3TPII

The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors
Total Genus 13
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords TRYPSINOGEN
publication title The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors
pubmed rcsb
total genus 13
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 1982-09-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 3tpiI00
2KAII 5JB4A 3BTWI 1DTXA 1LD6A 3AUCA 1BRCI 1IRHA 3TPII 2UUXA 4ISLB 3OTJI 1EAWB 6PTIA 3CI7A 1G6XA 3AUBA 3BTDI 1YKTB 1BHCA 3LDJA 5C67C 3P92E 4U32X 2M01A 3BTFI 2PTCI 3M7QB 2ZJXA 1T8LB 4BNRI 1P2OB 1TCPA 3FP8I 5JB6A 3P95E 1D0DB 1P2JI 1BPIA 1DEMA 1EJMB 1P2QB 1AAPA 4NTXB 8PTIA 1DTKA 2IJOI 1BTHP 4BD9B 1ZR0B 1Y62A 1MTND 2RA3C 1JV9A 2FI4I 1LD5A 1FY8I 1OA55 1SHPA 3BTKI 4NTWB 2FTLI 4NTYB 1KTHA 2TPII 3LDIA 2LFKA 1T7CB 1JV8A 3GYMI 3UOUB 3AUDA 1T8MB 4ISNB 1DENA 1D0DA 1BZXI 2FI3I 3BTGI 1TAPA 3L3TE 1BPTA 3LDMA 4U30W 1K6UA 2FI5I 1TPAI 4Y10I 2ZVXA 2DDIA 3AUEA 2HEXA 1ZJDB 2J6DA 3BTMI 9PTIA 1P2NB 1NAGA 3T62D 1CBWD 3L33E 2CA7A 1B0CA 1QLQA 3FP7J 2R9PE 3D65I 2TGPI 3BTEI 4TPII 2UUYB 1BRBI 1TAWB 4WXVC 1YC0I 2W8XA 3BTQI 1OA65 1KIGI 2ODYE 4BQDA 1BUNB 1FAKI 4ISOB 3AUHA 1YLCB 3BTTI 5PTIA 1F5RI 1ADZA 1F7ZI 5JB7A 1TOCR 3BTHI 3BYBA 1KNTA 4Y11I 4Y0ZI 1UUBA 3TGJI 3TGKI 1P2II 4WWYC 1KUNA 1T8NB 5JB5A 1P2MB 1BF0A 2JOTA 4PTIA 1AALA 1CA0D 1P2KI 1PITA 3OFWA 3AUGA 2LFLA 3U1JE 2DDJA 3AUIA 7PTIA 1CO7I 1TFXC 2KNTA 1JC6A 2FTMB 4DG4C 1BZ5A 2M99A 1BIKA 1BTIA 4DTGK 3TGII 1UUAA 3FP6I 4Y0YI 2KCRA 3WNYA 3UIRC 1YLDB 1FANA 1T8OB
chains in the Genus database with same CATH superfamily
2KAII 5JB4A 3BTWI 1DTXA 1LD6A 3AUCA 1BRCI 1IRHA 3TPII 2UUXA 4ISLB 3OTJI 1EAWB 6PTIA 3CI7A 1G6XA 3AUBA 3BTDI 1YKTB 1BHCA 3LDJA 5C67C 3P92E 4U32X 2M01A 3BTFI 2PTCI 3M7QB 2ZJXA 1T8LB 4BNRI 1P2OB 1TCPA 3FP8I 5JB6A 3P95E 1D0DB 1P2JI 1BPIA 1DEMA 1EJMB 1P2QB 1AAPA 4NTXB 8PTIA 1DTKA 2IJOI 1BTHP 4BD9B 1ZR0B 1Y62A 1MTND 2RA3C 1JV9A 2FI4I 1LD5A 1FY8I 1OA55 1SHPA 3BTKI 4NTWB 2FTLI 4NTYB 1KTHA 2TPII 3LDIA 2LFKA 1T7CB 1JV8A 3GYMI 3UOUB 3AUDA 1T8MB 4ISNB 1DENA 1D0DA 1BZXI 2FI3I 3BTGI 1TAPA 3L3TE 1BPTA 3LDMA 4U30W 1K6UA 2FI5I 1TPAI 4Y10I 2ZVXA 2DDIA 3AUEA 2HEXA 1ZJDB 2J6DA 3BTMI 9PTIA 1P2NB 1NAGA 3T62D 1CBWD 3L33E 2CA7A 1B0CA 1QLQA 3FP7J 2R9PE 3D65I 2TGPI 3BTEI 4TPII 2UUYB 1BRBI 1TAWB 4WXVC 1YC0I 2W8XA 3BTQI 1OA65 1KIGI 2ODYE 4BQDA 1BUNB 1FAKI 4ISOB 3AUHA 1YLCB 3BTTI 5PTIA 1F5RI 1ADZA 1F7ZI 5JB7A 1TOCR 3BTHI 3BYBA 1KNTA 4Y11I 4Y0ZI 1UUBA 3TGJI 3TGKI 1P2II 4WWYC 1KUNA 1T8NB 5JB5A 1P2MB 1BF0A 2JOTA 4PTIA 1AALA 1CA0D 1P2KI 1PITA 3OFWA 3AUGA 2LFLA 3U1JE 2DDJA 3AUIA 7PTIA 1CO7I 1TFXC 2KNTA 1JC6A 2FTMB 4DG4C 1BZ5A 2M99A 1BIKA 1BTIA 4DTGK 3TGII 1UUAA 3FP6I 4Y0YI 2KCRA 3WNYA 3UIRC 1YLDB 1FANA 1T8OB
chains in the Genus database with same CATH topology
2KAII 5JB4A 3BTWI 1DTXA 1LD6A 3AUCA 1BRCI 1IRHA 3TPII 2UUXA 4ISLB 3OTJI 1EAWB 6PTIA 3CI7A 1G6XA 3AUBA 3BTDI 1YKTB 1BHCA 3LDJA 5C67C 3P92E 4U32X 2M01A 3BTFI 2PTCI 3M7QB 2ZJXA 1T8LB 4BNRI 1P2OB 1TCPA 3FP8I 5JB6A 3P95E 1D0DB 1P2JI 1BPIA 1DEMA 1EJMB 1P2QB 1AAPA 4NTXB 8PTIA 1DTKA 2IJOI 1BTHP 4BD9B 1ZR0B 1Y62A 1MTND 2RA3C 1JV9A 2FI4I 1LD5A 1FY8I 1OA55 1SHPA 3BTKI 4NTWB 2FTLI 4NTYB 1KTHA 2TPII 3LDIA 2LFKA 1T7CB 1JV8A 3GYMI 3UOUB 3AUDA 1T8MB 4ISNB 1DENA 1D0DA 1BZXI 2FI3I 3BTGI 1TAPA 3L3TE 1BPTA 3LDMA 4U30W 1K6UA 2FI5I 1TPAI 4Y10I 2ZVXA 2DDIA 3AUEA 2HEXA 1ZJDB 2J6DA 3BTMI 9PTIA 1P2NB 1NAGA 3T62D 1CBWD 3L33E 2CA7A 1B0CA 1QLQA 3FP7J 2R9PE 3D65I 2TGPI 3BTEI 4TPII 2UUYB 1BRBI 1TAWB 4WXVC 1YC0I 2W8XA 3BTQI 1OA65 1KIGI 2ODYE 4BQDA 1BUNB 1FAKI 4ISOB 3AUHA 1YLCB 3BTTI 5PTIA 1F5RI 1ADZA 1F7ZI 5JB7A 1TOCR 3BTHI 3BYBA 1KNTA 4Y11I 4Y0ZI 1UUBA 3TGJI 3TGKI 1P2II 4WWYC 1KUNA 1T8NB 5JB5A 1P2MB 1BF0A 2JOTA 4PTIA 1AALA 1CA0D 1P2KI 1PITA 3OFWA 3AUGA 2LFLA 3U1JE 2DDJA 3AUIA 7PTIA 1CO7I 1TFXC 2KNTA 1JC6A 2FTMB 4DG4C 1BZ5A 2M99A 1BIKA 1BTIA 4DTGK 3TGII 1UUAA 3FP6I 4Y0YI 2KCRA 3WNYA 3UIRC 1YLDB 1FANA 1T8OB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KAI I;  5JB4 A;  3BTW I;  1DTX A;  1LD6 A;  3AUC A;  1BRC I;  1IRH A;  3TPI I;  2UUX A;  4ISL B;  3OTJ I;  1EAW B;  6PTI A;  3CI7 A;  1G6X A;  3AUB A;  3BTD I;  1YKT B;  1BHC A;  3LDJ A;  5C67 C;  3P92 E;  4U32 X;  2M01 A;  3BTF I;  2PTC I;  3M7Q B;  2ZJX A;  1T8L B;  4BNR I;  1P2O B;  1TCP A;  3FP8 I;  5JB6 A;  3P95 E;  1D0D B;  1P2J I;  1BPI A;  1DEM A;  1EJM B;  1P2Q B;  1AAP A;  4NTX B;  8PTI A;  1DTK A;  2IJO I;  1BTH P;  4BD9 B;  1ZR0 B;  1Y62 A;  1MTN D;  2RA3 C;  1JV9 A;  2FI4 I;  1LD5 A;  1FY8 I;  1OA5 5;  1SHP A;  3BTK I;  4NTW B;  2FTL I;  4NTY B;  1KTH A;  2TPI I;  3LDI A;  2LFK A;  1T7C B;  1JV8 A;  3GYM I;  3UOU B;  3AUD A;  1T8M B;  4ISN B;  1DEN A;  1D0D A;  1BZX I;  2FI3 I;  3BTG I;  1TAP A;  3L3T E;  1BPT A;  3LDM A;  4U30 W;  1K6U A;  2FI5 I;  1TPA I;  4Y10 I;  2ZVX A;  2DDI A;  3AUE A;  2HEX A;  1ZJD B;  2J6D A;  3BTM I;  9PTI A;  1P2N B;  1NAG A;  3T62 D;  1CBW D;  3L33 E;  2CA7 A;  1B0C A;  1QLQ A;  3FP7 J;  2R9P E;  3D65 I;  2TGP I;  3BTE I;  4TPI I;  2UUY B;  1BRB I;  1TAW B;  4WXV C;  1YC0 I;  2W8X A;  3BTQ I;  1OA6 5;  1KIG I;  2ODY E;  4BQD A;  1BUN B;  1FAK I;  4ISO B;  3AUH A;  1YLC B;  3BTT I;  5PTI A;  1F5R I;  1ADZ A;  1F7Z I;  5JB7 A;  1TOC R;  3BTH I;  3BYB A;  1KNT A;  4Y11 I;  4Y0Z I;  1UUB A;  3TGJ I;  3TGK I;  1P2I I;  4WWY C;  1KUN A;  1T8N B;  5JB5 A;  1P2M B;  1BF0 A;  2JOT A;  4PTI A;  1AAL A;  1CA0 D;  1P2K I;  1PIT A;  3OFW A;  3AUG A;  2LFL A;  3U1J E;  2DDJ A;  3AUI A;  7PTI A;  1CO7 I;  1TFX C;  2KNT A;  1JC6 A;  2FTM B;  4DG4 C;  1BZ5 A;  2M99 A;  1BIK A;  1BTI A;  4DTG K;  3TGI I;  1UUA A;  3FP6 I;  4Y0Y I;  2KCR A;  3WNY A;  3UIR C;  1YLD B;  1FAN A;  1T8O B; 
#chains in the Genus database with same CATH topology
 2KAI I;  5JB4 A;  3BTW I;  1DTX A;  1LD6 A;  3AUC A;  1BRC I;  1IRH A;  3TPI I;  2UUX A;  4ISL B;  3OTJ I;  1EAW B;  6PTI A;  3CI7 A;  1G6X A;  3AUB A;  3BTD I;  1YKT B;  1BHC A;  3LDJ A;  5C67 C;  3P92 E;  4U32 X;  2M01 A;  3BTF I;  2PTC I;  3M7Q B;  2ZJX A;  1T8L B;  4BNR I;  1P2O B;  1TCP A;  3FP8 I;  5JB6 A;  3P95 E;  1D0D B;  1P2J I;  1BPI A;  1DEM A;  1EJM B;  1P2Q B;  1AAP A;  4NTX B;  8PTI A;  1DTK A;  2IJO I;  1BTH P;  4BD9 B;  1ZR0 B;  1Y62 A;  1MTN D;  2RA3 C;  1JV9 A;  2FI4 I;  1LD5 A;  1FY8 I;  1OA5 5;  1SHP A;  3BTK I;  4NTW B;  2FTL I;  4NTY B;  1KTH A;  2TPI I;  3LDI A;  2LFK A;  1T7C B;  1JV8 A;  3GYM I;  3UOU B;  3AUD A;  1T8M B;  4ISN B;  1DEN A;  1D0D A;  1BZX I;  2FI3 I;  3BTG I;  1TAP A;  3L3T E;  1BPT A;  3LDM A;  4U30 W;  1K6U A;  2FI5 I;  1TPA I;  4Y10 I;  2ZVX A;  2DDI A;  3AUE A;  2HEX A;  1ZJD B;  2J6D A;  3BTM I;  9PTI A;  1P2N B;  1NAG A;  3T62 D;  1CBW D;  3L33 E;  2CA7 A;  1B0C A;  1QLQ A;  3FP7 J;  2R9P E;  3D65 I;  2TGP I;  3BTE I;  4TPI I;  2UUY B;  1BRB I;  1TAW B;  4WXV C;  1YC0 I;  2W8X A;  3BTQ I;  1OA6 5;  1KIG I;  2ODY E;  4BQD A;  1BUN B;  1FAK I;  4ISO B;  3AUH A;  1YLC B;  3BTT I;  5PTI A;  1F5R I;  1ADZ A;  1F7Z I;  5JB7 A;  1TOC R;  3BTH I;  3BYB A;  1KNT A;  4Y11 I;  4Y0Z I;  1UUB A;  3TGJ I;  3TGK I;  1P2I I;  4WWY C;  1KUN A;  1T8N B;  5JB5 A;  1P2M B;  1BF0 A;  2JOT A;  4PTI A;  1AAL A;  1CA0 D;  1P2K I;  1PIT A;  3OFW A;  3AUG A;  2LFL A;  3U1J E;  2DDJ A;  3AUI A;  7PTI A;  1CO7 I;  1TFX C;  2KNT A;  1JC6 A;  2FTM B;  4DG4 C;  1BZ5 A;  2M99 A;  1BIK A;  1BTI A;  4DTG K;  3TGI I;  1UUA A;  3FP6 I;  4Y0Y I;  2KCR A;  3WNY A;  3UIR C;  1YLD B;  1FAN A;  1T8O B; 
#chains in the Genus database with same CATH homology
 2KAI I;  5JB4 A;  3BTW I;  1DTX A;  1LD6 A;  3AUC A;  1BRC I;  1IRH A;  3TPI I;  2UUX A;  4ISL B;  3OTJ I;  1EAW B;  6PTI A;  3CI7 A;  1G6X A;  3AUB A;  3BTD I;  1YKT B;  1BHC A;  3LDJ A;  5C67 C;  3P92 E;  4U32 X;  2M01 A;  3BTF I;  2PTC I;  3M7Q B;  2ZJX A;  1T8L B;  4BNR I;  1P2O B;  1TCP A;  3FP8 I;  5JB6 A;  3P95 E;  1D0D B;  1P2J I;  1BPI A;  1DEM A;  1EJM B;  1P2Q B;  1AAP A;  4NTX B;  8PTI A;  1DTK A;  2IJO I;  1BTH P;  4BD9 B;  1ZR0 B;  1Y62 A;  1MTN D;  2RA3 C;  1JV9 A;  2FI4 I;  1LD5 A;  1FY8 I;  1OA5 5;  1SHP A;  3BTK I;  4NTW B;  2FTL I;  4NTY B;  1KTH A;  2TPI I;  3LDI A;  2LFK A;  1T7C B;  1JV8 A;  3GYM I;  3UOU B;  3AUD A;  1T8M B;  4ISN B;  1DEN A;  1D0D A;  1BZX I;  2FI3 I;  3BTG I;  1TAP A;  3L3T E;  1BPT A;  3LDM A;  4U30 W;  1K6U A;  2FI5 I;  1TPA I;  4Y10 I;  2ZVX A;  2DDI A;  3AUE A;  2HEX A;  1ZJD B;  2J6D A;  3BTM I;  9PTI A;  1P2N B;  1NAG A;  3T62 D;  1CBW D;  3L33 E;  2CA7 A;  1B0C A;  1QLQ A;  3FP7 J;  2R9P E;  3D65 I;  2TGP I;  3BTE I;  4TPI I;  2UUY B;  1BRB I;  1TAW B;  4WXV C;  1YC0 I;  2W8X A;  3BTQ I;  1OA6 5;  1KIG I;  2ODY E;  4BQD A;  1BUN B;  1FAK I;  4ISO B;  3AUH A;  1YLC B;  3BTT I;  5PTI A;  1F5R I;  1ADZ A;  1F7Z I;  5JB7 A;  1TOC R;  3BTH I;  3BYB A;  1KNT A;  4Y11 I;  4Y0Z I;  1UUB A;  3TGJ I;  3TGK I;  1P2I I;  4WWY C;  1KUN A;  1T8N B;  5JB5 A;  1P2M B;  1BF0 A;  2JOT A;  4PTI A;  1AAL A;  1CA0 D;  1P2K I;  1PIT A;  3OFW A;  3AUG A;  2LFL A;  3U1J E;  2DDJ A;  3AUI A;  7PTI A;  1CO7 I;  1TFX C;  2KNT A;  1JC6 A;  2FTM B;  4DG4 C;  1BZ5 A;  2M99 A;  1BIK A;  1BTI A;  4DTG K;  3TGI I;  1UUA A;  3FP6 I;  4Y0Y I;  2KCR A;  3WNY A;  3UIR C;  1YLD B;  1FAN A;  1T8O B; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...