3S5FA

Crystal structure of human frataxin variant w155f
Total Genus 33
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
33
sequence length
120
structure length
120
Chain Sequence
SLDETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIFLSSPSSGPKRYDWTGKNWVYSHDGVSLHELLAAELTKALKTKLDLSSLAYSGK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Friedreich's Ataxia Variants I154F and W155R Diminish Frataxin-Based Activation of the Iron-Sulfur Cluster Assembly Complex.
pubmed doi rcsb
molecule keywords Frataxin, mitochondrial
molecule tags Unknown function
source organism Homo sapiens
total genus 33
structure length 120
sequence length 120
chains with identical sequence B
ec nomenclature ec 1.16.3.1: Ferroxidase.
pdb deposition date 2011-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01491 Frataxin_Cyay Frataxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.920.10 Alpha Beta 2-Layer Sandwich Metal Transport, Frataxin; Chain A Frataxin/CyaY 3s5fA00
1LY7A 1EKGA 2EFFA 1SOYA 3S5EA 3T3KA 4LP1A 3S5FA 2GA5A 4JPDA 4LK8A 3T3TA 2FQLA 4EC2A 3OEQA 4HS5A 3S4MA 2P1XA 3T3XA 1EW4A 3OERA 3S5DA 3T3LA 3T3JA
chains in the Genus database with same CATH superfamily
1LY7A 3GD0A 3SSEA 4C26A 3A5PA 1EKGA 2EFFA 3I9V7 1SOYA 3SSDA 3S5EA 3GD9A 3T3KA 1V5RA 4LP1A 3S5FA 2GA5A 4JPDA 4LK8A 3T3JA 2FUG7 3T3TA 2FQLA 4EC2A 3OEQA 4P78C 4HEA7 3IAM7 4HS5A 3S4MA 3IAS7 2P1XA 1D2MA 3T3XA 1EW4A 3OERA 1WHZA 3SSCA 3S5DA 3T3LA 3IMOA
chains in the Genus database with same CATH topology
1LY7A 1EKGA 2EFFA 1SOYA 3S5EA 3T3KA 4LP1A 3S5FA 2GA5A 4JPDA 4LK8A 3T3TA 2FQLA 4EC2A 3OEQA 4HS5A 3S4MA 2P1XA 3T3XA 1EW4A 3OERA 3S5DA 3T3LA 3T3JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1LY7 A;  1EKG A;  2EFF A;  1SOY A;  3S5E A;  3T3K A;  4LP1 A;  3S5F A;  2GA5 A;  4JPD A;  4LK8 A;  3T3T A;  2FQL A;  4EC2 A;  3OEQ A;  4HS5 A;  3S4M A;  2P1X A;  3T3X A;  1EW4 A;  3OER A;  3S5D A;  3T3L A;  3T3J A; 
#chains in the Genus database with same CATH topology
 1LY7 A;  3GD0 A;  3SSE A;  4C26 A;  3A5P A;  1EKG A;  2EFF A;  3I9V 7;  1SOY A;  3SSD A;  3S5E A;  3GD9 A;  3T3K A;  1V5R A;  4LP1 A;  3S5F A;  2GA5 A;  4JPD A;  4LK8 A;  3T3J A;  2FUG 7;  3T3T A;  2FQL A;  4EC2 A;  3OEQ A;  4P78 C;  4HEA 7;  3IAM 7;  4HS5 A;  3S4M A;  3IAS 7;  2P1X A;  1D2M A;  3T3X A;  1EW4 A;  3OER A;  1WHZ A;  3SSC A;  3S5D A;  3T3L A;  3IMO A; 
#chains in the Genus database with same CATH homology
 1LY7 A;  1EKG A;  2EFF A;  1SOY A;  3S5E A;  3T3K A;  4LP1 A;  3S5F A;  2GA5 A;  4JPD A;  4LK8 A;  3T3T A;  2FQL A;  4EC2 A;  3OEQ A;  4HS5 A;  3S4M A;  2P1X A;  3T3X A;  1EW4 A;  3OER A;  3S5D A;  3T3L A;  3T3J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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