3ST6A

Structure of a m. tuberculosis synthase, mbti, in complex with an isochorismate analogue inhibitor
Total Genus 142
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
142
sequence length
436
structure length
436
Chain Sequence
SSSIPMPAGVNPADLAAELAAVVTESVDEDYLLYECDGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLLLETDQAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDRLLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAAGRYHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLGGIRALGYSPELVTAVRADGVVITEPLAGTRALGRGPAIDRLARDDLESNSKEIVEHAISVRSSLEEITDIAEPGSAAVIDFMTVRERGSVQHLGSTIRARLDPSSDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVARQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
pubmed doi rcsb
molecule tags Isomerase/isomerase inhibitor
source organism Mycobacterium tuberculosis
molecule keywords Isochorismate synthase/isochorismate-pyruvate lyase mbtI
total genus 142
structure length 436
sequence length 436
chains with identical sequence B, C, D
ec nomenclature ec 4.2.99.21: Isochorismate lyase.
pdb deposition date 2011-07-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00425 Chorismate_bind chorismate binding enzyme
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.120.10 Alpha Beta 4-Layer Sandwich Anthranilate synthase Anthranilate synthase 3st6A00
4GRHA 5JZDA 1I7SA 5JY8A 3RV7A 5KCKA 1K0EA 3RV9A 2G5FA 3BZNA 3RV8A 5JXZA 2I6YA 1I7QA 3OS6A 5JY4B 2EUAA 1K0GA 3VEHA 2FN1A 1QDLA 3R75A 3BZMA 3GSEA 3H9MA 3ST6A 5JY4A 3LOGA 1I1QA 2FN0A 5CWAA 3RV6A 3R74A 3HWOA 3R76A 5JY9A
chains in the Genus database with same CATH superfamily
4GRHA 5JZDA 1I7SA 5JY8A 3RV7A 5KCKA 1K0EA 3RV9A 2G5FA 3BZNA 3RV8A 5JXZA 2I6YA 1I7QA 3OS6A 5JY4B 2EUAA 1K0GA 3VEHA 2FN1A 1QDLA 3R75A 3BZMA 3GSEA 3H9MA 3ST6A 5JY4A 3LOGA 1I1QA 2FN0A 5CWAA 3RV6A 3R74A 3HWOA 3R76A 5JY9A
chains in the Genus database with same CATH topology
4GRHA 5JZDA 1I7SA 5JY8A 3RV7A 5KCKA 1K0EA 3RV9A 2G5FA 3BZNA 3RV8A 5JXZA 2I6YA 1I7QA 3OS6A 5JY4B 2EUAA 1K0GA 3VEHA 2FN1A 1QDLA 3R75A 3BZMA 3GSEA 3H9MA 3ST6A 5JY4A 3LOGA 1I1QA 2FN0A 5CWAA 3RV6A 3R74A 3HWOA 3R76A 5JY9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GRH A;  5JZD A;  1I7S A;  5JY8 A;  3RV7 A;  5KCK A;  1K0E A;  3RV9 A;  2G5F A;  3BZN A;  3RV8 A;  5JXZ A;  2I6Y A;  1I7Q A;  3OS6 A;  5JY4 B;  2EUA A;  1K0G A;  3VEH A;  2FN1 A;  1QDL A;  3R75 A;  3BZM A;  3GSE A;  3H9M A;  3ST6 A;  5JY4 A;  3LOG A;  1I1Q A;  2FN0 A;  5CWA A;  3RV6 A;  3R74 A;  3HWO A;  3R76 A;  5JY9 A; 
#chains in the Genus database with same CATH topology
 4GRH A;  5JZD A;  1I7S A;  5JY8 A;  3RV7 A;  5KCK A;  1K0E A;  3RV9 A;  2G5F A;  3BZN A;  3RV8 A;  5JXZ A;  2I6Y A;  1I7Q A;  3OS6 A;  5JY4 B;  2EUA A;  1K0G A;  3VEH A;  2FN1 A;  1QDL A;  3R75 A;  3BZM A;  3GSE A;  3H9M A;  3ST6 A;  5JY4 A;  3LOG A;  1I1Q A;  2FN0 A;  5CWA A;  3RV6 A;  3R74 A;  3HWO A;  3R76 A;  5JY9 A; 
#chains in the Genus database with same CATH homology
 4GRH A;  5JZD A;  1I7S A;  5JY8 A;  3RV7 A;  5KCK A;  1K0E A;  3RV9 A;  2G5F A;  3BZN A;  3RV8 A;  5JXZ A;  2I6Y A;  1I7Q A;  3OS6 A;  5JY4 B;  2EUA A;  1K0G A;  3VEH A;  2FN1 A;  1QDL A;  3R75 A;  3BZM A;  3GSE A;  3H9M A;  3ST6 A;  5JY4 A;  3LOG A;  1I1Q A;  2FN0 A;  5CWA A;  3RV6 A;  3R74 A;  3HWO A;  3R76 A;  5JY9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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