3T6GA

Structure of the complex between nsp3 (shep1) and p130cas
Total Genus 123
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
313
structure length
299
Chain Sequence
TVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGSTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLESEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein, cell adhesion
molecule keywords SH2 domain-containing protein 3C
total genus 123
structure length 299
sequence length 313
chains with identical sequence C
ec nomenclature
pdb deposition date 2011-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00617 RasGEF RasGEF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 3t6gA00
4URZS 2IJES 4JGWA 2BYVE 4F7ZA 4US1S 4MGIE 2II0A 1XD4A 4NYMS 4MGZE 3T6GA 4URXS 4URUS 3T6AA 5CM9A 4URYS 4US2S 3KSYA 4NYJS 1NVVS 1BKDS 1NVXS 1XD2C 4MGYE 1NVWS 4URWS 5CM8A 3CF6E 4L9MA 4MH0E 1NVUS 4NYIS 4MGKE 3QXLA 4URVS 4US0S
chains in the Genus database with same CATH superfamily
4URZS 2IJES 4JGWA 2BYVE 4F7ZA 4US1S 4MGIE 2II0A 1XD4A 4NYMS 4MGZE 3T6GA 4URXS 4URUS 3T6AA 5CM9A 4URYS 4US2S 3KSYA 4NYJS 1NVVS 1BKDS 1NVXS 1XD2C 4MGYE 1NVWS 4URWS 5CM8A 3CF6E 4L9MA 4MH0E 1NVUS 4NYIS 4MGKE 3QXLA 4URVS 4US0S
chains in the Genus database with same CATH topology
4URZS 2IJES 4JGWA 2BYVE 4F7ZA 4US1S 4MGIE 2II0A 1XD4A 4NYMS 4MGZE 3T6GA 4URXS 4URUS 3T6AA 5CM9A 4URYS 4US2S 3KSYA 4NYJS 1NVVS 1BKDS 1NVXS 1XD2C 4MGYE 1NVWS 4URWS 5CM8A 3CF6E 4L9MA 4MH0E 1NVUS 4NYIS 4MGKE 3QXLA 4URVS 4US0S
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4URZ S;  2IJE S;  4JGW A;  2BYV E;  4F7Z A;  4US1 S;  4MGI E;  2II0 A;  1XD4 A;  4NYM S;  4MGZ E;  3T6G A;  4URX S;  4URU S;  3T6A A;  5CM9 A;  4URY S;  4US2 S;  3KSY A;  4NYJ S;  1NVV S;  1BKD S;  1NVX S;  1XD2 C;  4MGY E;  1NVW S;  4URW S;  5CM8 A;  3CF6 E;  4L9M A;  4MH0 E;  1NVU S;  4NYI S;  4MGK E;  3QXL A;  4URV S;  4US0 S; 
#chains in the Genus database with same CATH topology
 4URZ S;  2IJE S;  4JGW A;  2BYV E;  4F7Z A;  4US1 S;  4MGI E;  2II0 A;  1XD4 A;  4NYM S;  4MGZ E;  3T6G A;  4URX S;  4URU S;  3T6A A;  5CM9 A;  4URY S;  4US2 S;  3KSY A;  4NYJ S;  1NVV S;  1BKD S;  1NVX S;  1XD2 C;  4MGY E;  1NVW S;  4URW S;  5CM8 A;  3CF6 E;  4L9M A;  4MH0 E;  1NVU S;  4NYI S;  4MGK E;  3QXL A;  4URV S;  4US0 S; 
#chains in the Genus database with same CATH homology
 4URZ S;  2IJE S;  4JGW A;  2BYV E;  4F7Z A;  4US1 S;  4MGI E;  2II0 A;  1XD4 A;  4NYM S;  4MGZ E;  3T6G A;  4URX S;  4URU S;  3T6A A;  5CM9 A;  4URY S;  4US2 S;  3KSY A;  4NYJ S;  1NVV S;  1BKD S;  1NVX S;  1XD2 C;  4MGY E;  1NVW S;  4URW S;  5CM8 A;  3CF6 E;  4L9M A;  4MH0 E;  1NVU S;  4NYI S;  4MGK E;  3QXL A;  4URV S;  4US0 S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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