3RRPA

Crystal structure of fumarate hydratase fum from mycobacterium abscessus with malate bound
Total Genus 182
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
182
sequence length
465
structure length
465
Chain Sequence
SEQQYRIEHDTMGEVRVPAEALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNKDLGLLAAEKADAIIAAAQEIADGKHDDQFPIDVFQTGSGTSSNMNANEVIASIAAQATPPVVVHPNDDVNMSQSSNDTFPTATHLAATEAAVRDLIPALEYLQQALATKAKAWKTVVKSGRTHLMDAVPVTLGQEFGGYARQIEAGIERVKATLPRLGELPIGGTAVGTGLNAPDGFGAKVVEVLKQSTGLSELKTASDSFEAQAARDGLVEGSGALKTIAASLTKIANDIRWMGSGPLTGLGEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAITVGGLSGAFELNVYIPVMARNLLESFTLLANVSRLFVDKCVDGLVANEDHLRTLAESSPSIVTPLNSAIGYEEAAAVAKEALKERKTIRQTVIDRGLIGDKLSIEELDKRLDVLAMAKVKD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Probable fumarate hydratase Fum
publication title Increasing the structural coverage of tuberculosis drug targets.
pubmed doi rcsb
source organism Mycobacterium abscessus
molecule tags Lyase
total genus 182
structure length 465
sequence length 465
chains with identical sequence B
ec nomenclature
pdb deposition date 2011-04-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 3rrpA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3rrpA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3rrpA02
1KQ7A 3C8TA 3OCFA 2O7DA 2O7FA 1TJ7A 1TJVA 1HY0A 2OHYA 1FUOA 2E9FA 1TJWA 1GK3A 3CZOA 3TV2A 1FUPA 4FFXA 4FLCA 5EYVA 3QBPA 3RRPA 2FUSA 1I0AA 2QGAB 1U15A 3RD8A 4ADLA 4MX2A 2J91A 1Y2MA 1K7WA 1YFMA 4EEIA 3NO9A 3UNVA 4APBA 4V2RA 1GK2A 1XWOA 1YFEA 3NZ4A 2NYNA 2NYFA 2VD6A 2YIIA 4NSLA 4BABA 4NLEA 2PTSA 1K62A 3R6YA 3GZHA 3BHGA 4V2QA 1TJUA 3E04A 2O7BA 2RJSA 1J3UA 3R6VA 5F92A 3GTDA 1YISA 3R6QA 2O7EA 3OCEA 1EB4A 1VDKA 3KDYA 4C6GA 5F91A 4EFCA 4C5UA 4ADMA 1U16A 1AUWA 3KDZA 1RE5A 2RJRA 1GKMA 2PFMA 4HGVA 2O78A 2O6YA 4CQ5A 1GKJA 1C3UA 1DCNA 1T6JA 2X75A 1JSWA 5D6BA 1FUQA 4C5SA 1B8FA 5HW2A 1FURA 4APAA 2PTQA 4C5RA 5EYTA 2HVGA 1W27A 1DOFA 2QVEA 1HY1A 1Q5NA 2PTRA 4BAAA 1T6PA 1C3CA
chains in the Genus database with same CATH superfamily
3U19A 1KQ7A 1Z4LA 2JARA 3C8TA 1U0LA 3OCFA 2O7DA 2O7FA 4L6AA 1TJ7A 1TJVA 1HY0A 2OHYA 1FUOA 2E9FA 4MUMA 1TJWA 1GK3A 3CZOA 1Z4PX 3TV2A 1FUPA 4FFXA 4FLCA 4MWOA 3BWVA 1XMCA 5EYVA 5M0IA 4A15A 3QBPA 4NFLA 3RRPA 2RCNA 2FUSA 1I0AA 2QGAB 1T6PA 1U15A 3RD8A 4ADLA 1Z4IA 4MX2A 3U13A 2J91A 1Y2MA 1K7WA 2YV5A 1YFMA 4EEIA 3CI0K 3NO9A 2FENA 3UNVA 4APBA 4V2RA 1GK2A 1XWOA 1YFEA 3NZ4A 2NYNA 2JAWA 2NYFA 2VD6A 1MH9A 2YIIA 4NSLA 2JAOA 4BABA 1Z4MA 1IW7D 2VSFA 4NLEA 2PTSA 1XMDA 1Q91A 1K62A 3R6YA 3GZHA 3BHGA 4V2QA 3F4SA 1TJUA 1XLYA 3E04A 2O7BA 5M0JA 3CRVA 2RJSA 3F4RA 1J3UA 4L57A 3R6VA 5F92A 3GTDA 2D27A 1YISA 3R6QA 2O7EA 3OCEA 1EB4A 2D28C 4YIKA 1VDKA 2FELA 1XL7A 3KDYA 2JAUA 4C6GA 5F91A 4EFCA 4C5UA 2I7DA 4ADMA 1U16A 1Z4KA 1AUWA 1Z4QA 3KDZA 1RE5A 2RJRA 2VL7A 1GKMA 2PFMA 4HGVA 1XL8A 2O78A 2O6YA 4WNLA 3CRW1 1T9HA 4CQ5A 5H8WA 1GKJA 1C3UA 1DCNA 4L6CA 1T6JA 2X75A 1JSWA 5D6BA 1FUQA 4C5SA 1B8FA 1Q92A 5HW2A 1FURA 4APAA 2PTQA 4C5RA 5EYTA 1Z4JA 3F4TA 2HVGA 1W27A 4IQJM 4YIHA 1DOFA 2QVEA 1HY1A 1Q5NA 2PTRA 4BAAA 4E88A 1C3CA
chains in the Genus database with same CATH topology
1KQ7A 3C8TA 3OCFA 2O7DA 2O7FA 1TJ7A 1TJVA 1HY0A 2OHYA 1FUOA 2E9FA 1TJWA 1GK3A 3CZOA 3TV2A 1FUPA 4FFXA 4FLCA 5EYVA 3QBPA 3RRPA 2FUSA 1I0AA 2QGAB 1U15A 3RD8A 4ADLA 4MX2A 2J91A 1Y2MA 1K7WA 1YFMA 4EEIA 3NO9A 3UNVA 4APBA 4V2RA 1GK2A 1XWOA 1YFEA 3NZ4A 2NYNA 2NYFA 2VD6A 2YIIA 4NSLA 4BABA 4NLEA 2PTSA 1K62A 3R6YA 3GZHA 3BHGA 4V2QA 1TJUA 3E04A 2O7BA 2RJSA 1J3UA 3R6VA 5F92A 3GTDA 1YISA 3R6QA 2O7EA 3OCEA 1EB4A 1VDKA 3KDYA 4C6GA 5F91A 4EFCA 4C5UA 4ADMA 1U16A 1AUWA 3KDZA 1RE5A 2RJRA 1GKMA 2PFMA 4HGVA 2O78A 2O6YA 4CQ5A 1GKJA 1C3UA 1DCNA 1T6JA 2X75A 1JSWA 5D6BA 1FUQA 4C5SA 1B8FA 5HW2A 1FURA 4APAA 2PTQA 4C5RA 5EYTA 2HVGA 1W27A 1DOFA 2QVEA 1HY1A 1Q5NA 2PTRA 4BAAA 1T6PA 1C3CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KQ7 A;  3C8T A;  3OCF A;  2O7D A;  2O7F A;  1TJ7 A;  1TJV A;  1HY0 A;  2OHY A;  1FUO A;  2E9F A;  1TJW A;  1GK3 A;  3CZO A;  3TV2 A;  1FUP A;  4FFX A;  4FLC A;  5EYV A;  3QBP A;  3RRP A;  2FUS A;  1I0A A;  2QGA B;  1U15 A;  3RD8 A;  4ADL A;  4MX2 A;  2J91 A;  1Y2M A;  1K7W A;  1YFM A;  4EEI A;  3NO9 A;  3UNV A;  4APB A;  4V2R A;  1GK2 A;  1XWO A;  1YFE A;  3NZ4 A;  2NYN A;  2NYF A;  2VD6 A;  2YII A;  4NSL A;  4BAB A;  4NLE A;  2PTS A;  1K62 A;  3R6Y A;  3GZH A;  3BHG A;  4V2Q A;  1TJU A;  3E04 A;  2O7B A;  2RJS A;  1J3U A;  3R6V A;  5F92 A;  3GTD A;  1YIS A;  3R6Q A;  2O7E A;  3OCE A;  1EB4 A;  1VDK A;  3KDY A;  4C6G A;  5F91 A;  4EFC A;  4C5U A;  4ADM A;  1U16 A;  1AUW A;  3KDZ A;  1RE5 A;  2RJR A;  1GKM A;  2PFM A;  4HGV A;  2O78 A;  2O6Y A;  4CQ5 A;  1GKJ A;  1C3U A;  1DCN A;  1T6J A;  2X75 A;  1JSW A;  5D6B A;  1FUQ A;  4C5S A;  1B8F A;  5HW2 A;  1FUR A;  4APA A;  2PTQ A;  4C5R A;  5EYT A;  2HVG A;  1W27 A;  1DOF A;  2QVE A;  1HY1 A;  1Q5N A;  2PTR A;  4BAA A;  1T6P A;  1C3C A; 
#chains in the Genus database with same CATH topology
 3U19 A;  1KQ7 A;  1Z4L A;  2JAR A;  3C8T A;  1U0L A;  3OCF A;  2O7D A;  2O7F A;  4L6A A;  1TJ7 A;  1TJV A;  1HY0 A;  2OHY A;  1FUO A;  2E9F A;  4MUM A;  1TJW A;  1GK3 A;  3CZO A;  1Z4P X;  3TV2 A;  1FUP A;  4FFX A;  4FLC A;  4MWO A;  3BWV A;  1XMC A;  5EYV A;  5M0I A;  4A15 A;  3QBP A;  4NFL A;  3RRP A;  2RCN A;  2FUS A;  1I0A A;  2QGA B;  1T6P A;  1U15 A;  3RD8 A;  4ADL A;  1Z4I A;  4MX2 A;  3U13 A;  2J91 A;  1Y2M A;  1K7W A;  2YV5 A;  1YFM A;  4EEI A;  3CI0 K;  3NO9 A;  2FEN A;  3UNV A;  4APB A;  4V2R A;  1GK2 A;  1XWO A;  1YFE A;  3NZ4 A;  2NYN A;  2JAW A;  2NYF A;  2VD6 A;  1MH9 A;  2YII A;  4NSL A;  2JAO A;  4BAB A;  1Z4M A;  1IW7 D;  2VSF A;  4NLE A;  2PTS A;  1XMD A;  1Q91 A;  1K62 A;  3R6Y A;  3GZH A;  3BHG A;  4V2Q A;  3F4S A;  1TJU A;  1XLY A;  3E04 A;  2O7B A;  5M0J A;  3CRV A;  2RJS A;  3F4R A;  1J3U A;  4L57 A;  3R6V A;  5F92 A;  3GTD A;  2D27 A;  1YIS A;  3R6Q A;  2O7E A;  3OCE A;  1EB4 A;  2D28 C;  4YIK A;  1VDK A;  2FEL A;  1XL7 A;  3KDY A;  2JAU A;  4C6G A;  5F91 A;  4EFC A;  4C5U A;  2I7D A;  4ADM A;  1U16 A;  1Z4K A;  1AUW A;  1Z4Q A;  3KDZ A;  1RE5 A;  2RJR A;  2VL7 A;  1GKM A;  2PFM A;  4HGV A;  1XL8 A;  2O78 A;  2O6Y A;  4WNL A;  3CRW 1;  1T9H A;  4CQ5 A;  5H8W A;  1GKJ A;  1C3U A;  1DCN A;  4L6C A;  1T6J A;  2X75 A;  1JSW A;  5D6B A;  1FUQ A;  4C5S A;  1B8F A;  1Q92 A;  5HW2 A;  1FUR A;  4APA A;  2PTQ A;  4C5R A;  5EYT A;  1Z4J A;  3F4T A;  2HVG A;  1W27 A;  4IQJ M;  4YIH A;  1DOF A;  2QVE A;  1HY1 A;  1Q5N A;  2PTR A;  4BAA A;  4E88 A;  1C3C A; 
#chains in the Genus database with same CATH homology
 1KQ7 A;  3C8T A;  3OCF A;  2O7D A;  2O7F A;  1TJ7 A;  1TJV A;  1HY0 A;  2OHY A;  1FUO A;  2E9F A;  1TJW A;  1GK3 A;  3CZO A;  3TV2 A;  1FUP A;  4FFX A;  4FLC A;  5EYV A;  3QBP A;  3RRP A;  2FUS A;  1I0A A;  2QGA B;  1U15 A;  3RD8 A;  4ADL A;  4MX2 A;  2J91 A;  1Y2M A;  1K7W A;  1YFM A;  4EEI A;  3NO9 A;  3UNV A;  4APB A;  4V2R A;  1GK2 A;  1XWO A;  1YFE A;  3NZ4 A;  2NYN A;  2NYF A;  2VD6 A;  2YII A;  4NSL A;  4BAB A;  4NLE A;  2PTS A;  1K62 A;  3R6Y A;  3GZH A;  3BHG A;  4V2Q A;  1TJU A;  3E04 A;  2O7B A;  2RJS A;  1J3U A;  3R6V A;  5F92 A;  3GTD A;  1YIS A;  3R6Q A;  2O7E A;  3OCE A;  1EB4 A;  1VDK A;  3KDY A;  4C6G A;  5F91 A;  4EFC A;  4C5U A;  4ADM A;  1U16 A;  1AUW A;  3KDZ A;  1RE5 A;  2RJR A;  1GKM A;  2PFM A;  4HGV A;  2O78 A;  2O6Y A;  4CQ5 A;  1GKJ A;  1C3U A;  1DCN A;  1T6J A;  2X75 A;  1JSW A;  5D6B A;  1FUQ A;  4C5S A;  1B8F A;  5HW2 A;  1FUR A;  4APA A;  2PTQ A;  4C5R A;  5EYT A;  2HVG A;  1W27 A;  1DOF A;  2QVE A;  1HY1 A;  1Q5N A;  2PTR A;  4BAA A;  1T6P A;  1C3C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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