3BDGA

Crystal structure of wild-type/t155v mixed dimer of e. coli alkaline phosphatase
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
Knots found
sequence length
448
structure length
434
Chain Sequence
b'PEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDAVPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 159
structure length 434
sequence length 448
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdgA00
4LRBA 5L0KA 4GTXA 3WAXA 3M8ZA 5DLVA 2W5XA 3UN3A 1EJJA 2GSNA 1EW2A 3E2DA 4UPKA 1K7HA 4KJDA 1URAA 4LQYA 3WAVA 4CXUA 2IUCA 3WAWA 1FSUA 1KH4A 1EW9A 5INHA 4CXKA 2XR9A 5IJQA 3CMRA 1EQJA 1Y6VA 3B5QA 1E3CP 1HJKA 3LXQA 4UOPA 3M8YA 1KH9A 1KHLA 1E33P 3MK1A 4UPIA 4CYSA 2IUCB 5DLTA 2QZUA 3BDGA 3DPCA 4ZG6A 5GRRA 1ANIA 1ANJA 3NKPA 5GOVA 1EW8A 4UOOA 1ALIA 4NWXA 1ALJA 1EI6A 1ALHA 1KHNA 1KH5A 2W5VA 1KH7A 4GTWA 3UN5A 4LR2A 5L0BA 4UPHA 1O99A 1ED9A 3IGZB 1ZEDA 4MY4A 5L0EA 4LRAA 3BDFA 1ED8A 2GSOA 1HDHA 2ZKTA 3A52A 3BDGB 1ALKA 3Q3QA 5LRMA 4CXSA 2IFYA 2W5TA 3M7VA 2XRGA 4UORA 3WBHA 2VQRA 4KM4A 3WAYA 3NKQA 3DYCA 3T00A 4NWJA 4KAVA 1AJAA 4MHXA 4FDJA 4LREA 4ZG7A 1ZEFA 4FDIA 1KHJA 3TG0A 2GA3A 3SZYA 1AJDA 1N2KA 4ZG9A 3TWZA 4UPLA 4YR1A 2W5WA 3NKRA 1E1ZP 5DLWA 2RH6A 1O98A 1ELXA 4KAYA 4QAXA 3NKNA 3TX0A 1ZEBA 3IDDA 4LR9A 3M8WA 5K4PA 5C66A 4LR7A 2W8DA 3NKMA 1P49A 1AJBA 2ANHA 2W5SA 4LRDA 4ZGAA 5IJSA 5LQQA 5EGHA 4GTYA 1SHQA 4N7TA 1ELZA 4B56A 4MIVA 3IGYB 2GLQA 3UNYA 4GTZA 3KD8A 4CYRA 3NKOA 3MK0A 3T02A 1AJCA 4KJGA 4LRFA 3UO0A 3UN2A 4LRCA 1KHKA 3SZZA 3OT9A 2W5RA 1E2SP 3MK2A 5AJ9A 1B8JA 2W8SA 1N2LA 5KXAA 5TJ3A 5HRTA 2GSUA 3T01A 1Y7AA 4TN0A 3NVLA 2D1GA 2G9YA 5LIAA 1ELYA 2W5QA 1HQAA 4LR8A 5EGEA 1SHNA 1URBA 3BDHA 1AUKA 5LRNA 3ED4A 2X98A
chains in the Genus database with same CATH superfamily
4LRBA 5L0KA 4GTXA 3WAXA 3M8ZA 5DLVA 2W5XA 3UN3A 1EJJA 2GSNA 1EW2A 3E2DA 4UPKA 1K7HA 4KJDA 1URAA 4LQYA 3WAVA 4CXUA 2IUCA 3WAWA 1FSUA 1KH4A 1EW9A 5INHA 4CXKA 2XR9A 5IJQA 3CMRA 1EQJA 1Y6VA 3B5QA 1E3CP 1HJKA 3LXQA 4UOPA 3M8YA 1KH9A 1KHLA 1E33P 3MK1A 4UPIA 4CYSA 2IUCB 5DLTA 2QZUA 3BDGA 3DPCA 4ZG6A 5GRRA 1ANIA 1ANJA 3NKPA 5GOVA 1EW8A 4UOOA 1ALIA 4NWXA 1ALJA 1EI6A 1ALHA 1KHNA 1KH5A 2W5VA 1KH7A 4GTWA 3UN5A 4LR2A 5L0BA 4UPHA 1O99A 1ED9A 3IGZB 1ZEDA 4MY4A 5L0EA 4LRAA 3BDFA 1ED8A 2GSOA 1HDHA 2ZKTA 3A52A 3BDGB 1ALKA 3Q3QA 5LRMA 4CXSA 2IFYA 2W5TA 3M7VA 2XRGA 4UORA 3WBHA 2VQRA 4KM4A 3WAYA 3NKQA 3DYCA 3T00A 4NWJA 4KAVA 1AJAA 4MHXA 4FDJA 4LREA 4ZG7A 1ZEFA 4FDIA 1KHJA 3TG0A 2GA3A 3SZYA 1AJDA 1N2KA 4ZG9A 3TWZA 4UPLA 4YR1A 2W5WA 3NKRA 1E1ZP 5DLWA 2RH6A 1O98A 1ELXA 4KAYA 4QAXA 3NKNA 3TX0A 1ZEBA 3IDDA 4LR9A 3M8WA 5K4PA 5C66A 4LR7A 2W8DA 3NKMA 1P49A 1AJBA 2ANHA 2W5SA 4LRDA 4ZGAA 5IJSA 5LQQA 5EGHA 4GTYA 1SHQA 4N7TA 1ELZA 4B56A 4MIVA 3IGYB 2GLQA 3UNYA 4GTZA 3KD8A 4CYRA 3NKOA 3MK0A 3T02A 1AJCA 4KJGA 4LRFA 3UO0A 3UN2A 4LRCA 1KHKA 3SZZA 3OT9A 2W5RA 1E2SP 3MK2A 5AJ9A 1B8JA 2W8SA 1N2LA 5KXAA 5TJ3A 5HRTA 2GSUA 3T01A 1Y7AA 4TN0A 3NVLA 2D1GA 2G9YA 5LIAA 1ELYA 2W5QA 1HQAA 4LR8A 5EGEA 1SHNA 1URBA 3BDHA 1AUKA 5LRNA 3ED4A 2X98A
chains in the Genus database with same CATH topology
4LRBA 5L0KA 4GTXA 3WAXA 3M8ZA 5DLVA 2W5XA 3UN3A 1EJJA 2GSNA 1EW2A 3E2DA 4UPKA 1K7HA 4KJDA 1URAA 4LQYA 3WAVA 4CXUA 2IUCA 3WAWA 1FSUA 1KH4A 1EW9A 5INHA 4CXKA 2XR9A 5IJQA 3CMRA 1EQJA 1Y6VA 3B5QA 1E3CP 1HJKA 3LXQA 4UOPA 3M8YA 1KH9A 1KHLA 1E33P 3MK1A 4UPIA 4CYSA 2IUCB 5DLTA 2QZUA 3BDGA 3DPCA 4ZG6A 5GRRA 1ANIA 1ANJA 3NKPA 5GOVA 1EW8A 4UOOA 1ALIA 4NWXA 1ALJA 1EI6A 1ALHA 1KHNA 1KH5A 2W5VA 1KH7A 4GTWA 3UN5A 4LR2A 5L0BA 4UPHA 1O99A 1ED9A 3IGZB 1ZEDA 4MY4A 5L0EA 4LRAA 3BDFA 1ED8A 2GSOA 1HDHA 2ZKTA 3A52A 3BDGB 1ALKA 3Q3QA 5LRMA 4CXSA 2IFYA 2W5TA 3M7VA 2XRGA 4UORA 3WBHA 2VQRA 4KM4A 3WAYA 3NKQA 3DYCA 3T00A 4NWJA 4KAVA 1AJAA 4MHXA 4FDJA 4LREA 4ZG7A 1ZEFA 4FDIA 1KHJA 3TG0A 2GA3A 3SZYA 1AJDA 1N2KA 4ZG9A 3TWZA 4UPLA 4YR1A 2W5WA 3NKRA 1E1ZP 5DLWA 2RH6A 1O98A 1ELXA 4KAYA 4QAXA 3NKNA 3TX0A 1ZEBA 3IDDA 4LR9A 3M8WA 5K4PA 5C66A 4LR7A 2W8DA 3NKMA 1P49A 1AJBA 2ANHA 2W5SA 4LRDA 4ZGAA 5IJSA 5LQQA 5EGHA 4GTYA 1SHQA 4N7TA 1ELZA 4B56A 4MIVA 3IGYB 2GLQA 3UNYA 4GTZA 3KD8A 4CYRA 3NKOA 3MK0A 3T02A 1AJCA 4KJGA 4LRFA 3UO0A 3UN2A 4LRCA 1KHKA 3SZZA 3OT9A 2W5RA 1E2SP 3MK2A 5AJ9A 1B8JA 2W8SA 1N2LA 5KXAA 5TJ3A 5HRTA 2GSUA 3T01A 1Y7AA 4TN0A 3NVLA 2D1GA 2G9YA 5LIAA 1ELYA 2W5QA 1HQAA 4LR8A 5EGEA 1SHNA 1URBA 3BDHA 1AUKA 5LRNA 3ED4A 2X98A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LRB A;  5L0K A;  4GTX A;  3WAX A;  3M8Z A;  5DLV A;  2W5X A;  3UN3 A;  1EJJ A;  2GSN A;  1EW2 A;  3E2D A;  4UPK A;  1K7H A;  4KJD A;  1URA A;  4LQY A;  3WAV A;  4CXU A;  2IUC A;  3WAW A;  1FSU A;  1KH4 A;  1EW9 A;  5INH A;  4CXK A;  2XR9 A;  5IJQ A;  3CMR A;  1EQJ A;  1Y6V A;  3B5Q A;  1E3C P;  1HJK A;  3LXQ A;  4UOP A;  3M8Y A;  1KH9 A;  1KHL A;  1E33 P;  3MK1 A;  4UPI A;  4CYS A;  2IUC B;  5DLT A;  2QZU A;  3BDG A;  3DPC A;  4ZG6 A;  5GRR A;  1ANI A;  1ANJ A;  3NKP A;  5GOV A;  1EW8 A;  4UOO A;  1ALI A;  4NWX A;  1ALJ A;  1EI6 A;  1ALH A;  1KHN A;  1KH5 A;  2W5V A;  1KH7 A;  4GTW A;  3UN5 A;  4LR2 A;  5L0B A;  4UPH A;  1O99 A;  1ED9 A;  3IGZ B;  1ZED A;  4MY4 A;  5L0E A;  4LRA A;  3BDF A;  1ED8 A;  2GSO A;  1HDH A;  2ZKT A;  3A52 A;  3BDG B;  1ALK A;  3Q3Q A;  5LRM A;  4CXS A;  2IFY A;  2W5T A;  3M7V A;  2XRG A;  4UOR A;  3WBH A;  2VQR A;  4KM4 A;  3WAY A;  3NKQ A;  3DYC A;  3T00 A;  4NWJ A;  4KAV A;  1AJA A;  4MHX A;  4FDJ A;  4LRE A;  4ZG7 A;  1ZEF A;  4FDI A;  1KHJ A;  3TG0 A;  2GA3 A;  3SZY A;  1AJD A;  1N2K A;  4ZG9 A;  3TWZ A;  4UPL A;  4YR1 A;  2W5W A;  3NKR A;  1E1Z P;  5DLW A;  2RH6 A;  1O98 A;  1ELX A;  4KAY A;  4QAX A;  3NKN A;  3TX0 A;  1ZEB A;  3IDD A;  4LR9 A;  3M8W A;  5K4P A;  5C66 A;  4LR7 A;  2W8D A;  3NKM A;  1P49 A;  1AJB A;  2ANH A;  2W5S A;  4LRD A;  4ZGA A;  5IJS A;  5LQQ A;  5EGH A;  4GTY A;  1SHQ A;  4N7T A;  1ELZ A;  4B56 A;  4MIV A;  3IGY B;  2GLQ A;  3UNY A;  4GTZ A;  3KD8 A;  4CYR A;  3NKO A;  3MK0 A;  3T02 A;  1AJC A;  4KJG A;  4LRF A;  3UO0 A;  3UN2 A;  4LRC A;  1KHK A;  3SZZ A;  3OT9 A;  2W5R A;  1E2S P;  3MK2 A;  5AJ9 A;  1B8J A;  2W8S A;  1N2L A;  5KXA A;  5TJ3 A;  5HRT A;  2GSU A;  3T01 A;  1Y7A A;  4TN0 A;  3NVL A;  2D1G A;  2G9Y A;  5LIA A;  1ELY A;  2W5Q A;  1HQA A;  4LR8 A;  5EGE A;  1SHN A;  1URB A;  3BDH A;  1AUK A;  5LRN A;  3ED4 A;  2X98 A; 
#chains in the Genus database with same CATH topology
 4LRB A;  5L0K A;  4GTX A;  3WAX A;  3M8Z A;  5DLV A;  2W5X A;  3UN3 A;  1EJJ A;  2GSN A;  1EW2 A;  3E2D A;  4UPK A;  1K7H A;  4KJD A;  1URA A;  4LQY A;  3WAV A;  4CXU A;  2IUC A;  3WAW A;  1FSU A;  1KH4 A;  1EW9 A;  5INH A;  4CXK A;  2XR9 A;  5IJQ A;  3CMR A;  1EQJ A;  1Y6V A;  3B5Q A;  1E3C P;  1HJK A;  3LXQ A;  4UOP A;  3M8Y A;  1KH9 A;  1KHL A;  1E33 P;  3MK1 A;  4UPI A;  4CYS A;  2IUC B;  5DLT A;  2QZU A;  3BDG A;  3DPC A;  4ZG6 A;  5GRR A;  1ANI A;  1ANJ A;  3NKP A;  5GOV A;  1EW8 A;  4UOO A;  1ALI A;  4NWX A;  1ALJ A;  1EI6 A;  1ALH A;  1KHN A;  1KH5 A;  2W5V A;  1KH7 A;  4GTW A;  3UN5 A;  4LR2 A;  5L0B A;  4UPH A;  1O99 A;  1ED9 A;  3IGZ B;  1ZED A;  4MY4 A;  5L0E A;  4LRA A;  3BDF A;  1ED8 A;  2GSO A;  1HDH A;  2ZKT A;  3A52 A;  3BDG B;  1ALK A;  3Q3Q A;  5LRM A;  4CXS A;  2IFY A;  2W5T A;  3M7V A;  2XRG A;  4UOR A;  3WBH A;  2VQR A;  4KM4 A;  3WAY A;  3NKQ A;  3DYC A;  3T00 A;  4NWJ A;  4KAV A;  1AJA A;  4MHX A;  4FDJ A;  4LRE A;  4ZG7 A;  1ZEF A;  4FDI A;  1KHJ A;  3TG0 A;  2GA3 A;  3SZY A;  1AJD A;  1N2K A;  4ZG9 A;  3TWZ A;  4UPL A;  4YR1 A;  2W5W A;  3NKR A;  1E1Z P;  5DLW A;  2RH6 A;  1O98 A;  1ELX A;  4KAY A;  4QAX A;  3NKN A;  3TX0 A;  1ZEB A;  3IDD A;  4LR9 A;  3M8W A;  5K4P A;  5C66 A;  4LR7 A;  2W8D A;  3NKM A;  1P49 A;  1AJB A;  2ANH A;  2W5S A;  4LRD A;  4ZGA A;  5IJS A;  5LQQ A;  5EGH A;  4GTY A;  1SHQ A;  4N7T A;  1ELZ A;  4B56 A;  4MIV A;  3IGY B;  2GLQ A;  3UNY A;  4GTZ A;  3KD8 A;  4CYR A;  3NKO A;  3MK0 A;  3T02 A;  1AJC A;  4KJG A;  4LRF A;  3UO0 A;  3UN2 A;  4LRC A;  1KHK A;  3SZZ A;  3OT9 A;  2W5R A;  1E2S P;  3MK2 A;  5AJ9 A;  1B8J A;  2W8S A;  1N2L A;  5KXA A;  5TJ3 A;  5HRT A;  2GSU A;  3T01 A;  1Y7A A;  4TN0 A;  3NVL A;  2D1G A;  2G9Y A;  5LIA A;  1ELY A;  2W5Q A;  1HQA A;  4LR8 A;  5EGE A;  1SHN A;  1URB A;  3BDH A;  1AUK A;  5LRN A;  3ED4 A;  2X98 A; 
#chains in the Genus database with same CATH homology
 4LRB A;  5L0K A;  4GTX A;  3WAX A;  3M8Z A;  5DLV A;  2W5X A;  3UN3 A;  1EJJ A;  2GSN A;  1EW2 A;  3E2D A;  4UPK A;  1K7H A;  4KJD A;  1URA A;  4LQY A;  3WAV A;  4CXU A;  2IUC A;  3WAW A;  1FSU A;  1KH4 A;  1EW9 A;  5INH A;  4CXK A;  2XR9 A;  5IJQ A;  3CMR A;  1EQJ A;  1Y6V A;  3B5Q A;  1E3C P;  1HJK A;  3LXQ A;  4UOP A;  3M8Y A;  1KH9 A;  1KHL A;  1E33 P;  3MK1 A;  4UPI A;  4CYS A;  2IUC B;  5DLT A;  2QZU A;  3BDG A;  3DPC A;  4ZG6 A;  5GRR A;  1ANI A;  1ANJ A;  3NKP A;  5GOV A;  1EW8 A;  4UOO A;  1ALI A;  4NWX A;  1ALJ A;  1EI6 A;  1ALH A;  1KHN A;  1KH5 A;  2W5V A;  1KH7 A;  4GTW A;  3UN5 A;  4LR2 A;  5L0B A;  4UPH A;  1O99 A;  1ED9 A;  3IGZ B;  1ZED A;  4MY4 A;  5L0E A;  4LRA A;  3BDF A;  1ED8 A;  2GSO A;  1HDH A;  2ZKT A;  3A52 A;  3BDG B;  1ALK A;  3Q3Q A;  5LRM A;  4CXS A;  2IFY A;  2W5T A;  3M7V A;  2XRG A;  4UOR A;  3WBH A;  2VQR A;  4KM4 A;  3WAY A;  3NKQ A;  3DYC A;  3T00 A;  4NWJ A;  4KAV A;  1AJA A;  4MHX A;  4FDJ A;  4LRE A;  4ZG7 A;  1ZEF A;  4FDI A;  1KHJ A;  3TG0 A;  2GA3 A;  3SZY A;  1AJD A;  1N2K A;  4ZG9 A;  3TWZ A;  4UPL A;  4YR1 A;  2W5W A;  3NKR A;  1E1Z P;  5DLW A;  2RH6 A;  1O98 A;  1ELX A;  4KAY A;  4QAX A;  3NKN A;  3TX0 A;  1ZEB A;  3IDD A;  4LR9 A;  3M8W A;  5K4P A;  5C66 A;  4LR7 A;  2W8D A;  3NKM A;  1P49 A;  1AJB A;  2ANH A;  2W5S A;  4LRD A;  4ZGA A;  5IJS A;  5LQQ A;  5EGH A;  4GTY A;  1SHQ A;  4N7T A;  1ELZ A;  4B56 A;  4MIV A;  3IGY B;  2GLQ A;  3UNY A;  4GTZ A;  3KD8 A;  4CYR A;  3NKO A;  3MK0 A;  3T02 A;  1AJC A;  4KJG A;  4LRF A;  3UO0 A;  3UN2 A;  4LRC A;  1KHK A;  3SZZ A;  3OT9 A;  2W5R A;  1E2S P;  3MK2 A;  5AJ9 A;  1B8J A;  2W8S A;  1N2L A;  5KXA A;  5TJ3 A;  5HRT A;  2GSU A;  3T01 A;  1Y7A A;  4TN0 A;  3NVL A;  2D1G A;  2G9Y A;  5LIA A;  1ELY A;  2W5Q A;  1HQA A;  4LR8 A;  5EGE A;  1SHN A;  1URB A;  3BDH A;  1AUK A;  5LRN A;  3ED4 A;  2X98 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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