3ZS0C

Human myeloperoxidase inactivated by tx2
Total Genus 146
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
146
sequence length
466
structure length
465
Chain Sequence
VNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWREA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title 2-Thioxanthines are Mechanism-Based Inactivators of Myeloperoxidase that Block Oxidative Stress During Inflammation.
pubmed doi rcsb
molecule keywords MYELOPEROXIDASE LIGHT CHAIN
molecule tags Oxidoreductase
total genus 146
structure length 465
sequence length 466
chains with identical sequence D
ec nomenclature ec 1.11.2.2: Myeloperoxidase.
pdb deposition date 2011-06-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.640.10 Mainly Alpha Orthogonal Bundle Myeloperoxidase, subunit C Haem peroxidase domain superfamily, animal type 3zs0C00
1D5LC 1PGEA 3TZIA 4KVJA 3R4XA 3OLUA 1PRHA 2OYEP 4M11A 4RRYA 3RR3A 1DNUC 1Q4GA 5IKVA 3ERHA 3GCKA 1U67A 4MSFA 4FM5A 4IG5A 4KVLA 3MDLA 2QQTA 3QF1A 3V6QA 3F9PC 4NT3A 1DDXA 3LN1A 1CVUA 4OEKA 3QMOA 1PXXA 5GH0A 3Q7DA 3R5OA 1CXPC 3N8FA 4Y55A 3NAKA 2IKCA 3KRQA 4E1GA 4GM7A 5KIRA 1MHLC 3N8YB 3S4FA 1DNWC 2E9EA 4RRWA 5JVYA 5JW1A 5GLSA 3ZS1C 3GCJA 3GCLA 4HHRA 4QYQA 1IGZA 4PH9A 3FAQA 3PGHA 5F19A 2OYUP 3MQEA 1HT5A 4KSZA 1EQHA 3FNLA 3HS6A 4PNXA 3HS5A 4KVKA 3PY4A 3KK6A 4Z0LA 5JVZA 3NYHA 2GJMA 3BXIA 2OJVA 3N8VA 2O86A 3N8WA 2QPKA 4C1MC 4COXA 1EQGA 3GC1A 3KRKA 3NTBA 1PTHA 3RKEA 3NIUA 1D7WC 1FE2A 2EHAA 4RS0A 2PT3A 2EFBA 3NT1A 5FIWC 1IGXA 3TGYA 3OGWA 3SXVA 3Q9KA 4QJQA 3NTGA 3I6NA 5IKQA 5COXA 3R55A 3ERIA 1EBVA 2R5LA 4M10A 4GN6A 4O1ZA 3N8XA 4N7AA 2NQXA 1MYPC 4LJJA 3HS7A 2QRBA 1CX2A 3ZS0C 5HPWA 1HT8A 2Z5ZA 5FDQA 5IKRA 1D2VC 3QL6A 2IPSA 3R5QA 4RRZA 3N8WB 3N8ZA 6COXA 3QH0A 4NJBA 2AYLA 2PUMA 3OLTA 4DL1C 1CQEA 5F1AA 4RRXA 3UBAA 1DIYA 5B72A 4OTYA 4OTJA 3N8YA 4RUTA 4HHSA 5FF1A 3LN0A 5IKTA
chains in the Genus database with same CATH superfamily
1D5LC 1PGEA 3TZIA 4KVJA 3R4XA 3OLUA 1PRHA 2OYEP 4M11A 4RRYA 3RR3A 1DNUC 1Q4GA 5IKVA 3ERHA 3GCKA 1U67A 4MSFA 4FM5A 4IG5A 4KVLA 3MDLA 2QQTA 3QF1A 3V6QA 3F9PC 4NT3A 1DDXA 3LN1A 1CVUA 4OEKA 3QMOA 1PXXA 5GH0A 3Q7DA 3R5OA 1CXPC 3N8FA 4Y55A 3NAKA 2IKCA 3KRQA 4E1GA 4GM7A 5KIRA 1MHLC 3N8YB 3S4FA 1DNWC 2E9EA 4RRWA 5JVYA 5JW1A 5GLSA 3ZS1C 3GCJA 3GCLA 4HHRA 4QYQA 1IGZA 4PH9A 3FAQA 3PGHA 5F19A 2OYUP 3MQEA 1HT5A 4KSZA 1EQHA 3FNLA 3HS6A 4PNXA 3HS5A 4KVKA 3PY4A 3KK6A 4Z0LA 5JVZA 3NYHA 2GJMA 3BXIA 2OJVA 3N8VA 2O86A 3N8WA 2QPKA 4C1MC 4COXA 1EQGA 3GC1A 3KRKA 3NTBA 1PTHA 3RKEA 3NIUA 1D7WC 1FE2A 2EHAA 4RS0A 2PT3A 2EFBA 3NT1A 5FIWC 1IGXA 3TGYA 3OGWA 3SXVA 3Q9KA 4QJQA 3NTGA 3I6NA 5IKQA 5COXA 3R55A 3ERIA 1EBVA 2R5LA 4M10A 4GN6A 4O1ZA 3N8XA 4N7AA 2NQXA 1MYPC 4LJJA 3HS7A 2QRBA 1CX2A 3ZS0C 5HPWA 1HT8A 2Z5ZA 5FDQA 5IKRA 1D2VC 3QL6A 2IPSA 3R5QA 4RRZA 3N8WB 3N8ZA 6COXA 3QH0A 4NJBA 2AYLA 2PUMA 3OLTA 4DL1C 1CQEA 5F1AA 4RRXA 3UBAA 1DIYA 5B72A 4OTYA 4OTJA 3N8YA 4RUTA 4HHSA 5FF1A 3LN0A 5IKTA
chains in the Genus database with same CATH topology
1D5LC 1PGEA 3TZIA 4KVJA 3R4XA 3OLUA 1PRHA 2OYEP 4M11A 4RRYA 3RR3A 1DNUC 1Q4GA 5IKVA 3ERHA 3GCKA 1U67A 4MSFA 4FM5A 4IG5A 4KVLA 3MDLA 2QQTA 3QF1A 3V6QA 3F9PC 4NT3A 1DDXA 3LN1A 1CVUA 4OEKA 3QMOA 1PXXA 5GH0A 3Q7DA 3R5OA 1CXPC 3N8FA 4Y55A 3NAKA 2IKCA 3KRQA 4E1GA 4GM7A 5KIRA 1MHLC 3N8YB 3S4FA 1DNWC 2E9EA 4RRWA 5JVYA 5JW1A 5GLSA 3ZS1C 3GCJA 3GCLA 4HHRA 4QYQA 1IGZA 4PH9A 3FAQA 3PGHA 5F19A 2OYUP 3MQEA 1HT5A 4KSZA 1EQHA 3FNLA 3HS6A 4PNXA 3HS5A 4KVKA 3PY4A 3KK6A 4Z0LA 5JVZA 3NYHA 2GJMA 3BXIA 2OJVA 3N8VA 2O86A 3N8WA 2QPKA 4C1MC 4COXA 1EQGA 3GC1A 3KRKA 3NTBA 1PTHA 3RKEA 3NIUA 1D7WC 1FE2A 2EHAA 4RS0A 2PT3A 2EFBA 3NT1A 5FIWC 1IGXA 3TGYA 3OGWA 3SXVA 3Q9KA 4QJQA 3NTGA 3I6NA 5IKQA 5COXA 3R55A 3ERIA 1EBVA 2R5LA 4M10A 4GN6A 4O1ZA 3N8XA 4N7AA 2NQXA 1MYPC 4LJJA 3HS7A 2QRBA 1CX2A 3ZS0C 5HPWA 1HT8A 2Z5ZA 5FDQA 5IKRA 1D2VC 3QL6A 2IPSA 3R5QA 4RRZA 3N8WB 3N8ZA 6COXA 3QH0A 4NJBA 2AYLA 2PUMA 3OLTA 4DL1C 1CQEA 5F1AA 4RRXA 3UBAA 1DIYA 5B72A 4OTYA 4OTJA 3N8YA 4RUTA 4HHSA 5FF1A 3LN0A 5IKTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1D5L C;  1PGE A;  3TZI A;  4KVJ A;  3R4X A;  3OLU A;  1PRH A;  2OYE P;  4M11 A;  4RRY A;  3RR3 A;  1DNU C;  1Q4G A;  5IKV A;  3ERH A;  3GCK A;  1U67 A;  4MSF A;  4FM5 A;  4IG5 A;  4KVL A;  3MDL A;  2QQT A;  3QF1 A;  3V6Q A;  3F9P C;  4NT3 A;  1DDX A;  3LN1 A;  1CVU A;  4OEK A;  3QMO A;  1PXX A;  5GH0 A;  3Q7D A;  3R5O A;  1CXP C;  3N8F A;  4Y55 A;  3NAK A;  2IKC A;  3KRQ A;  4E1G A;  4GM7 A;  5KIR A;  1MHL C;  3N8Y B;  3S4F A;  1DNW C;  2E9E A;  4RRW A;  5JVY A;  5JW1 A;  5GLS A;  3ZS1 C;  3GCJ A;  3GCL A;  4HHR A;  4QYQ A;  1IGZ A;  4PH9 A;  3FAQ A;  3PGH A;  5F19 A;  2OYU P;  3MQE A;  1HT5 A;  4KSZ A;  1EQH A;  3FNL A;  3HS6 A;  4PNX A;  3HS5 A;  4KVK A;  3PY4 A;  3KK6 A;  4Z0L A;  5JVZ A;  3NYH A;  2GJM A;  3BXI A;  2OJV A;  3N8V A;  2O86 A;  3N8W A;  2QPK A;  4C1M C;  4COX A;  1EQG A;  3GC1 A;  3KRK A;  3NTB A;  1PTH A;  3RKE A;  3NIU A;  1D7W C;  1FE2 A;  2EHA A;  4RS0 A;  2PT3 A;  2EFB A;  3NT1 A;  5FIW C;  1IGX A;  3TGY A;  3OGW A;  3SXV A;  3Q9K A;  4QJQ A;  3NTG A;  3I6N A;  5IKQ A;  5COX A;  3R55 A;  3ERI A;  1EBV A;  2R5L A;  4M10 A;  4GN6 A;  4O1Z A;  3N8X A;  4N7A A;  2NQX A;  1MYP C;  4LJJ A;  3HS7 A;  2QRB A;  1CX2 A;  3ZS0 C;  5HPW A;  1HT8 A;  2Z5Z A;  5FDQ A;  5IKR A;  1D2V C;  3QL6 A;  2IPS A;  3R5Q A;  4RRZ A;  3N8W B;  3N8Z A;  6COX A;  3QH0 A;  4NJB A;  2AYL A;  2PUM A;  3OLT A;  4DL1 C;  1CQE A;  5F1A A;  4RRX A;  3UBA A;  1DIY A;  5B72 A;  4OTY A;  4OTJ A;  3N8Y A;  4RUT A;  4HHS A;  5FF1 A;  3LN0 A;  5IKT A; 
#chains in the Genus database with same CATH topology
 1D5L C;  1PGE A;  3TZI A;  4KVJ A;  3R4X A;  3OLU A;  1PRH A;  2OYE P;  4M11 A;  4RRY A;  3RR3 A;  1DNU C;  1Q4G A;  5IKV A;  3ERH A;  3GCK A;  1U67 A;  4MSF A;  4FM5 A;  4IG5 A;  4KVL A;  3MDL A;  2QQT A;  3QF1 A;  3V6Q A;  3F9P C;  4NT3 A;  1DDX A;  3LN1 A;  1CVU A;  4OEK A;  3QMO A;  1PXX A;  5GH0 A;  3Q7D A;  3R5O A;  1CXP C;  3N8F A;  4Y55 A;  3NAK A;  2IKC A;  3KRQ A;  4E1G A;  4GM7 A;  5KIR A;  1MHL C;  3N8Y B;  3S4F A;  1DNW C;  2E9E A;  4RRW A;  5JVY A;  5JW1 A;  5GLS A;  3ZS1 C;  3GCJ A;  3GCL A;  4HHR A;  4QYQ A;  1IGZ A;  4PH9 A;  3FAQ A;  3PGH A;  5F19 A;  2OYU P;  3MQE A;  1HT5 A;  4KSZ A;  1EQH A;  3FNL A;  3HS6 A;  4PNX A;  3HS5 A;  4KVK A;  3PY4 A;  3KK6 A;  4Z0L A;  5JVZ A;  3NYH A;  2GJM A;  3BXI A;  2OJV A;  3N8V A;  2O86 A;  3N8W A;  2QPK A;  4C1M C;  4COX A;  1EQG A;  3GC1 A;  3KRK A;  3NTB A;  1PTH A;  3RKE A;  3NIU A;  1D7W C;  1FE2 A;  2EHA A;  4RS0 A;  2PT3 A;  2EFB A;  3NT1 A;  5FIW C;  1IGX A;  3TGY A;  3OGW A;  3SXV A;  3Q9K A;  4QJQ A;  3NTG A;  3I6N A;  5IKQ A;  5COX A;  3R55 A;  3ERI A;  1EBV A;  2R5L A;  4M10 A;  4GN6 A;  4O1Z A;  3N8X A;  4N7A A;  2NQX A;  1MYP C;  4LJJ A;  3HS7 A;  2QRB A;  1CX2 A;  3ZS0 C;  5HPW A;  1HT8 A;  2Z5Z A;  5FDQ A;  5IKR A;  1D2V C;  3QL6 A;  2IPS A;  3R5Q A;  4RRZ A;  3N8W B;  3N8Z A;  6COX A;  3QH0 A;  4NJB A;  2AYL A;  2PUM A;  3OLT A;  4DL1 C;  1CQE A;  5F1A A;  4RRX A;  3UBA A;  1DIY A;  5B72 A;  4OTY A;  4OTJ A;  3N8Y A;  4RUT A;  4HHS A;  5FF1 A;  3LN0 A;  5IKT A; 
#chains in the Genus database with same CATH homology
 1D5L C;  1PGE A;  3TZI A;  4KVJ A;  3R4X A;  3OLU A;  1PRH A;  2OYE P;  4M11 A;  4RRY A;  3RR3 A;  1DNU C;  1Q4G A;  5IKV A;  3ERH A;  3GCK A;  1U67 A;  4MSF A;  4FM5 A;  4IG5 A;  4KVL A;  3MDL A;  2QQT A;  3QF1 A;  3V6Q A;  3F9P C;  4NT3 A;  1DDX A;  3LN1 A;  1CVU A;  4OEK A;  3QMO A;  1PXX A;  5GH0 A;  3Q7D A;  3R5O A;  1CXP C;  3N8F A;  4Y55 A;  3NAK A;  2IKC A;  3KRQ A;  4E1G A;  4GM7 A;  5KIR A;  1MHL C;  3N8Y B;  3S4F A;  1DNW C;  2E9E A;  4RRW A;  5JVY A;  5JW1 A;  5GLS A;  3ZS1 C;  3GCJ A;  3GCL A;  4HHR A;  4QYQ A;  1IGZ A;  4PH9 A;  3FAQ A;  3PGH A;  5F19 A;  2OYU P;  3MQE A;  1HT5 A;  4KSZ A;  1EQH A;  3FNL A;  3HS6 A;  4PNX A;  3HS5 A;  4KVK A;  3PY4 A;  3KK6 A;  4Z0L A;  5JVZ A;  3NYH A;  2GJM A;  3BXI A;  2OJV A;  3N8V A;  2O86 A;  3N8W A;  2QPK A;  4C1M C;  4COX A;  1EQG A;  3GC1 A;  3KRK A;  3NTB A;  1PTH A;  3RKE A;  3NIU A;  1D7W C;  1FE2 A;  2EHA A;  4RS0 A;  2PT3 A;  2EFB A;  3NT1 A;  5FIW C;  1IGX A;  3TGY A;  3OGW A;  3SXV A;  3Q9K A;  4QJQ A;  3NTG A;  3I6N A;  5IKQ A;  5COX A;  3R55 A;  3ERI A;  1EBV A;  2R5L A;  4M10 A;  4GN6 A;  4O1Z A;  3N8X A;  4N7A A;  2NQX A;  1MYP C;  4LJJ A;  3HS7 A;  2QRB A;  1CX2 A;  3ZS0 C;  5HPW A;  1HT8 A;  2Z5Z A;  5FDQ A;  5IKR A;  1D2V C;  3QL6 A;  2IPS A;  3R5Q A;  4RRZ A;  3N8W B;  3N8Z A;  6COX A;  3QH0 A;  4NJB A;  2AYL A;  2PUM A;  3OLT A;  4DL1 C;  1CQE A;  5F1A A;  4RRX A;  3UBA A;  1DIY A;  5B72 A;  4OTY A;  4OTJ A;  3N8Y A;  4RUT A;  4HHS A;  5FF1 A;  3LN0 A;  5IKT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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