3S5EA

Crystal structure of human frataxin variant w155r, one of the friedreich's ataxia point mutations
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
121
structure length
121
Chain Sequence
GSLDETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIRLSSPSSGPKRYDWTGKNWVYSHDGVSLHELLAAELTKALKTKLDLSSLAYSGK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Friedreich's Ataxia Variants I154F and W155R Diminish Frataxin-Based Activation of the Iron-Sulfur Cluster Assembly Complex.
pubmed doi rcsb
molecule keywords Frataxin, mitochondrial
molecule tags Unknown function
source organism Homo sapiens
total genus 32
structure length 121
sequence length 121
ec nomenclature ec 1.16.3.1: Ferroxidase.
pdb deposition date 2011-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01491 Frataxin_Cyay Frataxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.920.10 Alpha Beta 2-Layer Sandwich Metal Transport, Frataxin; Chain A Frataxin/CyaY 3s5eA00
4LK8A 2GA5A 3OERA 1SOYA 4EC2A 4HS5A 3OEQA 3S5EA 1LY7A 3S4MA 2EFFA 2P1XA 3S5DA 3S5FA 3T3KA 4LP1A 3T3JA 3T3LA 3T3XA 2FQLA 1EW4A 3T3TA 1EKGA 4JPDA
chains in the Genus database with same CATH superfamily
4LK8A 2GA5A 3IAS7 3OERA 1SOYA 3SSDA 4EC2A 3SSCA 4HS5A 3SSEA 1D2MA 4HEA7 4P78C 3OEQA 3IAM7 1V5RA 1LY7A 3S5EA 3S4MA 4C26A 2EFFA 2FUG7 2P1XA 3S5DA 3S5FA 3A5PA 3T3KA 3GD0A 4LP1A 3T3JA 3IMOA 3GD9A 3T3LA 3T3XA 2FQLA 1EW4A 4JPDA 3T3TA 1WHZA 1EKGA 3I9V7
chains in the Genus database with same CATH topology
4LK8A 2GA5A 3OERA 1SOYA 4EC2A 4HS5A 3OEQA 3S5EA 1LY7A 3S4MA 2EFFA 2P1XA 3S5DA 3S5FA 3T3KA 4LP1A 3T3JA 3T3LA 3T3XA 2FQLA 1EW4A 3T3TA 1EKGA 4JPDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LK8 A;  2GA5 A;  3OER A;  1SOY A;  4EC2 A;  4HS5 A;  3OEQ A;  3S5E A;  1LY7 A;  3S4M A;  2EFF A;  2P1X A;  3S5D A;  3S5F A;  3T3K A;  4LP1 A;  3T3J A;  3T3L A;  3T3X A;  2FQL A;  1EW4 A;  3T3T A;  1EKG A;  4JPD A; 
#chains in the Genus database with same CATH topology
 4LK8 A;  2GA5 A;  3IAS 7;  3OER A;  1SOY A;  3SSD A;  4EC2 A;  3SSC A;  4HS5 A;  3SSE A;  1D2M A;  4HEA 7;  4P78 C;  3OEQ A;  3IAM 7;  1V5R A;  1LY7 A;  3S5E A;  3S4M A;  4C26 A;  2EFF A;  2FUG 7;  2P1X A;  3S5D A;  3S5F A;  3A5P A;  3T3K A;  3GD0 A;  4LP1 A;  3T3J A;  3IMO A;  3GD9 A;  3T3L A;  3T3X A;  2FQL A;  1EW4 A;  4JPD A;  3T3T A;  1WHZ A;  1EKG A;  3I9V 7; 
#chains in the Genus database with same CATH homology
 4LK8 A;  2GA5 A;  3OER A;  1SOY A;  4EC2 A;  4HS5 A;  3OEQ A;  3S5E A;  1LY7 A;  3S4M A;  2EFF A;  2P1X A;  3S5D A;  3S5F A;  3T3K A;  4LP1 A;  3T3J A;  3T3L A;  3T3X A;  2FQL A;  1EW4 A;  3T3T A;  1EKG A;  4JPD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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