3SQ6A

Crystal structures of the ligand binding domain of a pentameric alpha7 nicotinic receptor chimera with its agonist epibatidine
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
204
structure length
204
Chain Sequence
EFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ligand-binding domain of an alpha 7-nicotinic receptor chimera and its complex with agonist.
pubmed doi rcsb
molecule tags Transport protein/receptor/agonist
source organism Homo sapiens, lymnaea stagnalis
molecule keywords Neuronal acetylcholine receptor subunit alpha-7, Acetylcholi
total genus 45
structure length 204
sequence length 204
chains with identical sequence B, C, D, E, F, G, H, I, J
ec nomenclature
pdb deposition date 2011-07-05
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 3sq6A00
5JMEA 3RIFA 2BG9B 4TNVA 3UQ4A 3T4MA 4ZJTA 4IL4A 3C79A 4UXUA 3UU6A 3ZKRA 3IGQA 3LSVA 3SIOA 4UM3S 4Z90A 5KE4A 4ZK1A 2WNJA 4ZK4A 3P50A 4IREA 4WV9A 3WTKA 2Y58A 5LXBA 3SQ6A 5HEGA 3RIAA 5SYOA 2C9TA 2BR7A 2XQ8A 3TLSA 5AFKA 5AFHA 5BP0A 3U8JA 4LMLA 3JAFA 4XK9A 2ZJUA 4BQTA 4TNWA 4TWDA 2XNUA 5J5GA 2Y57A 3U8MA 3UUBA 4PIRA 2XQ6A 5HEHA 4COFA 3UU3A 4HFCA 4ILCA 3C84A 2YKSA 4ZRUA 5L4EA 2ZJVA 4TWHA 3WTNA 2BYRA 4B5DA 2BG9E 3U8NA 4HFEA 4ILBA 2BYPA 4XHEA 3UU8A 5CFBA 2WNCA 2W8GA 3WTHA 3WTJA 4LMJA 5AFMA 5J0ZA 3EI0A 3ZDGA 4IL9A 4AFTA 5KZUA 2WNLA 4TWFA 3WTOA 2WZYA 2YOEA 4UM3P 4ALXA 4NPPA 3UQ7A 2XNTA 2BJ0A 3TLUA 2PGZA 3GUAA 2BG9C 4HQPA 5HEUA 2X00D 4Z91A 4HFIA 5L47A 4BFQA 3JAEA 5HCMA 4QH4A 2VL0A 3ZDHA 2XZ5A 1I9BA 2PH9A 3P4WA 5L4HA 5AFMB 5J5HA 3PEOA 4F8HA 3WTMA 3TLWA 4FRRA 3TLTA 2BYQA 3SQ9A 5LG3A 4D01A 4QABA 4EZ1A 3EAMA 4QH5A 4UY2A 3UU5A 4AFGA 5AFLA 3PMZA 4A97A 3EHZA 4HFHA 2XQ4A 4ZJSA 2YN6A 2XQ3A 5BW2A 4DBMA 4ZZCA 5HCJA 2XZ6A 2XQ7A 4HFBA 5TVCA 5HEJA 4QH1A 5HEOA 2YMEA 2XYSA 5J5IA 1UV6A 2XNVA 2UZ6A 4QAAA 2XQAA 2WN9A 4UM1A 5IUXA 3RQUA 5AFNA 2Y7YA 3WTIA 3RHWA 2X00A 3WIPA 4ZR6A 3WTLA 2XQ9A 3SH1A 3UU4A 4ILAA 5AFJA 3JADA 1UX2A 2BR8A 3TLVA 2BG9A 2BYNA 4ZZBA 4HFDA 2BYSA 3U8LA 2W8FA 2XYTA 4QACA 5FJVA 2Y56A 3U8KA 4LMKA 4UM3A 4A98A 2QC1B 5AINA 4NZBA 5BRXA 2XQ5A 4X5TA 1UW6A 3RQWA 5J5FA 5CO5A 2YMDA 3RI5A 2Y54A 4AFHA
chains in the Genus database with same CATH superfamily
5JMEA 3RIFA 2BG9B 4TNVA 3UQ4A 3T4MA 4ZJTA 4IL4A 3C79A 4UXUA 3UU6A 3ZKRA 3IGQA 3LSVA 3SIOA 4UM3S 4Z90A 5KE4A 4ZK1A 2WNJA 4ZK4A 3P50A 4IREA 4WV9A 3WTKA 2Y58A 5LXBA 3SQ6A 5HEGA 3RIAA 5SYOA 2C9TA 2BR7A 2XQ8A 3TLSA 5AFKA 5AFHA 5BP0A 3U8JA 4LMLA 3JAFA 4XK9A 2ZJUA 4BQTA 4TNWA 4TWDA 2XNUA 5J5GA 2Y57A 3U8MA 3UUBA 4PIRA 2XQ6A 5HEHA 4COFA 3UU3A 4HFCA 4ILCA 3C84A 2YKSA 4ZRUA 5L4EA 2ZJVA 4TWHA 3WTNA 2BYRA 4B5DA 2BG9E 3U8NA 4HFEA 4ILBA 2BYPA 4XHEA 3UU8A 5CFBA 2WNCA 2W8GA 3WTHA 3WTJA 4LMJA 5AFMA 5J0ZA 3EI0A 3ZDGA 4IL9A 4AFTA 5KZUA 2WNLA 4TWFA 3WTOA 2WZYA 2YOEA 4UM3P 4ALXA 4NPPA 3UQ7A 2XNTA 2BJ0A 3TLUA 2PGZA 3GUAA 2BG9C 4HQPA 5HEUA 2X00D 4Z91A 4HFIA 5L47A 4BFQA 3JAEA 5HCMA 4QH4A 2VL0A 3ZDHA 2XZ5A 1I9BA 2PH9A 3P4WA 5L4HA 5AFMB 5J5HA 3PEOA 4F8HA 3WTMA 3TLWA 4FRRA 3TLTA 2BYQA 3SQ9A 5LG3A 4D01A 4QABA 4EZ1A 3EAMA 4QH5A 4UY2A 3UU5A 4AFGA 5AFLA 3PMZA 4A97A 3EHZA 4HFHA 2XQ4A 4ZJSA 2YN6A 2XQ3A 5BW2A 4DBMA 4ZZCA 5HCJA 2XZ6A 2XQ7A 4HFBA 5TVCA 5HEJA 4QH1A 5HEOA 2YMEA 2XYSA 5J5IA 1UV6A 2XNVA 2UZ6A 4QAAA 2XQAA 2WN9A 4UM1A 5IUXA 3RQUA 5AFNA 2Y7YA 3WTIA 3RHWA 2X00A 3WIPA 4ZR6A 3WTLA 2XQ9A 3SH1A 3UU4A 4ILAA 5AFJA 3JADA 1UX2A 2BR8A 3TLVA 2BG9A 2BYNA 4ZZBA 4HFDA 2BYSA 3U8LA 2W8FA 2XYTA 4QACA 5FJVA 2Y56A 3U8KA 4LMKA 4UM3A 4A98A 2QC1B 5AINA 4NZBA 5BRXA 2XQ5A 4X5TA 1UW6A 3RQWA 5J5FA 5CO5A 2YMDA 3RI5A 2Y54A 4AFHA
chains in the Genus database with same CATH topology
5JMEA 3RIFA 2BG9B 4TNVA 3UQ4A 3T4MA 4ZJTA 4IL4A 3C79A 4UXUA 3UU6A 3ZKRA 3IGQA 3LSVA 3SIOA 4UM3S 4Z90A 5KE4A 4ZK1A 2WNJA 4ZK4A 3P50A 4IREA 4WV9A 3WTKA 2Y58A 5LXBA 3SQ6A 5HEGA 3RIAA 5SYOA 2C9TA 2BR7A 2XQ8A 3TLSA 5AFKA 5AFHA 5BP0A 3U8JA 4LMLA 3JAFA 4XK9A 2ZJUA 4BQTA 4TNWA 4TWDA 2XNUA 5J5GA 2Y57A 3U8MA 3UUBA 4PIRA 2XQ6A 5HEHA 4COFA 3UU3A 4HFCA 4ILCA 3C84A 2YKSA 4ZRUA 5L4EA 2ZJVA 4TWHA 3WTNA 2BYRA 4B5DA 2BG9E 3U8NA 4HFEA 4ILBA 2BYPA 4XHEA 3UU8A 5CFBA 2WNCA 2W8GA 3WTHA 3WTJA 4LMJA 5AFMA 5J0ZA 3EI0A 3ZDGA 4IL9A 4AFTA 5KZUA 2WNLA 4TWFA 3WTOA 2WZYA 2YOEA 4UM3P 4ALXA 4NPPA 3UQ7A 2XNTA 2BJ0A 3TLUA 2PGZA 3GUAA 2BG9C 4HQPA 5HEUA 2X00D 4Z91A 4HFIA 5L47A 4BFQA 3JAEA 5HCMA 4QH4A 2VL0A 3ZDHA 2XZ5A 1I9BA 2PH9A 3P4WA 5L4HA 5AFMB 5J5HA 3PEOA 4F8HA 3WTMA 3TLWA 4FRRA 3TLTA 2BYQA 3SQ9A 5LG3A 4D01A 4QABA 4EZ1A 3EAMA 4QH5A 4UY2A 3UU5A 4AFGA 5AFLA 3PMZA 4A97A 3EHZA 4HFHA 2XQ4A 4ZJSA 2YN6A 2XQ3A 5BW2A 4DBMA 4ZZCA 5HCJA 2XZ6A 2XQ7A 4HFBA 5TVCA 5HEJA 4QH1A 5HEOA 2YMEA 2XYSA 5J5IA 1UV6A 2XNVA 2UZ6A 4QAAA 2XQAA 2WN9A 4UM1A 5IUXA 3RQUA 5AFNA 2Y7YA 3WTIA 3RHWA 2X00A 3WIPA 4ZR6A 3WTLA 2XQ9A 3SH1A 3UU4A 4ILAA 5AFJA 3JADA 1UX2A 2BR8A 3TLVA 2BG9A 2BYNA 4ZZBA 4HFDA 2BYSA 3U8LA 2W8FA 2XYTA 4QACA 5FJVA 2Y56A 3U8KA 4LMKA 4UM3A 4A98A 2QC1B 5AINA 4NZBA 5BRXA 2XQ5A 4X5TA 1UW6A 3RQWA 5J5FA 5CO5A 2YMDA 3RI5A 2Y54A 4AFHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5JME A;  3RIF A;  2BG9 B;  4TNV A;  3UQ4 A;  3T4M A;  4ZJT A;  4IL4 A;  3C79 A;  4UXU A;  3UU6 A;  3ZKR A;  3IGQ A;  3LSV A;  3SIO A;  4UM3 S;  4Z90 A;  5KE4 A;  4ZK1 A;  2WNJ A;  4ZK4 A;  3P50 A;  4IRE A;  4WV9 A;  3WTK A;  2Y58 A;  5LXB A;  3SQ6 A;  5HEG A;  3RIA A;  5SYO A;  2C9T A;  2BR7 A;  2XQ8 A;  3TLS A;  5AFK A;  5AFH A;  5BP0 A;  3U8J A;  4LML A;  3JAF A;  4XK9 A;  2ZJU A;  4BQT A;  4TNW A;  4TWD A;  2XNU A;  5J5G A;  2Y57 A;  3U8M A;  3UUB A;  4PIR A;  2XQ6 A;  5HEH A;  4COF A;  3UU3 A;  4HFC A;  4ILC A;  3C84 A;  2YKS A;  4ZRU A;  5L4E A;  2ZJV A;  4TWH A;  3WTN A;  2BYR A;  4B5D A;  2BG9 E;  3U8N A;  4HFE A;  4ILB A;  2BYP A;  4XHE A;  3UU8 A;  5CFB A;  2WNC A;  2W8G A;  3WTH A;  3WTJ A;  4LMJ A;  5AFM A;  5J0Z A;  3EI0 A;  3ZDG A;  4IL9 A;  4AFT A;  5KZU A;  2WNL A;  4TWF A;  3WTO A;  2WZY A;  2YOE A;  4UM3 P;  4ALX A;  4NPP A;  3UQ7 A;  2XNT A;  2BJ0 A;  3TLU A;  2PGZ A;  3GUA A;  2BG9 C;  4HQP A;  5HEU A;  2X00 D;  4Z91 A;  4HFI A;  5L47 A;  4BFQ A;  3JAE A;  5HCM A;  4QH4 A;  2VL0 A;  3ZDH A;  2XZ5 A;  1I9B A;  2PH9 A;  3P4W A;  5L4H A;  5AFM B;  5J5H A;  3PEO A;  4F8H A;  3WTM A;  3TLW A;  4FRR A;  3TLT A;  2BYQ A;  3SQ9 A;  5LG3 A;  4D01 A;  4QAB A;  4EZ1 A;  3EAM A;  4QH5 A;  4UY2 A;  3UU5 A;  4AFG A;  5AFL A;  3PMZ A;  4A97 A;  3EHZ A;  4HFH A;  2XQ4 A;  4ZJS A;  2YN6 A;  2XQ3 A;  5BW2 A;  4DBM A;  4ZZC A;  5HCJ A;  2XZ6 A;  2XQ7 A;  4HFB A;  5TVC A;  5HEJ A;  4QH1 A;  5HEO A;  2YME A;  2XYS A;  5J5I A;  1UV6 A;  2XNV A;  2UZ6 A;  4QAA A;  2XQA A;  2WN9 A;  4UM1 A;  5IUX A;  3RQU A;  5AFN A;  2Y7Y A;  3WTI A;  3RHW A;  2X00 A;  3WIP A;  4ZR6 A;  3WTL A;  2XQ9 A;  3SH1 A;  3UU4 A;  4ILA A;  5AFJ A;  3JAD A;  1UX2 A;  2BR8 A;  3TLV A;  2BG9 A;  2BYN A;  4ZZB A;  4HFD A;  2BYS A;  3U8L A;  2W8F A;  2XYT A;  4QAC A;  5FJV A;  2Y56 A;  3U8K A;  4LMK A;  4UM3 A;  4A98 A;  2QC1 B;  5AIN A;  4NZB A;  5BRX A;  2XQ5 A;  4X5T A;  1UW6 A;  3RQW A;  5J5F A;  5CO5 A;  2YMD A;  3RI5 A;  2Y54 A;  4AFH A; 
#chains in the Genus database with same CATH topology
 5JME A;  3RIF A;  2BG9 B;  4TNV A;  3UQ4 A;  3T4M A;  4ZJT A;  4IL4 A;  3C79 A;  4UXU A;  3UU6 A;  3ZKR A;  3IGQ A;  3LSV A;  3SIO A;  4UM3 S;  4Z90 A;  5KE4 A;  4ZK1 A;  2WNJ A;  4ZK4 A;  3P50 A;  4IRE A;  4WV9 A;  3WTK A;  2Y58 A;  5LXB A;  3SQ6 A;  5HEG A;  3RIA A;  5SYO A;  2C9T A;  2BR7 A;  2XQ8 A;  3TLS A;  5AFK A;  5AFH A;  5BP0 A;  3U8J A;  4LML A;  3JAF A;  4XK9 A;  2ZJU A;  4BQT A;  4TNW A;  4TWD A;  2XNU A;  5J5G A;  2Y57 A;  3U8M A;  3UUB A;  4PIR A;  2XQ6 A;  5HEH A;  4COF A;  3UU3 A;  4HFC A;  4ILC A;  3C84 A;  2YKS A;  4ZRU A;  5L4E A;  2ZJV A;  4TWH A;  3WTN A;  2BYR A;  4B5D A;  2BG9 E;  3U8N A;  4HFE A;  4ILB A;  2BYP A;  4XHE A;  3UU8 A;  5CFB A;  2WNC A;  2W8G A;  3WTH A;  3WTJ A;  4LMJ A;  5AFM A;  5J0Z A;  3EI0 A;  3ZDG A;  4IL9 A;  4AFT A;  5KZU A;  2WNL A;  4TWF A;  3WTO A;  2WZY A;  2YOE A;  4UM3 P;  4ALX A;  4NPP A;  3UQ7 A;  2XNT A;  2BJ0 A;  3TLU A;  2PGZ A;  3GUA A;  2BG9 C;  4HQP A;  5HEU A;  2X00 D;  4Z91 A;  4HFI A;  5L47 A;  4BFQ A;  3JAE A;  5HCM A;  4QH4 A;  2VL0 A;  3ZDH A;  2XZ5 A;  1I9B A;  2PH9 A;  3P4W A;  5L4H A;  5AFM B;  5J5H A;  3PEO A;  4F8H A;  3WTM A;  3TLW A;  4FRR A;  3TLT A;  2BYQ A;  3SQ9 A;  5LG3 A;  4D01 A;  4QAB A;  4EZ1 A;  3EAM A;  4QH5 A;  4UY2 A;  3UU5 A;  4AFG A;  5AFL A;  3PMZ A;  4A97 A;  3EHZ A;  4HFH A;  2XQ4 A;  4ZJS A;  2YN6 A;  2XQ3 A;  5BW2 A;  4DBM A;  4ZZC A;  5HCJ A;  2XZ6 A;  2XQ7 A;  4HFB A;  5TVC A;  5HEJ A;  4QH1 A;  5HEO A;  2YME A;  2XYS A;  5J5I A;  1UV6 A;  2XNV A;  2UZ6 A;  4QAA A;  2XQA A;  2WN9 A;  4UM1 A;  5IUX A;  3RQU A;  5AFN A;  2Y7Y A;  3WTI A;  3RHW A;  2X00 A;  3WIP A;  4ZR6 A;  3WTL A;  2XQ9 A;  3SH1 A;  3UU4 A;  4ILA A;  5AFJ A;  3JAD A;  1UX2 A;  2BR8 A;  3TLV A;  2BG9 A;  2BYN A;  4ZZB A;  4HFD A;  2BYS A;  3U8L A;  2W8F A;  2XYT A;  4QAC A;  5FJV A;  2Y56 A;  3U8K A;  4LMK A;  4UM3 A;  4A98 A;  2QC1 B;  5AIN A;  4NZB A;  5BRX A;  2XQ5 A;  4X5T A;  1UW6 A;  3RQW A;  5J5F A;  5CO5 A;  2YMD A;  3RI5 A;  2Y54 A;  4AFH A; 
#chains in the Genus database with same CATH homology
 5JME A;  3RIF A;  2BG9 B;  4TNV A;  3UQ4 A;  3T4M A;  4ZJT A;  4IL4 A;  3C79 A;  4UXU A;  3UU6 A;  3ZKR A;  3IGQ A;  3LSV A;  3SIO A;  4UM3 S;  4Z90 A;  5KE4 A;  4ZK1 A;  2WNJ A;  4ZK4 A;  3P50 A;  4IRE A;  4WV9 A;  3WTK A;  2Y58 A;  5LXB A;  3SQ6 A;  5HEG A;  3RIA A;  5SYO A;  2C9T A;  2BR7 A;  2XQ8 A;  3TLS A;  5AFK A;  5AFH A;  5BP0 A;  3U8J A;  4LML A;  3JAF A;  4XK9 A;  2ZJU A;  4BQT A;  4TNW A;  4TWD A;  2XNU A;  5J5G A;  2Y57 A;  3U8M A;  3UUB A;  4PIR A;  2XQ6 A;  5HEH A;  4COF A;  3UU3 A;  4HFC A;  4ILC A;  3C84 A;  2YKS A;  4ZRU A;  5L4E A;  2ZJV A;  4TWH A;  3WTN A;  2BYR A;  4B5D A;  2BG9 E;  3U8N A;  4HFE A;  4ILB A;  2BYP A;  4XHE A;  3UU8 A;  5CFB A;  2WNC A;  2W8G A;  3WTH A;  3WTJ A;  4LMJ A;  5AFM A;  5J0Z A;  3EI0 A;  3ZDG A;  4IL9 A;  4AFT A;  5KZU A;  2WNL A;  4TWF A;  3WTO A;  2WZY A;  2YOE A;  4UM3 P;  4ALX A;  4NPP A;  3UQ7 A;  2XNT A;  2BJ0 A;  3TLU A;  2PGZ A;  3GUA A;  2BG9 C;  4HQP A;  5HEU A;  2X00 D;  4Z91 A;  4HFI A;  5L47 A;  4BFQ A;  3JAE A;  5HCM A;  4QH4 A;  2VL0 A;  3ZDH A;  2XZ5 A;  1I9B A;  2PH9 A;  3P4W A;  5L4H A;  5AFM B;  5J5H A;  3PEO A;  4F8H A;  3WTM A;  3TLW A;  4FRR A;  3TLT A;  2BYQ A;  3SQ9 A;  5LG3 A;  4D01 A;  4QAB A;  4EZ1 A;  3EAM A;  4QH5 A;  4UY2 A;  3UU5 A;  4AFG A;  5AFL A;  3PMZ A;  4A97 A;  3EHZ A;  4HFH A;  2XQ4 A;  4ZJS A;  2YN6 A;  2XQ3 A;  5BW2 A;  4DBM A;  4ZZC A;  5HCJ A;  2XZ6 A;  2XQ7 A;  4HFB A;  5TVC A;  5HEJ A;  4QH1 A;  5HEO A;  2YME A;  2XYS A;  5J5I A;  1UV6 A;  2XNV A;  2UZ6 A;  4QAA A;  2XQA A;  2WN9 A;  4UM1 A;  5IUX A;  3RQU A;  5AFN A;  2Y7Y A;  3WTI A;  3RHW A;  2X00 A;  3WIP A;  4ZR6 A;  3WTL A;  2XQ9 A;  3SH1 A;  3UU4 A;  4ILA A;  5AFJ A;  3JAD A;  1UX2 A;  2BR8 A;  3TLV A;  2BG9 A;  2BYN A;  4ZZB A;  4HFD A;  2BYS A;  3U8L A;  2W8F A;  2XYT A;  4QAC A;  5FJV A;  2Y56 A;  3U8K A;  4LMK A;  4UM3 A;  4A98 A;  2QC1 B;  5AIN A;  4NZB A;  5BRX A;  2XQ5 A;  4X5T A;  1UW6 A;  3RQW A;  5J5F A;  5CO5 A;  2YMD A;  3RI5 A;  2Y54 A;  4AFH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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