3T3KA

1.24 a structure of friedreich's ataxia frataxin variant q148r
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
122
structure length
122
Chain Sequence
SLDETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDLGTYVINKRTPNKQIWLSSPSSGPKRYDWTGKNWVYSHDGVSLHELLAAELTKALKTKLDLSSLAYSGKDA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-Function Analysis of Friedreich's Ataxia Mutants Reveals Determinants of Frataxin Binding and Activation of the Fe-S Assembly Complex.
pubmed doi rcsb
molecule keywords Frataxin, mitochondrial
molecule tags Oxidoreductase
source organism Homo sapiens
total genus 34
structure length 122
sequence length 122
ec nomenclature ec 1.16.3.1: Ferroxidase.
pdb deposition date 2011-07-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01491 Frataxin_Cyay Frataxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.920.10 Alpha Beta 2-Layer Sandwich Metal Transport, Frataxin; Chain A Frataxin/CyaY 3t3kA00
2FQLA 3S5FA 3T3LA 3OERA 4LK8A 1EW4A 2GA5A 3S4MA 4EC2A 1LY7A 1SOYA 3S5EA 3T3XA 3OEQA 3T3TA 3T3JA 2EFFA 4LP1A 3T3KA 4HS5A 1EKGA 2P1XA 4JPDA 3S5DA
chains in the Genus database with same CATH superfamily
2FQLA 3S5FA 3GD0A 3T3LA 3OERA 3SSCA 3I9V7 4LK8A 1EW4A 2GA5A 3S5DA 3IAS7 1V5RA 4P78C 3SSDA 3S4MA 3A5PA 2FUG7 4EC2A 1LY7A 1SOYA 3IMOA 3IAM7 3S5EA 3T3XA 4C26A 3OEQA 3T3TA 3T3JA 2EFFA 4LP1A 3T3KA 4HS5A 3GD9A 1EKGA 2P1XA 3SSEA 4JPDA 1D2MA 1WHZA 4HEA7
chains in the Genus database with same CATH topology
2FQLA 3S5FA 3T3LA 3OERA 4LK8A 1EW4A 2GA5A 3S4MA 4EC2A 1LY7A 1SOYA 3S5EA 3T3XA 3OEQA 3T3TA 3T3JA 2EFFA 4LP1A 3T3KA 4HS5A 1EKGA 2P1XA 4JPDA 3S5DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FQL A;  3S5F A;  3T3L A;  3OER A;  4LK8 A;  1EW4 A;  2GA5 A;  3S4M A;  4EC2 A;  1LY7 A;  1SOY A;  3S5E A;  3T3X A;  3OEQ A;  3T3T A;  3T3J A;  2EFF A;  4LP1 A;  3T3K A;  4HS5 A;  1EKG A;  2P1X A;  4JPD A;  3S5D A; 
#chains in the Genus database with same CATH topology
 2FQL A;  3S5F A;  3GD0 A;  3T3L A;  3OER A;  3SSC A;  3I9V 7;  4LK8 A;  1EW4 A;  2GA5 A;  3S5D A;  3IAS 7;  1V5R A;  4P78 C;  3SSD A;  3S4M A;  3A5P A;  2FUG 7;  4EC2 A;  1LY7 A;  1SOY A;  3IMO A;  3IAM 7;  3S5E A;  3T3X A;  4C26 A;  3OEQ A;  3T3T A;  3T3J A;  2EFF A;  4LP1 A;  3T3K A;  4HS5 A;  3GD9 A;  1EKG A;  2P1X A;  3SSE A;  4JPD A;  1D2M A;  1WHZ A;  4HEA 7; 
#chains in the Genus database with same CATH homology
 2FQL A;  3S5F A;  3T3L A;  3OER A;  4LK8 A;  1EW4 A;  2GA5 A;  3S4M A;  4EC2 A;  1LY7 A;  1SOY A;  3S5E A;  3T3X A;  3OEQ A;  3T3T A;  3T3J A;  2EFF A;  4LP1 A;  3T3K A;  4HS5 A;  1EKG A;  2P1X A;  4JPD A;  3S5D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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