3WN7A

Crystal structure of keap1 in complex with the n-terminal region of the nrf2 transcription factor
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
286
structure length
286
Chain Sequence
VGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1
pubmed doi rcsb
molecule tags Transcription
source organism Mus musculus
molecule keywords Kelch-like ECH-associated protein 1
total genus 64
structure length 286
sequence length 286
chains with identical sequence L
ec nomenclature
pdb deposition date 2013-12-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 3wn7A00
2VPJA 2Z32A 4N1BA 3VNGA 4ZY3A 3WN7A 5FZNA 4IFLX 2DYHA 4L7DA 5FNUA 4IFJA 4ZGCA 4L7CA 2FLUX 4IN4A 2XN4A 4IQKA 4ASCA 4CHBA 3VNHA 3WDZA 3ADEA 1U6DX 3ZGCA 1ZGKA 5FNRA 4YY8A 4IFNX 3II7A 2ZW9A 4L7BA 4CH9A 3ZGDA 2ZWAA 5CGJA 1X2RA 5FNTA 2ZZKA 5FNQA 4XMBA 5FNSA 5FZJA 5F72C 2WOZA 1X2JA
chains in the Genus database with same CATH superfamily
1IVGA 3SANA 2F10A 2QWJA 2HTYA 4MWYA 2YA8A 2XN4A 4IQKA 2X9MA 4FOQA 1N6EA 1N1VA 1L7HA 2W8BB 5HUMA 4XJQA 3E5ZA 1SO7A 3TC9A 5EO8A 4H53A 4YY8A 4QN5A 3S8VA 4GJTA 3KYAA 3H72A 1V0FA 5GX1A 4QNPA 4FP2A 2H2UA 1X2JA 2VPJA 4K1JA 4X6KA 4N1BA 2VK5A 3IAXA 4JMLA 4IFLX 3TI6A 4MZAA 4D52B 4MWLA 1W8OA 3VNHA 3CL2A 4YZ3A 2FPCA 4CPOA 4UOUA 1MZ6A 4H52A 2H2NA 1E8TA 2HT5A 2VW2A 2G8SA 4C1YA 3LI5A 3K37A 4FQ4A 3V64C 1WCSA 1V2IA 2F11A 3OPZA 4R40A 4YZ5A 4K3YA 3KGGA 5FNUA 3CL0A 4A0PA 5D9CA 3SOVA 5JYYA 2VVZA 3GVLA 4IMBA 4XIOA 4XJ8A 2QWFA 3TI5A 4CSDA 2ZW9A 2BERA 3AMSA 5GX4A 1S0IA 1X2RA 3LI3A 2ZZKA 2W20A 1H6LA 2QWDA 4NC5A 5B2CA 4AGTA 2HT7A 1NNCA 4HW6A 4FPLA 1E8UA 2BATA 4B7MA 2SLIA 4FJ6A 2ZB6A 2F13A 3A72A 5FZNA 3Q6PA 4J9TA 2VAQA 1W8NA 1RWLA 4HZXA 1W21A 3TIAA 3CKZA 4WEGA 1V0ZA 1U6DX 2GVUA 5GX5A 1Q7FA 2GHSA 1CQ1A 3TI8A 1NN2A 2V91A 1Z50A 1DIMA 2QWBA 5FZJA 4GZOA 1SUUA 4GZQA 4O5TA 4DGRA 1IVBA 3U0SA 3L6VA 4KS3A 1KITA 4QN4A 1MZ5A 3BYCA 1W0OA 4FOYA 3HLIA 1NSDA 4GN7A 1NMAN 4MWQA 3K38A 2F29A 1EURA 1IVDA 1VCUA 2GVXA 4WA4A 4XJRA 2JKBA 4KS4A 5NN9A 3O4PA 2IAUA 4Q1UA 2IAPA 4XMBA 1XOEA 2QWGA 4FZHA 4QN7A 4GNAA 2IAWA 3FVZA 4MWUA 3Q6TA 4HZVA 3WN7A 4YW1A 2VW0A 1NSBA 1MS0A 1C9UA 1MS1A 2QWKA 4NCSA 3NO0A 2XZJA 1WCQA 4D8SA 4KS1A 1NMCA 3DR2A 4CH9A 1NCCN 5CGJA 1V3DA 2FP8A 3BEQA 4XE9A 3HLHA 1MS5A 7NN9A 1V3BA 3H71A 4MC7A 3I1CA 2IAOA 3WWAA 3SREA 2YA7A 1L7GA 3FW0A 3INBA 4XYXA 2W8BA 4O5SA 2HTRA 3LI4A 1WP5A 4HZWA 2YDTA 3SLIA 4IYGA 3D11A 2VSMA 4K1HA 3V65B 3ZGCA 3B69A 2F12A 3Q6KA 1N1TA 2OJHA 4FOVA 3TI3A 2HTVA 2IASA 4MWWA 1N1SA 1Z4XA 4B7NA 4MWRA 1MWEA 5HX0A 2XZKA 2VSKA 4FPOB 3A9GA 4C1YB 1INVA 2CMLA 3O9JA 1BJIA 3SOQA 2FLUX 4XOGA 4GNBA 4GZXA 4ASCA 1MR5A 1EUUA 4XILA 5D9BA 2HU4A 4GZSA 4X49A 3G4EA 4GZPA 1EUTA 4JF7A 3O9KA 4M3MA 1MS8A 4DG6A 4XJAA 3WW9A 1IJQA 3HRPA 4HZYA 2C4LA 2BF6A 3NN9A 1NCBN 1MS9A 2DYHA 4L7DA 2P4OA 1INWA 2AEPA 3SALA 2POOA 1IUCA 1MS4A 4GB1A 2ZB5A 4FPGA 4X4AA 2SIMA 1V0EA 1EUSA 4MJVA 3SILA 4M4VA 4CPNA 1N7DA 4GDJA 4MWXA 5GX2A 2FHRA 2GVWA 4BBWA 2F26A 4XMIA 1NNBA 1XOGA 2DG0A 4X47A 4AGIA 3PJQA 2IAQA 3JU4A 4ZY3A 4B7JA 3K3AA 3NSSA 5M1ZA 3P5BL 4YW2A 1NPEA 1K32A 1A14N 2IARA 4HZZA 4CPYA 4QN6A 2XCYA 4XJUA 1SLIA 1E1AA 1SNTA 3A9HA 5F9TA 1F8CA 4UF7A 3H73A 4WA3A 2DSOA 4FP3A 1QLGA 2QWEA 1MS3A 4B7RA 5FNRA 3S94A 1INXA 4GZTA 5HUGA 4PWZA 1CVMA 3K39A 1INGA 2A75A 4IFJA 1W1XA 1Z4WA 2HT8A 2IAVA 2B8HA 4IN4A 4YZ2A 1W20A 2RKCA 3A71A 1A4GA 4KS2A 1ZGKA 2QWIA 1N6FA 3GVJA 1F8EA 1E8VA 2QWCA 3UC1A 5FWWA 4YW4A 1DILA 4FPJA 1IUBA 2SILA 2HTQA 4MWJA 4MZEA 5FNSA 5HUKA 5HUNA 4K1KA 3TICA 2F27A 3K36A 3CYEA 4HIZA 3AMRA 4NN9A 1V3EA 2YDPA 2IATA 2YA6A 4YW3A 1INFA 1N6DA 4CHBA 4GN9A 1USRA 3TIBA 1ZI0A 3II7A 4L7BA 1USXA 1S1DA 4XJWA 2AEQA 4I00A 2ISMA 3GVKA 4HHOA 4D52A 2DG1A 4M4NA 1OFZA 3VNGA 4CPLA 4D52C 1NNAA 4CPZA 1Z4ZA 2IAXA 4KS5A 4D4UA 1A4QA 4XHXA 5GX3A 1Z4YA 4Q6KA 4GZWA 3WDZA 3DASA 5B2DA 2YA4A 4FPKA 4IFNX 2IVZA 1B9SA 4FPYA 2ZWAA 1F8BA 2W5NA 4AHAA 3B7EA 2VK6A 2VWDA 4G3NA 4K1IA 1B9TA 4YZ4A 1IVCA 2HTWA 4WA5A 3T1EA 4GNCA 1C5KA 3D12A 4MWVA 4WEFA 4FVKA 3G4HA 1Z4VA 3ALXA 2YA5A 1NSCA 2HTUA 1IVEA 5FNQA 6NN9A 1F8DA 5EX7A 5F72C 4SLIA 2WOZA 3V1SA 2AGSA 1IVFA 5EO7A 1S18A 1NMBN 4CPMA 4YZ1A 1W0PA 1INYA 1V3CA 4HHQA 4ZLRA 4FOWA 4FPCA 3TI4A 2FP9A 1L7FA 1S0JA 2HQSA 1RWIA 4M4UA 3H6JA 2QWAA 4AH4A 2GVVA 3ADEA 4XHBA 4MJUA 4FPEA 4GEZA 4QN3A 2F25A 1N1YA 2QWHA 5H47A 5FNTA 1POOA 2FPBA 2QE8A 2VK7A 2W38A 1PJXA 4XIKA 2BZDA 3W09A 5GTQA 1B9VA 3SOBB 4GDIA 4XMAA 1CRZA 2Z32A 1SLLA 4XJ9A 1V04A 1NCAN 2C4AA 2XZIA 1VCJA 4XJZA 2VW1A 4ZGCA 4L7CA 3S2KA 3ALWA 2AH2A 2W5OA 2F28A 1CRUA 1QBIA 2F0ZA 4FPFA 4FPHA 2F24A 4GN8A 5D9DA 3ZGDA 1INHA 4YW5A 3S8ZA 4MX0A 3SRGA 4B7QA 1NCDN 2HU0A
chains in the Genus database with same CATH topology
2VPJA 2Z32A 4N1BA 3VNGA 4ZY3A 3WN7A 5FZNA 4IFLX 2DYHA 4L7DA 5FNUA 4IFJA 4ZGCA 4L7CA 2FLUX 4IN4A 2XN4A 4IQKA 4ASCA 4CHBA 3VNHA 3WDZA 3ADEA 1U6DX 3ZGCA 1ZGKA 5FNRA 4YY8A 4IFNX 3II7A 2ZW9A 4L7BA 4CH9A 3ZGDA 2ZWAA 5CGJA 1X2RA 5FNTA 2ZZKA 5FNQA 4XMBA 5FNSA 5FZJA 5F72C 2WOZA 1X2JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VPJ A;  2Z32 A;  4N1B A;  3VNG A;  4ZY3 A;  3WN7 A;  5FZN A;  4IFL X;  2DYH A;  4L7D A;  5FNU A;  4IFJ A;  4ZGC A;  4L7C A;  2FLU X;  4IN4 A;  2XN4 A;  4IQK A;  4ASC A;  4CHB A;  3VNH A;  3WDZ A;  3ADE A;  1U6D X;  3ZGC A;  1ZGK A;  5FNR A;  4YY8 A;  4IFN X;  3II7 A;  2ZW9 A;  4L7B A;  4CH9 A;  3ZGD A;  2ZWA A;  5CGJ A;  1X2R A;  5FNT A;  2ZZK A;  5FNQ A;  4XMB A;  5FNS A;  5FZJ A;  5F72 C;  2WOZ A;  1X2J A; 
#chains in the Genus database with same CATH topology
 1IVG A;  3SAN A;  2F10 A;  2QWJ A;  2HTY A;  4MWY A;  2YA8 A;  2XN4 A;  4IQK A;  2X9M A;  4FOQ A;  1N6E A;  1N1V A;  1L7H A;  2W8B B;  5HUM A;  4XJQ A;  3E5Z A;  1SO7 A;  3TC9 A;  5EO8 A;  4H53 A;  4YY8 A;  4QN5 A;  3S8V A;  4GJT A;  3KYA A;  3H72 A;  1V0F A;  5GX1 A;  4QNP A;  4FP2 A;  2H2U A;  1X2J A;  2VPJ A;  4K1J A;  4X6K A;  4N1B A;  2VK5 A;  3IAX A;  4JML A;  4IFL X;  3TI6 A;  4MZA A;  4D52 B;  4MWL A;  1W8O A;  3VNH A;  3CL2 A;  4YZ3 A;  2FPC A;  4CPO A;  4UOU A;  1MZ6 A;  4H52 A;  2H2N A;  1E8T A;  2HT5 A;  2VW2 A;  2G8S A;  4C1Y A;  3LI5 A;  3K37 A;  4FQ4 A;  3V64 C;  1WCS A;  1V2I A;  2F11 A;  3OPZ A;  4R40 A;  4YZ5 A;  4K3Y A;  3KGG A;  5FNU A;  3CL0 A;  4A0P A;  5D9C A;  3SOV A;  5JYY A;  2VVZ A;  3GVL A;  4IMB A;  4XIO A;  4XJ8 A;  2QWF A;  3TI5 A;  4CSD A;  2ZW9 A;  2BER A;  3AMS A;  5GX4 A;  1S0I A;  1X2R A;  3LI3 A;  2ZZK A;  2W20 A;  1H6L A;  2QWD A;  4NC5 A;  5B2C A;  4AGT A;  2HT7 A;  1NNC A;  4HW6 A;  4FPL A;  1E8U A;  2BAT A;  4B7M A;  2SLI A;  4FJ6 A;  2ZB6 A;  2F13 A;  3A72 A;  5FZN A;  3Q6P A;  4J9T A;  2VAQ A;  1W8N A;  1RWL A;  4HZX A;  1W21 A;  3TIA A;  3CKZ A;  4WEG A;  1V0Z A;  1U6D X;  2GVU A;  5GX5 A;  1Q7F A;  2GHS A;  1CQ1 A;  3TI8 A;  1NN2 A;  2V91 A;  1Z50 A;  1DIM A;  2QWB A;  5FZJ A;  4GZO A;  1SUU A;  4GZQ A;  4O5T A;  4DGR A;  1IVB A;  3U0S A;  3L6V A;  4KS3 A;  1KIT A;  4QN4 A;  1MZ5 A;  3BYC A;  1W0O A;  4FOY A;  3HLI A;  1NSD A;  4GN7 A;  1NMA N;  4MWQ A;  3K38 A;  2F29 A;  1EUR A;  1IVD A;  1VCU A;  2GVX A;  4WA4 A;  4XJR A;  2JKB A;  4KS4 A;  5NN9 A;  3O4P A;  2IAU A;  4Q1U A;  2IAP A;  4XMB A;  1XOE A;  2QWG A;  4FZH A;  4QN7 A;  4GNA A;  2IAW A;  3FVZ A;  4MWU A;  3Q6T A;  4HZV A;  3WN7 A;  4YW1 A;  2VW0 A;  1NSB A;  1MS0 A;  1C9U A;  1MS1 A;  2QWK A;  4NCS A;  3NO0 A;  2XZJ A;  1WCQ A;  4D8S A;  4KS1 A;  1NMC A;  3DR2 A;  4CH9 A;  1NCC N;  5CGJ A;  1V3D A;  2FP8 A;  3BEQ A;  4XE9 A;  3HLH A;  1MS5 A;  7NN9 A;  1V3B A;  3H71 A;  4MC7 A;  3I1C A;  2IAO A;  3WWA A;  3SRE A;  2YA7 A;  1L7G A;  3FW0 A;  3INB A;  4XYX A;  2W8B A;  4O5S A;  2HTR A;  3LI4 A;  1WP5 A;  4HZW A;  2YDT A;  3SLI A;  4IYG A;  3D11 A;  2VSM A;  4K1H A;  3V65 B;  3ZGC A;  3B69 A;  2F12 A;  3Q6K A;  1N1T A;  2OJH A;  4FOV A;  3TI3 A;  2HTV A;  2IAS A;  4MWW A;  1N1S A;  1Z4X A;  4B7N A;  4MWR A;  1MWE A;  5HX0 A;  2XZK A;  2VSK A;  4FPO B;  3A9G A;  4C1Y B;  1INV A;  2CML A;  3O9J A;  1BJI A;  3SOQ A;  2FLU X;  4XOG A;  4GNB A;  4GZX A;  4ASC A;  1MR5 A;  1EUU A;  4XIL A;  5D9B A;  2HU4 A;  4GZS A;  4X49 A;  3G4E A;  4GZP A;  1EUT A;  4JF7 A;  3O9K A;  4M3M A;  1MS8 A;  4DG6 A;  4XJA A;  3WW9 A;  1IJQ A;  3HRP A;  4HZY A;  2C4L A;  2BF6 A;  3NN9 A;  1NCB N;  1MS9 A;  2DYH A;  4L7D A;  2P4O A;  1INW A;  2AEP A;  3SAL A;  2POO A;  1IUC A;  1MS4 A;  4GB1 A;  2ZB5 A;  4FPG A;  4X4A A;  2SIM A;  1V0E A;  1EUS A;  4MJV A;  3SIL A;  4M4V A;  4CPN A;  1N7D A;  4GDJ A;  4MWX A;  5GX2 A;  2FHR A;  2GVW A;  4BBW A;  2F26 A;  4XMI A;  1NNB A;  1XOG A;  2DG0 A;  4X47 A;  4AGI A;  3PJQ A;  2IAQ A;  3JU4 A;  4ZY3 A;  4B7J A;  3K3A A;  3NSS A;  5M1Z A;  3P5B L;  4YW2 A;  1NPE A;  1K32 A;  1A14 N;  2IAR A;  4HZZ A;  4CPY A;  4QN6 A;  2XCY A;  4XJU A;  1SLI A;  1E1A A;  1SNT A;  3A9H A;  5F9T A;  1F8C A;  4UF7 A;  3H73 A;  4WA3 A;  2DSO A;  4FP3 A;  1QLG A;  2QWE A;  1MS3 A;  4B7R A;  5FNR A;  3S94 A;  1INX A;  4GZT A;  5HUG A;  4PWZ A;  1CVM A;  3K39 A;  1ING A;  2A75 A;  4IFJ A;  1W1X A;  1Z4W A;  2HT8 A;  2IAV A;  2B8H A;  4IN4 A;  4YZ2 A;  1W20 A;  2RKC A;  3A71 A;  1A4G A;  4KS2 A;  1ZGK A;  2QWI A;  1N6F A;  3GVJ A;  1F8E A;  1E8V A;  2QWC A;  3UC1 A;  5FWW A;  4YW4 A;  1DIL A;  4FPJ A;  1IUB A;  2SIL A;  2HTQ A;  4MWJ A;  4MZE A;  5FNS A;  5HUK A;  5HUN A;  4K1K A;  3TIC A;  2F27 A;  3K36 A;  3CYE A;  4HIZ A;  3AMR A;  4NN9 A;  1V3E A;  2YDP A;  2IAT A;  2YA6 A;  4YW3 A;  1INF A;  1N6D A;  4CHB A;  4GN9 A;  1USR A;  3TIB A;  1ZI0 A;  3II7 A;  4L7B A;  1USX A;  1S1D A;  4XJW A;  2AEQ A;  4I00 A;  2ISM A;  3GVK A;  4HHO A;  4D52 A;  2DG1 A;  4M4N A;  1OFZ A;  3VNG A;  4CPL A;  4D52 C;  1NNA A;  4CPZ A;  1Z4Z A;  2IAX A;  4KS5 A;  4D4U A;  1A4Q A;  4XHX A;  5GX3 A;  1Z4Y A;  4Q6K A;  4GZW A;  3WDZ A;  3DAS A;  5B2D A;  2YA4 A;  4FPK A;  4IFN X;  2IVZ A;  1B9S A;  4FPY A;  2ZWA A;  1F8B A;  2W5N A;  4AHA A;  3B7E A;  2VK6 A;  2VWD A;  4G3N A;  4K1I A;  1B9T A;  4YZ4 A;  1IVC A;  2HTW A;  4WA5 A;  3T1E A;  4GNC A;  1C5K A;  3D12 A;  4MWV A;  4WEF A;  4FVK A;  3G4H A;  1Z4V A;  3ALX A;  2YA5 A;  1NSC A;  2HTU A;  1IVE A;  5FNQ A;  6NN9 A;  1F8D A;  5EX7 A;  5F72 C;  4SLI A;  2WOZ A;  3V1S A;  2AGS A;  1IVF A;  5EO7 A;  1S18 A;  1NMB N;  4CPM A;  4YZ1 A;  1W0P A;  1INY A;  1V3C A;  4HHQ A;  4ZLR A;  4FOW A;  4FPC A;  3TI4 A;  2FP9 A;  1L7F A;  1S0J A;  2HQS A;  1RWI A;  4M4U A;  3H6J A;  2QWA A;  4AH4 A;  2GVV A;  3ADE A;  4XHB A;  4MJU A;  4FPE A;  4GEZ A;  4QN3 A;  2F25 A;  1N1Y A;  2QWH A;  5H47 A;  5FNT A;  1POO A;  2FPB A;  2QE8 A;  2VK7 A;  2W38 A;  1PJX A;  4XIK A;  2BZD A;  3W09 A;  5GTQ A;  1B9V A;  3SOB B;  4GDI A;  4XMA A;  1CRZ A;  2Z32 A;  1SLL A;  4XJ9 A;  1V04 A;  1NCA N;  2C4A A;  2XZI A;  1VCJ A;  4XJZ A;  2VW1 A;  4ZGC A;  4L7C A;  3S2K A;  3ALW A;  2AH2 A;  2W5O A;  2F28 A;  1CRU A;  1QBI A;  2F0Z A;  4FPF A;  4FPH A;  2F24 A;  4GN8 A;  5D9D A;  3ZGD A;  1INH A;  4YW5 A;  3S8Z A;  4MX0 A;  3SRG A;  4B7Q A;  1NCD N;  2HU0 A; 
#chains in the Genus database with same CATH homology
 2VPJ A;  2Z32 A;  4N1B A;  3VNG A;  4ZY3 A;  3WN7 A;  5FZN A;  4IFL X;  2DYH A;  4L7D A;  5FNU A;  4IFJ A;  4ZGC A;  4L7C A;  2FLU X;  4IN4 A;  2XN4 A;  4IQK A;  4ASC A;  4CHB A;  3VNH A;  3WDZ A;  3ADE A;  1U6D X;  3ZGC A;  1ZGK A;  5FNR A;  4YY8 A;  4IFN X;  3II7 A;  2ZW9 A;  4L7B A;  4CH9 A;  3ZGD A;  2ZWA A;  5CGJ A;  1X2R A;  5FNT A;  2ZZK A;  5FNQ A;  4XMB A;  5FNS A;  5FZJ A;  5F72 C;  2WOZ A;  1X2J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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