3SIGA

The x-ray crystal structure of poly(adp-ribose) glycohydrolase (parg) bound to adp-ribose from thermomonospora curvata
Total Genus 92
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
92
Knots found
sequence length
274
structure length
265
Chain Sequence
RHSRRAIAAETVEILERGRYTAPSGRVVPIADHVAQAVRGTRLYRPEKLAVLLEGTRIEVTEETTLAAARRLTGAAGDQVACLNFASAEHPGGGFLSGAHAQEEGLARSSGLYASLRAVPQFYAFHHRQRDPLYSDHLIYSPGVPVFRDDAGRLLEEPYRVAFLTSPAPNRRAIGDLRTVEEIGRVLRGRAAKVLAAARHHGHRRLVLGAWGCGVFGNDPAQVAETFAGLLLDGGPFAGRFAHVVFAVWDTAPGAPRHAAFARRF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Thermomonospora curvata
molecule keywords poly(ADP-ribose) glycohydrolase
total genus 92
structure length 265
sequence length 274
other databases KnotProt 2.0: K +31
ec nomenclature ec 3.2.1.143: Poly(ADP-ribose) glycohydrolase.
pdb deposition date 2011-06-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF10021 DUF2263 Uncharacterized protein conserved in bacteria (DUF2263)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 3sigA00
2J9AA 3H8FA 2X47A 3IIDA 1ZR5A 1VHUA 1HJZA 5CMSA 5HIHA 3H8EA 3EKEA 3KQZA 2L8RA 3EJFA 3SIJA 5CB5A 5D8NA 1GYTA 4R7MA 4ABKA 4ZI6A 4ETKA 5CB3A 4X2TA 2EEEA 3KR5A 3JRUA 4ZY1A 1NJRA 3GPOA 5FSYA 1ZR3A 3Q6ZA 4J4ZA 5FSZA 5E3BA 2AFCA 3PEIA 3EW5A 4KSIA 3VFQA 4IQYA 1BPMA 3IJ3A 4JVVA 3SIGA 5FSUA 4R6TA 1LAPA 4JGKA 4J5SA 3EWPA 1LAMA 2BFQA 4ZX8A 1LCPA 1BLLE 4K0CA 3V2BA 5CBMA 2VRIA 4D86A 4ZX9A 3GQEA 4TU0A 3EWRA 4ABLA 2XD7A 1SPVA 3EWOA 3SIHA 4ZY2A 4GVVA 4J5QA 3KZWA 1LANA 3ETIA 4KYBA 3Q71A 3H8GA 3EWQA 4K3NA 1TXZA 3GPQA 4JCAA 1BPNA 4J5RA 4GVWA 5DUSA 4ESSA 4ZYQA 2DX6A 1TY8A 4ZY0A 3EJGA 3JZTA 2LGRA 3GQOA 3SIIA 2EWBA 2FAVA 5HOLA 3KQXA 4JLLA 4ETJA 3T8WA 4R76A 2FG1A 3KR4A 1YD9A 4UMLA 3IIFA 3GPGA 5FSXA 2FXKA 3V45A 5FSVA 2BFRA 5AILA 2ACFA 4GUAA
chains in the Genus database with same CATH superfamily
2J9AA 3H8FA 2X47A 3IIDA 1ZR5A 1VHUA 1HJZA 5CMSA 2JZDA 5HIHA 3H8EA 3EKEA 3KQZA 2L8RA 3EJFA 3SIJA 5CB5A 5D8NA 1GYTA 4R7MA 4ABKA 4ZI6A 4ETKA 5CB3A 4X2TA 2EEEA 3KR5A 3JRUA 4ZY1A 1NJRA 3GPOA 5FSYA 1ZR3A 3Q6ZA 4J4ZA 5FSZA 2JZEA 5E3BA 2AFCA 3PEIA 2KQVA 3EW5A 4KSIA 3VFQA 4IQYA 1BPMA 3IJ3A 4JVVA 3SIGA 2JZFA 5FSUA 4R6TA 2W2GA 1LAPA 4JGKA 4J5SA 3EWPA 1LAMA 2BFQA 4ZX8A 2WCTA 1LCPA 1BLLE 4K0CA 3V2BA 5CBMA 2VRIA 4D86A 4ZX9A 3GQEA 4TU0A 3EWRA 4ABLA 2XD7A 1SPVA 2RNKA 3EWOA 3SIHA 4ZY2A 4GVVA 4J5QA 3KZWA 1LANA 3ETIA 4KYBA 3Q71A 3H8GA 3EWQA 4K3NA 1TXZA 3GPQA 4JCAA 1BPNA 4J5RA 4GVWA 5DUSA 4ESSA 4ZYQA 2DX6A 1TY8A 4ZY0A 3EJGA 3JZTA 2LGRA 3GQOA 3SIIA 2EWBA 2FAVA 5HOLA 3KQXA 4JLLA 4ETJA 3T8WA 4R76A 2FG1A 3KR4A 1YD9A 4UMLA 3IIFA 3GPGA 5FSXA 2FXKA 3V45A 5FSVA 2BFRA 5AILA 2ACFA 4GUAA
chains in the Genus database with same CATH topology
2J9AA 3H8FA 2X47A 3IIDA 1ZR5A 1VHUA 1HJZA 5CMSA 5HIHA 3H8EA 3EKEA 3KQZA 2L8RA 3EJFA 3SIJA 5CB5A 5D8NA 1GYTA 4R7MA 4ABKA 4ZI6A 4ETKA 5CB3A 4X2TA 2EEEA 3KR5A 3JRUA 4ZY1A 1NJRA 3GPOA 5FSYA 1ZR3A 3Q6ZA 4J4ZA 5FSZA 5E3BA 2AFCA 3PEIA 3EW5A 4KSIA 3VFQA 4IQYA 1BPMA 3IJ3A 4JVVA 3SIGA 5FSUA 4R6TA 1LAPA 4JGKA 4J5SA 3EWPA 1LAMA 2BFQA 4ZX8A 1LCPA 1BLLE 4K0CA 3V2BA 5CBMA 2VRIA 4D86A 4ZX9A 3GQEA 4TU0A 3EWRA 4ABLA 2XD7A 1SPVA 3EWOA 3SIHA 4ZY2A 4GVVA 4J5QA 3KZWA 1LANA 3ETIA 4KYBA 3Q71A 3H8GA 3EWQA 4K3NA 1TXZA 3GPQA 4JCAA 1BPNA 4J5RA 4GVWA 5DUSA 4ESSA 4ZYQA 2DX6A 1TY8A 4ZY0A 3EJGA 3JZTA 2LGRA 3GQOA 3SIIA 2EWBA 2FAVA 5HOLA 3KQXA 4JLLA 4ETJA 3T8WA 4R76A 2FG1A 3KR4A 1YD9A 4UMLA 3IIFA 3GPGA 5FSXA 2FXKA 3V45A 5FSVA 2BFRA 5AILA 2ACFA 4GUAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2J9A A;  3H8F A;  2X47 A;  3IID A;  1ZR5 A;  1VHU A;  1HJZ A;  5CMS A;  5HIH A;  3H8E A;  3EKE A;  3KQZ A;  2L8R A;  3EJF A;  3SIJ A;  5CB5 A;  5D8N A;  1GYT A;  4R7M A;  4ABK A;  4ZI6 A;  4ETK A;  5CB3 A;  4X2T A;  2EEE A;  3KR5 A;  3JRU A;  4ZY1 A;  1NJR A;  3GPO A;  5FSY A;  1ZR3 A;  3Q6Z A;  4J4Z A;  5FSZ A;  5E3B A;  2AFC A;  3PEI A;  3EW5 A;  4KSI A;  3VFQ A;  4IQY A;  1BPM A;  3IJ3 A;  4JVV A;  3SIG A;  5FSU A;  4R6T A;  1LAP A;  4JGK A;  4J5S A;  3EWP A;  1LAM A;  2BFQ A;  4ZX8 A;  1LCP A;  1BLL E;  4K0C A;  3V2B A;  5CBM A;  2VRI A;  4D86 A;  4ZX9 A;  3GQE A;  4TU0 A;  3EWR A;  4ABL A;  2XD7 A;  1SPV A;  3EWO A;  3SIH A;  4ZY2 A;  4GVV A;  4J5Q A;  3KZW A;  1LAN A;  3ETI A;  4KYB A;  3Q71 A;  3H8G A;  3EWQ A;  4K3N A;  1TXZ A;  3GPQ A;  4JCA A;  1BPN A;  4J5R A;  4GVW A;  5DUS A;  4ESS A;  4ZYQ A;  2DX6 A;  1TY8 A;  4ZY0 A;  3EJG A;  3JZT A;  2LGR A;  3GQO A;  3SII A;  2EWB A;  2FAV A;  5HOL A;  3KQX A;  4JLL A;  4ETJ A;  3T8W A;  4R76 A;  2FG1 A;  3KR4 A;  1YD9 A;  4UML A;  3IIF A;  3GPG A;  5FSX A;  2FXK A;  3V45 A;  5FSV A;  2BFR A;  5AIL A;  2ACF A;  4GUA A; 
#chains in the Genus database with same CATH topology
 2J9A A;  3H8F A;  2X47 A;  3IID A;  1ZR5 A;  1VHU A;  1HJZ A;  5CMS A;  2JZD A;  5HIH A;  3H8E A;  3EKE A;  3KQZ A;  2L8R A;  3EJF A;  3SIJ A;  5CB5 A;  5D8N A;  1GYT A;  4R7M A;  4ABK A;  4ZI6 A;  4ETK A;  5CB3 A;  4X2T A;  2EEE A;  3KR5 A;  3JRU A;  4ZY1 A;  1NJR A;  3GPO A;  5FSY A;  1ZR3 A;  3Q6Z A;  4J4Z A;  5FSZ A;  2JZE A;  5E3B A;  2AFC A;  3PEI A;  2KQV A;  3EW5 A;  4KSI A;  3VFQ A;  4IQY A;  1BPM A;  3IJ3 A;  4JVV A;  3SIG A;  2JZF A;  5FSU A;  4R6T A;  2W2G A;  1LAP A;  4JGK A;  4J5S A;  3EWP A;  1LAM A;  2BFQ A;  4ZX8 A;  2WCT A;  1LCP A;  1BLL E;  4K0C A;  3V2B A;  5CBM A;  2VRI A;  4D86 A;  4ZX9 A;  3GQE A;  4TU0 A;  3EWR A;  4ABL A;  2XD7 A;  1SPV A;  2RNK A;  3EWO A;  3SIH A;  4ZY2 A;  4GVV A;  4J5Q A;  3KZW A;  1LAN A;  3ETI A;  4KYB A;  3Q71 A;  3H8G A;  3EWQ A;  4K3N A;  1TXZ A;  3GPQ A;  4JCA A;  1BPN A;  4J5R A;  4GVW A;  5DUS A;  4ESS A;  4ZYQ A;  2DX6 A;  1TY8 A;  4ZY0 A;  3EJG A;  3JZT A;  2LGR A;  3GQO A;  3SII A;  2EWB A;  2FAV A;  5HOL A;  3KQX A;  4JLL A;  4ETJ A;  3T8W A;  4R76 A;  2FG1 A;  3KR4 A;  1YD9 A;  4UML A;  3IIF A;  3GPG A;  5FSX A;  2FXK A;  3V45 A;  5FSV A;  2BFR A;  5AIL A;  2ACF A;  4GUA A; 
#chains in the Genus database with same CATH homology
 2J9A A;  3H8F A;  2X47 A;  3IID A;  1ZR5 A;  1VHU A;  1HJZ A;  5CMS A;  5HIH A;  3H8E A;  3EKE A;  3KQZ A;  2L8R A;  3EJF A;  3SIJ A;  5CB5 A;  5D8N A;  1GYT A;  4R7M A;  4ABK A;  4ZI6 A;  4ETK A;  5CB3 A;  4X2T A;  2EEE A;  3KR5 A;  3JRU A;  4ZY1 A;  1NJR A;  3GPO A;  5FSY A;  1ZR3 A;  3Q6Z A;  4J4Z A;  5FSZ A;  5E3B A;  2AFC A;  3PEI A;  3EW5 A;  4KSI A;  3VFQ A;  4IQY A;  1BPM A;  3IJ3 A;  4JVV A;  3SIG A;  5FSU A;  4R6T A;  1LAP A;  4JGK A;  4J5S A;  3EWP A;  1LAM A;  2BFQ A;  4ZX8 A;  1LCP A;  1BLL E;  4K0C A;  3V2B A;  5CBM A;  2VRI A;  4D86 A;  4ZX9 A;  3GQE A;  4TU0 A;  3EWR A;  4ABL A;  2XD7 A;  1SPV A;  3EWO A;  3SIH A;  4ZY2 A;  4GVV A;  4J5Q A;  3KZW A;  1LAN A;  3ETI A;  4KYB A;  3Q71 A;  3H8G A;  3EWQ A;  4K3N A;  1TXZ A;  3GPQ A;  4JCA A;  1BPN A;  4J5R A;  4GVW A;  5DUS A;  4ESS A;  4ZYQ A;  2DX6 A;  1TY8 A;  4ZY0 A;  3EJG A;  3JZT A;  2LGR A;  3GQO A;  3SII A;  2EWB A;  2FAV A;  5HOL A;  3KQX A;  4JLL A;  4ETJ A;  3T8W A;  4R76 A;  2FG1 A;  3KR4 A;  1YD9 A;  4UML A;  3IIF A;  3GPG A;  5FSX A;  2FXK A;  3V45 A;  5FSV A;  2BFR A;  5AIL A;  2ACF A;  4GUA A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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