3VEHA

Structure of a m. tuberculosis salicylate synthase, mbti, in complex with an inhibitor methylamt
Total Genus 147
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
147
sequence length
435
structure length
435
Chain Sequence
SSSIPMPAGVNPADLAAELAAVVTESVDEDYLLYECDGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLLLETDQAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDRLLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAAGRYHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLGGIRALGYSPELVTAVRADGVVITEPLAGTRALGRGPAIDRLARDDLESNSKEIVEHAISVRSSLEEITDIAEPGSAAVIDFMTVRERGSVQHLGSTIRARLDPSSDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVAR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis.
pubmed doi rcsb
molecule tags Lyase, isomerase
source organism Mycobacterium tuberculosis
molecule keywords Isochorismate synthase/isochorismate-pyruvate lyase mbtI
total genus 147
structure length 435
sequence length 435
chains with identical sequence B, C, D
ec nomenclature ec 4.2.99.21: Isochorismate lyase.
pdb deposition date 2012-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00425 Chorismate_bind chorismate binding enzyme
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.120.10 Alpha Beta 4-Layer Sandwich Anthranilate synthase Anthranilate synthase 3vehA00
3RV7A 5JY8A 3BZNA 5JY4A 3R75A 1K0EA 5JY4B 3RV9A 3OS6A 2G5FA 5JZDA 3HWOA 3RV6A 2FN0A 3GSEA 3LOGA 5CWAA 1I1QA 2I6YA 3R74A 3VEHA 3H9MA 3RV8A 1I7SA 1K0GA 3BZMA 1I7QA 5KCKA 2FN1A 5JY9A 3ST6A 1QDLA 5JXZA 4GRHA 3R76A 2EUAA
chains in the Genus database with same CATH superfamily
3RV7A 5JY8A 3BZNA 5JY4A 3R75A 1K0EA 5JY4B 3RV9A 3OS6A 2G5FA 5JZDA 3HWOA 3RV6A 2FN0A 3GSEA 3LOGA 5CWAA 1I1QA 2I6YA 3R74A 3VEHA 3H9MA 3RV8A 1I7SA 1K0GA 3BZMA 1I7QA 5KCKA 2FN1A 5JY9A 3ST6A 1QDLA 5JXZA 4GRHA 3R76A 2EUAA
chains in the Genus database with same CATH topology
3RV7A 5JY8A 3BZNA 5JY4A 3R75A 1K0EA 5JY4B 3RV9A 3OS6A 2G5FA 5JZDA 3HWOA 3RV6A 2FN0A 3GSEA 3LOGA 5CWAA 1I1QA 2I6YA 3R74A 3VEHA 3H9MA 3RV8A 1I7SA 1K0GA 3BZMA 1I7QA 5KCKA 2FN1A 5JY9A 3ST6A 1QDLA 5JXZA 4GRHA 3R76A 2EUAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RV7 A;  5JY8 A;  3BZN A;  5JY4 A;  3R75 A;  1K0E A;  5JY4 B;  3RV9 A;  3OS6 A;  2G5F A;  5JZD A;  3HWO A;  3RV6 A;  2FN0 A;  3GSE A;  3LOG A;  5CWA A;  1I1Q A;  2I6Y A;  3R74 A;  3VEH A;  3H9M A;  3RV8 A;  1I7S A;  1K0G A;  3BZM A;  1I7Q A;  5KCK A;  2FN1 A;  5JY9 A;  3ST6 A;  1QDL A;  5JXZ A;  4GRH A;  3R76 A;  2EUA A; 
#chains in the Genus database with same CATH topology
 3RV7 A;  5JY8 A;  3BZN A;  5JY4 A;  3R75 A;  1K0E A;  5JY4 B;  3RV9 A;  3OS6 A;  2G5F A;  5JZD A;  3HWO A;  3RV6 A;  2FN0 A;  3GSE A;  3LOG A;  5CWA A;  1I1Q A;  2I6Y A;  3R74 A;  3VEH A;  3H9M A;  3RV8 A;  1I7S A;  1K0G A;  3BZM A;  1I7Q A;  5KCK A;  2FN1 A;  5JY9 A;  3ST6 A;  1QDL A;  5JXZ A;  4GRH A;  3R76 A;  2EUA A; 
#chains in the Genus database with same CATH homology
 3RV7 A;  5JY8 A;  3BZN A;  5JY4 A;  3R75 A;  1K0E A;  5JY4 B;  3RV9 A;  3OS6 A;  2G5F A;  5JZD A;  3HWO A;  3RV6 A;  2FN0 A;  3GSE A;  3LOG A;  5CWA A;  1I1Q A;  2I6Y A;  3R74 A;  3VEH A;  3H9M A;  3RV8 A;  1I7S A;  1K0G A;  3BZM A;  1I7Q A;  5KCK A;  2FN1 A;  5JY9 A;  3ST6 A;  1QDL A;  5JXZ A;  4GRH A;  3R76 A;  2EUA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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