3T3JA

1.70 a structure of friedreich's ataxia frataxin variant n146k
Total Genus 36
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
36
sequence length
123
structure length
123
Chain Sequence
HPGSLDETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDLGTYVIKKQTPNKQIWLSSPSSGPKRYDWTGKNWVYSHDGVSLHELLAAELTKALKTKLDLSSLAYSGK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-Function Analysis of Friedreich's Ataxia Mutants Reveals Determinants of Frataxin Binding and Activation of the Fe-S Assembly Complex.
pubmed doi rcsb
molecule keywords Frataxin, mitochondrial
molecule tags Oxidoreductase
source organism Homo sapiens
total genus 36
structure length 123
sequence length 123
ec nomenclature ec 1.16.3.1: Ferroxidase.
pdb deposition date 2011-07-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01491 Frataxin_Cyay Frataxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.920.10 Alpha Beta 2-Layer Sandwich Metal Transport, Frataxin; Chain A Frataxin/CyaY 3t3jA00
3S5DA 2EFFA 4HS5A 2GA5A 4JPDA 4LK8A 1SOYA 2FQLA 1EW4A 3OEQA 4EC2A 3T3KA 3T3JA 3OERA 4LP1A 1EKGA 3S5EA 3S4MA 3S5FA 3T3XA 3T3LA 3T3TA 1LY7A 2P1XA
chains in the Genus database with same CATH superfamily
3S5DA 2EFFA 1V5RA 3SSDA 4HS5A 3IAM7 2GA5A 3GD0A 4JPDA 1SOYA 4LK8A 3GD9A 2FQLA 3I9V7 1D2MA 4P78C 1WHZA 1EW4A 3OEQA 4EC2A 3T3KA 3T3JA 3IMOA 3A5PA 3OERA 3SSCA 4C26A 3SSEA 4LP1A 1EKGA 3S5EA 4HEA7 3S4MA 3S5FA 3IAS7 3T3XA 3T3LA 2FUG7 3T3TA 1LY7A 2P1XA
chains in the Genus database with same CATH topology
3S5DA 2EFFA 4HS5A 2GA5A 4JPDA 4LK8A 1SOYA 2FQLA 1EW4A 3OEQA 4EC2A 3T3KA 3T3JA 3OERA 4LP1A 1EKGA 3S5EA 3S4MA 3S5FA 3T3XA 3T3LA 3T3TA 1LY7A 2P1XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3S5D A;  2EFF A;  4HS5 A;  2GA5 A;  4JPD A;  4LK8 A;  1SOY A;  2FQL A;  1EW4 A;  3OEQ A;  4EC2 A;  3T3K A;  3T3J A;  3OER A;  4LP1 A;  1EKG A;  3S5E A;  3S4M A;  3S5F A;  3T3X A;  3T3L A;  3T3T A;  1LY7 A;  2P1X A; 
#chains in the Genus database with same CATH topology
 3S5D A;  2EFF A;  1V5R A;  3SSD A;  4HS5 A;  3IAM 7;  2GA5 A;  3GD0 A;  4JPD A;  1SOY A;  4LK8 A;  3GD9 A;  2FQL A;  3I9V 7;  1D2M A;  4P78 C;  1WHZ A;  1EW4 A;  3OEQ A;  4EC2 A;  3T3K A;  3T3J A;  3IMO A;  3A5P A;  3OER A;  3SSC A;  4C26 A;  3SSE A;  4LP1 A;  1EKG A;  3S5E A;  4HEA 7;  3S4M A;  3S5F A;  3IAS 7;  3T3X A;  3T3L A;  2FUG 7;  3T3T A;  1LY7 A;  2P1X A; 
#chains in the Genus database with same CATH homology
 3S5D A;  2EFF A;  4HS5 A;  2GA5 A;  4JPD A;  4LK8 A;  1SOY A;  2FQL A;  1EW4 A;  3OEQ A;  4EC2 A;  3T3K A;  3T3J A;  3OER A;  4LP1 A;  1EKG A;  3S5E A;  3S4M A;  3S5F A;  3T3X A;  3T3L A;  3T3T A;  1LY7 A;  2P1X A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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