3SFHA

Crystal structure of human hdac8 inhibitor complex, an amino acid derived inhibitor
Total Genus 130
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
130
sequence length
364
structure length
342
Chain Sequence
LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Histone deacetylase 8
publication title Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/hydrolase inhibitor
total genus 130
structure length 342
sequence length 364
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2011-06-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 3sfhA00
5EEKA 5EFHA 4BKXB 1C3PA 5JI5A 4BZ8A 4ZUPA 5EENA 5G0XA 4ZURA 4RN0A 4CQFA 3ZNSA 5G0IA 5G13A 5EF7A 2V5XA 4CBYA 3F0RA 4ZUNA 5FCWA 4ZUMA 3C0ZA 4BZ7A 5FUEA 5G0HA 3Q9CA 5EFKB 1C3RA 5EFBD 1ZZ0A 4QA7A 5A2SA 1ZZ1A 5BWZA 5D1CA 4A69A 5G17A 5THVA 4RN1A 3MAXA 5EFJD 5G10A 3C10A 3EZTA 4QA0A 1T64A 5EEIA 5EF8A 3MZ6A 5DC7A 3F06A 2VQJA 2VQMA 5G12A 3Q9BA 4QA5A 2VQWG 4BZ5A 1W22A 1C3SA 5G1BA 5G11A 4LY1A 3F07A 5G3WA 1ZZ3A 4ZUOA 2V5WA 5DC8A 5G1CA 2VCGA 4CBTA 5THUA 4QA4A 2VQQA 2VQVA 3SFFA 2GH6A 4RN2A 3EZPA 5DC5A 3RQDA 3EWFA 5G0JA 3MZ3A 3EW8A 5D1BA 3Q9FA 4QA2A 3MENA 5G0GA 5THSA 3C0YA 4QA6A 5IX0A 4ZUQA 5THTA 5ICNB 5D1DA 4QA3A 5EFNA 5G1AA 5LI3A 3MZ7A 3ZNRA 2VQOA 1VKGA 5EEFA 4BZ9A 3MZ4A 3SFHA 4QA1A 5DC6A 1T69A 4BZ6A 5EEMA 4LXZA 5G0YA 3Q9EA 5IWGA 5EFGA 1T67A
chains in the Genus database with same CATH superfamily
5EEKA 3PZLA 5EFHA 1C3PA 4BKXB 4BZ8A 5JI5A 4RHLA 1T5GA 1P8SA 4ZUPA 5EENA 4HZEA 3LHLA 5G0XA 4ZURA 2PHAA 4RN0A 4Q3RC 4CQFA 3ZNSA 5G0IA 1HQXA 1TBJA 5HJ9A 5G13A 5EF7A 1T4RA 4GWCA 1P8PA 5RLAA 4IXVA 5CEVA 2V5XA 4CBYA 4IU4A 3F0RA 4ZUNA 5FCWA 3MJLA 4DZ4A 4Q41A 2EF5A 4ZUMA 3C0ZA 4BZ7A 5FUEA 3GMZA 1WOGA 3LP4A 4Q42A 1GQ7A 3MMRA 5G0HA 3F80A 3Q9CA 5EFKB 1C3RA 4CEVA 4MYLA 3E6KA 5EFBD 3DJ8A 1ZZ0A 5IWGA 4MYKA 1T5FA 4QA7A 3E9BA 3LP7A 1ZZ1A 5A2SA 5BWZA 5D1CA 3SL1A 4A69A 1RLAA 5G17A 1HQ5A 1WVAA 3M1RA 4GWDA 4Q3QA 5THVA 1P8OA 4RN1A 4Q40A 1TBHA 3MAXA 5EFJD 5G10A 1CEVA 4RLAA 3KV2A 4HWWA 3C10A 3EZTA 4QA0A 1T64A 5EEIA 4RHJA 2PLLA 5EF8A 3E8ZA 4Q3VA 3MZ6A 3E6VA 4IE2A 5DC7A 1HQHA 4IXUA 3F06A 1ZPEA 2VQJA 1XFKA 2VQMA 4ITYA 2CEVA 5G12A 4RHKA 3SKKA 3Q9BA 4QA5A 4RHQA 2VQWG 4BZ5A 4IE3A 1W22A 3CEVA 1C3SA 3NIQA 4FCIA 4MXRA 1P8NA 5G1BA 5G11A 1HQGA 3THJA 3NIPA 4LY1A 3F07A 1P8QA 1ZZ3A 4Q3PA 4ZUOA 2V5WA 5DC8A 5G3WA 5HJAA 4IE1A 3E8QA 5G1CA 2VCGA 4CBTA 5THUA 2EF4A 4Q3UA 4QA4A 3TH7A 2VQQA 1T4PA 2VQVA 3SFFA 3SJTA 2AEBA 4GSVA 2GH6A 4RHMA 4RN2A 4RHIA 3EZPA 4GSZA 4Q3SA 5DC5A 4G3HA 3RQDA 1GQ6A 4Q3RA 3THEA 4Q3TA 3EWFA 2EIVA 5G0JA 3MZ3A 2PHOA 4I06A 1R1OA 3EW8A 4HXQA 1TBLA 3THHA 5D1BA 3Q9FA 1P8RA 4QA2A 3MENA 5G0GA 5THSA 3C0YA 4QA6A 1HQFA 5IX0A 1TA1A 3RLAA 5THTA 4ZUQA 4FCKA 1T4SA 3GN0A 5ICNB 1T4TA 4MYFA 5D1DA 4QA3A 1PQ3A 5EFNA 5G1AA 5LI3A 1WVBA 3MZ7A 4GSMA 2VQOA 3ZNRA 1VKGA 3MFWA 5EEFA 3NIOA 1P8MA 2A0MA 4IU0A 4BZ9A 3MZ4A 3TF3A 3SFHA 4QA1A 5DC6A 1D3VA 2ZAVA 1T69A 2RLAA 4BZ6A 3MFVA 4LXZA 5EEMA 5G0YA 4MYNA 1WOHA 1ZPGA 3Q9EA 4IU5A 4IU1A 5EFGA 1T67A 3SL0A 1WOIA
chains in the Genus database with same CATH topology
5EEKA 5EFHA 4BKXB 1C3PA 5JI5A 4BZ8A 4ZUPA 5EENA 5G0XA 4ZURA 4RN0A 4CQFA 3ZNSA 5G0IA 5G13A 5EF7A 2V5XA 4CBYA 3F0RA 4ZUNA 5FCWA 4ZUMA 3C0ZA 4BZ7A 5FUEA 5G0HA 3Q9CA 5EFKB 1C3RA 5EFBD 1ZZ0A 4QA7A 5A2SA 1ZZ1A 5BWZA 5D1CA 4A69A 5G17A 5THVA 4RN1A 3MAXA 5EFJD 5G10A 3C10A 3EZTA 4QA0A 1T64A 5EEIA 5EF8A 3MZ6A 5DC7A 3F06A 2VQJA 2VQMA 5G12A 3Q9BA 4QA5A 2VQWG 4BZ5A 1W22A 1C3SA 5G1BA 5G11A 4LY1A 3F07A 5G3WA 1ZZ3A 4ZUOA 2V5WA 5DC8A 5G1CA 2VCGA 4CBTA 5THUA 4QA4A 2VQQA 2VQVA 3SFFA 2GH6A 4RN2A 3EZPA 5DC5A 3RQDA 3EWFA 5G0JA 3MZ3A 3EW8A 5D1BA 3Q9FA 4QA2A 3MENA 5G0GA 5THSA 3C0YA 4QA6A 5IX0A 4ZUQA 5THTA 5ICNB 5D1DA 4QA3A 5EFNA 5G1AA 5LI3A 3MZ7A 3ZNRA 2VQOA 1VKGA 5EEFA 4BZ9A 3MZ4A 3SFHA 4QA1A 5DC6A 1T69A 4BZ6A 5EEMA 4LXZA 5G0YA 3Q9EA 5IWGA 5EFGA 1T67A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5EEK A;  5EFH A;  4BKX B;  1C3P A;  5JI5 A;  4BZ8 A;  4ZUP A;  5EEN A;  5G0X A;  4ZUR A;  4RN0 A;  4CQF A;  3ZNS A;  5G0I A;  5G13 A;  5EF7 A;  2V5X A;  4CBY A;  3F0R A;  4ZUN A;  5FCW A;  4ZUM A;  3C0Z A;  4BZ7 A;  5FUE A;  5G0H A;  3Q9C A;  5EFK B;  1C3R A;  5EFB D;  1ZZ0 A;  4QA7 A;  5A2S A;  1ZZ1 A;  5BWZ A;  5D1C A;  4A69 A;  5G17 A;  5THV A;  4RN1 A;  3MAX A;  5EFJ D;  5G10 A;  3C10 A;  3EZT A;  4QA0 A;  1T64 A;  5EEI A;  5EF8 A;  3MZ6 A;  5DC7 A;  3F06 A;  2VQJ A;  2VQM A;  5G12 A;  3Q9B A;  4QA5 A;  2VQW G;  4BZ5 A;  1W22 A;  1C3S A;  5G1B A;  5G11 A;  4LY1 A;  3F07 A;  5G3W A;  1ZZ3 A;  4ZUO A;  2V5W A;  5DC8 A;  5G1C A;  2VCG A;  4CBT A;  5THU A;  4QA4 A;  2VQQ A;  2VQV A;  3SFF A;  2GH6 A;  4RN2 A;  3EZP A;  5DC5 A;  3RQD A;  3EWF A;  5G0J A;  3MZ3 A;  3EW8 A;  5D1B A;  3Q9F A;  4QA2 A;  3MEN A;  5G0G A;  5THS A;  3C0Y A;  4QA6 A;  5IX0 A;  4ZUQ A;  5THT A;  5ICN B;  5D1D A;  4QA3 A;  5EFN A;  5G1A A;  5LI3 A;  3MZ7 A;  3ZNR A;  2VQO A;  1VKG A;  5EEF A;  4BZ9 A;  3MZ4 A;  3SFH A;  4QA1 A;  5DC6 A;  1T69 A;  4BZ6 A;  5EEM A;  4LXZ A;  5G0Y A;  3Q9E A;  5IWG A;  5EFG A;  1T67 A; 
#chains in the Genus database with same CATH topology
 5EEK A;  3PZL A;  5EFH A;  1C3P A;  4BKX B;  4BZ8 A;  5JI5 A;  4RHL A;  1T5G A;  1P8S A;  4ZUP A;  5EEN A;  4HZE A;  3LHL A;  5G0X A;  4ZUR A;  2PHA A;  4RN0 A;  4Q3R C;  4CQF A;  3ZNS A;  5G0I A;  1HQX A;  1TBJ A;  5HJ9 A;  5G13 A;  5EF7 A;  1T4R A;  4GWC A;  1P8P A;  5RLA A;  4IXV A;  5CEV A;  2V5X A;  4CBY A;  4IU4 A;  3F0R A;  4ZUN A;  5FCW A;  3MJL A;  4DZ4 A;  4Q41 A;  2EF5 A;  4ZUM A;  3C0Z A;  4BZ7 A;  5FUE A;  3GMZ A;  1WOG A;  3LP4 A;  4Q42 A;  1GQ7 A;  3MMR A;  5G0H A;  3F80 A;  3Q9C A;  5EFK B;  1C3R A;  4CEV A;  4MYL A;  3E6K A;  5EFB D;  3DJ8 A;  1ZZ0 A;  5IWG A;  4MYK A;  1T5F A;  4QA7 A;  3E9B A;  3LP7 A;  1ZZ1 A;  5A2S A;  5BWZ A;  5D1C A;  3SL1 A;  4A69 A;  1RLA A;  5G17 A;  1HQ5 A;  1WVA A;  3M1R A;  4GWD A;  4Q3Q A;  5THV A;  1P8O A;  4RN1 A;  4Q40 A;  1TBH A;  3MAX A;  5EFJ D;  5G10 A;  1CEV A;  4RLA A;  3KV2 A;  4HWW A;  3C10 A;  3EZT A;  4QA0 A;  1T64 A;  5EEI A;  4RHJ A;  2PLL A;  5EF8 A;  3E8Z A;  4Q3V A;  3MZ6 A;  3E6V A;  4IE2 A;  5DC7 A;  1HQH A;  4IXU A;  3F06 A;  1ZPE A;  2VQJ A;  1XFK A;  2VQM A;  4ITY A;  2CEV A;  5G12 A;  4RHK A;  3SKK A;  3Q9B A;  4QA5 A;  4RHQ A;  2VQW G;  4BZ5 A;  4IE3 A;  1W22 A;  3CEV A;  1C3S A;  3NIQ A;  4FCI A;  4MXR A;  1P8N A;  5G1B A;  5G11 A;  1HQG A;  3THJ A;  3NIP A;  4LY1 A;  3F07 A;  1P8Q A;  1ZZ3 A;  4Q3P A;  4ZUO A;  2V5W A;  5DC8 A;  5G3W A;  5HJA A;  4IE1 A;  3E8Q A;  5G1C A;  2VCG A;  4CBT A;  5THU A;  2EF4 A;  4Q3U A;  4QA4 A;  3TH7 A;  2VQQ A;  1T4P A;  2VQV A;  3SFF A;  3SJT A;  2AEB A;  4GSV A;  2GH6 A;  4RHM A;  4RN2 A;  4RHI A;  3EZP A;  4GSZ A;  4Q3S A;  5DC5 A;  4G3H A;  3RQD A;  1GQ6 A;  4Q3R A;  3THE A;  4Q3T A;  3EWF A;  2EIV A;  5G0J A;  3MZ3 A;  2PHO A;  4I06 A;  1R1O A;  3EW8 A;  4HXQ A;  1TBL A;  3THH A;  5D1B A;  3Q9F A;  1P8R A;  4QA2 A;  3MEN A;  5G0G A;  5THS A;  3C0Y A;  4QA6 A;  1HQF A;  5IX0 A;  1TA1 A;  3RLA A;  5THT A;  4ZUQ A;  4FCK A;  1T4S A;  3GN0 A;  5ICN B;  1T4T A;  4MYF A;  5D1D A;  4QA3 A;  1PQ3 A;  5EFN A;  5G1A A;  5LI3 A;  1WVB A;  3MZ7 A;  4GSM A;  2VQO A;  3ZNR A;  1VKG A;  3MFW A;  5EEF A;  3NIO A;  1P8M A;  2A0M A;  4IU0 A;  4BZ9 A;  3MZ4 A;  3TF3 A;  3SFH A;  4QA1 A;  5DC6 A;  1D3V A;  2ZAV A;  1T69 A;  2RLA A;  4BZ6 A;  3MFV A;  4LXZ A;  5EEM A;  5G0Y A;  4MYN A;  1WOH A;  1ZPG A;  3Q9E A;  4IU5 A;  4IU1 A;  5EFG A;  1T67 A;  3SL0 A;  1WOI A; 
#chains in the Genus database with same CATH homology
 5EEK A;  5EFH A;  4BKX B;  1C3P A;  5JI5 A;  4BZ8 A;  4ZUP A;  5EEN A;  5G0X A;  4ZUR A;  4RN0 A;  4CQF A;  3ZNS A;  5G0I A;  5G13 A;  5EF7 A;  2V5X A;  4CBY A;  3F0R A;  4ZUN A;  5FCW A;  4ZUM A;  3C0Z A;  4BZ7 A;  5FUE A;  5G0H A;  3Q9C A;  5EFK B;  1C3R A;  5EFB D;  1ZZ0 A;  4QA7 A;  5A2S A;  1ZZ1 A;  5BWZ A;  5D1C A;  4A69 A;  5G17 A;  5THV A;  4RN1 A;  3MAX A;  5EFJ D;  5G10 A;  3C10 A;  3EZT A;  4QA0 A;  1T64 A;  5EEI A;  5EF8 A;  3MZ6 A;  5DC7 A;  3F06 A;  2VQJ A;  2VQM A;  5G12 A;  3Q9B A;  4QA5 A;  2VQW G;  4BZ5 A;  1W22 A;  1C3S A;  5G1B A;  5G11 A;  4LY1 A;  3F07 A;  5G3W A;  1ZZ3 A;  4ZUO A;  2V5W A;  5DC8 A;  5G1C A;  2VCG A;  4CBT A;  5THU A;  4QA4 A;  2VQQ A;  2VQV A;  3SFF A;  2GH6 A;  4RN2 A;  3EZP A;  5DC5 A;  3RQD A;  3EWF A;  5G0J A;  3MZ3 A;  3EW8 A;  5D1B A;  3Q9F A;  4QA2 A;  3MEN A;  5G0G A;  5THS A;  3C0Y A;  4QA6 A;  5IX0 A;  4ZUQ A;  5THT A;  5ICN B;  5D1D A;  4QA3 A;  5EFN A;  5G1A A;  5LI3 A;  3MZ7 A;  3ZNR A;  2VQO A;  1VKG A;  5EEF A;  4BZ9 A;  3MZ4 A;  3SFH A;  4QA1 A;  5DC6 A;  1T69 A;  4BZ6 A;  5EEM A;  4LXZ A;  5G0Y A;  3Q9E A;  5IWG A;  5EFG A;  1T67 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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