3SP5A

Crystal structure of human 14-3-3 sigma c38v/n166h in complex with task-3 peptide and stabilizer cotylenol
Total Genus 102
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
235
structure length
235
Chain Sequence
AMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSVEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTHPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface.
pubmed doi rcsb
molecule tags Peptide binding protein
source organism Homo sapiens
molecule keywords 14-3-3 protein sigma
total genus 102
structure length 235
sequence length 235
ec nomenclature
pdb deposition date 2011-07-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 3sp5A00
2C63A 3CU8A 2O98A 1A38A 4DAUA 4DHMA 5EWZA 4FR3A 5BY9A 3T0MA 5LVZA 3MHRA 4N7GA 3M51A 4HKCA 4J6SA 2C23A 2BR9A 3O8IA 1QJAA 2B05A 3EFZA 4DNKA 5LU1A 3P1NA 4GNTA 4JC3A 4IEAA 4DHUA 5D2DA 4DX0A 4Y32A 3P1QA 3T0LA 5EXAA 3M50A 2O02A 4QLIA 4ZQ0A 3SPRA 3UBWA 4FL5A 3P1OA 5HF3A 4ZDRA 2BTPA 4WRQA 4E2EA 3NKXA 4FJ3A 3LW1A 3P1PA 2V7DA 5LHOA 4DHNA 5LX2A 4DHSA 4F7RA 2C74A 3AXYC 4DHPA 3SMLA 4JDDA 1YWTA 2C1NA 3UALA 1O9EA 1O9FA 3IQJA 3P1RA 4IHLA 3SMOA 3UZDA 5IQPA 1A37A 4DHQA 4DHTA 3IQUA 4DHOA 5J31A 1O9DA 4BG6A 3IQVA 4O46A 5D3EA 3SMMA 1IB1A 4DHRA 4N84A 3SP5A 2NPMA 3UX0A 3U9XA 2O8PA 4Y5IA 4Y3BA 5LU2A 2WH0A 5BTVA 1YZ5A 3P1SA 5D3FA 2C1JA 1QJBA 3SMKA 3E6YA 1A4OA 4N7YA 5F74A 1O9CA 2BQ0A 4DATA 3RDHA 3SMNA
chains in the Genus database with same CATH superfamily
2C63A 3CU8A 2O98A 1A38A 4DAUA 4ARYA 4DHMA 5EWZA 4FR3A 5BY9A 3T0MA 4ARXA 5LVZA 3MHRA 4N7GA 3M51A 4HKCA 1W99A 4J6SA 2C23A 2BR9A 3O8IA 1QJAA 2B05A 3EFZA 4DNKA 1CIYA 3P1NA 5LU1A 4GNTA 4JC3A 4IEAA 4DHUA 5D2DA 4DX0A 4Y32A 3X0UA 3P1QA 3T0LA 5EXAA 3M50A 2O02A 4QLIA 3CQCA 3ZHEB 4ZQ0A 3SPRA 3UBWA 4FL5A 3P1OA 5HF3A 4ZDRA 2BTPA 4WRQA 4D8MA 4E2EA 3NKXA 4FJ3A 3LW1A 3P1PA 2V7DA 5LHOA 4DHNA 5LX2A 4DHSA 4F7RA 2C74A 3AXYC 4MOAA 4DHPA 3SMLA 4JDDA 4W8JA 1YWTA 2C1NA 3UALA 2C9KA 1O9EA 1O9FA 3IQJA 3P1RA 4IHLA 3SMOA 3UZDA 5IQPA 1A37A 4DHQA 4QX1A 3IQUA 4DHOA 4DHTA 5J31A 1O9DA 4BG6A 3IQVA 4O46A 5D3EA 3SMMA 1IB1A 3CQGA 1URJA 4QX2A 4DHRA 3I4RA 1S2XA 4N84A 4QX0A 3SP5A 4QX3A 2NPMA 1JI6A 3UX0A 3U9XA 2O8PA 4Y5IA 4Y3BA 5LU2A 2WH0A 5BTVA 1YZ5A 3P1SA 5D3FA 1I5PA 1QJBA 2C1JA 3SMKA 1DLCA 3E6YA 3EB7A 1A4OA 4N7YA 5F74A 1O9CA 2BQ0A 4DATA 3RDHA 3SMNA
chains in the Genus database with same CATH topology
2C63A 3CU8A 2O98A 1A38A 4DAUA 4DHMA 5EWZA 4FR3A 5BY9A 3T0MA 5LVZA 3MHRA 4N7GA 3M51A 4HKCA 4J6SA 2C23A 2BR9A 3O8IA 1QJAA 2B05A 3EFZA 4DNKA 5LU1A 3P1NA 4GNTA 4JC3A 4IEAA 4DHUA 5D2DA 4DX0A 4Y32A 3P1QA 3T0LA 5EXAA 3M50A 2O02A 4QLIA 4ZQ0A 3SPRA 3UBWA 4FL5A 3P1OA 5HF3A 4ZDRA 2BTPA 4WRQA 4E2EA 3NKXA 4FJ3A 3LW1A 3P1PA 2V7DA 5LHOA 4DHNA 5LX2A 4DHSA 4F7RA 2C74A 3AXYC 4DHPA 3SMLA 4JDDA 1YWTA 2C1NA 3UALA 1O9EA 1O9FA 3IQJA 3P1RA 4IHLA 3SMOA 3UZDA 5IQPA 1A37A 4DHQA 4DHTA 3IQUA 4DHOA 5J31A 1O9DA 4BG6A 3IQVA 4O46A 5D3EA 3SMMA 1IB1A 4DHRA 4N84A 3SP5A 2NPMA 3UX0A 3U9XA 2O8PA 4Y5IA 4Y3BA 5LU2A 2WH0A 5BTVA 1YZ5A 3P1SA 5D3FA 2C1JA 1QJBA 3SMKA 3E6YA 1A4OA 4N7YA 5F74A 1O9CA 2BQ0A 4DATA 3RDHA 3SMNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2C63 A;  3CU8 A;  2O98 A;  1A38 A;  4DAU A;  4DHM A;  5EWZ A;  4FR3 A;  5BY9 A;  3T0M A;  5LVZ A;  3MHR A;  4N7G A;  3M51 A;  4HKC A;  4J6S A;  2C23 A;  2BR9 A;  3O8I A;  1QJA A;  2B05 A;  3EFZ A;  4DNK A;  5LU1 A;  3P1N A;  4GNT A;  4JC3 A;  4IEA A;  4DHU A;  5D2D A;  4DX0 A;  4Y32 A;  3P1Q A;  3T0L A;  5EXA A;  3M50 A;  2O02 A;  4QLI A;  4ZQ0 A;  3SPR A;  3UBW A;  4FL5 A;  3P1O A;  5HF3 A;  4ZDR A;  2BTP A;  4WRQ A;  4E2E A;  3NKX A;  4FJ3 A;  3LW1 A;  3P1P A;  2V7D A;  5LHO A;  4DHN A;  5LX2 A;  4DHS A;  4F7R A;  2C74 A;  3AXY C;  4DHP A;  3SML A;  4JDD A;  1YWT A;  2C1N A;  3UAL A;  1O9E A;  1O9F A;  3IQJ A;  3P1R A;  4IHL A;  3SMO A;  3UZD A;  5IQP A;  1A37 A;  4DHQ A;  4DHT A;  3IQU A;  4DHO A;  5J31 A;  1O9D A;  4BG6 A;  3IQV A;  4O46 A;  5D3E A;  3SMM A;  1IB1 A;  4DHR A;  4N84 A;  3SP5 A;  2NPM A;  3UX0 A;  3U9X A;  2O8P A;  4Y5I A;  4Y3B A;  5LU2 A;  2WH0 A;  5BTV A;  1YZ5 A;  3P1S A;  5D3F A;  2C1J A;  1QJB A;  3SMK A;  3E6Y A;  1A4O A;  4N7Y A;  5F74 A;  1O9C A;  2BQ0 A;  4DAT A;  3RDH A;  3SMN A; 
#chains in the Genus database with same CATH topology
 2C63 A;  3CU8 A;  2O98 A;  1A38 A;  4DAU A;  4ARY A;  4DHM A;  5EWZ A;  4FR3 A;  5BY9 A;  3T0M A;  4ARX A;  5LVZ A;  3MHR A;  4N7G A;  3M51 A;  4HKC A;  1W99 A;  4J6S A;  2C23 A;  2BR9 A;  3O8I A;  1QJA A;  2B05 A;  3EFZ A;  4DNK A;  1CIY A;  3P1N A;  5LU1 A;  4GNT A;  4JC3 A;  4IEA A;  4DHU A;  5D2D A;  4DX0 A;  4Y32 A;  3X0U A;  3P1Q A;  3T0L A;  5EXA A;  3M50 A;  2O02 A;  4QLI A;  3CQC A;  3ZHE B;  4ZQ0 A;  3SPR A;  3UBW A;  4FL5 A;  3P1O A;  5HF3 A;  4ZDR A;  2BTP A;  4WRQ A;  4D8M A;  4E2E A;  3NKX A;  4FJ3 A;  3LW1 A;  3P1P A;  2V7D A;  5LHO A;  4DHN A;  5LX2 A;  4DHS A;  4F7R A;  2C74 A;  3AXY C;  4MOA A;  4DHP A;  3SML A;  4JDD A;  4W8J A;  1YWT A;  2C1N A;  3UAL A;  2C9K A;  1O9E A;  1O9F A;  3IQJ A;  3P1R A;  4IHL A;  3SMO A;  3UZD A;  5IQP A;  1A37 A;  4DHQ A;  4QX1 A;  3IQU A;  4DHO A;  4DHT A;  5J31 A;  1O9D A;  4BG6 A;  3IQV A;  4O46 A;  5D3E A;  3SMM A;  1IB1 A;  3CQG A;  1URJ A;  4QX2 A;  4DHR A;  3I4R A;  1S2X A;  4N84 A;  4QX0 A;  3SP5 A;  4QX3 A;  2NPM A;  1JI6 A;  3UX0 A;  3U9X A;  2O8P A;  4Y5I A;  4Y3B A;  5LU2 A;  2WH0 A;  5BTV A;  1YZ5 A;  3P1S A;  5D3F A;  1I5P A;  1QJB A;  2C1J A;  3SMK A;  1DLC A;  3E6Y A;  3EB7 A;  1A4O A;  4N7Y A;  5F74 A;  1O9C A;  2BQ0 A;  4DAT A;  3RDH A;  3SMN A; 
#chains in the Genus database with same CATH homology
 2C63 A;  3CU8 A;  2O98 A;  1A38 A;  4DAU A;  4DHM A;  5EWZ A;  4FR3 A;  5BY9 A;  3T0M A;  5LVZ A;  3MHR A;  4N7G A;  3M51 A;  4HKC A;  4J6S A;  2C23 A;  2BR9 A;  3O8I A;  1QJA A;  2B05 A;  3EFZ A;  4DNK A;  5LU1 A;  3P1N A;  4GNT A;  4JC3 A;  4IEA A;  4DHU A;  5D2D A;  4DX0 A;  4Y32 A;  3P1Q A;  3T0L A;  5EXA A;  3M50 A;  2O02 A;  4QLI A;  4ZQ0 A;  3SPR A;  3UBW A;  4FL5 A;  3P1O A;  5HF3 A;  4ZDR A;  2BTP A;  4WRQ A;  4E2E A;  3NKX A;  4FJ3 A;  3LW1 A;  3P1P A;  2V7D A;  5LHO A;  4DHN A;  5LX2 A;  4DHS A;  4F7R A;  2C74 A;  3AXY C;  4DHP A;  3SML A;  4JDD A;  1YWT A;  2C1N A;  3UAL A;  1O9E A;  1O9F A;  3IQJ A;  3P1R A;  4IHL A;  3SMO A;  3UZD A;  5IQP A;  1A37 A;  4DHQ A;  4DHT A;  3IQU A;  4DHO A;  5J31 A;  1O9D A;  4BG6 A;  3IQV A;  4O46 A;  5D3E A;  3SMM A;  1IB1 A;  4DHR A;  4N84 A;  3SP5 A;  2NPM A;  3UX0 A;  3U9X A;  2O8P A;  4Y5I A;  4Y3B A;  5LU2 A;  2WH0 A;  5BTV A;  1YZ5 A;  3P1S A;  5D3F A;  2C1J A;  1QJB A;  3SMK A;  3E6Y A;  1A4O A;  4N7Y A;  5F74 A;  1O9C A;  2BQ0 A;  4DAT A;  3RDH A;  3SMN A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...