The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
89
|
sequence length |
299
|
structure length |
299
|
Chain Sequence |
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Potent inhibitors of LpxC for the treatment of Gram-negative infections.
pubmed doi rcsb |
| molecule keywords |
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
|
| source organism |
Pseudomonas aeruginosa
|
| molecule tags |
Hydrolase/hydrolase inhibitor
|
| total genus |
89
|
| structure length |
299
|
| sequence length |
299
|
| chains with identical sequence |
B
|
| ec nomenclature |
ec
3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase. |
| pdb deposition date | 2011-09-30 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF03331 | LpxC | UDP-3-O-acyl N-acetylglycosamine deacetylase |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 2-Layer Sandwich | Ribosomal Protein S5; domain 2 | lpxc deacetylase, domain 1 | ||
| Alpha Beta | 2-Layer Sandwich | lpxc deacetylase, domain 1 | lpxc deacetylase, domain 2 |
#chains in the Genus database with same CATH superfamily 5DRP A; 1YH8 A; 2IES A; 3PS2 A; 4MQY A; 4U3D A; 4IS9 A; 4FW7 A; 4FW5 A; 4OKG A; 3P3G A; 2VES A; 4U3B A; 5DRQ A; 5DRO A; 4FW4 A; 3UHM A; 3PS1 A; 3P76 A; 2J65 A; 4MDT A; 4J3D A; 2GO4 A; 3P3C A; 1P42 A; 3NZK A; 5DRR A; 4LCF A; 4FW6 A; 2IER A; 1XXE A; 4OZE A; 2GO3 A; 4ISA A; 4LCG A; 3U1Y A; 4FW3 A; 4LCH A; 2O3Z A; 3P3E A; 3PS3 A; 2JT2 A; 1YHC A; #chains in the Genus database with same CATH topology 2HKE A; 3J7A M; 1Y6Z A; 3K17 A; 2HHH I; 3J80 Q; 2IES A; 2ZIT A; 4KHP E; 2CVE A; 4LF4 E; 4OO1 F; 1Y60 A; 1ZM9 A; 2J65 A; 2V2Q A; 2BM0 A; 4DPX A; 4KHP I; 4DPY A; 2JE6 A; 4JV5 E; 2UU9 E; 4IZK B; 2LJP A; 3HUL A; 4R1F A; 1DAR A; 4DV0 E; 4NXN E; 3T1Y I; 5GME A; 5JEA D; 4DPW A; 2XEX A; 1KIJ A; 4FW7 A; 2UXD I; 4X64 I; 2C38 B; 4DV6 E; 2VQE E; 4JV5 I; 3M85 D; 1RR9 A; 1VI7 A; 1OYR A; 2UUA E; 1N32 E; 1WUU A; 2O1V A; 4AQY E; 2BA1 D; 1XMO I; 2ZBK B; 4FW6 A; 2R3V A; 3GLL A; 2Z5C B; 1I94 E; 3ZKD A; 2F1D A; 4WUB A; 1XHK A; 3ZZ0 A; 3HKM A; 1YH8 A; 4AQY I; 4IS9 A; 1OYP A; 4NBQ A; 1Z0W A; 4LF8 E; 4YHH E; 1ZM2 A; 4FWG A; 4HAC A; 5FLX C; 2WP8 A; 4IFD F; 5IWA I; 3K1J A; 3Q6M A; 1N33 I; 3LPS A; 4ZVI A; 5EL9 A; 2V34 A; 2EFG A; 4OX9 I; 1P42 A; 3CDJ A; 1N36 E; 4BA2 B; 1ZM3 A; 5BR8 I; 2DEI A; 3H4L A; 3P06 A; 1N34 I; 4LCG A; 2PNZ B; 3M6A A; 2WNR A; 4DR2 I; 4FW4 A; 3UHM A; 2UUC E; 4JI4 E; 4U3D A; 4KQV A; 4K0K E; 1Z5B A; 1N36 I; 2CG9 A; 4FWH A; 4LF5 E; 4DUZ E; 4AM3 A; 1E3P A; 1FWK A; 4LF6 E; 5DRO A; 2PO2 A; 5A2Q Q; 2IOP A; 2J7K A; 4JI2 E; 5C0X E; 4JI4 I; 4DV7 E; 4AIM A; 2Q2E B; 5DRR A; 4UT4 A; 3NZK A; 2PO1 A; 1ZXN A; 4LF5 I; 3QT6 A; 4ISA A; 4LF6 I; 2JT2 A; 4DV1 I; 4HXZ A; 2JEA A; 3PYF A; 5K36 F; 1UDS A; 4X62 I; 4GKK I; 1ELO A; 2NN6 C; 1IBK E; 1VIS A; 4DR6 E; 4GKJ E; 1J5E E; 1H72 C; 4BA1 A; 2F4V I; 1HK7 A; 2PO0 A; 2HFS A; 4QNK A; 4DV3 I; 1IBM I; 4USK A; 2UXC I; 1ZXM A; 4DR3 I; 2BR2 A; 5GMD A; 4DR5 I; 2O1T A; 2GO4 A; 2HKJ A; 2HHH E; 3F0N A; 2V2Z A; 2IER A; 4DR6 I; 4GKJ I; 1H73 A; 4B3S I; 5JEA C; 4OO1 A; 1XMQ I; 2UXB E; 4HY1 A; 5JEA E; 3GCM A; 4JI8 I; 3B82 A; 1MX0 A; 1XNR I; 3H1C A; 3J80 C; 4JI6 E; 4DR4 I; 2C39 B; 1E3H A; 2R42 A; 2NN6 D; 4LFB E; 1MG7 A; 4WUD A; 2Z5B A; 2UXB I; 3T1Y E; 4MDT A; 4B3M E; 1Z0T A; 2CGE A; 4IZJ A; 2UXD E; 3QT5 A; 4X64 E; 4JI6 I; 3JAM Q; 2NN6 B; 4URL A; 2JEB A; 1HNW I; 4LFA I; 2PNL A; 4LFB I; 3PS3 A; 4Z7Y A; 4DV2 I; 3WU6 A; 4B3M I; 2VF3 A; 4MQY A; 1XMO E; 4NXM I; 2DEJ A; 4XTJ A; 4DR1 I; 1Z0V A; 1UDQ A; 5LMU I; 4LOM A; 1B63 A; 1S16 A; 3CWV A; 5JEA B; 2C37 B; 1Z0C A; 4DU8 A; 4OO1 D; 1Z5A A; 3OTO E; 4DUY I; 4IFD A; 5ELW A; 2BR2 B; 5IWA E; 3T1H I; 5DNX A; 1N33 E; 3PYD A; 3PS2 A; 4B3T E; 4OX9 E; 1Z0B A; 3L7Z B; 4MU4 A; 3OTO I; 4DXL A; 5BR8 E; 1N34 E; 5DRQ A; 2BM1 A; 1Z0G A; 4FW9 A; 1HNZ I; 4IFD C; 3PS1 A; 1RRE A; 4DR2 E; 4IZJ D; 4X66 E; 2AJ4 A; 2NPF A; 1HR0 I; 4DU7 A; 3PYG A; 2BA0 D; 4ED4 A; 4B3T I; 2Z5B B; 2HK3 A; 1XNQ I; 3U1Y A; 4LF9 I; 1USU A; 4JI1 I; 2JE6 B; 3B8H A; 4DPT A; 1OJ4 A; 4X66 I; 4OKG A; 3WU4 A; 4MYU A; 3ZKB A; 4JG4 A; 3D4J A; 5A2Q C; 4DV1 E; 1PKP A; 1HNX I; 5K36 A; 5C0X A; 2ZM6 I; 1FKA E; 4X62 E; 3WU3 A; 1QZR A; 4GKK E; 5DNL A; 4IFD D; 4LCF A; 2O1W A; 2V8P A; 4MU3 A; 2F4V E; 1OYS A; 1D6T A; 4USM A; 4DV3 E; 3WU5 A; 1IBM E; 2UXC E; 4DR3 E; 1RHY A; 4N3O A; 4DR5 E; 2X7I A; 4IFD B; 2X36 A; 5C0X F; 4DV4 I; 4LFC I; 4M1K A; 4JI7 E; 2NN6 E; 5LMN E; 4B3S E; 4MU1 A; 2E1R A; 4B3R I; 1N0V C; 1XMQ E; 4JI3 E; 4IZK A; 1USV A; 2BV3 A; 4YY3 I; 2V2V A; 5IT9 Q; 4JI8 E; 3PYE A; 1XNR E; 4HAC B; 3V5R A; 2WP8 B; 1UDO A; 4DR4 E; 2PNM A; 1S4E A; 2UUB E; 4JI7 I; 4LCH A; 1ZM4 A; 5LMN I; 1FJG I; 3J81 Q; 4LF7 I; 2VQF I; 3QT8 A; 5L3J A; 3B78 A; 4JI3 I; 4FWD A; 5FWK A; 4FW5 A; 4WUC A; 3P3G A; 2WNR B; 4MU0 A; 2UUB I; 1HNW E; 4JI5 I; 4LFA E; 5K36 D; 4EMD A; 2AE8 A; 4DV2 E; 2Z5C A; 4OO1 C; 4DR7 I; 1N0U A; 5JEA F; 4NXM E; 3K85 A; 4OO1 E; 2PO2 B; 1Z59 A; 4DR1 E; 4DV5 I; 1R6L A; 3JAM C; 5LMU E; 3V2U C; 4X65 I; 5DRP A; 3CDI A; 2PO1 B; 1H7U A; 4DUY E; 2JEA B; 4BA2 A; 4PRV A; 3B4T A; 3T1H E; 2PNZ A; 4J3D A; 4FN5 A; 4MYT A; 4BA1 B; 2PO0 B; 3LTO A; 4LF4 I; 4FW3 A; 2O3Z A; 4QNJ A; 3J7A G; 3M7N G; 1YHC A; 1HNZ E; 4JYA E; 2Z5E A; 5EKW A; 1HR0 E; 4OO1 B; 2UU9 I; 5LL6 R; 4DPU A; 1NHJ A; 1R6M A; 1XNQ E; 2A2D A; 1PVG A; 4LF9 E; 1H74 A; 1KKH A; 4DV0 I; 4NXN I; 4JI1 E; 1UDN A; 1Z0E A; 3U1K A; 3GME A; 4JYA I; 3ZM7 A; 4DV6 I; 2VQE I; 4IFD E; 4AID A; 2OI2 A; 2HFU A; 3Q1Q A; 1PIE A; 2UUA I; 1N32 I; 4UTG A; 1NHH A; 1K47 A; 4IZJ B; 3KRN A; 1FI4 A; 1HNX E; 2ZM6 E; 1KTV A; 2JEB B; 4RPF A; 5FLX Q; 2VES A; 3ZZT A; 1I94 I; 1FWL A; 1BKN A; 3GON A; 1NZ0 A; 1H7S A; 2CZ9 A; 1MU5 A; 1Y4U A; 2GQ0 A; 3P3C A; 4LF8 I; 4YHH I; 4DV4 E; 3QT7 A; 4LFC E; 2GO3 A; 2WW4 A; 2C39 A; 4B3R E; 2E5L E; 2IOQ A; 4YY3 E; 4JI0 E; 5K36 C; 1U2R A; 3HJC A; 2GS8 A; 5C0X C; 3M85 G; 5K36 E; 1FJG E; 2NN6 A; 2UUC I; 2VQF E; 4LF7 E; 2E5L I; 4I3H A; 1B62 A; 4P7A A; 2BA1 G; 5IT9 C; 3PRY A; 4K0K I; 2O1U A; 4JI0 I; 1FNM A; 1UEK A; 1XXE A; 4OZE A; 4P52 A; 4DUZ I; 1A6F A; 1IBL E; 3P3E A; 1EA6 A; 2C38 A; 4JI5 E; 3M7N D; 4JI2 I; 1NHI A; 4PRX A; 3J81 C; 3DD6 A; 4HYM A; 2NN6 F; 1EI1 A; 4DV7 I; 3ZZU A; 4DR7 E; 5JEA A; 4PU9 A; 2C37 A; 3LNU A; 4DV5 E; 2A2C A; 2HK2 A; 1Z5C A; 4U3B A; 1IBL I; 3Q6N A; 3P76 A; 4X65 E; 5C0X D; 4GQU A; 4Z7C A; 1IBK I; 2BA0 G; 1J5E I; 1Y4S A; 1Y5Y A; 1KVK A; 3L7Z A; 5K36 B; 5C0X B; 4LPF A; #chains in the Genus database with same CATH homology 5DRP A; 1YH8 A; 2IES A; 3PS2 A; 4MQY A; 4U3D A; 4IS9 A; 4FW7 A; 4FW5 A; 4OKG A; 3P3G A; 2VES A; 4U3B A; 5DRQ A; 5DRO A; 4FW4 A; 3UHM A; 3PS1 A; 3P76 A; 2J65 A; 4MDT A; 4J3D A; 2GO4 A; 3P3C A; 1P42 A; 3NZK A; 5DRR A; 4LCF A; 4FW6 A; 2IER A; 1XXE A; 4OZE A; 2GO3 A; 4ISA A; 4LCG A; 3U1Y A; 4FW3 A; 4LCH A; 2O3Z A; 3P3E A; 3PS3 A; 2JT2 A; 1YHC A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
