3ZD2A

The structure of the two n-terminal domains of complement factor h related protein 1 shows formation of a novel dimerisation interface
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
125
structure length
125
Chain Sequence
EATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRST
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords COMPLEMENT FACTOR H-RELATED PROTEIN 1
publication title Dimerization of Complement Factor H-Related Proteins Modulates Complement Activation in Vivo.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Immune system
total genus 22
structure length 125
sequence length 125
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-11-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 3zd2A02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 3zd2A01
3GOVA 1Q3XA 2JGXA 1VVDA 1LY2A 1TPGA 1ZJKA 1E88A 1HFIA 2JRAA 5HZPB 2JGWA 2RL0A 2RKYA 3RJ3D 1C1ZA 3TVJA 1QGBA 2XRDA 1MD8A 1OK1A 3IX0A 3ZD2A 4AYIA 4B2SA 1O9AA 2BZMA 1MD7A 2CKUA 2RKZA 4CSYA 2WIIC 4JHSA 1H2QP 2MCYA 2YRAA 1QUBA 3OEDC 1TPMA 1OJWA 4C16A 3INBC 3ZD1A 1OJYA 4PZ5A 1H2PP 4AYDA 2O39C 4IGDA 3SW0X 4ONTD 1GKGA 1TPNA 2A55A 5JPMG 2IZ4A 3ERBA 2XWJI 2G7IA 5HYTB 4YNXA 3IU3I 1E5GA 2QY0A 2EC3A 2XRBA 2V8EA 2W81A 5HYPA 1HCCA 1UOTP 1NWVA 3EJHA 3KZJA 3O8EB 2B5ID 1GPZA 2KRIA 1SRZA 3M7PA 2EHFA 3ZRZA 2CG7A 1SS2A 4LOSA 1G4FA 1OJVA 1OK3A 2ERJA 4KKDA 1PPQA 1VVCA 1QO6A 2YBYA 2W80A 1H04P 2RLQA 3KXVA 4AYEA 3OXUD 4ZH1D 4K12A 5FO8C 1E8BA 4MUCA 5I0QB 4F4OC 1GKNA 1CKLA 1FBRA 2MCZA 2LOJA 4WJG2 1ELVA 1OK2A 3MQLA 4J38B 3CALA 2RLPA 5HYUB 2XWBF 1G4GA 3OP8A 4LOTA 1OK9A 3GXEA 1Z92B 3L89M 3NFPI 4AYMA 4A5WB 3R62A 1H03P 2IZ3A 2KMSA 1HFHA 2CG6A 3T5OA 2XQWC 4B2RA 4FXGG 1GHQB 1U5MA 4DJZA 2UWNA
chains in the Genus database with same CATH superfamily
3GOVA 1Q3XA 4MSLA 2JGXA 1VVDA 1LY2A 1TPGA 1ZJKA 1E88A 1HFIA 2JRAA 5HZPB 2JGWA 2RL0A 2RKYA 5DN4A 3WSXA 3RJ3D 1C1ZA 3TVJA 1QGBA 2I2LA 2XRDA 1MD8A 1OK1A 3IX0A 2ZYCA 3ZD2A 4AYIA 4B2SA 1O9AA 2BZMA 1MD7A 2CKUA 2RKZA 3WSYA 4CSYA 2WIIC 3ZLEA 4JHSA 1H2QP 2MCYA 2YRAA 1QUBA 3OEDC 3K3TA 1TPMA 1OJWA 4C16A 3INBC 3ZD1A 1OJYA 4PZ5A 1H2PP 4AYDA 2O39C 4IGDA 3VWOA 3SW0X 5DN5A 4ONTD 1GKGA 1TPNA 2A55A 3ZLDA 2IZ4A 5JPMG 3ERBA 2X2ZA 2XWJI 2G7IA 3FGRA 5HYTB 4YNXA 3IU3I 1E5GA 2QY0A 2EC3A 2XRBA 2V8EA 2W81A 5HYPA 1HCCA 1UOTP 1NWVA 3EJHA 3KZJA 3O8EB 2B5ID 1GPZA 2KRIA 1SRZA 4N7EA 3M7PA 2EHFA 3ZRZA 2CG7A 1SS2A 4BWCA 4LOSA 1G4FA 1OJVA 1OK3A 2Y8RA 2ERJA 2Y8TA 4KKDA 1PPQA 1VVCA 1QO6A 2YBYA 2W80A 1H04P 2RLQA 1RLHA 3KXVA 4AYEA 3OXUD 4ZH1D 4K12A 3CI0J 5FO8C 1E8BA 4MUCA 5I0QB 4F4OC 1GKNA 1CKLA 1FBRA 2MCZA 2LOJA 4WJG2 1ELVA 1OK2A 3MQLA 4J38B 3CALA 4APLA 2RLPA 5HYUB 2XWBF 1G4GA 3F6KA 4YIZA 3OP8A 4LOTA 2Y8SA 1OK9A 3GXEA 1Z92B 3NJAA 3L89M 3NFPI 4AYMA 4A5WB 3R62A 4PO7A 1H03P 3FGTA 2IZ3A 2KMSA 1HFHA 2CG6A 3T5OA 2XQWC 4B2RA 4FXGG 1GHQB 1U5MA 4DJZA 2UWNA
chains in the Genus database with same CATH topology
3GOVA 1Q3XA 2JGXA 1VVDA 1LY2A 1TPGA 1ZJKA 1E88A 1HFIA 2JRAA 5HZPB 2JGWA 2RL0A 2RKYA 3RJ3D 1C1ZA 3TVJA 1QGBA 2XRDA 1MD8A 1OK1A 3IX0A 3ZD2A 4AYIA 4B2SA 1O9AA 2BZMA 1MD7A 2CKUA 2RKZA 4CSYA 2WIIC 4JHSA 1H2QP 2MCYA 2YRAA 1QUBA 3OEDC 1TPMA 1OJWA 4C16A 3INBC 3ZD1A 1OJYA 4PZ5A 1H2PP 4AYDA 2O39C 4IGDA 3SW0X 4ONTD 1GKGA 1TPNA 2A55A 5JPMG 2IZ4A 3ERBA 2XWJI 2G7IA 5HYTB 4YNXA 3IU3I 1E5GA 2QY0A 2EC3A 2XRBA 2V8EA 2W81A 5HYPA 1HCCA 1UOTP 1NWVA 3EJHA 3KZJA 3O8EB 2B5ID 1GPZA 2KRIA 1SRZA 3M7PA 2EHFA 3ZRZA 2CG7A 1SS2A 4LOSA 1G4FA 1OJVA 1OK3A 2ERJA 4KKDA 1PPQA 1VVCA 1QO6A 2YBYA 2W80A 1H04P 2RLQA 3KXVA 4AYEA 3OXUD 4ZH1D 4K12A 5FO8C 1E8BA 4MUCA 5I0QB 4F4OC 1GKNA 1CKLA 1FBRA 2MCZA 2LOJA 4WJG2 1ELVA 1OK2A 3MQLA 4J38B 3CALA 2RLPA 5HYUB 2XWBF 1G4GA 3OP8A 4LOTA 1OK9A 3GXEA 1Z92B 3L89M 3NFPI 4AYMA 4A5WB 3R62A 1H03P 2IZ3A 2KMSA 1HFHA 2CG6A 3T5OA 2XQWC 4B2RA 4FXGG 1GHQB 1U5MA 4DJZA 2UWNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3GOV A;  1Q3X A;  2JGX A;  1VVD A;  1LY2 A;  1TPG A;  1ZJK A;  1E88 A;  1HFI A;  2JRA A;  5HZP B;  2JGW A;  2RL0 A;  2RKY A;  3RJ3 D;  1C1Z A;  3TVJ A;  1QGB A;  2XRD A;  1MD8 A;  1OK1 A;  3IX0 A;  3ZD2 A;  4AYI A;  4B2S A;  1O9A A;  2BZM A;  1MD7 A;  2CKU A;  2RKZ A;  4CSY A;  2WII C;  4JHS A;  1H2Q P;  2MCY A;  2YRA A;  1QUB A;  3OED C;  1TPM A;  1OJW A;  4C16 A;  3INB C;  3ZD1 A;  1OJY A;  4PZ5 A;  1H2P P;  4AYD A;  2O39 C;  4IGD A;  3SW0 X;  4ONT D;  1GKG A;  1TPN A;  2A55 A;  5JPM G;  2IZ4 A;  3ERB A;  2XWJ I;  2G7I A;  5HYT B;  4YNX A;  3IU3 I;  1E5G A;  2QY0 A;  2EC3 A;  2XRB A;  2V8E A;  2W81 A;  5HYP A;  1HCC A;  1UOT P;  1NWV A;  3EJH A;  3KZJ A;  3O8E B;  2B5I D;  1GPZ A;  2KRI A;  1SRZ A;  3M7P A;  2EHF A;  3ZRZ A;  2CG7 A;  1SS2 A;  4LOS A;  1G4F A;  1OJV A;  1OK3 A;  2ERJ A;  4KKD A;  1PPQ A;  1VVC A;  1QO6 A;  2YBY A;  2W80 A;  1H04 P;  2RLQ A;  3KXV A;  4AYE A;  3OXU D;  4ZH1 D;  4K12 A;  5FO8 C;  1E8B A;  4MUC A;  5I0Q B;  4F4O C;  1GKN A;  1CKL A;  1FBR A;  2MCZ A;  2LOJ A;  4WJG 2;  1ELV A;  1OK2 A;  3MQL A;  4J38 B;  3CAL A;  2RLP A;  5HYU B;  2XWB F;  1G4G A;  3OP8 A;  4LOT A;  1OK9 A;  3GXE A;  1Z92 B;  3L89 M;  3NFP I;  4AYM A;  4A5W B;  3R62 A;  1H03 P;  2IZ3 A;  2KMS A;  1HFH A;  2CG6 A;  3T5O A;  2XQW C;  4B2R A;  4FXG G;  1GHQ B;  1U5M A;  4DJZ A;  2UWN A; 
#chains in the Genus database with same CATH topology
 3GOV A;  1Q3X A;  4MSL A;  2JGX A;  1VVD A;  1LY2 A;  1TPG A;  1ZJK A;  1E88 A;  1HFI A;  2JRA A;  5HZP B;  2JGW A;  2RL0 A;  2RKY A;  5DN4 A;  3WSX A;  3RJ3 D;  1C1Z A;  3TVJ A;  1QGB A;  2I2L A;  2XRD A;  1MD8 A;  1OK1 A;  3IX0 A;  2ZYC A;  3ZD2 A;  4AYI A;  4B2S A;  1O9A A;  2BZM A;  1MD7 A;  2CKU A;  2RKZ A;  3WSY A;  4CSY A;  2WII C;  3ZLE A;  4JHS A;  1H2Q P;  2MCY A;  2YRA A;  1QUB A;  3OED C;  3K3T A;  1TPM A;  1OJW A;  4C16 A;  3INB C;  3ZD1 A;  1OJY A;  4PZ5 A;  1H2P P;  4AYD A;  2O39 C;  4IGD A;  3VWO A;  3SW0 X;  5DN5 A;  4ONT D;  1GKG A;  1TPN A;  2A55 A;  3ZLD A;  2IZ4 A;  5JPM G;  3ERB A;  2X2Z A;  2XWJ I;  2G7I A;  3FGR A;  5HYT B;  4YNX A;  3IU3 I;  1E5G A;  2QY0 A;  2EC3 A;  2XRB A;  2V8E A;  2W81 A;  5HYP A;  1HCC A;  1UOT P;  1NWV A;  3EJH A;  3KZJ A;  3O8E B;  2B5I D;  1GPZ A;  2KRI A;  1SRZ A;  4N7E A;  3M7P A;  2EHF A;  3ZRZ A;  2CG7 A;  1SS2 A;  4BWC A;  4LOS A;  1G4F A;  1OJV A;  1OK3 A;  2Y8R A;  2ERJ A;  2Y8T A;  4KKD A;  1PPQ A;  1VVC A;  1QO6 A;  2YBY A;  2W80 A;  1H04 P;  2RLQ A;  1RLH A;  3KXV A;  4AYE A;  3OXU D;  4ZH1 D;  4K12 A;  3CI0 J;  5FO8 C;  1E8B A;  4MUC A;  5I0Q B;  4F4O C;  1GKN A;  1CKL A;  1FBR A;  2MCZ A;  2LOJ A;  4WJG 2;  1ELV A;  1OK2 A;  3MQL A;  4J38 B;  3CAL A;  4APL A;  2RLP A;  5HYU B;  2XWB F;  1G4G A;  3F6K A;  4YIZ A;  3OP8 A;  4LOT A;  2Y8S A;  1OK9 A;  3GXE A;  1Z92 B;  3NJA A;  3L89 M;  3NFP I;  4AYM A;  4A5W B;  3R62 A;  4PO7 A;  1H03 P;  3FGT A;  2IZ3 A;  2KMS A;  1HFH A;  2CG6 A;  3T5O A;  2XQW C;  4B2R A;  4FXG G;  1GHQ B;  1U5M A;  4DJZ A;  2UWN A; 
#chains in the Genus database with same CATH homology
 3GOV A;  1Q3X A;  2JGX A;  1VVD A;  1LY2 A;  1TPG A;  1ZJK A;  1E88 A;  1HFI A;  2JRA A;  5HZP B;  2JGW A;  2RL0 A;  2RKY A;  3RJ3 D;  1C1Z A;  3TVJ A;  1QGB A;  2XRD A;  1MD8 A;  1OK1 A;  3IX0 A;  3ZD2 A;  4AYI A;  4B2S A;  1O9A A;  2BZM A;  1MD7 A;  2CKU A;  2RKZ A;  4CSY A;  2WII C;  4JHS A;  1H2Q P;  2MCY A;  2YRA A;  1QUB A;  3OED C;  1TPM A;  1OJW A;  4C16 A;  3INB C;  3ZD1 A;  1OJY A;  4PZ5 A;  1H2P P;  4AYD A;  2O39 C;  4IGD A;  3SW0 X;  4ONT D;  1GKG A;  1TPN A;  2A55 A;  5JPM G;  2IZ4 A;  3ERB A;  2XWJ I;  2G7I A;  5HYT B;  4YNX A;  3IU3 I;  1E5G A;  2QY0 A;  2EC3 A;  2XRB A;  2V8E A;  2W81 A;  5HYP A;  1HCC A;  1UOT P;  1NWV A;  3EJH A;  3KZJ A;  3O8E B;  2B5I D;  1GPZ A;  2KRI A;  1SRZ A;  3M7P A;  2EHF A;  3ZRZ A;  2CG7 A;  1SS2 A;  4LOS A;  1G4F A;  1OJV A;  1OK3 A;  2ERJ A;  4KKD A;  1PPQ A;  1VVC A;  1QO6 A;  2YBY A;  2W80 A;  1H04 P;  2RLQ A;  3KXV A;  4AYE A;  3OXU D;  4ZH1 D;  4K12 A;  5FO8 C;  1E8B A;  4MUC A;  5I0Q B;  4F4O C;  1GKN A;  1CKL A;  1FBR A;  2MCZ A;  2LOJ A;  4WJG 2;  1ELV A;  1OK2 A;  3MQL A;  4J38 B;  3CAL A;  2RLP A;  5HYU B;  2XWB F;  1G4G A;  3OP8 A;  4LOT A;  1OK9 A;  3GXE A;  1Z92 B;  3L89 M;  3NFP I;  4AYM A;  4A5W B;  3R62 A;  1H03 P;  2IZ3 A;  2KMS A;  1HFH A;  2CG6 A;  3T5O A;  2XQW C;  4B2R A;  4FXG G;  1GHQ B;  1U5M A;  4DJZ A;  2UWN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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