3K7VC

Protein phosphatase 2a core complex bound to dinophysistoxin-1
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
288
structure length
288
Chain Sequence
FTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A structural basis for the reduced toxicity of dinophysistoxin-2.
pubmed doi rcsb
molecule tags Signaling protein/hydrolase
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase 2A 65 kDa regulatory su
total genus 107
structure length 288
sequence length 288
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2009-10-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3k7vC00
1XM7A 4ORAA 5GTUA 4OR9A 3RL3A 3JYFA 4JA7A 1OIEA 4J6OA 3C5WC 4H2GA 1V73A 3H62B 1U32A 2YVTA 4O5GA 3RL4A 4KBPA 3FGAC 4I5LC 4TUGA 2O8GA 4DT2A 3EGHA 4IYPC 1W24A 4LACC 4H2FA 2WDFA 4M0VA 3RL5A 1S3NA 1Z2XA 4F0ZA 4H1YP 1USHA 5B8IA 1KBPA 3E7AA 1WARA 3DW8C 3THOB 4FBWA 1NNWA 1T70A 2GJUA 1OI8A 3AV0A 3TGHA 2DFJA 1UTEA 4Q7FA 3HVQA 2Z72A 1HO5A 1HPUA 3IVEA 4G9JA 4FCXA 4ORBA 2KKNA 3H63A 2NYLC 1HP1A 4ORCA 1S8EA 2O8AA 3PSNA 2BDXA 4NZVA 4O43A 4FBQA 3QFKA 4MOVA 3K7VC 3DSCA 5J28A 1QHWA 5C1VA 1G5BA 2WDEA 4I5NC 4TUIA 1T71A 3P71C 1S3LA 2USHA 2WDCA 3CK2A 3K7WC 4O24A 4ZX2A 3QG5C 3QFMA 3H60A 3E7BA 3ICFA 2P6BA 2WDDA 4HD0A 5INBA 5JJTA 3IB8A 3LL8A 2NPPC 4UT2A 4V0WA 5DNYA 1SU1A 2QFRA 2AHDA 4UT3A 3QFOA 3DSDA 2QJCA 5HPEA 2HYPA 3H67A 3C9FA 1M63A 1MF8A 2A22A 1XZWA 2NYMC 3V4YA 4IL1A 1II7A 3H69A 4LTYA 2IE4C 4LU9A 1Z2WA 4FBKA 5IOHA 2Z1AA 1TCOA 3PSOA 2QFPA 3T1IA 3RQZA 3GVEA 1S70A 4UWQA 4DHLA 2JOGA 3KBPA 3ZTVA 4WWLA 4ZVZA 3ZU0A 2Q8UA 4H2IA 3IB7A 3H64A 5F3WA 1FJMA 1S3MA 4UT3B 5JPFA 2CV9A 2ZBMA 1AUIA 3AUZA 4DSYA 4YKEA 4KKZA 3QFNA 1QFCA 1WAO1 4O4KA 2R17A 1OIDA 2HY1A 3IVDA 3H66A 4JA9A 4MP0A 2IAEC 1UF3A 1JK7A 4H1SA 4V0VA 4H2BA 2NXFA 2BQ8X 3THNA 2BCDA 4XPNA 3H68A 2Z06A 1IT6A 1S95A 3EGGA 4MOYA 5JPEA 2HYOA 2IE3C 2XMOA 3N5UA 4V0XA 5EQVA 3H61A 4B2OA
chains in the Genus database with same CATH superfamily
1XM7A 4ORAA 5GTUA 4OR9A 3RL3A 3JYFA 4JA7A 1OIEA 4J6OA 3C5WC 4H2GA 2ZOAA 1V73A 3H62B 1U32A 2YVTA 4O5GA 3RL4A 4KBPA 3FGAC 4I5LC 4TUGA 2O8GA 4DT2A 3EGHA 4IYPC 1W24A 4LACC 4H2FA 2WDFA 4M0VA 3RL5A 1S3NA 1Z2XA 4F0ZA 3FLOA 4H1YP 1USHA 5B8IA 1KBPA 3E7AA 1WARA 3DW8C 2DXLA 3THOB 4FBWA 1NNWA 1T70A 2GJUA 1OI8A 3AV0A 3TGHA 2DFJA 1UTEA 4Q7FA 3HVQA 2Z72A 1HO5A 1HPUA 3IVEA 4G9JA 4FCXA 4ORBA 2KKNA 2ZO9B 3H63A 2NYLC 1HP1A 4ORCA 1S8EA 2O8AA 3PSNA 2BDXA 4NZVA 4O43A 4FBQA 2YEQA 3QFKA 4MOVA 3K7VC 3DSCA 5J28A 1QHWA 5C1VA 1G5BA 2WDEA 4I5NC 4TUIA 1T71A 3P71C 1S3LA 2USHA 2WDCA 3CK2A 3K7WC 4O24A 4ZX2A 3QG5C 3QFMA 3H60A 3E7BA 3ICFA 2P6BA 2WDDA 4HD0A 5INBA 5JJTA 3IB8A 3LL8A 2NPPC 4UT2A 4V0WA 5DNYA 2DXNA 1SU1A 2QFRA 2AHDA 4UT3A 3QFOA 3DSDA 2QJCA 5HPEA 2HYPA 3H67A 3C9FA 1M63A 1MF8A 2A22A 1XZWA 2NYMC 3V4YA 4IL1A 1II7A 3H69A 4LTYA 2IE4C 4LU9A 1Z2WA 4FBKA 5IOHA 2Z1AA 1TCOA 3PSOA 2QFPA 3T1IA 3RQZA 3GVEA 1S70A 3E0JA 4UWQA 4DHLA 2JOGA 3KBPA 3ZTVA 4WWLA 3D03A 4ZVZA 3ZU0A 2Q8UA 4H2IA 3IB7A 3H64A 5F3WA 1FJMA 1S3MA 4UT3B 5JPFA 2CV9A 2ZBMA 1AUIA 3AUZA 4DSYA 4YKEA 4KKZA 3QFNA 1QFCA 1WAO1 4O4KA 2R17A 1OIDA 2HY1A 3IVDA 3H66A 4JA9A 4MP0A 2IAEC 1UF3A 1JK7A 4H1SA 4V0VA 4H2BA 2NXFA 2BQ8X 3THNA 2BCDA 4XPNA 3H68A 2Z06A 1IT6A 1S95A 3EGGA 4MOYA 5JPEA 2HYOA 2IE3C 2XMOA 3N5UA 4V0XA 5EQVA 3H61A 4B2OA
chains in the Genus database with same CATH topology
1XM7A 4ORAA 5GTUA 4OR9A 3RL3A 3JYFA 4JA7A 1OIEA 4J6OA 3C5WC 4H2GA 2ZOAA 1V73A 3H62B 1U32A 2YVTA 4O5GA 3RL4A 4KBPA 3FGAC 4I5LC 4TUGA 2O8GA 4DT2A 3EGHA 4IYPC 1W24A 4LACC 4H2FA 2WDFA 4M0VA 3RL5A 1S3NA 1Z2XA 4F0ZA 3FLOA 4H1YP 1USHA 5B8IA 1KBPA 3E7AA 1WARA 3DW8C 2DXLA 3THOB 4FBWA 1NNWA 1T70A 2GJUA 1OI8A 3AV0A 3TGHA 2DFJA 1UTEA 4Q7FA 3HVQA 2Z72A 1HO5A 1HPUA 3IVEA 4G9JA 4FCXA 4ORBA 2KKNA 2ZO9B 3H63A 2NYLC 1HP1A 4ORCA 1S8EA 2O8AA 3PSNA 2BDXA 4NZVA 4O43A 4FBQA 2YEQA 3QFKA 4MOVA 3K7VC 3DSCA 5J28A 1QHWA 5C1VA 1G5BA 2WDEA 4I5NC 4TUIA 1T71A 3P71C 1S3LA 2USHA 2WDCA 3CK2A 3K7WC 4O24A 4ZX2A 3QG5C 3QFMA 3H60A 3E7BA 3ICFA 2P6BA 2WDDA 4HD0A 5INBA 5JJTA 3IB8A 3LL8A 2NPPC 4UT2A 4V0WA 5DNYA 2DXNA 1SU1A 2QFRA 2AHDA 4UT3A 3QFOA 3DSDA 2QJCA 5HPEA 2HYPA 3H67A 3C9FA 1M63A 1MF8A 2A22A 1XZWA 2NYMC 3V4YA 4IL1A 1II7A 3H69A 4LTYA 2IE4C 4LU9A 1Z2WA 4FBKA 5IOHA 2Z1AA 1TCOA 3PSOA 2QFPA 3T1IA 3RQZA 3GVEA 1S70A 3E0JA 4UWQA 4DHLA 2JOGA 3KBPA 3ZTVA 4WWLA 3D03A 4ZVZA 3ZU0A 2Q8UA 4H2IA 3IB7A 3H64A 5F3WA 1FJMA 1S3MA 4UT3B 5JPFA 2CV9A 2ZBMA 1AUIA 3AUZA 4DSYA 4YKEA 4KKZA 3QFNA 1QFCA 1WAO1 4O4KA 2R17A 1OIDA 2HY1A 3IVDA 3H66A 4JA9A 4MP0A 2IAEC 1UF3A 1JK7A 4H1SA 4V0VA 4H2BA 2NXFA 2BQ8X 3THNA 2BCDA 4XPNA 3H68A 2Z06A 1IT6A 1S95A 3EGGA 4MOYA 5JPEA 2HYOA 2IE3C 2XMOA 3N5UA 4V0XA 5EQVA 3H61A 4B2OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XM7 A;  4ORA A;  5GTU A;  4OR9 A;  3RL3 A;  3JYF A;  4JA7 A;  1OIE A;  4J6O A;  3C5W C;  4H2G A;  1V73 A;  3H62 B;  1U32 A;  2YVT A;  4O5G A;  3RL4 A;  4KBP A;  3FGA C;  4I5L C;  4TUG A;  2O8G A;  4DT2 A;  3EGH A;  4IYP C;  1W24 A;  4LAC C;  4H2F A;  2WDF A;  4M0V A;  3RL5 A;  1S3N A;  1Z2X A;  4F0Z A;  4H1Y P;  1USH A;  5B8I A;  1KBP A;  3E7A A;  1WAR A;  3DW8 C;  3THO B;  4FBW A;  1NNW A;  1T70 A;  2GJU A;  1OI8 A;  3AV0 A;  3TGH A;  2DFJ A;  1UTE A;  4Q7F A;  3HVQ A;  2Z72 A;  1HO5 A;  1HPU A;  3IVE A;  4G9J A;  4FCX A;  4ORB A;  2KKN A;  3H63 A;  2NYL C;  1HP1 A;  4ORC A;  1S8E A;  2O8A A;  3PSN A;  2BDX A;  4NZV A;  4O43 A;  4FBQ A;  3QFK A;  4MOV A;  3K7V C;  3DSC A;  5J28 A;  1QHW A;  5C1V A;  1G5B A;  2WDE A;  4I5N C;  4TUI A;  1T71 A;  3P71 C;  1S3L A;  2USH A;  2WDC A;  3CK2 A;  3K7W C;  4O24 A;  4ZX2 A;  3QG5 C;  3QFM A;  3H60 A;  3E7B A;  3ICF A;  2P6B A;  2WDD A;  4HD0 A;  5INB A;  5JJT A;  3IB8 A;  3LL8 A;  2NPP C;  4UT2 A;  4V0W A;  5DNY A;  1SU1 A;  2QFR A;  2AHD A;  4UT3 A;  3QFO A;  3DSD A;  2QJC A;  5HPE A;  2HYP A;  3H67 A;  3C9F A;  1M63 A;  1MF8 A;  2A22 A;  1XZW A;  2NYM C;  3V4Y A;  4IL1 A;  1II7 A;  3H69 A;  4LTY A;  2IE4 C;  4LU9 A;  1Z2W A;  4FBK A;  5IOH A;  2Z1A A;  1TCO A;  3PSO A;  2QFP A;  3T1I A;  3RQZ A;  3GVE A;  1S70 A;  4UWQ A;  4DHL A;  2JOG A;  3KBP A;  3ZTV A;  4WWL A;  4ZVZ A;  3ZU0 A;  2Q8U A;  4H2I A;  3IB7 A;  3H64 A;  5F3W A;  1FJM A;  1S3M A;  4UT3 B;  5JPF A;  2CV9 A;  2ZBM A;  1AUI A;  3AUZ A;  4DSY A;  4YKE A;  4KKZ A;  3QFN A;  1QFC A;  1WAO 1;  4O4K A;  2R17 A;  1OID A;  2HY1 A;  3IVD A;  3H66 A;  4JA9 A;  4MP0 A;  2IAE C;  1UF3 A;  1JK7 A;  4H1S A;  4V0V A;  4H2B A;  2NXF A;  2BQ8 X;  3THN A;  2BCD A;  4XPN A;  3H68 A;  2Z06 A;  1IT6 A;  1S95 A;  3EGG A;  4MOY A;  5JPE A;  2HYO A;  2IE3 C;  2XMO A;  3N5U A;  4V0X A;  5EQV A;  3H61 A;  4B2O A; 
#chains in the Genus database with same CATH topology
 1XM7 A;  4ORA A;  5GTU A;  4OR9 A;  3RL3 A;  3JYF A;  4JA7 A;  1OIE A;  4J6O A;  3C5W C;  4H2G A;  2ZOA A;  1V73 A;  3H62 B;  1U32 A;  2YVT A;  4O5G A;  3RL4 A;  4KBP A;  3FGA C;  4I5L C;  4TUG A;  2O8G A;  4DT2 A;  3EGH A;  4IYP C;  1W24 A;  4LAC C;  4H2F A;  2WDF A;  4M0V A;  3RL5 A;  1S3N A;  1Z2X A;  4F0Z A;  3FLO A;  4H1Y P;  1USH A;  5B8I A;  1KBP A;  3E7A A;  1WAR A;  3DW8 C;  2DXL A;  3THO B;  4FBW A;  1NNW A;  1T70 A;  2GJU A;  1OI8 A;  3AV0 A;  3TGH A;  2DFJ A;  1UTE A;  4Q7F A;  3HVQ A;  2Z72 A;  1HO5 A;  1HPU A;  3IVE A;  4G9J A;  4FCX A;  4ORB A;  2KKN A;  2ZO9 B;  3H63 A;  2NYL C;  1HP1 A;  4ORC A;  1S8E A;  2O8A A;  3PSN A;  2BDX A;  4NZV A;  4O43 A;  4FBQ A;  2YEQ A;  3QFK A;  4MOV A;  3K7V C;  3DSC A;  5J28 A;  1QHW A;  5C1V A;  1G5B A;  2WDE A;  4I5N C;  4TUI A;  1T71 A;  3P71 C;  1S3L A;  2USH A;  2WDC A;  3CK2 A;  3K7W C;  4O24 A;  4ZX2 A;  3QG5 C;  3QFM A;  3H60 A;  3E7B A;  3ICF A;  2P6B A;  2WDD A;  4HD0 A;  5INB A;  5JJT A;  3IB8 A;  3LL8 A;  2NPP C;  4UT2 A;  4V0W A;  5DNY A;  2DXN A;  1SU1 A;  2QFR A;  2AHD A;  4UT3 A;  3QFO A;  3DSD A;  2QJC A;  5HPE A;  2HYP A;  3H67 A;  3C9F A;  1M63 A;  1MF8 A;  2A22 A;  1XZW A;  2NYM C;  3V4Y A;  4IL1 A;  1II7 A;  3H69 A;  4LTY A;  2IE4 C;  4LU9 A;  1Z2W A;  4FBK A;  5IOH A;  2Z1A A;  1TCO A;  3PSO A;  2QFP A;  3T1I A;  3RQZ A;  3GVE A;  1S70 A;  3E0J A;  4UWQ A;  4DHL A;  2JOG A;  3KBP A;  3ZTV A;  4WWL A;  3D03 A;  4ZVZ A;  3ZU0 A;  2Q8U A;  4H2I A;  3IB7 A;  3H64 A;  5F3W A;  1FJM A;  1S3M A;  4UT3 B;  5JPF A;  2CV9 A;  2ZBM A;  1AUI A;  3AUZ A;  4DSY A;  4YKE A;  4KKZ A;  3QFN A;  1QFC A;  1WAO 1;  4O4K A;  2R17 A;  1OID A;  2HY1 A;  3IVD A;  3H66 A;  4JA9 A;  4MP0 A;  2IAE C;  1UF3 A;  1JK7 A;  4H1S A;  4V0V A;  4H2B A;  2NXF A;  2BQ8 X;  3THN A;  2BCD A;  4XPN A;  3H68 A;  2Z06 A;  1IT6 A;  1S95 A;  3EGG A;  4MOY A;  5JPE A;  2HYO A;  2IE3 C;  2XMO A;  3N5U A;  4V0X A;  5EQV A;  3H61 A;  4B2O A; 
#chains in the Genus database with same CATH homology
 1XM7 A;  4ORA A;  5GTU A;  4OR9 A;  3RL3 A;  3JYF A;  4JA7 A;  1OIE A;  4J6O A;  3C5W C;  4H2G A;  2ZOA A;  1V73 A;  3H62 B;  1U32 A;  2YVT A;  4O5G A;  3RL4 A;  4KBP A;  3FGA C;  4I5L C;  4TUG A;  2O8G A;  4DT2 A;  3EGH A;  4IYP C;  1W24 A;  4LAC C;  4H2F A;  2WDF A;  4M0V A;  3RL5 A;  1S3N A;  1Z2X A;  4F0Z A;  3FLO A;  4H1Y P;  1USH A;  5B8I A;  1KBP A;  3E7A A;  1WAR A;  3DW8 C;  2DXL A;  3THO B;  4FBW A;  1NNW A;  1T70 A;  2GJU A;  1OI8 A;  3AV0 A;  3TGH A;  2DFJ A;  1UTE A;  4Q7F A;  3HVQ A;  2Z72 A;  1HO5 A;  1HPU A;  3IVE A;  4G9J A;  4FCX A;  4ORB A;  2KKN A;  2ZO9 B;  3H63 A;  2NYL C;  1HP1 A;  4ORC A;  1S8E A;  2O8A A;  3PSN A;  2BDX A;  4NZV A;  4O43 A;  4FBQ A;  2YEQ A;  3QFK A;  4MOV A;  3K7V C;  3DSC A;  5J28 A;  1QHW A;  5C1V A;  1G5B A;  2WDE A;  4I5N C;  4TUI A;  1T71 A;  3P71 C;  1S3L A;  2USH A;  2WDC A;  3CK2 A;  3K7W C;  4O24 A;  4ZX2 A;  3QG5 C;  3QFM A;  3H60 A;  3E7B A;  3ICF A;  2P6B A;  2WDD A;  4HD0 A;  5INB A;  5JJT A;  3IB8 A;  3LL8 A;  2NPP C;  4UT2 A;  4V0W A;  5DNY A;  2DXN A;  1SU1 A;  2QFR A;  2AHD A;  4UT3 A;  3QFO A;  3DSD A;  2QJC A;  5HPE A;  2HYP A;  3H67 A;  3C9F A;  1M63 A;  1MF8 A;  2A22 A;  1XZW A;  2NYM C;  3V4Y A;  4IL1 A;  1II7 A;  3H69 A;  4LTY A;  2IE4 C;  4LU9 A;  1Z2W A;  4FBK A;  5IOH A;  2Z1A A;  1TCO A;  3PSO A;  2QFP A;  3T1I A;  3RQZ A;  3GVE A;  1S70 A;  3E0J A;  4UWQ A;  4DHL A;  2JOG A;  3KBP A;  3ZTV A;  4WWL A;  3D03 A;  4ZVZ A;  3ZU0 A;  2Q8U A;  4H2I A;  3IB7 A;  3H64 A;  5F3W A;  1FJM A;  1S3M A;  4UT3 B;  5JPF A;  2CV9 A;  2ZBM A;  1AUI A;  3AUZ A;  4DSY A;  4YKE A;  4KKZ A;  3QFN A;  1QFC A;  1WAO 1;  4O4K A;  2R17 A;  1OID A;  2HY1 A;  3IVD A;  3H66 A;  4JA9 A;  4MP0 A;  2IAE C;  1UF3 A;  1JK7 A;  4H1S A;  4V0V A;  4H2B A;  2NXF A;  2BQ8 X;  3THN A;  2BCD A;  4XPN A;  3H68 A;  2Z06 A;  1IT6 A;  1S95 A;  3EGG A;  4MOY A;  5JPE A;  2HYO A;  2IE3 C;  2XMO A;  3N5U A;  4V0X A;  5EQV A;  3H61 A;  4B2O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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