
sequence length
465
structure length
465
Chain Sequence
b'SEQQYRIEHDTMGEVRVPAEALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNKDLGLLAAEKADAIIAAAQEIADGKHDDQFPIDVFQTGSGTSSNMNANEVIASIAAQATPPVVVHPNDDVNMSQSSNDTFPTATHLAATEAAVRDLIPALEYLQQALATKAKAWKTVVKSGRTHLMDAVPVTLGQEFGGYARQIEAGIERVKATLPRLGELPIGGTAVGTGLNAPDGFGAKVVEVLKQSTGLSELKTASDSFEAQAARDGLVEGSGALKTIAASLTKIANDIRWMGSGPLTGLGEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAITVGGLSGAFELNVYIPVMARNLLESFTLLANVSRLFVDKCVDGLVANEDHLRTLAESSPSIVTPLNSAIGYEEAAAVAKEALKERKTIRQTVIDRGLIGDKLSIEELDKRLDVLAMAKVKD'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Probable fumarate hydratase Fum
publication title Increasing the structural coverage of tuberculosis drug targets.
pubmed doi rcsb
source organism Mycobacterium abscessus
molecule tags Lyase
total genus 182
structure length 465
sequence length 465
chains with identical sequence B
ec nomenclature
pdb deposition date 2011-04-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 3rrpA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3rrpA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3rrpA02
1U16A 4V2QA 2PTQA 1HY1A 5F91A 2O7EA 4C5UA 1RE5A 4BABA 5EYVA 1EB4A 1Y2MA 5HW2A 2OHYA 1FUQA 3KDZA 1W27A 1KQ7A 4EFCA 1YISA 2RJRA 3NO9A 1U15A 1DCNA 3RRPA 1K7WA 2YIIA 1GK3A 4C5RA 1B8FA 1GKMA 2PTSA 3CZOA 4NSLA 3KDYA 1YFMA 1GKJA 1FUPA 2RJSA 2QGAB 1T6PA 4V2RA 1TJ7A 1DOFA 1AUWA 2NYFA 4BAAA 1FURA 2QVEA 3QBPA 3RD8A 1TJUA 1J3UA 4HGVA 2PFMA 3UNVA 1C3CA 1XWOA 1TJVA 2VD6A 1C3UA 3OCFA 2E9FA 4C6GA 4NLEA 5EYTA 4MX2A 3E04A 2O7DA 3OCEA 2HVGA 3NZ4A 3C8TA 2NYNA 2O6YA 4ADMA 4FLCA 2J91A 2O7BA 1FUOA 3R6VA 1T6JA 4APAA 4APBA 3GZHA 2O7FA 4ADLA 3R6YA 3BHGA 3R6QA 2X75A 2O78A 1JSWA 3TV2A 5D6BA 4FFXA 1GK2A 1I0AA 1YFEA 4C5SA 1VDKA 1TJWA 4EEIA 3GTDA 1HY0A 2FUSA 4CQ5A 1Q5NA 1K62A 2PTRA 5F92A
chains in the Genus database with same CATH superfamily
1U16A 4V2QA 2PTQA 3F4SA 1HY1A 5F91A 2O7EA 2FENA 4C5UA 1RE5A 1Z4QA 4BABA 5EYVA 2JARA 1EB4A 4MUMA 1Y2MA 5HW2A 1XMDA 2OHYA 5M0IA 1FUQA 3KDZA 1W27A 5M0JA 3U19A 1KQ7A 4EFCA 1Z4MA 1YISA 2RJRA 3CRVA 3NO9A 3F4RA 1U15A 1DCNA 3RRPA 1K7WA 2YIIA 1GK3A 4C5RA 1B8FA 1GKMA 2PTSA 4L6AA 3CZOA 4NSLA 3KDYA 1XLYA 1YFMA 1GKJA 1FUPA 1IW7D 2RJSA 1U0LA 2QGAB 1Z4KA 2RCNA 1T6PA 2VSFA 1TJ7A 1DOFA 2YV5A 3F4TA 4V2RA 1AUWA 2NYFA 2JAOA 4BAAA 4IQJM 1Z4LA 1FURA 4YIKA 2QVEA 1T9HA 4A15A 3QBPA 3RD8A 1TJUA 2JAWA 1J3UA 4L6CA 4HGVA 2PFMA 3UNVA 1C3CA 1XWOA 1TJVA 2VD6A 3CI0K 1C3UA 3OCFA 1XL7A 2E9FA 4C6GA 4NLEA 5EYTA 4MX2A 3E04A 2O7DA 3OCEA 2HVGA 3NZ4A 3C8TA 2NYNA 3U13A 1Z4PX 4L57A 2O6YA 2FELA 4ADMA 4FLCA 2J91A 2O7BA 1FUOA 1Q92A 3R6VA 1T6JA 2D28C 4APAA 4YIHA 4NFLA 4APBA 3GZHA 2O7FA 4ADLA 3R6YA 3BHGA 3R6QA 2X75A 4E88A 2O78A 2D27A 1XL8A 3CRW1 1JSWA 1MH9A 3TV2A 1Z4JA 5H8WA 5D6BA 4FFXA 1GK2A 1I0AA 1YFEA 4C5SA 1VDKA 2JAUA 3BWVA 1Q91A 1TJWA 4EEIA 2VL7A 3GTDA 1XMCA 1HY0A 2FUSA 4CQ5A 1Q5NA 1Z4IA 2I7DA 4MWOA 4WNLA 1K62A 2PTRA 5F92A
chains in the Genus database with same CATH topology
1U16A 4V2QA 2PTQA 1HY1A 5F91A 2O7EA 4C5UA 1RE5A 4BABA 5EYVA 1EB4A 1Y2MA 5HW2A 2OHYA 1FUQA 3KDZA 1W27A 1KQ7A 4EFCA 1YISA 2RJRA 3NO9A 1U15A 1DCNA 3RRPA 1K7WA 2YIIA 1GK3A 4C5RA 1B8FA 1GKMA 2PTSA 3CZOA 4NSLA 3KDYA 1YFMA 1GKJA 1FUPA 2RJSA 2QGAB 1T6PA 4V2RA 1TJ7A 1DOFA 1AUWA 2NYFA 4BAAA 1FURA 2QVEA 3QBPA 3RD8A 1TJUA 1J3UA 4HGVA 2PFMA 3UNVA 1C3CA 1XWOA 1TJVA 2VD6A 1C3UA 3OCFA 2E9FA 4C6GA 4NLEA 5EYTA 4MX2A 3E04A 2O7DA 3OCEA 2HVGA 3NZ4A 3C8TA 2NYNA 2O6YA 4ADMA 4FLCA 2J91A 2O7BA 1FUOA 3R6VA 1T6JA 4APAA 4APBA 3GZHA 2O7FA 4ADLA 3R6YA 3BHGA 3R6QA 2X75A 2O78A 1JSWA 3TV2A 5D6BA 4FFXA 1GK2A 1I0AA 1YFEA 4C5SA 1VDKA 1TJWA 4EEIA 3GTDA 1HY0A 2FUSA 4CQ5A 1Q5NA 1K62A 2PTRA 5F92A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1U16 A;  4V2Q A;  2PTQ A;  1HY1 A;  5F91 A;  2O7E A;  4C5U A;  1RE5 A;  4BAB A;  5EYV A;  1EB4 A;  1Y2M A;  5HW2 A;  2OHY A;  1FUQ A;  3KDZ A;  1W27 A;  1KQ7 A;  4EFC A;  1YIS A;  2RJR A;  3NO9 A;  1U15 A;  1DCN A;  3RRP A;  1K7W A;  2YII A;  1GK3 A;  4C5R A;  1B8F A;  1GKM A;  2PTS A;  3CZO A;  4NSL A;  3KDY A;  1YFM A;  1GKJ A;  1FUP A;  2RJS A;  2QGA B;  1T6P A;  4V2R A;  1TJ7 A;  1DOF A;  1AUW A;  2NYF A;  4BAA A;  1FUR A;  2QVE A;  3QBP A;  3RD8 A;  1TJU A;  1J3U A;  4HGV A;  2PFM A;  3UNV A;  1C3C A;  1XWO A;  1TJV A;  2VD6 A;  1C3U A;  3OCF A;  2E9F A;  4C6G A;  4NLE A;  5EYT A;  4MX2 A;  3E04 A;  2O7D A;  3OCE A;  2HVG A;  3NZ4 A;  3C8T A;  2NYN A;  2O6Y A;  4ADM A;  4FLC A;  2J91 A;  2O7B A;  1FUO A;  3R6V A;  1T6J A;  4APA A;  4APB A;  3GZH A;  2O7F A;  4ADL A;  3R6Y A;  3BHG A;  3R6Q A;  2X75 A;  2O78 A;  1JSW A;  3TV2 A;  5D6B A;  4FFX A;  1GK2 A;  1I0A A;  1YFE A;  4C5S A;  1VDK A;  1TJW A;  4EEI A;  3GTD A;  1HY0 A;  2FUS A;  4CQ5 A;  1Q5N A;  1K62 A;  2PTR A;  5F92 A; 
#chains in the Genus database with same CATH topology
 1U16 A;  4V2Q A;  2PTQ A;  3F4S A;  1HY1 A;  5F91 A;  2O7E A;  2FEN A;  4C5U A;  1RE5 A;  1Z4Q A;  4BAB A;  5EYV A;  2JAR A;  1EB4 A;  4MUM A;  1Y2M A;  5HW2 A;  1XMD A;  2OHY A;  5M0I A;  1FUQ A;  3KDZ A;  1W27 A;  5M0J A;  3U19 A;  1KQ7 A;  4EFC A;  1Z4M A;  1YIS A;  2RJR A;  3CRV A;  3NO9 A;  3F4R A;  1U15 A;  1DCN A;  3RRP A;  1K7W A;  2YII A;  1GK3 A;  4C5R A;  1B8F A;  1GKM A;  2PTS A;  4L6A A;  3CZO A;  4NSL A;  3KDY A;  1XLY A;  1YFM A;  1GKJ A;  1FUP A;  1IW7 D;  2RJS A;  1U0L A;  2QGA B;  1Z4K A;  2RCN A;  1T6P A;  2VSF A;  1TJ7 A;  1DOF A;  2YV5 A;  3F4T A;  4V2R A;  1AUW A;  2NYF A;  2JAO A;  4BAA A;  4IQJ M;  1Z4L A;  1FUR A;  4YIK A;  2QVE A;  1T9H A;  4A15 A;  3QBP A;  3RD8 A;  1TJU A;  2JAW A;  1J3U A;  4L6C A;  4HGV A;  2PFM A;  3UNV A;  1C3C A;  1XWO A;  1TJV A;  2VD6 A;  3CI0 K;  1C3U A;  3OCF A;  1XL7 A;  2E9F A;  4C6G A;  4NLE A;  5EYT A;  4MX2 A;  3E04 A;  2O7D A;  3OCE A;  2HVG A;  3NZ4 A;  3C8T A;  2NYN A;  3U13 A;  1Z4P X;  4L57 A;  2O6Y A;  2FEL A;  4ADM A;  4FLC A;  2J91 A;  2O7B A;  1FUO A;  1Q92 A;  3R6V A;  1T6J A;  2D28 C;  4APA A;  4YIH A;  4NFL A;  4APB A;  3GZH A;  2O7F A;  4ADL A;  3R6Y A;  3BHG A;  3R6Q A;  2X75 A;  4E88 A;  2O78 A;  2D27 A;  1XL8 A;  3CRW 1;  1JSW A;  1MH9 A;  3TV2 A;  1Z4J A;  5H8W A;  5D6B A;  4FFX A;  1GK2 A;  1I0A A;  1YFE A;  4C5S A;  1VDK A;  2JAU A;  3BWV A;  1Q91 A;  1TJW A;  4EEI A;  2VL7 A;  3GTD A;  1XMC A;  1HY0 A;  2FUS A;  4CQ5 A;  1Q5N A;  1Z4I A;  2I7D A;  4MWO A;  4WNL A;  1K62 A;  2PTR A;  5F92 A; 
#chains in the Genus database with same CATH homology
 1U16 A;  4V2Q A;  2PTQ A;  1HY1 A;  5F91 A;  2O7E A;  4C5U A;  1RE5 A;  4BAB A;  5EYV A;  1EB4 A;  1Y2M A;  5HW2 A;  2OHY A;  1FUQ A;  3KDZ A;  1W27 A;  1KQ7 A;  4EFC A;  1YIS A;  2RJR A;  3NO9 A;  1U15 A;  1DCN A;  3RRP A;  1K7W A;  2YII A;  1GK3 A;  4C5R A;  1B8F A;  1GKM A;  2PTS A;  3CZO A;  4NSL A;  3KDY A;  1YFM A;  1GKJ A;  1FUP A;  2RJS A;  2QGA B;  1T6P A;  4V2R A;  1TJ7 A;  1DOF A;  1AUW A;  2NYF A;  4BAA A;  1FUR A;  2QVE A;  3QBP A;  3RD8 A;  1TJU A;  1J3U A;  4HGV A;  2PFM A;  3UNV A;  1C3C A;  1XWO A;  1TJV A;  2VD6 A;  1C3U A;  3OCF A;  2E9F A;  4C6G A;  4NLE A;  5EYT A;  4MX2 A;  3E04 A;  2O7D A;  3OCE A;  2HVG A;  3NZ4 A;  3C8T A;  2NYN A;  2O6Y A;  4ADM A;  4FLC A;  2J91 A;  2O7B A;  1FUO A;  3R6V A;  1T6J A;  4APA A;  4APB A;  3GZH A;  2O7F A;  4ADL A;  3R6Y A;  3BHG A;  3R6Q A;  2X75 A;  2O78 A;  1JSW A;  3TV2 A;  5D6B A;  4FFX A;  1GK2 A;  1I0A A;  1YFE A;  4C5S A;  1VDK A;  1TJW A;  4EEI A;  3GTD A;  1HY0 A;  2FUS A;  4CQ5 A;  1Q5N A;  1K62 A;  2PTR A;  5F92 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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