3UEJA

Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase cdelta
Total Genus 10
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
65
structure length
65
Chain Sequence
GSRRASVGSHRFKVYNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCEFIVTD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural and Functional Characterization of an Anesthetic Binding Site in the Second Cysteine-Rich Domain of Protein Kinase Cdelta
pubmed doi rcsb
molecule keywords Protein kinase C delta type
molecule tags Metal binding protein
source organism Mus musculus
total genus 10
structure length 65
sequence length 65
chains with identical sequence B
ec nomenclature ec 2.7.10.2: Non-specific protein-tyrosine kinase.
pdb deposition date 2011-10-30
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.60.20 Alpha Beta 2-Layer Sandwich Wheat Germ Agglutinin (Isolectin 2); domain 1 Wheat Germ Agglutinin (Isolectin 2); domain 1 3uejA01
1TBOA 4UXJA 2DB6A 2ENNA 4UXHA 3UEJA 2GVIA 3UGLA 4FKDA 1TBNA 2J87A 1PTRA 2QQEA 1KBEA 2E73A 4L9MA 2QPOA 5FUVA 3UEYA 2YUUA 2ORVA 3UFFA 2UZ3A 1W4RA 2ORWA 2B8TA 1R79A 1XA6A 2FNFX 3KY9A 5FUWA 1RFHA 4B6DA 3UGDA 1KBFA 1FARA 1PTQA 2ENZA 5FUXA 5FUYA 2J9RA 2VRWB 4UXIA 1FAQA 3UGIA 3CXLA 1XBTA 2QQ0A 2ROWA 1XX6A 2ELIA 2WVJA 3BJIA 1Y8FA 3E2IA 2JA1A
chains in the Genus database with same CATH superfamily
2NU1I 2KMPA 1OMUA 3SGQI 4AMLA 4UXHA 2GKTI 2YQPA 2GVIA 3SEKC 2J87A 3OL0A 3D00A 2JYYA 2E73A 4L9MA 1TGSI 2QPOA 2W0TA 1SGPI 1ULNA 3GOXA 1MJ9A 2NU2I 2L8EA 3TOAA 5CCLA 2ORWA 5JHWC 3KY9A 2FNFX 1IW4A 1WGCA 3SGBI 1KBFA 3MEKA 3OXGA 1KMAA 3RU0A 1K7UA 2OU2A 4UXIA 5HQ8A 1H0ZA 1V1HA 2F3CI 1P9GA 1P9ZA 3TJQA 1Y8FA 1K7VA 2JA1A 3B4VC 1PJUA 5DAEA 2P6AC 1DS2I 1LR9A 1TIHA 1UUCA 2QQCA 1S20A 5HI7A 2RC4A 1Z2IA 1TUSA 4E1RA 1SGYI 2V53A 1CE3A 2CWGA 1SGDI 1TOTA 2SGQI 1N13A 1K7TA 2NU3I 2CWHA 2RIJA 1TURA 1Z7KB 2SGPI 2N52A 4E1PA 2LUYA 1CT0I 1W3SA 2GKRI 5E3QA 1R79A 1TBQR 2M5XA 1R0RI 2Y0MA 3FC3A 3OXLA 2L7XA 1FARA 7WGAA 5FUYA 3TOBA 1LR7A 2VRWB 1FAQA 1Y1BA 2LB7A 2ERWA 2SGFI 1YTPA 2ELIA 2WVJA 3TO9A 1HJAI 3E59A 1OMTA 3E2IA 3UEJA 1VDDA 4GI3C 2ARPF 3VDPA 4DNCA 1CT2I 5E3PA 3QWPA 1BUSA 1M8BA 2E5RA 2ENNA 1MT1A 5J8CA 2N17A 2V1CA 3VDUA 1IY5A 3PDNA 1PTRA 2QQEA 3UOEA 1AN1I 1FYBA 1KBEA 2BUSA 3OVOA 1CT4I 5FUVA 1U5KA 2YUUA 2N71A 2KCXA 2OD1A 1WGTA 1HDLA 1CGJI 1NUBA 1FY7A 1UVFA 1W4RA 2B8TA 1XA6A 2LEOA 2X52A 3R5AA 5FUWA 1OVOA 1X4SA 1NXUA 2JZMA 5E3RA 3UGDA 2KMRA 1DS3I 1V1IA 2DIPA 3OXFA 2GKVA 5FUXA 2GIVA 3FSXA 3UGIA 1LR8A 5J8FA 1IY6A 1HEVA 1MJBA 1UVGA 3QTLD 1XX6A 2KMOA 2QQDA 1OYVI 5CCMA 1PCEA 1TBRR 1ULKA 2SGDI 1TBOA 2A20A 1BMOA 2WCYA 4UXJA 1CSOI 2DB6A 9WGAA 2SGEI 2X3TA 1PPFI 4WP4A 3UGLA 2KMQA 1TBNA 2NU0I 1MJAA 3R5BA 4FKDA 1CHOI 2ODDA 3TO7A 3HH2C 2OZUA 2DKVA 5EX3A 1SGNI 1SGQI 1ULMA 2NU4I 3UEYA 1WTJA 2ORVA 2CJSC 2JW6A 2N1AB 1CGII 5EX0A 1M8CA 3UFFA 1Q9BA 2UZ3A 4OVOA 3VE5A 2WGCA 2XRCA 3R5CA 4B6DA 1RFHA 1Y1CA 2UVOA 2JXDA 2OVOA 1X74A 2K9HA 4SGBI 3TO6A 1PTQA 2ENZA 1YU6C 4A24A 3FSYA 2J9RA 1WKXA 2V1CC 1SGRI 3CXLA 4JCVE 1XBTA 2QQ0A 2ROWA 3R5DA 2CWFA 2PQ8A 3BJIA 4HGUA 4MPIA 1HPTA 1UHAA 3QAHA 2B0UC 1SGEI
chains in the Genus database with same CATH topology
2NU1I 2KMPA 1OMUA 3SGQI 4UXHA 2GKTI 2YQPA 2GVIA 3SEKC 2J87A 3OL0A 3D00A 2JYYA 2E73A 4L9MA 1TGSI 2QPOA 2W0TA 1SGPI 3GOXA 2NU2I 2L8EA 5CCLA 2ORWA 5JHWC 3KY9A 2FNFX 1IW4A 3SGBI 1KBFA 3MEKA 3OXGA 1KMAA 3RU0A 4UXIA 5HQ8A 1H0ZA 1V1HA 2F3CI 3TJQA 1Y8FA 2JA1A 3B4VC 1PJUA 5DAEA 2P6AC 1DS2I 1LR9A 1TIHA 1UUCA 2QQCA 5HI7A 1TUSA 4E1RA 1SGYI 2V53A 1CE3A 1SGDI 1TOTA 2SGQI 1N13A 2NU3I 1TURA 1Z7KB 2SGPI 2N52A 4E1PA 2LUYA 1CT0I 1W3SA 2GKRI 1R79A 1TBQR 2M5XA 1R0RI 3FC3A 3OXLA 2L7XA 1FARA 5FUYA 1LR7A 2VRWB 1FAQA 1Y1BA 2ERWA 2SGFI 1YTPA 2ELIA 2WVJA 1HJAI 3E59A 1OMTA 3E2IA 3UEJA 1VDDA 4GI3C 2ARPF 3VDPA 1BUSA 1CT2I 3QWPA 1M8BA 2E5RA 2ENNA 1MT1A 2N17A 2V1CA 3VDUA 1IY5A 3PDNA 1PTRA 2QQEA 1AN1I 1FYBA 1KBEA 2BUSA 3OVOA 1CT4I 5FUVA 1U5KA 2YUUA 2N71A 2KCXA 2OD1A 1HDLA 1CGJI 1NUBA 1UVFA 1W4RA 2LEOA 2B8TA 1XA6A 5FUWA 1OVOA 1X4SA 2JZMA 3UGDA 2KMRA 1DS3I 1V1IA 2DIPA 3OXFA 2GKVA 5FUXA 3UGIA 1LR8A 1IY6A 1UVGA 3QTLD 1XX6A 2KMOA 2QQDA 1OYVI 5CCMA 1PCEA 1TBRR 2SGDI 1TBOA 2A20A 1BMOA 2WCYA 4UXJA 1CSOI 2DB6A 2SGEI 1PPFI 3UGLA 2KMQA 1TBNA 2NU0I 4FKDA 1CHOI 2ODDA 3HH2C 5EX3A 1SGNI 1SGQI 2NU4I 3UEYA 2ORVA 2CJSC 2JW6A 2N1AB 1CGII 5EX0A 1M8CA 3UFFA 2UZ3A 4OVOA 3VE5A 2XRCA 4B6DA 1RFHA 1Y1CA 2JXDA 2OVOA 1X74A 2K9HA 4SGBI 4A24A 1PTQA 2ENZA 1YU6C 2J9RA 2V1CC 1SGRI 3CXLA 4JCVE 1XBTA 2QQ0A 2ROWA 4HGUA 3BJIA 1HPTA 2B0UC 1SGEI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TBO A;  4UXJ A;  2DB6 A;  2ENN A;  4UXH A;  3UEJ A;  2GVI A;  3UGL A;  4FKD A;  1TBN A;  2J87 A;  1PTR A;  2QQE A;  1KBE A;  2E73 A;  4L9M A;  2QPO A;  5FUV A;  3UEY A;  2YUU A;  2ORV A;  3UFF A;  2UZ3 A;  1W4R A;  2ORW A;  2B8T A;  1R79 A;  1XA6 A;  2FNF X;  3KY9 A;  5FUW A;  1RFH A;  4B6D A;  3UGD A;  1KBF A;  1FAR A;  1PTQ A;  2ENZ A;  5FUX A;  5FUY A;  2J9R A;  2VRW B;  4UXI A;  1FAQ A;  3UGI A;  3CXL A;  1XBT A;  2QQ0 A;  2ROW A;  1XX6 A;  2ELI A;  2WVJ A;  3BJI A;  1Y8F A;  3E2I A;  2JA1 A; 
#chains in the Genus database with same CATH topology
 2NU1 I;  2KMP A;  1OMU A;  3SGQ I;  4AML A;  4UXH A;  2GKT I;  2YQP A;  2GVI A;  3SEK C;  2J87 A;  3OL0 A;  3D00 A;  2JYY A;  2E73 A;  4L9M A;  1TGS I;  2QPO A;  2W0T A;  1SGP I;  1ULN A;  3GOX A;  1MJ9 A;  2NU2 I;  2L8E A;  3TOA A;  5CCL A;  2ORW A;  5JHW C;  3KY9 A;  2FNF X;  1IW4 A;  1WGC A;  3SGB I;  1KBF A;  3MEK A;  3OXG A;  1KMA A;  3RU0 A;  1K7U A;  2OU2 A;  4UXI A;  5HQ8 A;  1H0Z A;  1V1H A;  2F3C I;  1P9G A;  1P9Z A;  3TJQ A;  1Y8F A;  1K7V A;  2JA1 A;  3B4V C;  1PJU A;  5DAE A;  2P6A C;  1DS2 I;  1LR9 A;  1TIH A;  1UUC A;  2QQC A;  1S20 A;  5HI7 A;  2RC4 A;  1Z2I A;  1TUS A;  4E1R A;  1SGY I;  2V53 A;  1CE3 A;  2CWG A;  1SGD I;  1TOT A;  2SGQ I;  1N13 A;  1K7T A;  2NU3 I;  2CWH A;  2RIJ A;  1TUR A;  1Z7K B;  2SGP I;  2N52 A;  4E1P A;  2LUY A;  1CT0 I;  1W3S A;  2GKR I;  5E3Q A;  1R79 A;  1TBQ R;  2M5X A;  1R0R I;  2Y0M A;  3FC3 A;  3OXL A;  2L7X A;  1FAR A;  7WGA A;  5FUY A;  3TOB A;  1LR7 A;  2VRW B;  1FAQ A;  1Y1B A;  2LB7 A;  2ERW A;  2SGF I;  1YTP A;  2ELI A;  2WVJ A;  3TO9 A;  1HJA I;  3E59 A;  1OMT A;  3E2I A;  3UEJ A;  1VDD A;  4GI3 C;  2ARP F;  3VDP A;  4DNC A;  1CT2 I;  5E3P A;  3QWP A;  1BUS A;  1M8B A;  2E5R A;  2ENN A;  1MT1 A;  5J8C A;  2N17 A;  2V1C A;  3VDU A;  1IY5 A;  3PDN A;  1PTR A;  2QQE A;  3UOE A;  1AN1 I;  1FYB A;  1KBE A;  2BUS A;  3OVO A;  1CT4 I;  5FUV A;  1U5K A;  2YUU A;  2N71 A;  2KCX A;  2OD1 A;  1WGT A;  1HDL A;  1CGJ I;  1NUB A;  1FY7 A;  1UVF A;  1W4R A;  2B8T A;  1XA6 A;  2LEO A;  2X52 A;  3R5A A;  5FUW A;  1OVO A;  1X4S A;  1NXU A;  2JZM A;  5E3R A;  3UGD A;  2KMR A;  1DS3 I;  1V1I A;  2DIP A;  3OXF A;  2GKV A;  5FUX A;  2GIV A;  3FSX A;  3UGI A;  1LR8 A;  5J8F A;  1IY6 A;  1HEV A;  1MJB A;  1UVG A;  3QTL D;  1XX6 A;  2KMO A;  2QQD A;  1OYV I;  5CCM A;  1PCE A;  1TBR R;  1ULK A;  2SGD I;  1TBO A;  2A20 A;  1BMO A;  2WCY A;  4UXJ A;  1CSO I;  2DB6 A;  9WGA A;  2SGE I;  2X3T A;  1PPF I;  4WP4 A;  3UGL A;  2KMQ A;  1TBN A;  2NU0 I;  1MJA A;  3R5B A;  4FKD A;  1CHO I;  2ODD A;  3TO7 A;  3HH2 C;  2OZU A;  2DKV A;  5EX3 A;  1SGN I;  1SGQ I;  1ULM A;  2NU4 I;  3UEY A;  1WTJ A;  2ORV A;  2CJS C;  2JW6 A;  2N1A B;  1CGI I;  5EX0 A;  1M8C A;  3UFF A;  1Q9B A;  2UZ3 A;  4OVO A;  3VE5 A;  2WGC A;  2XRC A;  3R5C A;  4B6D A;  1RFH A;  1Y1C A;  2UVO A;  2JXD A;  2OVO A;  1X74 A;  2K9H A;  4SGB I;  3TO6 A;  1PTQ A;  2ENZ A;  1YU6 C;  4A24 A;  3FSY A;  2J9R A;  1WKX A;  2V1C C;  1SGR I;  3CXL A;  4JCV E;  1XBT A;  2QQ0 A;  2ROW A;  3R5D A;  2CWF A;  2PQ8 A;  3BJI A;  4HGU A;  4MPI A;  1HPT A;  1UHA A;  3QAH A;  2B0U C;  1SGE I; 
#chains in the Genus database with same CATH homology
 2NU1 I;  2KMP A;  1OMU A;  3SGQ I;  4UXH A;  2GKT I;  2YQP A;  2GVI A;  3SEK C;  2J87 A;  3OL0 A;  3D00 A;  2JYY A;  2E73 A;  4L9M A;  1TGS I;  2QPO A;  2W0T A;  1SGP I;  3GOX A;  2NU2 I;  2L8E A;  5CCL A;  2ORW A;  5JHW C;  3KY9 A;  2FNF X;  1IW4 A;  3SGB I;  1KBF A;  3MEK A;  3OXG A;  1KMA A;  3RU0 A;  4UXI A;  5HQ8 A;  1H0Z A;  1V1H A;  2F3C I;  3TJQ A;  1Y8F A;  2JA1 A;  3B4V C;  1PJU A;  5DAE A;  2P6A C;  1DS2 I;  1LR9 A;  1TIH A;  1UUC A;  2QQC A;  5HI7 A;  1TUS A;  4E1R A;  1SGY I;  2V53 A;  1CE3 A;  1SGD I;  1TOT A;  2SGQ I;  1N13 A;  2NU3 I;  1TUR A;  1Z7K B;  2SGP I;  2N52 A;  4E1P A;  2LUY A;  1CT0 I;  1W3S A;  2GKR I;  1R79 A;  1TBQ R;  2M5X A;  1R0R I;  3FC3 A;  3OXL A;  2L7X A;  1FAR A;  5FUY A;  1LR7 A;  2VRW B;  1FAQ A;  1Y1B A;  2ERW A;  2SGF I;  1YTP A;  2ELI A;  2WVJ A;  1HJA I;  3E59 A;  1OMT A;  3E2I A;  3UEJ A;  1VDD A;  4GI3 C;  2ARP F;  3VDP A;  1BUS A;  1CT2 I;  3QWP A;  1M8B A;  2E5R A;  2ENN A;  1MT1 A;  2N17 A;  2V1C A;  3VDU A;  1IY5 A;  3PDN A;  1PTR A;  2QQE A;  1AN1 I;  1FYB A;  1KBE A;  2BUS A;  3OVO A;  1CT4 I;  5FUV A;  1U5K A;  2YUU A;  2N71 A;  2KCX A;  2OD1 A;  1HDL A;  1CGJ I;  1NUB A;  1UVF A;  1W4R A;  2LEO A;  2B8T A;  1XA6 A;  5FUW A;  1OVO A;  1X4S A;  2JZM A;  3UGD A;  2KMR A;  1DS3 I;  1V1I A;  2DIP A;  3OXF A;  2GKV A;  5FUX A;  3UGI A;  1LR8 A;  1IY6 A;  1UVG A;  3QTL D;  1XX6 A;  2KMO A;  2QQD A;  1OYV I;  5CCM A;  1PCE A;  1TBR R;  2SGD I;  1TBO A;  2A20 A;  1BMO A;  2WCY A;  4UXJ A;  1CSO I;  2DB6 A;  2SGE I;  1PPF I;  3UGL A;  2KMQ A;  1TBN A;  2NU0 I;  4FKD A;  1CHO I;  2ODD A;  3HH2 C;  5EX3 A;  1SGN I;  1SGQ I;  2NU4 I;  3UEY A;  2ORV A;  2CJS C;  2JW6 A;  2N1A B;  1CGI I;  5EX0 A;  1M8C A;  3UFF A;  2UZ3 A;  4OVO A;  3VE5 A;  2XRC A;  4B6D A;  1RFH A;  1Y1C A;  2JXD A;  2OVO A;  1X74 A;  2K9H A;  4SGB I;  4A24 A;  1PTQ A;  2ENZ A;  1YU6 C;  2J9R A;  2V1C C;  1SGR I;  3CXL A;  4JCV E;  1XBT A;  2QQ0 A;  2ROW A;  4HGU A;  3BJI A;  1HPT A;  2B0U C;  1SGE I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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