3ZUQA

Crystal structure of an engineered botulinum neurotoxin type b - derivative, lc-b-gs-hn-b
Total Genus 273
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
273
sequence length
892
structure length
850
Chain Sequence
MPVTINNFNYNDPIDNNNIIMMEPPFARGTGRYYKAFKITDRIWIIPERYTFGYKPEDFNKSSGIFNRDVCEYYDPDYLNTNDKKNIFLQTMIKLFNRIKSKPLGEKLLEMIINGIPYLGDRRVPLEEFNTNIASVTVNKLISNPGEVERKKGIFANLIIFGPGPVLNENETIDIGIQNHFASREGFGGIMQMKFCPEYVSVFNNVQENKGASIFNRRGYFSDPALILMHELIHVLHGLYGIKVDDLPIVPNEKKFFMQSTDAIQAEELYTFGGQDPSIITPSTDKSIYDKVLQNFRGIVDRLNKVLVCISDPNININIYKNKFKDKYKFVEDSEGKYSIDVESFDKLYKSLMFGFTETNIAENYKIKTRASYFSDSLPPVKIKNLLDNEIYTIEEGFNISDKDMEKEYRGQNKAINKQAYEEISKEHLAVYKIQMCVDLVLQCIDVDNEDLFFIADKNSFSDDLSKNERIEYNTQSNYIENDFPINELILDTDLISKIELPSENTESLTDFNVDVPVYEKQPAIKKIFTDENTIFQYLYSQTFPLDIRDISLTSSFDDALLFSNKVYSFFSMDYIKTANKVVEAGLFAGWVKQIVNDFVIEANKSNTDISLIVPYIGLALNVGNETAKGNFENAFEIAGASILLEFIPELLIPVVGAFLLESYIDNKNKIIKTIDNALTKRNEKWSDMYGLIVAQWLSTVNTQFYTIKEGMYKALNYQAQALEEIIKYRYNIYSEKEKSNINIDFNDINSKLNEGINQAIDNINNFINGCSVSYLMKKMIPLAVEKLLDFDNTLKKNLLNYIDENKLYLIGSAEYEKSKVNKYLKTIMPFDLSIYTNDTILIEMFNKYN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structures of Engineered Clostridium Botulinum Neurotoxin Derivatives
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords BOTULINUM NEUROTOXIN TYPE B
total genus 273
structure length 850
sequence length 892
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2011-07-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
A PF07952 Toxin_trans Clostridium neurotoxin, Translocation domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1120.10 Mainly Alpha Up-down Bundle Clostridium botulinum neurotoxin B, "coiled-coil" domain Clostridium botulinum neurotoxin b, "coiled-coil" domain 3zuqA02
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 3zuqA01
1G9CA 2G7NA 3FFZA 2NP0A 2IMBA 4ZJXA 1Z7HA 1S0CA 3C8AA 1ZL6A 1S0EA 3C89A 1G9BA 3QW5A 4HEVA 3V0AA 1ZB7A 3QIZA 2A97A 4KS6A 1EPWA 2ISEA 3ZUSA 4ZKTB 3DDBA 2ILPA 4KUFA 2W2DA 2XHLA 3NF3A 2W2DB 1T3AA 3QW7A 2XHLB 1YVGA 3C8BA 2ISHA 3V0AB 4ELCA 3BOKA 3ZURA 1S0DA 1ZN3A 5BQMA 2IMAA 3QW6A 2G7PA 3DS9A 4J1LA 1ZKXA 1S0FA 3QIYA 3FIIA 2G7KA 3C88A 1G9AA 1ZL5A 2G7QA 3V0BA 3QIXA 1I1EA 3BOOA 3BWIA 3V0BB 3BTAA 1F82A 1XTFA 5BQNA 3BONA 2ISGA 2FPQA 1S0BA 3K3QB 1XTGA 2A8AA 3ZUQA 3VUOA 2IMCA 1F31A 3D3XA 3DDAA 5BQMB 1S0GA 3DSEA 1E1HA 3FIEA 3QW8A 2ETFA 3QJ0A 1ZKWA 3DEBA 1G9DA 2QN0A 4EJ5A 4KTXA 4EL4A 1T3CA 2NYYA 2NZ9A
chains in the Genus database with same CATH superfamily
1G9CA 2G7NA 3FFZA 2NP0A 2IMBA 4ZJXA 1Z7HA 1S0CA 3C8AA 1ZL6A 1S0EA 3E11A 3C89A 1G9BA 3QW5A 4HEVA 3V0AA 1ZB7A 3QIZA 2A97A 4KS6A 1EPWA 2ISEA 3ZUSA 4ZKTB 3DDBA 2ILPA 4KUFA 2W2DA 2XHLA 3NF3A 4JIXA 2W2DB 1T3AA 3QW7A 2XHLB 1YVGA 3C8BA 2ISHA 3V0AB 4ELCA 4QHFA 3BOKA 3ZURA 1S0DA 1ZN3A 4IL3A 5BQMA 2IMAA 3QW6A 2G7PA 3DS9A 4J1LA 1ZKXA 1S0FA 3QIYA 3FIIA 2G7KA 3C88A 1G9AA 1ZL5A 2G7QA 3V0BA 3QIXA 1I1EA 3BOOA 3BWIA 3V0BB 3BTAA 4JIUA 1F82A 1XTFA 5BQNA 3BONA 2ISGA 2FPQA 1S0BA 3K3QB 1XTGA 2A8AA 3ZUQA 3VUOA 2IMCA 3CQBA 1F31A 3D3XA 3DDAA 5BQMB 1S0GA 3DSEA 1E1HA 3FIEA 4AW6A 3QW8A 2ETFA 3QJ0A 1ZKWA 3DEBA 1G9DA 2QN0A 4EJ5A 2EJQA 2YPTA 4KTXA 4EL4A 1T3CA 2NYYA 2NZ9A
chains in the Genus database with same CATH topology
1G9CA 2G7NA 3FFZA 2NP0A 2IMBA 4ZJXA 1Z7HA 1S0CA 3C8AA 1ZL6A 1S0EA 3C89A 1G9BA 3QW5A 4HEVA 3V0AA 1ZB7A 3QIZA 2A97A 4KS6A 1EPWA 2ISEA 3ZUSA 4ZKTB 3DDBA 2ILPA 4KUFA 2W2DA 2XHLA 3NF3A 2W2DB 1T3AA 3QW7A 2XHLB 1YVGA 3C8BA 2ISHA 3V0AB 4ELCA 3BOKA 3ZURA 1S0DA 1ZN3A 5BQMA 2IMAA 3QW6A 2G7PA 3DS9A 4J1LA 1ZKXA 1S0FA 3QIYA 3FIIA 2G7KA 3C88A 1G9AA 1ZL5A 2G7QA 3V0BA 3QIXA 1I1EA 3BOOA 3BWIA 3V0BB 3BTAA 1F82A 1XTFA 5BQNA 3BONA 2ISGA 2FPQA 1S0BA 3K3QB 1XTGA 2A8AA 3ZUQA 3VUOA 2IMCA 1F31A 3D3XA 3DDAA 5BQMB 1S0GA 3DSEA 1E1HA 3FIEA 3QW8A 2ETFA 3QJ0A 1ZKWA 3DEBA 1G9DA 2QN0A 4EJ5A 4KTXA 4EL4A 1T3CA 2NYYA 2NZ9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1G9C A;  2G7N A;  3FFZ A;  2NP0 A;  2IMB A;  4ZJX A;  1Z7H A;  1S0C A;  3C8A A;  1ZL6 A;  1S0E A;  3C89 A;  1G9B A;  3QW5 A;  4HEV A;  3V0A A;  1ZB7 A;  3QIZ A;  2A97 A;  4KS6 A;  1EPW A;  2ISE A;  3ZUS A;  4ZKT B;  3DDB A;  2ILP A;  4KUF A;  2W2D A;  2XHL A;  3NF3 A;  2W2D B;  1T3A A;  3QW7 A;  2XHL B;  1YVG A;  3C8B A;  2ISH A;  3V0A B;  4ELC A;  3BOK A;  3ZUR A;  1S0D A;  1ZN3 A;  5BQM A;  2IMA A;  3QW6 A;  2G7P A;  3DS9 A;  4J1L A;  1ZKX A;  1S0F A;  3QIY A;  3FII A;  2G7K A;  3C88 A;  1G9A A;  1ZL5 A;  2G7Q A;  3V0B A;  3QIX A;  1I1E A;  3BOO A;  3BWI A;  3V0B B;  3BTA A;  1F82 A;  1XTF A;  5BQN A;  3BON A;  2ISG A;  2FPQ A;  1S0B A;  3K3Q B;  1XTG A;  2A8A A;  3ZUQ A;  3VUO A;  2IMC A;  1F31 A;  3D3X A;  3DDA A;  5BQM B;  1S0G A;  3DSE A;  1E1H A;  3FIE A;  3QW8 A;  2ETF A;  3QJ0 A;  1ZKW A;  3DEB A;  1G9D A;  2QN0 A;  4EJ5 A;  4KTX A;  4EL4 A;  1T3C A;  2NYY A;  2NZ9 A; 
#chains in the Genus database with same CATH topology
 1G9C A;  2G7N A;  3FFZ A;  2NP0 A;  2IMB A;  4ZJX A;  1Z7H A;  1S0C A;  3C8A A;  1ZL6 A;  1S0E A;  3E11 A;  3C89 A;  1G9B A;  3QW5 A;  4HEV A;  3V0A A;  1ZB7 A;  3QIZ A;  2A97 A;  4KS6 A;  1EPW A;  2ISE A;  3ZUS A;  4ZKT B;  3DDB A;  2ILP A;  4KUF A;  2W2D A;  2XHL A;  3NF3 A;  4JIX A;  2W2D B;  1T3A A;  3QW7 A;  2XHL B;  1YVG A;  3C8B A;  2ISH A;  3V0A B;  4ELC A;  4QHF A;  3BOK A;  3ZUR A;  1S0D A;  1ZN3 A;  4IL3 A;  5BQM A;  2IMA A;  3QW6 A;  2G7P A;  3DS9 A;  4J1L A;  1ZKX A;  1S0F A;  3QIY A;  3FII A;  2G7K A;  3C88 A;  1G9A A;  1ZL5 A;  2G7Q A;  3V0B A;  3QIX A;  1I1E A;  3BOO A;  3BWI A;  3V0B B;  3BTA A;  4JIU A;  1F82 A;  1XTF A;  5BQN A;  3BON A;  2ISG A;  2FPQ A;  1S0B A;  3K3Q B;  1XTG A;  2A8A A;  3ZUQ A;  3VUO A;  2IMC A;  3CQB A;  1F31 A;  3D3X A;  3DDA A;  5BQM B;  1S0G A;  3DSE A;  1E1H A;  3FIE A;  4AW6 A;  3QW8 A;  2ETF A;  3QJ0 A;  1ZKW A;  3DEB A;  1G9D A;  2QN0 A;  4EJ5 A;  2EJQ A;  2YPT A;  4KTX A;  4EL4 A;  1T3C A;  2NYY A;  2NZ9 A; 
#chains in the Genus database with same CATH homology
 1G9C A;  2G7N A;  3FFZ A;  2NP0 A;  2IMB A;  4ZJX A;  1Z7H A;  1S0C A;  3C8A A;  1ZL6 A;  1S0E A;  3C89 A;  1G9B A;  3QW5 A;  4HEV A;  3V0A A;  1ZB7 A;  3QIZ A;  2A97 A;  4KS6 A;  1EPW A;  2ISE A;  3ZUS A;  4ZKT B;  3DDB A;  2ILP A;  4KUF A;  2W2D A;  2XHL A;  3NF3 A;  2W2D B;  1T3A A;  3QW7 A;  2XHL B;  1YVG A;  3C8B A;  2ISH A;  3V0A B;  4ELC A;  3BOK A;  3ZUR A;  1S0D A;  1ZN3 A;  5BQM A;  2IMA A;  3QW6 A;  2G7P A;  3DS9 A;  4J1L A;  1ZKX A;  1S0F A;  3QIY A;  3FII A;  2G7K A;  3C88 A;  1G9A A;  1ZL5 A;  2G7Q A;  3V0B A;  3QIX A;  1I1E A;  3BOO A;  3BWI A;  3V0B B;  3BTA A;  1F82 A;  1XTF A;  5BQN A;  3BON A;  2ISG A;  2FPQ A;  1S0B A;  3K3Q B;  1XTG A;  2A8A A;  3ZUQ A;  3VUO A;  2IMC A;  1F31 A;  3D3X A;  3DDA A;  5BQM B;  1S0G A;  3DSE A;  1E1H A;  3FIE A;  3QW8 A;  2ETF A;  3QJ0 A;  1ZKW A;  3DEB A;  1G9D A;  2QN0 A;  4EJ5 A;  4KTX A;  4EL4 A;  1T3C A;  2NYY A;  2NZ9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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