3WX2A

Mouse cereblon thalidomide binding domain, native
Total Genus 20
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
108
structure length
108
Chain Sequence
GPTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Metal binding protein
molecule keywords Protein cereblon
publication title Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs
pubmed doi rcsb
source organism Mus musculus
total genus 20
structure length 108
sequence length 108
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-07-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.150.20 Mainly Beta Beta Complex Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A Peptide methionine sulfoxide reductase. 3wx2A00
2KZNA 3HCJA 4V2ZA 2K8DA 4TZ4C 4TZCA 4CI3B 3CEZA 3HCGA 4CI1B 3E0MA 1L1DA 2KV1A 3E0OA 4V30A 4TZUA 3CXKA 4V2YA 3WX2A 3HCIA 3WX1A 5AMHA 4CI2B 3HCHA 3MAOA 4V31A
chains in the Genus database with same CATH superfamily
2KZNA 3HCJA 2HR9A 4V2ZA 2K8DA 4TZ4C 1HXRA 4TZCA 1H6QA 4BPBA 3OG8A 3P3KA 4CI3B 2QFBA 2KWBA 3CEZA 3LRNA 4A2XA 2LOYA 3HCGA 4CI1B 3LRRA 3ZD7A 4A2VA 3E0MA 3NCUA 1FWQA 1L1DA 2KV1A 3GA3A 3E0OA 4V30A 2RQAA 4TZUA 3EBMA 2YKGA 5F9FA 1H7YA 2LVLA 5F98A 3CXKA 4V2YA 3WX2A 3HCIA 3WX1A 2W4RA 3EQTA 4AY2A 3ZD6A 5AMHA 2QFDA 4CI2B 5F9HA 3DJMA 3FACA 5E3HA 3HCHA 2FU5A 2RMJA 1TXJA 3MAOA 4V31A 1YZ1A 2RQBA
chains in the Genus database with same CATH topology
2KZNA 3HCJA 4V2ZA 2K8DA 4TZ4C 4TZCA 4CI3B 3CEZA 3HCGA 4CI1B 3E0MA 1L1DA 2KV1A 3E0OA 4V30A 4TZUA 3CXKA 4V2YA 3WX2A 3HCIA 3WX1A 5AMHA 4CI2B 3HCHA 3MAOA 4V31A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KZN A;  3HCJ A;  4V2Z A;  2K8D A;  4TZ4 C;  4TZC A;  4CI3 B;  3CEZ A;  3HCG A;  4CI1 B;  3E0M A;  1L1D A;  2KV1 A;  3E0O A;  4V30 A;  4TZU A;  3CXK A;  4V2Y A;  3WX2 A;  3HCI A;  3WX1 A;  5AMH A;  4CI2 B;  3HCH A;  3MAO A;  4V31 A; 
#chains in the Genus database with same CATH topology
 2KZN A;  3HCJ A;  2HR9 A;  4V2Z A;  2K8D A;  4TZ4 C;  1HXR A;  4TZC A;  1H6Q A;  4BPB A;  3OG8 A;  3P3K A;  4CI3 B;  2QFB A;  2KWB A;  3CEZ A;  3LRN A;  4A2X A;  2LOY A;  3HCG A;  4CI1 B;  3LRR A;  3ZD7 A;  4A2V A;  3E0M A;  3NCU A;  1FWQ A;  1L1D A;  2KV1 A;  3GA3 A;  3E0O A;  4V30 A;  2RQA A;  4TZU A;  3EBM A;  2YKG A;  5F9F A;  1H7Y A;  2LVL A;  5F98 A;  3CXK A;  4V2Y A;  3WX2 A;  3HCI A;  3WX1 A;  2W4R A;  3EQT A;  4AY2 A;  3ZD6 A;  5AMH A;  2QFD A;  4CI2 B;  5F9H A;  3DJM A;  3FAC A;  5E3H A;  3HCH A;  2FU5 A;  2RMJ A;  1TXJ A;  3MAO A;  4V31 A;  1YZ1 A;  2RQB A; 
#chains in the Genus database with same CATH homology
 2KZN A;  3HCJ A;  4V2Z A;  2K8D A;  4TZ4 C;  4TZC A;  4CI3 B;  3CEZ A;  3HCG A;  4CI1 B;  3E0M A;  1L1D A;  2KV1 A;  3E0O A;  4V30 A;  4TZU A;  3CXK A;  4V2Y A;  3WX2 A;  3HCI A;  3WX1 A;  5AMH A;  4CI2 B;  3HCH A;  3MAO A;  4V31 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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