3T6GA

Structure of the complex between nsp3 (shep1) and p130cas
Total Genus 123
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
313
structure length
299
Chain Sequence
TVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGSTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLESEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Signaling protein, cell adhesion
molecule keywords SH2 domain-containing protein 3C
total genus 123
structure length 299
sequence length 313
chains with identical sequence C
ec nomenclature
pdb deposition date 2011-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00617 RasGEF RasGEF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.840.10 Mainly Alpha Orthogonal Bundle Son of Sevenless (SoS) protein; Chain S, domain 2 Ras guanine-nucleotide exchange factors catalytic domain 3t6gA00
1XD4A 1NVWS 1BKDS 1NVXS 4F7ZA 2IJES 4US0S 2II0A 4NYJS 4NYIS 4URXS 3T6GA 3QXLA 1XD2C 4MGZE 4URYS 4URZS 4NYMS 2BYVE 4MH0E 3KSYA 4URWS 4URVS 4US1S 5CM8A 1NVVS 3CF6E 4MGYE 4URUS 1NVUS 5CM9A 4JGWA 4MGIE 4L9MA 4MGKE 4US2S 3T6AA
chains in the Genus database with same CATH superfamily
1XD4A 1NVWS 1BKDS 1NVXS 4F7ZA 2IJES 4US0S 2II0A 4NYJS 4NYIS 4URXS 3T6GA 3QXLA 1XD2C 4MGZE 4URYS 4URZS 4NYMS 2BYVE 4MH0E 3KSYA 4URWS 4URVS 4US1S 5CM8A 1NVVS 3CF6E 4MGYE 4URUS 1NVUS 5CM9A 4JGWA 4MGIE 4L9MA 4MGKE 4US2S 3T6AA
chains in the Genus database with same CATH topology
1XD4A 1NVWS 1BKDS 1NVXS 4F7ZA 2IJES 4US0S 2II0A 4NYJS 4NYIS 4URXS 3T6GA 3QXLA 1XD2C 4MGZE 4URYS 4URZS 4NYMS 2BYVE 4MH0E 3KSYA 4URWS 4URVS 4US1S 5CM8A 1NVVS 3CF6E 4MGYE 4URUS 1NVUS 5CM9A 4JGWA 4MGIE 4L9MA 4MGKE 4US2S 3T6AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XD4 A;  1NVW S;  1BKD S;  1NVX S;  4F7Z A;  2IJE S;  4US0 S;  2II0 A;  4NYJ S;  4NYI S;  4URX S;  3T6G A;  3QXL A;  1XD2 C;  4MGZ E;  4URY S;  4URZ S;  4NYM S;  2BYV E;  4MH0 E;  3KSY A;  4URW S;  4URV S;  4US1 S;  5CM8 A;  1NVV S;  3CF6 E;  4MGY E;  4URU S;  1NVU S;  5CM9 A;  4JGW A;  4MGI E;  4L9M A;  4MGK E;  4US2 S;  3T6A A; 
#chains in the Genus database with same CATH topology
 1XD4 A;  1NVW S;  1BKD S;  1NVX S;  4F7Z A;  2IJE S;  4US0 S;  2II0 A;  4NYJ S;  4NYI S;  4URX S;  3T6G A;  3QXL A;  1XD2 C;  4MGZ E;  4URY S;  4URZ S;  4NYM S;  2BYV E;  4MH0 E;  3KSY A;  4URW S;  4URV S;  4US1 S;  5CM8 A;  1NVV S;  3CF6 E;  4MGY E;  4URU S;  1NVU S;  5CM9 A;  4JGW A;  4MGI E;  4L9M A;  4MGK E;  4US2 S;  3T6A A; 
#chains in the Genus database with same CATH homology
 1XD4 A;  1NVW S;  1BKD S;  1NVX S;  4F7Z A;  2IJE S;  4US0 S;  2II0 A;  4NYJ S;  4NYI S;  4URX S;  3T6G A;  3QXL A;  1XD2 C;  4MGZ E;  4URY S;  4URZ S;  4NYM S;  2BYV E;  4MH0 E;  3KSY A;  4URW S;  4URV S;  4US1 S;  5CM8 A;  1NVV S;  3CF6 E;  4MGY E;  4URU S;  1NVU S;  5CM9 A;  4JGW A;  4MGI E;  4L9M A;  4MGK E;  4US2 S;  3T6A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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