3ZNSA

Hdac7 bound with tfmo inhibitor tmp942
Total Genus 134
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
134
sequence length
386
structure length
368
Chain Sequence
LPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords HISTONE DEACETYLASE 7
publication title Selective Class Iia Histone Deacetylase Inhibition Via a Non-Chelating Zinc Binding Group
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 134
structure length 368
sequence length 386
chains with identical sequence B, C
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2013-02-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 3znsA00
5G3WA 3Q9CA 5JI5A 4BZ9A 3MZ7A 4BZ8A 5FCWA 5G10A 5D1CA 4BZ6A 1C3PA 3MZ3A 2V5WA 5EENA 5G0XA 5EEMA 4QA7A 4ZUQA 2VQWG 4BZ7A 4ZUOA 2VQJA 3F06A 5ICNB 3EWFA 5THUA 5G0YA 1ZZ3A 5BWZA 5G1CA 5EEIA 1T69A 3Q9FA 4RN2A 4ZUPA 5EFNA 5A2SA 5EFGA 5EFHA 1T64A 1T67A 1C3RA 4QA2A 4ZUNA 3Q9BA 5DC8A 4QA6A 4QA3A 5EFKB 4CBTA 3SFFA 5LI3A 1ZZ1A 2VQQA 5G0JA 2VCGA 5EEKA 5D1DA 5EEFA 4LY1A 3C0ZA 4QA4A 4ZURA 5EFJD 5THTA 5G12A 2VQOA 4LXZA 1VKGA 3C10A 3MZ4A 3MAXA 1W22A 3RQDA 3ZNRA 4BKXB 5IWGA 5G0IA 4CBYA 3MZ6A 3F0RA 5DC6A 5DC7A 5IX0A 5G13A 5THVA 3MENA 5DC5A 5FUEA 2GH6A 5D1BA 3SFHA 2VQMA 5THSA 5G11A 4A69A 5G1AA 5G0HA 1ZZ0A 5G17A 5EF8A 3EZTA 4ZUMA 5G0GA 3EW8A 4BZ5A 4CQFA 4QA5A 5EF7A 1C3SA 2VQVA 4RN1A 4QA1A 3ZNSA 2V5XA 3F07A 4QA0A 4RN0A 3EZPA 5G1BA 3Q9EA 3C0YA 5EFBD
chains in the Genus database with same CATH superfamily
3PZLA 5G3WA 3Q9CA 3TF3A 2A0MA 1T4RA 5JI5A 5CEVA 1D3VA 1P8OA 4BZ9A 3MZ7A 1R1OA 4BZ8A 5FCWA 5G10A 4GWCA 4IE3A 5D1CA 4BZ6A 1C3PA 4RHIA 3MZ3A 1HQHA 2V5WA 4FCIA 4HWWA 3MFVA 4Q3PA 5EENA 5EEMA 5G0XA 1TBHA 3NIQA 1HQXA 2EIVA 2PHOA 4I06A 3LP7A 1GQ7A 2PHAA 4QA7A 4ZUQA 2VQWG 4BZ7A 4GSMA 1TBJA 4ZUOA 4Q3VA 4IU0A 2VQJA 3MJLA 3F06A 4G3HA 3THEA 5ICNB 1HQGA 3EWFA 1HQFA 3SL0A 5THUA 5G0YA 3E8ZA 1P8NA 1ZZ3A 3NIOA 1T5FA 1ZPGA 5BWZA 4RHJA 5G1CA 5EEIA 4HZEA 1T4PA 1T69A 1T5GA 3Q9FA 2EF4A 1P8QA 3E6VA 4IU5A 4RN2A 4ZUPA 5EFNA 3TH7A 3E6KA 5A2SA 3LP4A 1ZPEA 4RHQA 1T4SA 5EFGA 5EFHA 1T64A 4GSZA 1HQ5A 2ZAVA 3M1RA 1T67A 1C3RA 1WVBA 3MFWA 2RLAA 4QA2A 4ZUNA 3SKKA 3Q9BA 5DC8A 4QA6A 4QA3A 5EFKB 3F80A 3SFFA 4RHKA 3SL1A 4CBTA 5LI3A 1ZZ1A 2VQQA 5G0JA 2VCGA 5EEKA 1XFKA 1PQ3A 5D1DA 4MYKA 4RHLA 5EEFA 4LY1A 3C0ZA 2PLLA 3CEVA 4QA4A 4IXUA 4ZURA 5EFJD 4IE1A 4Q3RC 5G12A 5THTA 3E9BA 2VQOA 1VKGA 4LXZA 3THJA 4Q41A 3C10A 5HJ9A 4GWDA 3MAXA 1W22A 4MYLA 3RQDA 3ZNRA 1WOHA 4BKXB 5IWGA 4Q42A 4Q3TA 1P8RA 5G0IA 3THHA 2AEBA 4MYFA 4CBYA 3LHLA 4RLAA 3DJ8A 3MZ6A 3F0RA 5DC6A 5HJAA 3GMZA 5DC7A 1P8MA 1CEVA 5G13A 5IX0A 5THVA 3MENA 4RHMA 1RLAA 5DC5A 5FUEA 2GH6A 5D1BA 1WVAA 2CEVA 3SFHA 4GSVA 4Q40A 2VQMA 5THSA 3KV2A 5EFBD 4Q3SA 5G11A 4A69A 5G1AA 5G0HA 1ZZ0A 4IU1A 5G17A 5EF8A 3EZTA 4Q3UA 4ZUMA 3MMRA 5G0GA 1TBLA 3EW8A 4Q3RA 4BZ5A 4CQFA 4QA5A 1C3SA 5EF7A 4DZ4A 2VQVA 4RN1A 4Q3QA 2EF5A 4IU4A 4QA1A 3ZNSA 2V5XA 1GQ6A 3F07A 4QA0A 4RN0A 5RLAA 1TA1A 3E8QA 1P8PA 3GN0A 3NIPA 4IXVA 3RLAA 4MYNA 3EZPA 5G1BA 4CEVA 4MXRA 1WOGA 3Q9EA 4HXQA 1WOIA 4ITYA 3SJTA 1P8SA 3C0YA 1T4TA 3MZ4A 4FCKA 4IE2A
chains in the Genus database with same CATH topology
5G3WA 3Q9CA 5JI5A 4BZ9A 3MZ7A 4BZ8A 5FCWA 5G10A 5D1CA 4BZ6A 1C3PA 3MZ3A 2V5WA 5EENA 5G0XA 5EEMA 4QA7A 4ZUQA 2VQWG 4BZ7A 4ZUOA 2VQJA 3F06A 5ICNB 3EWFA 5THUA 5G0YA 1ZZ3A 5BWZA 5G1CA 5EEIA 1T69A 3Q9FA 4RN2A 4ZUPA 5EFNA 5A2SA 5EFGA 5EFHA 1T64A 1T67A 1C3RA 4QA2A 4ZUNA 3Q9BA 5DC8A 4QA6A 4QA3A 5EFKB 4CBTA 3SFFA 5LI3A 1ZZ1A 2VQQA 5G0JA 2VCGA 5EEKA 5D1DA 5EEFA 4LY1A 3C0ZA 4QA4A 4ZURA 5EFJD 5THTA 5G12A 2VQOA 4LXZA 1VKGA 3C10A 3MZ4A 3MAXA 1W22A 3RQDA 3ZNRA 4BKXB 5IWGA 5G0IA 4CBYA 3MZ6A 3F0RA 5DC6A 5DC7A 5IX0A 5G13A 5THVA 3MENA 5DC5A 5FUEA 2GH6A 5D1BA 3SFHA 2VQMA 5THSA 5G11A 4A69A 5G1AA 5G0HA 1ZZ0A 5G17A 5EF8A 3EZTA 4ZUMA 5G0GA 3EW8A 4BZ5A 4CQFA 4QA5A 5EF7A 1C3SA 2VQVA 4RN1A 4QA1A 3ZNSA 2V5XA 3F07A 4QA0A 4RN0A 3EZPA 5G1BA 3Q9EA 3C0YA 5EFBD
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5G3W A;  3Q9C A;  5JI5 A;  4BZ9 A;  3MZ7 A;  4BZ8 A;  5FCW A;  5G10 A;  5D1C A;  4BZ6 A;  1C3P A;  3MZ3 A;  2V5W A;  5EEN A;  5G0X A;  5EEM A;  4QA7 A;  4ZUQ A;  2VQW G;  4BZ7 A;  4ZUO A;  2VQJ A;  3F06 A;  5ICN B;  3EWF A;  5THU A;  5G0Y A;  1ZZ3 A;  5BWZ A;  5G1C A;  5EEI A;  1T69 A;  3Q9F A;  4RN2 A;  4ZUP A;  5EFN A;  5A2S A;  5EFG A;  5EFH A;  1T64 A;  1T67 A;  1C3R A;  4QA2 A;  4ZUN A;  3Q9B A;  5DC8 A;  4QA6 A;  4QA3 A;  5EFK B;  4CBT A;  3SFF A;  5LI3 A;  1ZZ1 A;  2VQQ A;  5G0J A;  2VCG A;  5EEK A;  5D1D A;  5EEF A;  4LY1 A;  3C0Z A;  4QA4 A;  4ZUR A;  5EFJ D;  5THT A;  5G12 A;  2VQO A;  4LXZ A;  1VKG A;  3C10 A;  3MZ4 A;  3MAX A;  1W22 A;  3RQD A;  3ZNR A;  4BKX B;  5IWG A;  5G0I A;  4CBY A;  3MZ6 A;  3F0R A;  5DC6 A;  5DC7 A;  5IX0 A;  5G13 A;  5THV A;  3MEN A;  5DC5 A;  5FUE A;  2GH6 A;  5D1B A;  3SFH A;  2VQM A;  5THS A;  5G11 A;  4A69 A;  5G1A A;  5G0H A;  1ZZ0 A;  5G17 A;  5EF8 A;  3EZT A;  4ZUM A;  5G0G A;  3EW8 A;  4BZ5 A;  4CQF A;  4QA5 A;  5EF7 A;  1C3S A;  2VQV A;  4RN1 A;  4QA1 A;  3ZNS A;  2V5X A;  3F07 A;  4QA0 A;  4RN0 A;  3EZP A;  5G1B A;  3Q9E A;  3C0Y A;  5EFB D; 
#chains in the Genus database with same CATH topology
 3PZL A;  5G3W A;  3Q9C A;  3TF3 A;  2A0M A;  1T4R A;  5JI5 A;  5CEV A;  1D3V A;  1P8O A;  4BZ9 A;  3MZ7 A;  1R1O A;  4BZ8 A;  5FCW A;  5G10 A;  4GWC A;  4IE3 A;  5D1C A;  4BZ6 A;  1C3P A;  4RHI A;  3MZ3 A;  1HQH A;  2V5W A;  4FCI A;  4HWW A;  3MFV A;  4Q3P A;  5EEN A;  5EEM A;  5G0X A;  1TBH A;  3NIQ A;  1HQX A;  2EIV A;  2PHO A;  4I06 A;  3LP7 A;  1GQ7 A;  2PHA A;  4QA7 A;  4ZUQ A;  2VQW G;  4BZ7 A;  4GSM A;  1TBJ A;  4ZUO A;  4Q3V A;  4IU0 A;  2VQJ A;  3MJL A;  3F06 A;  4G3H A;  3THE A;  5ICN B;  1HQG A;  3EWF A;  1HQF A;  3SL0 A;  5THU A;  5G0Y A;  3E8Z A;  1P8N A;  1ZZ3 A;  3NIO A;  1T5F A;  1ZPG A;  5BWZ A;  4RHJ A;  5G1C A;  5EEI A;  4HZE A;  1T4P A;  1T69 A;  1T5G A;  3Q9F A;  2EF4 A;  1P8Q A;  3E6V A;  4IU5 A;  4RN2 A;  4ZUP A;  5EFN A;  3TH7 A;  3E6K A;  5A2S A;  3LP4 A;  1ZPE A;  4RHQ A;  1T4S A;  5EFG A;  5EFH A;  1T64 A;  4GSZ A;  1HQ5 A;  2ZAV A;  3M1R A;  1T67 A;  1C3R A;  1WVB A;  3MFW A;  2RLA A;  4QA2 A;  4ZUN A;  3SKK A;  3Q9B A;  5DC8 A;  4QA6 A;  4QA3 A;  5EFK B;  3F80 A;  3SFF A;  4RHK A;  3SL1 A;  4CBT A;  5LI3 A;  1ZZ1 A;  2VQQ A;  5G0J A;  2VCG A;  5EEK A;  1XFK A;  1PQ3 A;  5D1D A;  4MYK A;  4RHL A;  5EEF A;  4LY1 A;  3C0Z A;  2PLL A;  3CEV A;  4QA4 A;  4IXU A;  4ZUR A;  5EFJ D;  4IE1 A;  4Q3R C;  5G12 A;  5THT A;  3E9B A;  2VQO A;  1VKG A;  4LXZ A;  3THJ A;  4Q41 A;  3C10 A;  5HJ9 A;  4GWD A;  3MAX A;  1W22 A;  4MYL A;  3RQD A;  3ZNR A;  1WOH A;  4BKX B;  5IWG A;  4Q42 A;  4Q3T A;  1P8R A;  5G0I A;  3THH A;  2AEB A;  4MYF A;  4CBY A;  3LHL A;  4RLA A;  3DJ8 A;  3MZ6 A;  3F0R A;  5DC6 A;  5HJA A;  3GMZ A;  5DC7 A;  1P8M A;  1CEV A;  5G13 A;  5IX0 A;  5THV A;  3MEN A;  4RHM A;  1RLA A;  5DC5 A;  5FUE A;  2GH6 A;  5D1B A;  1WVA A;  2CEV A;  3SFH A;  4GSV A;  4Q40 A;  2VQM A;  5THS A;  3KV2 A;  5EFB D;  4Q3S A;  5G11 A;  4A69 A;  5G1A A;  5G0H A;  1ZZ0 A;  4IU1 A;  5G17 A;  5EF8 A;  3EZT A;  4Q3U A;  4ZUM A;  3MMR A;  5G0G A;  1TBL A;  3EW8 A;  4Q3R A;  4BZ5 A;  4CQF A;  4QA5 A;  1C3S A;  5EF7 A;  4DZ4 A;  2VQV A;  4RN1 A;  4Q3Q A;  2EF5 A;  4IU4 A;  4QA1 A;  3ZNS A;  2V5X A;  1GQ6 A;  3F07 A;  4QA0 A;  4RN0 A;  5RLA A;  1TA1 A;  3E8Q A;  1P8P A;  3GN0 A;  3NIP A;  4IXV A;  3RLA A;  4MYN A;  3EZP A;  5G1B A;  4CEV A;  4MXR A;  1WOG A;  3Q9E A;  4HXQ A;  1WOI A;  4ITY A;  3SJT A;  1P8S A;  3C0Y A;  1T4T A;  3MZ4 A;  4FCK A;  4IE2 A; 
#chains in the Genus database with same CATH homology
 5G3W A;  3Q9C A;  5JI5 A;  4BZ9 A;  3MZ7 A;  4BZ8 A;  5FCW A;  5G10 A;  5D1C A;  4BZ6 A;  1C3P A;  3MZ3 A;  2V5W A;  5EEN A;  5G0X A;  5EEM A;  4QA7 A;  4ZUQ A;  2VQW G;  4BZ7 A;  4ZUO A;  2VQJ A;  3F06 A;  5ICN B;  3EWF A;  5THU A;  5G0Y A;  1ZZ3 A;  5BWZ A;  5G1C A;  5EEI A;  1T69 A;  3Q9F A;  4RN2 A;  4ZUP A;  5EFN A;  5A2S A;  5EFG A;  5EFH A;  1T64 A;  1T67 A;  1C3R A;  4QA2 A;  4ZUN A;  3Q9B A;  5DC8 A;  4QA6 A;  4QA3 A;  5EFK B;  4CBT A;  3SFF A;  5LI3 A;  1ZZ1 A;  2VQQ A;  5G0J A;  2VCG A;  5EEK A;  5D1D A;  5EEF A;  4LY1 A;  3C0Z A;  4QA4 A;  4ZUR A;  5EFJ D;  5THT A;  5G12 A;  2VQO A;  4LXZ A;  1VKG A;  3C10 A;  3MZ4 A;  3MAX A;  1W22 A;  3RQD A;  3ZNR A;  4BKX B;  5IWG A;  5G0I A;  4CBY A;  3MZ6 A;  3F0R A;  5DC6 A;  5DC7 A;  5IX0 A;  5G13 A;  5THV A;  3MEN A;  5DC5 A;  5FUE A;  2GH6 A;  5D1B A;  3SFH A;  2VQM A;  5THS A;  5G11 A;  4A69 A;  5G1A A;  5G0H A;  1ZZ0 A;  5G17 A;  5EF8 A;  3EZT A;  4ZUM A;  5G0G A;  3EW8 A;  4BZ5 A;  4CQF A;  4QA5 A;  5EF7 A;  1C3S A;  2VQV A;  4RN1 A;  4QA1 A;  3ZNS A;  2V5X A;  3F07 A;  4QA0 A;  4RN0 A;  3EZP A;  5G1B A;  3Q9E A;  3C0Y A;  5EFB D; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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