3T5OA

Crystal structure of human complement component c6
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
913
structure length
871
Chain Sequence
CFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVCTRKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVGFEVQTAEDDLKTDFYKDLTSLGHVPIFYSSKRSENINHNSAFKQAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETKKRVLFAKKTKVEHRCTTNKLSEKHEGSFIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEKTFSEWLESVKENPAVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTECLCVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCTPCINDDEEDSGCPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPPISNSLTCEKDTGHCQLGQKQSGSECICMSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGSCQDGRQLEWGLERTRLSSNSTKKESCGYDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKMGSSTSEKTLNICEVGTIRCANRKMEILHPGKCLA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Complement component C6
publication title Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC).
pubmed doi rcsb
molecule tags Immune system
total genus 177
structure length 871
sequence length 913
ec nomenclature
pdb deposition date 2011-07-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00057 Ldl_recept_a Low-density lipoprotein receptor domain class A
A PF00084 Sushi Sushi repeat (SCR repeat)
A PF00090 TSP_1 Thrombospondin type 1 domain
A PF01823 MACPF MAC/Perforin domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 3t5oA03
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 3t5oA04
2.20.100.10 Mainly Beta Single Sheet TSP-1 type 1 repeat Thrombospondin type-1 (TSP1) repeat 3t5oA01
3MQLA 1TPGA 4B2SA 2JGXA 2IZ4A 1H03P 2MCYA 2UWNA 1TPNA 2RKZA 1VVCA 2ERJA 1HFHA 3EJHA 4AYDA 3TVJA 3VDKA 1SRZA 3VDLA 2BZMA 4HQOA 1OK3A 4IGDA 1Q3XA 4CSYA 2XQWC 2EHFA 2G7IA 3IU3I 4JHSA 1OJYA 1E8BA 5FO8C 4DJZA 4K12A 1GPZA 3CALA 1ZJKA 3NFPI 2IZ3A 2RLPA 1OK9A 4J38B 4MUCA 1GKGA 2QY0A 2MCZA 2YRAA 3R6BA 1VVDA 5I0QB 3SW0X 2CKUA 5HZPB 3KXVA 4LOTA 4AYMA 1E88A 1OJVA 3T5OA 4YNXA 1G4FA 2WIIC 2W81A 1Z92B 3INBC 1CKLA 3OEDC 3OXUD 1H2PP 2EC3A 3IX0A 2JRAA 1QO6A 1UOTP 2W80A 2KMSA 3ERBA 5JPMG 1HFIA 2LOJA 5HYTB 3ZRZA 3O8EB 4A5WB 3GOVA 1ELVA 2KRIA 3L89M 4HQNA 2O39C 4B2RA 1NWVA 3GXEA 1LSLA 1H2QP 1HCCA 3ZD1A 1SS2A 4ZH1D 2YBYA 1C1ZA 3KZJA 3RJ3D 4WJG2 2XWJI 1G4GA 1GKNA 2RL0A 2A55A 1TPMA 2CG6A 2V8EA 3VDJA 2XRBA 2XWBF 4C16A 1MD7A 1OK2A 5HYPA 2JGWA 5HYUB 1FBRA 1GHQB 1MD8A 1QUBA 4ONTD 4PZ5A 4FXGG 1PPQA 1QGBA 2B5ID 4LOSA 4AYEA 1U5MA 1O9AA 1VEXA 3R62A 1SZLA 4HQLA 2XRDA 1OJWA 2RLQA 1H04P 4F4OC 3ZD2A 4KKDA 2CG7A 1OK1A 3OP8A 4AYIA 2RKYA 1E5GA 3M7PA 1LY2A
chains in the Genus database with same CATH superfamily
2Y8SA 3MQLA 1TPGA 4B2SA 2JGXA 2IZ4A 1H03P 2MCYA 2UWNA 1TPNA 2RKZA 1VVCA 2ERJA 1HFHA 3EJHA 4AYDA 3TVJA 3VDKA 1SRZA 3VDLA 2BZMA 4HQOA 1OK3A 4IGDA 1Q3XA 4CSYA 2XQWC 2EHFA 2G7IA 3IU3I 4JHSA 1OJYA 5DN4A 1E8BA 5FO8C 4DJZA 4K12A 1GPZA 3CALA 1ZJKA 3NFPI 2IZ3A 2RLPA 1OK9A 3F6KA 4MSLA 4J38B 4MUCA 1GKGA 2QY0A 2MCZA 2YRAA 3R6BA 1VVDA 5I0QB 3SW0X 2CKUA 5HZPB 3KXVA 4LOTA 4AYMA 1E88A 5DN5A 1OJVA 3T5OA 4YNXA 2X2ZA 2WIIC 1G4FA 2W81A 1Z92B 3INBC 1CKLA 3OEDC 3ZLDA 2I2LA 3OXUD 1H2PP 2EC3A 3IX0A 2JRAA 1QO6A 1UOTP 4N7EA 3CI0J 2W80A 2KMSA 3ERBA 5JPMG 1HFIA 2LOJA 2Y8TA 5HYTB 3ZRZA 3O8EB 4A5WB 3WSXA 3GOVA 1ELVA 2KRIA 3L89M 2Y8RA 4HQNA 2O39C 4B2RA 1NWVA 3GXEA 4YIZA 3VWOA 1LSLA 1H2QP 1HCCA 3ZD1A 1SS2A 4ZH1D 2YBYA 1C1ZA 3KZJA 3RJ3D 4WJG2 2XWJI 3ZLEA 1G4GA 4APLA 1RLHA 1GKNA 2RL0A 2A55A 1TPMA 3FGTA 3NJAA 2CG6A 2V8EA 3VDJA 2XRBA 2XWBF 4C16A 1MD7A 1OK2A 5HYPA 2JGWA 5HYUB 1FBRA 1GHQB 1MD8A 1QUBA 4ONTD 4PZ5A 4FXGG 1PPQA 1QGBA 2B5ID 4LOSA 4AYEA 1U5MA 1O9AA 3FGRA 4PO7A 1VEXA 3R62A 4BWCA 1SZLA 3K3TA 4HQLA 2ZYCA 2XRDA 1OJWA 2RLQA 1H04P 3WSYA 4F4OC 3ZD2A 4KKDA 2CG7A 1OK1A 3OP8A 4AYIA 2RKYA 1E5GA 3M7PA 1LY2A
chains in the Genus database with same CATH topology
3MQLA 1TPGA 4B2SA 2JGXA 2IZ4A 1H03P 2MCYA 2UWNA 1TPNA 2RKZA 1VVCA 2ERJA 1HFHA 3EJHA 4AYDA 3TVJA 3VDKA 1SRZA 3VDLA 2BZMA 4HQOA 1OK3A 4IGDA 1Q3XA 4CSYA 2XQWC 2EHFA 2G7IA 3IU3I 4JHSA 1OJYA 1E8BA 5FO8C 4DJZA 4K12A 1GPZA 3CALA 1ZJKA 3NFPI 2IZ3A 2RLPA 1OK9A 4J38B 4MUCA 1GKGA 2QY0A 2MCZA 2YRAA 3R6BA 1VVDA 5I0QB 3SW0X 2CKUA 5HZPB 3KXVA 4LOTA 4AYMA 1E88A 1OJVA 3T5OA 4YNXA 1G4FA 2WIIC 2W81A 1Z92B 3INBC 1CKLA 3OEDC 3OXUD 1H2PP 2EC3A 3IX0A 2JRAA 1QO6A 1UOTP 2W80A 2KMSA 3ERBA 5JPMG 1HFIA 2LOJA 5HYTB 3ZRZA 3O8EB 4A5WB 3GOVA 1ELVA 2KRIA 3L89M 4HQNA 2O39C 4B2RA 1NWVA 3GXEA 1LSLA 1H2QP 1HCCA 3ZD1A 1SS2A 4ZH1D 2YBYA 1C1ZA 3KZJA 3RJ3D 4WJG2 2XWJI 1G4GA 1GKNA 2RL0A 2A55A 1TPMA 2CG6A 2V8EA 3VDJA 2XRBA 2XWBF 4C16A 1MD7A 1OK2A 5HYPA 2JGWA 5HYUB 1FBRA 1GHQB 1MD8A 1QUBA 4ONTD 4PZ5A 4FXGG 1PPQA 1QGBA 2B5ID 4LOSA 4AYEA 1U5MA 1O9AA 1VEXA 3R62A 1SZLA 4HQLA 2XRDA 1OJWA 2RLQA 1H04P 4F4OC 3ZD2A 4KKDA 2CG7A 1OK1A 3OP8A 4AYIA 2RKYA 1E5GA 3M7PA 1LY2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MQL A;  1TPG A;  4B2S A;  2JGX A;  2IZ4 A;  1H03 P;  2MCY A;  2UWN A;  1TPN A;  2RKZ A;  1VVC A;  2ERJ A;  1HFH A;  3EJH A;  4AYD A;  3TVJ A;  3VDK A;  1SRZ A;  3VDL A;  2BZM A;  4HQO A;  1OK3 A;  4IGD A;  1Q3X A;  4CSY A;  2XQW C;  2EHF A;  2G7I A;  3IU3 I;  4JHS A;  1OJY A;  1E8B A;  5FO8 C;  4DJZ A;  4K12 A;  1GPZ A;  3CAL A;  1ZJK A;  3NFP I;  2IZ3 A;  2RLP A;  1OK9 A;  4J38 B;  4MUC A;  1GKG A;  2QY0 A;  2MCZ A;  2YRA A;  3R6B A;  1VVD A;  5I0Q B;  3SW0 X;  2CKU A;  5HZP B;  3KXV A;  4LOT A;  4AYM A;  1E88 A;  1OJV A;  3T5O A;  4YNX A;  1G4F A;  2WII C;  2W81 A;  1Z92 B;  3INB C;  1CKL A;  3OED C;  3OXU D;  1H2P P;  2EC3 A;  3IX0 A;  2JRA A;  1QO6 A;  1UOT P;  2W80 A;  2KMS A;  3ERB A;  5JPM G;  1HFI A;  2LOJ A;  5HYT B;  3ZRZ A;  3O8E B;  4A5W B;  3GOV A;  1ELV A;  2KRI A;  3L89 M;  4HQN A;  2O39 C;  4B2R A;  1NWV A;  3GXE A;  1LSL A;  1H2Q P;  1HCC A;  3ZD1 A;  1SS2 A;  4ZH1 D;  2YBY A;  1C1Z A;  3KZJ A;  3RJ3 D;  4WJG 2;  2XWJ I;  1G4G A;  1GKN A;  2RL0 A;  2A55 A;  1TPM A;  2CG6 A;  2V8E A;  3VDJ A;  2XRB A;  2XWB F;  4C16 A;  1MD7 A;  1OK2 A;  5HYP A;  2JGW A;  5HYU B;  1FBR A;  1GHQ B;  1MD8 A;  1QUB A;  4ONT D;  4PZ5 A;  4FXG G;  1PPQ A;  1QGB A;  2B5I D;  4LOS A;  4AYE A;  1U5M A;  1O9A A;  1VEX A;  3R62 A;  1SZL A;  4HQL A;  2XRD A;  1OJW A;  2RLQ A;  1H04 P;  4F4O C;  3ZD2 A;  4KKD A;  2CG7 A;  1OK1 A;  3OP8 A;  4AYI A;  2RKY A;  1E5G A;  3M7P A;  1LY2 A; 
#chains in the Genus database with same CATH topology
 2Y8S A;  3MQL A;  1TPG A;  4B2S A;  2JGX A;  2IZ4 A;  1H03 P;  2MCY A;  2UWN A;  1TPN A;  2RKZ A;  1VVC A;  2ERJ A;  1HFH A;  3EJH A;  4AYD A;  3TVJ A;  3VDK A;  1SRZ A;  3VDL A;  2BZM A;  4HQO A;  1OK3 A;  4IGD A;  1Q3X A;  4CSY A;  2XQW C;  2EHF A;  2G7I A;  3IU3 I;  4JHS A;  1OJY A;  5DN4 A;  1E8B A;  5FO8 C;  4DJZ A;  4K12 A;  1GPZ A;  3CAL A;  1ZJK A;  3NFP I;  2IZ3 A;  2RLP A;  1OK9 A;  3F6K A;  4MSL A;  4J38 B;  4MUC A;  1GKG A;  2QY0 A;  2MCZ A;  2YRA A;  3R6B A;  1VVD A;  5I0Q B;  3SW0 X;  2CKU A;  5HZP B;  3KXV A;  4LOT A;  4AYM A;  1E88 A;  5DN5 A;  1OJV A;  3T5O A;  4YNX A;  2X2Z A;  2WII C;  1G4F A;  2W81 A;  1Z92 B;  3INB C;  1CKL A;  3OED C;  3ZLD A;  2I2L A;  3OXU D;  1H2P P;  2EC3 A;  3IX0 A;  2JRA A;  1QO6 A;  1UOT P;  4N7E A;  3CI0 J;  2W80 A;  2KMS A;  3ERB A;  5JPM G;  1HFI A;  2LOJ A;  2Y8T A;  5HYT B;  3ZRZ A;  3O8E B;  4A5W B;  3WSX A;  3GOV A;  1ELV A;  2KRI A;  3L89 M;  2Y8R A;  4HQN A;  2O39 C;  4B2R A;  1NWV A;  3GXE A;  4YIZ A;  3VWO A;  1LSL A;  1H2Q P;  1HCC A;  3ZD1 A;  1SS2 A;  4ZH1 D;  2YBY A;  1C1Z A;  3KZJ A;  3RJ3 D;  4WJG 2;  2XWJ I;  3ZLE A;  1G4G A;  4APL A;  1RLH A;  1GKN A;  2RL0 A;  2A55 A;  1TPM A;  3FGT A;  3NJA A;  2CG6 A;  2V8E A;  3VDJ A;  2XRB A;  2XWB F;  4C16 A;  1MD7 A;  1OK2 A;  5HYP A;  2JGW A;  5HYU B;  1FBR A;  1GHQ B;  1MD8 A;  1QUB A;  4ONT D;  4PZ5 A;  4FXG G;  1PPQ A;  1QGB A;  2B5I D;  4LOS A;  4AYE A;  1U5M A;  1O9A A;  3FGR A;  4PO7 A;  1VEX A;  3R62 A;  4BWC A;  1SZL A;  3K3T A;  4HQL A;  2ZYC A;  2XRD A;  1OJW A;  2RLQ A;  1H04 P;  3WSY A;  4F4O C;  3ZD2 A;  4KKD A;  2CG7 A;  1OK1 A;  3OP8 A;  4AYI A;  2RKY A;  1E5G A;  3M7P A;  1LY2 A; 
#chains in the Genus database with same CATH homology
 3MQL A;  1TPG A;  4B2S A;  2JGX A;  2IZ4 A;  1H03 P;  2MCY A;  2UWN A;  1TPN A;  2RKZ A;  1VVC A;  2ERJ A;  1HFH A;  3EJH A;  4AYD A;  3TVJ A;  3VDK A;  1SRZ A;  3VDL A;  2BZM A;  4HQO A;  1OK3 A;  4IGD A;  1Q3X A;  4CSY A;  2XQW C;  2EHF A;  2G7I A;  3IU3 I;  4JHS A;  1OJY A;  1E8B A;  5FO8 C;  4DJZ A;  4K12 A;  1GPZ A;  3CAL A;  1ZJK A;  3NFP I;  2IZ3 A;  2RLP A;  1OK9 A;  4J38 B;  4MUC A;  1GKG A;  2QY0 A;  2MCZ A;  2YRA A;  3R6B A;  1VVD A;  5I0Q B;  3SW0 X;  2CKU A;  5HZP B;  3KXV A;  4LOT A;  4AYM A;  1E88 A;  1OJV A;  3T5O A;  4YNX A;  1G4F A;  2WII C;  2W81 A;  1Z92 B;  3INB C;  1CKL A;  3OED C;  3OXU D;  1H2P P;  2EC3 A;  3IX0 A;  2JRA A;  1QO6 A;  1UOT P;  2W80 A;  2KMS A;  3ERB A;  5JPM G;  1HFI A;  2LOJ A;  5HYT B;  3ZRZ A;  3O8E B;  4A5W B;  3GOV A;  1ELV A;  2KRI A;  3L89 M;  4HQN A;  2O39 C;  4B2R A;  1NWV A;  3GXE A;  1LSL A;  1H2Q P;  1HCC A;  3ZD1 A;  1SS2 A;  4ZH1 D;  2YBY A;  1C1Z A;  3KZJ A;  3RJ3 D;  4WJG 2;  2XWJ I;  1G4G A;  1GKN A;  2RL0 A;  2A55 A;  1TPM A;  2CG6 A;  2V8E A;  3VDJ A;  2XRB A;  2XWB F;  4C16 A;  1MD7 A;  1OK2 A;  5HYP A;  2JGW A;  5HYU B;  1FBR A;  1GHQ B;  1MD8 A;  1QUB A;  4ONT D;  4PZ5 A;  4FXG G;  1PPQ A;  1QGB A;  2B5I D;  4LOS A;  4AYE A;  1U5M A;  1O9A A;  1VEX A;  3R62 A;  1SZL A;  4HQL A;  2XRD A;  1OJW A;  2RLQ A;  1H04 P;  4F4O C;  3ZD2 A;  4KKD A;  2CG7 A;  1OK1 A;  3OP8 A;  4AYI A;  2RKY A;  1E5G A;  3M7P A;  1LY2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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