3CF5S

Thiopeptide antibiotic thiostrepton bound to the large ribosomal subunit of deinococcus radiodurans
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
175
structure length
175
Chain Sequence
MELTAKPRTPKQKLDESMIAAVAYNKENNVSFALDRKAFDRAFRQQSTTGLFDITVEGGETFPALVKAVQMDKRKRAPIHVDFYMVTYGEPVEVSVPVHTTGRSQGEVQGGLVDIVVHNLQIVAPGPRRIPQELVVDVTKMNIGDHITAGDIKLPEGCTLAADPELTVVSVLPPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Translational Regulation Via L11: Molecular Switches on the Ribosome Turned on and Off by Thiostrepton and Micrococcin.
pubmed doi rcsb
molecule tags Ribosome/antibiotic
molecule keywords 50S RIBOSOMAL PROTEIN L33
total genus 18
structure length 175
sequence length 175
ec nomenclature
pdb deposition date 2008-03-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 3cf5S01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 3cf5S02
5DM7S 4IOAS 1NYLA 5GAGW 4U67S 1QTQA 1FEUA 3AIIA 2ZJQS 3CF5S 4JYZA 4WCES 1EXDA 1QRUA 1GTRA 3DLLS 4P2BA 4JXZA 1QRSA 5HL7S 3PIPS 5GAEW 5IZNA 2ZJPS 5GAHW 5GADW 4WFNS 2ZJRS 1QRTA 4UY88 4WFBS 3PIOS 1O0CA 4WF9S 1EUYA 1DFUP 4H3SA 3J7ZV 2RE8A 2HZ7A 1ZJWA 4WFAS 5DM6S 2RD2A 5JVHS 4JXXA 1GTSA 1EUQA 1B75A 4IO9S 4IOCS 1D6KA 5JVGS 1O0BA 5BNZA
chains in the Genus database with same CATH superfamily
5DM7S 4IOAS 4G7OA 3RZDC 2PA8D 1NYLA 4XSZA 3S2DC 3I4MC 4LJZA 4XLNA 2G6GA 3AIIA 2ZJQS 3W2VB 3X1LB 4C2MC 4LK0A 4YFNA 4WCES 4A3GC 4OIPA 3DLLS 4P2BA 4Q4ZA 3GTPC 2EGWA 4A3LC 4QJVA 4MQ9A 1HQMA 5TMCA 4MEYA 5GAHW 1I6HC 1SFOC 4BY1C 1QRTA 2WAQD 5C3EC 4UY88 3PIOS 4A3JC 2E2JC 4WF9S 2NWAA 4QIWD 5D4DA 2JA8C 2HZ7A 3PO3C 3K7AC 4LLGA 3EQLA 4Y7NC 4C3IC 4A3KC 1Z85A 3RZOC 1EUQA 4OINA 1B75A 2A68A 4A3CC 4IO9S 4C3HC 2NVTC 4J3CA 2VUMC 4OIOA 1Y1WC 3S14C 5C44C 5GAGW 2PI8A 4U67S 2L3UA 2O5IA 2NVXC 1IW7A 2A6EA 2O5JA 4KMUA 1EXDA 1BDFA 2Z0YA 5FLMC 2NVYC 1UDXA 2Y0SD 3HKZD 4YFKA 3S2HC 3S1MC 1VHKA 5IZNA 5IYDC 5GADW 4JK1A 4C3JC 3HOXC 4WFBS 4A3MC 2CX8A 1O0CA 3DXJA 1VHYA 2KQ1A 3GTJC 4H4KA 3H3VD 4WFAS 5TMFA 2PNWA 5DM6S 2RD2A 5JVHS 1TWHC 4LK1A 2E2IC 3GTQC 3PO2C 1TWGC 4E8BA 3LYWA 3S1NC 3CZBA 3FKIC 4A3BC 4XLPA 1O0BA 5IP9C 1TWCC 1QTQA 2L5NA 1FEUA 2GAEA 3HOVC 3CF5S 4JYZA 1WCMC 2R92C 2EGVA 4A93C 2AE0X 1QRUA 3S1QC 2BE5A 2JA7C 2R93C 2CW0A 4L69A 3M3YC 3S15C 4A3EC 1QRSA 5HL7S 3GTLC 1I3QC 5GAEW 2ZJPS 2KPUA 5C4JC 3S1RC 4WFNS 2R7ZC 3I4NC 3HOZC 3KW2A 1ZYRA 3H0GC 2PMZD 2KXYA 1NXZA 5IYCC 4A3FC 2JA6C 4Q5SA 3J7ZV 2RE8A 1ZJWA 4OIQA 2PPBA 4BBRC 4G7HA 4JXXA 3CQZC 4YFXA 2G5DA 1GTSA 1Y1VC 4G7ZA 2WB1D 3GTKC 4BXXC 3W2WB 4IOCS 1SMYA 1YNJA 1D6KA 1V6ZA 3HOUC 5BNZA 4NOIA 1K83C 1YNNA 2NVQC 2A69A 3S16C 4A3IC 5HQHA 5C4XC 4GZYA 1I6VA 4BBSC 4XSXA 3GTMC 4KN4A 1GTRA 4KN7A 3HOYC 4YG2A 4Y52C 5IP7C 4JXZA 1R9TC 4OIRA 1TWAC 3PIPS 4BY7C 2PICA 1I50C 2YU9C 2ZJRS 4A3DC 4MEXA 3GTGC 3HOWC 3M4OC 2PJJA 3S17C 1EUYA 1DFUP 4ZH4A 4H3SA 3WODA 3GTOC 2B63C 2E2HC 2A6HA 2JA5C 5IYBC 4AYBD 4X6AC 5JVGS 4V194 1TWFC
chains in the Genus database with same CATH topology
5DM7S 4IOAS 1NYLA 5GAGW 4U67S 1QTQA 1FEUA 3AIIA 2ZJQS 3W2VB 3X1LB 3CF5S 4JYZA 4WCES 1EXDA 1QRUA 1GTRA 3DLLS 4P2BA 1UDXA 4JXZA 1QRSA 5HL7S 3PIPS 5GAEW 5IZNA 2ZJPS 5GAHW 5GADW 4WFNS 2ZJRS 1QRTA 4UY88 4WFBS 3PIOS 1O0CA 4WF9S 1EUYA 1DFUP 4H3SA 4H4KA 3J7ZV 2RE8A 2HZ7A 1ZJWA 4WFAS 5DM6S 2RD2A 5JVHS 4JXXA 1GTSA 1EUQA 1B75A 3W2WB 4IO9S 4IOCS 1D6KA 5JVGS 4V194 1O0BA 5BNZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DM7 S;  4IOA S;  1NYL A;  5GAG W;  4U67 S;  1QTQ A;  1FEU A;  3AII A;  2ZJQ S;  3CF5 S;  4JYZ A;  4WCE S;  1EXD A;  1QRU A;  1GTR A;  3DLL S;  4P2B A;  4JXZ A;  1QRS A;  5HL7 S;  3PIP S;  5GAE W;  5IZN A;  2ZJP S;  5GAH W;  5GAD W;  4WFN S;  2ZJR S;  1QRT A;  4UY8 8;  4WFB S;  3PIO S;  1O0C A;  4WF9 S;  1EUY A;  1DFU P;  4H3S A;  3J7Z V;  2RE8 A;  2HZ7 A;  1ZJW A;  4WFA S;  5DM6 S;  2RD2 A;  5JVH S;  4JXX A;  1GTS A;  1EUQ A;  1B75 A;  4IO9 S;  4IOC S;  1D6K A;  5JVG S;  1O0B A;  5BNZ A; 
#chains in the Genus database with same CATH topology
 5DM7 S;  4IOA S;  4G7O A;  3RZD C;  2PA8 D;  1NYL A;  4XSZ A;  3S2D C;  3I4M C;  4LJZ A;  4XLN A;  2G6G A;  3AII A;  2ZJQ S;  3W2V B;  3X1L B;  4C2M C;  4LK0 A;  4YFN A;  4WCE S;  4A3G C;  4OIP A;  3DLL S;  4P2B A;  4Q4Z A;  3GTP C;  2EGW A;  4A3L C;  4QJV A;  4MQ9 A;  1HQM A;  5TMC A;  4MEY A;  5GAH W;  1I6H C;  1SFO C;  4BY1 C;  1QRT A;  2WAQ D;  5C3E C;  4UY8 8;  3PIO S;  4A3J C;  2E2J C;  4WF9 S;  2NWA A;  4QIW D;  5D4D A;  2JA8 C;  2HZ7 A;  3PO3 C;  3K7A C;  4LLG A;  3EQL A;  4Y7N C;  4C3I C;  4A3K C;  1Z85 A;  3RZO C;  1EUQ A;  4OIN A;  1B75 A;  2A68 A;  4A3C C;  4IO9 S;  4C3H C;  2NVT C;  4J3C A;  2VUM C;  4OIO A;  1Y1W C;  3S14 C;  5C44 C;  5GAG W;  2PI8 A;  4U67 S;  2L3U A;  2O5I A;  2NVX C;  1IW7 A;  2A6E A;  2O5J A;  4KMU A;  1EXD A;  1BDF A;  2Z0Y A;  5FLM C;  2NVY C;  1UDX A;  2Y0S D;  3HKZ D;  4YFK A;  3S2H C;  3S1M C;  1VHK A;  5IZN A;  5IYD C;  5GAD W;  4JK1 A;  4C3J C;  3HOX C;  4WFB S;  4A3M C;  2CX8 A;  1O0C A;  3DXJ A;  1VHY A;  2KQ1 A;  3GTJ C;  4H4K A;  3H3V D;  4WFA S;  5TMF A;  2PNW A;  5DM6 S;  2RD2 A;  5JVH S;  1TWH C;  4LK1 A;  2E2I C;  3GTQ C;  3PO2 C;  1TWG C;  4E8B A;  3LYW A;  3S1N C;  3CZB A;  3FKI C;  4A3B C;  4XLP A;  1O0B A;  5IP9 C;  1TWC C;  1QTQ A;  2L5N A;  1FEU A;  2GAE A;  3HOV C;  3CF5 S;  4JYZ A;  1WCM C;  2R92 C;  2EGV A;  4A93 C;  2AE0 X;  1QRU A;  3S1Q C;  2BE5 A;  2JA7 C;  2R93 C;  2CW0 A;  4L69 A;  3M3Y C;  3S15 C;  4A3E C;  1QRS A;  5HL7 S;  3GTL C;  1I3Q C;  5GAE W;  2ZJP S;  2KPU A;  5C4J C;  3S1R C;  4WFN S;  2R7Z C;  3I4N C;  3HOZ C;  3KW2 A;  1ZYR A;  3H0G C;  2PMZ D;  2KXY A;  1NXZ A;  5IYC C;  4A3F C;  2JA6 C;  4Q5S A;  3J7Z V;  2RE8 A;  1ZJW A;  4OIQ A;  2PPB A;  4BBR C;  4G7H A;  4JXX A;  3CQZ C;  4YFX A;  2G5D A;  1GTS A;  1Y1V C;  4G7Z A;  2WB1 D;  3GTK C;  4BXX C;  3W2W B;  4IOC S;  1SMY A;  1YNJ A;  1D6K A;  1V6Z A;  3HOU C;  5BNZ A;  4NOI A;  1K83 C;  1YNN A;  2NVQ C;  2A69 A;  3S16 C;  4A3I C;  5HQH A;  5C4X C;  4GZY A;  1I6V A;  4BBS C;  4XSX A;  3GTM C;  4KN4 A;  1GTR A;  4KN7 A;  3HOY C;  4YG2 A;  4Y52 C;  5IP7 C;  4JXZ A;  1R9T C;  4OIR A;  1TWA C;  3PIP S;  4BY7 C;  2PIC A;  1I50 C;  2YU9 C;  2ZJR S;  4A3D C;  4MEX A;  3GTG C;  3HOW C;  3M4O C;  2PJJ A;  3S17 C;  1EUY A;  1DFU P;  4ZH4 A;  4H3S A;  3WOD A;  3GTO C;  2B63 C;  2E2H C;  2A6H A;  2JA5 C;  5IYB C;  4AYB D;  4X6A C;  5JVG S;  4V19 4;  1TWF C; 
#chains in the Genus database with same CATH homology
 5DM7 S;  4IOA S;  1NYL A;  5GAG W;  4U67 S;  1QTQ A;  1FEU A;  3AII A;  2ZJQ S;  3W2V B;  3X1L B;  3CF5 S;  4JYZ A;  4WCE S;  1EXD A;  1QRU A;  1GTR A;  3DLL S;  4P2B A;  1UDX A;  4JXZ A;  1QRS A;  5HL7 S;  3PIP S;  5GAE W;  5IZN A;  2ZJP S;  5GAH W;  5GAD W;  4WFN S;  2ZJR S;  1QRT A;  4UY8 8;  4WFB S;  3PIO S;  1O0C A;  4WF9 S;  1EUY A;  1DFU P;  4H3S A;  4H4K A;  3J7Z V;  2RE8 A;  2HZ7 A;  1ZJW A;  4WFA S;  5DM6 S;  2RD2 A;  5JVH S;  4JXX A;  1GTS A;  1EUQ A;  1B75 A;  3W2W B;  4IO9 S;  4IOC S;  1D6K A;  5JVG S;  4V19 4;  1O0B A;  5BNZ A; 
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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