3L24A

Crystal structure of the nerve agent degrading organophosphate anhydrolase/prolidase in complex with inhibitors
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
440
structure length
425
Chain Sequence
MNKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKVPDEPNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDNPYGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALMNQLAPGKLYGELHLDCHQRVAQTLSDFNIVDLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMALRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELRLR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural insights into the dual activities of the nerve agent degrading organophosphate anhydrolase/prolidase.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
molecule keywords Xaa-Pro dipeptidase
total genus 148
structure length 425
sequence length 440
chains with identical sequence B, C
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2009-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 3l24A01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 3l24A02
4IDYA 2BWWA 2ZSGA 4IKTA 2Q95A 1YJ3A 1XGSA 1Y1NA 1R5GA 3FMRA 2HOWA 1W7VA 3PKDA 4IPAA 4RZYA 2EA2A 1WY2A 5CNXA 5E5BA 1YW7A 3OOOA 2BHBA 4U75A 1WBQA 5JFRA 1B6AA 2GG8A 1R58A 2GU4A 2V3XA 5CDLA 3IG4A 2BHAA 5CDVA 4U6JA 1C23A 4U70A 2B3HA 4U6ZA 4JUQA 1WLRA 1KQ0A 3IL0A 5CE6A 3FM3A 2BN7A 3PKCA 4IKRA 4QR8A 3BIPA 1QXWA 2BB7A 1C22A 3BIQA 2G6PA 2BWTA 4EGEA 3PKAA 2B3LA 1R5HA 4ZWPA 3OVKA 2P9AA 3PEBA 4FKCA 1N51A 1YVMA 3D27A 1KP0A 4HXXA 3L7GA 5CLSA 4IKUA 1BOAA 2NQ6A 3MX6A 1WL6A 4U69A 3TAVA 4OOKA 1O0XA 3BITA 4PV4A 3PKBA 1WL9A 4FLLA 4FO7A 2GZ5A 4FO8A 5D6FA 1JAWA 1C21A 2GGBA 3PKEA 2GG7A 3IU7A 1QXYA 2BHDA 4ZWUA 4ZNGA 4U71A 4S2TP 1WKMA 2BWUA 3O5VA 1QXZA 4U6CA 2P99A 2GG9A 4B28A 4IECA 4U73A 4S00A 1PV9A 4S2RP 2BH3A 4IF7A 2EVOA 3CTZA 2BWSA 1YW8A 2GGCA 1QZYA 3TB5A 5CIKA 2GTXA 2EVMA 4RGZ1 4U1BA 1XGMA 2Q94A 3RVAA 3PN9A 4U76A 2Q93A 3MATA 2V3YA 2GA2A 4IU6A 5E2CA 1XNZA 4U6WA 3IU9A 2Q96A 2Q8KA 1C24A 4A6VA 2GG2A 4U6EA 4S01A 4A6WA 4PNCA 1XGNA 1YW9A 4Z7MA 2Q92A 3IU8A 4KM3A 4R60A 3Q6DA 2DFIA 1M35A 2IW2A 3FMQA 1BN5A 4FLKA 1MATA 2V6CA 1A16A 2BWYA 2GU7A 2P98A 4RZZA 2OKNA 2EVCA 2GU6A 2GG0A 3CB6A 2BHCA 4IKSA 2B3KA 5D6EA 3MR1A 2BWXA 2EA4A 4FLJA 5CDEA 3L24A 1C27A 2OAZA 5JHUA 5FCHA 1W2MA 2BWVA 5FCFA 3I7MA 1B59A 2V3ZA 1CHMA 2NQ7A 1WN1A 3RORA 4ZWOA 2GU5A 4MATA 2GG5A 4FUKA 1KQ9A 3CB5A 1XGOA 2GG3A 4FLIA 5JI6A 3QOCA 2ADUA 3S6BA 2MATA
chains in the Genus database with same CATH superfamily
4IDYA 2BWWA 2ZSGA 4IKTA 2Q95A 1YJ3A 1XGSA 1Y1NA 1R5GA 3FMRA 2HOWA 1W7VA 3PKDA 4IPAA 4RZYA 2EA2A 1WY2A 5CNXA 5E5BA 1YW7A 3OOOA 2BHBA 4U75A 1WBQA 5JFRA 1B6AA 2GG8A 1R58A 2GU4A 2V3XA 5CDLA 3IG4A 2BHAA 5CDVA 4U6JA 1C23A 4U70A 2B3HA 4U6ZA 4JUQA 1WLRA 1KQ0A 3IL0A 5CE6A 3FM3A 2BN7A 3PKCA 4IKRA 4QR8A 3BIPA 1QXWA 2BB7A 1C22A 3BIQA 2G6PA 2BWTA 4EGEA 3PKAA 2B3LA 1R5HA 4ZWPA 3OVKA 2P9AA 3PEBA 4FKCA 1N51A 1YVMA 3D27A 1KP0A 4HXXA 3L7GA 5CLSA 4IKUA 1BOAA 2NQ6A 3MX6A 1WL6A 4U69A 3TAVA 4OOKA 1O0XA 3BITA 4PV4A 3PKBA 1WL9A 4FLLA 4FO7A 2GZ5A 4FO8A 5D6FA 1JAWA 1C21A 2GGBA 3PKEA 2GG7A 3IU7A 1QXYA 2BHDA 4ZWUA 4ZNGA 4U71A 4S2TP 1WKMA 2BWUA 3O5VA 1QXZA 4U6CA 2P99A 2GG9A 4B28A 4IECA 4U73A 4S00A 1PV9A 4S2RP 2BH3A 4IF7A 2EVOA 3CTZA 2BWSA 1YW8A 2GGCA 1QZYA 3TB5A 5CIKA 2GTXA 2EVMA 4RGZ1 4U1BA 1XGMA 2Q94A 3RVAA 3PN9A 4U76A 2Q93A 3MATA 2V3YA 2GA2A 4IU6A 5E2CA 1XNZA 4U6WA 3IU9A 2Q96A 2Q8KA 1C24A 4A6VA 2GG2A 4U6EA 4S01A 4A6WA 4PNCA 1XGNA 1YW9A 4Z7MA 2Q92A 3IU8A 4KM3A 4R60A 3Q6DA 2DFIA 1M35A 2IW2A 3FMQA 1BN5A 4FLKA 1MATA 2V6CA 1A16A 2BWYA 2GU7A 2P98A 4RZZA 2OKNA 2EVCA 2GU6A 2GG0A 3CB6A 2BHCA 4IKSA 2B3KA 5D6EA 3MR1A 2BWXA 2EA4A 4FLJA 5CDEA 3L24A 1C27A 2OAZA 5JHUA 5FCHA 1W2MA 2BWVA 5FCFA 3I7MA 1B59A 2V3ZA 1CHMA 2NQ7A 1WN1A 3RORA 4ZWOA 2GU5A 4MATA 2GG5A 4FUKA 1KQ9A 3CB5A 1XGOA 2GG3A 4FLIA 5JI6A 3QOCA 2ADUA 3S6BA 2MATA
chains in the Genus database with same CATH topology
4IDYA 2BWWA 2ZSGA 4IKTA 2Q95A 1YJ3A 1XGSA 1Y1NA 1R5GA 3FMRA 2HOWA 1W7VA 3PKDA 4IPAA 4RZYA 2EA2A 1WY2A 5CNXA 5E5BA 1YW7A 3OOOA 2BHBA 4U75A 1WBQA 5JFRA 1B6AA 2GG8A 1R58A 2GU4A 2V3XA 5CDLA 3IG4A 2BHAA 5CDVA 4U6JA 1C23A 4U70A 2B3HA 4U6ZA 4JUQA 1WLRA 1KQ0A 3IL0A 5CE6A 3FM3A 2BN7A 3PKCA 4IKRA 4QR8A 3BIPA 1QXWA 2BB7A 1C22A 3BIQA 2G6PA 2BWTA 4EGEA 3PKAA 2B3LA 1R5HA 4ZWPA 3OVKA 2P9AA 3PEBA 4FKCA 1N51A 1YVMA 3D27A 1KP0A 4HXXA 3L7GA 5CLSA 4IKUA 1BOAA 2NQ6A 3MX6A 1WL6A 4U69A 3TAVA 4OOKA 1O0XA 3BITA 4PV4A 3PKBA 1WL9A 4FLLA 4FO7A 2GZ5A 4FO8A 5D6FA 1JAWA 1C21A 2GGBA 3PKEA 2GG7A 3IU7A 1QXYA 2BHDA 4ZWUA 4ZNGA 4U71A 4S2TP 1WKMA 2BWUA 3O5VA 1QXZA 4U6CA 2P99A 2GG9A 4B28A 4IECA 4U73A 4S00A 1PV9A 4S2RP 2BH3A 4IF7A 2EVOA 3CTZA 2BWSA 1YW8A 2GGCA 1QZYA 3TB5A 5CIKA 2GTXA 2EVMA 4RGZ1 4U1BA 1XGMA 2Q94A 3RVAA 3PN9A 4U76A 2Q93A 3MATA 2V3YA 2GA2A 4IU6A 5E2CA 1XNZA 4U6WA 3IU9A 2Q96A 2Q8KA 1C24A 4A6VA 2GG2A 4U6EA 4S01A 4A6WA 4PNCA 1XGNA 1YW9A 4Z7MA 2Q92A 3IU8A 4KM3A 4R60A 3Q6DA 2DFIA 1M35A 2IW2A 3FMQA 1BN5A 4FLKA 1MATA 2V6CA 1A16A 2BWYA 2GU7A 2P98A 4RZZA 2OKNA 2EVCA 2GU6A 2GG0A 3CB6A 2BHCA 4IKSA 2B3KA 5D6EA 3MR1A 2BWXA 2EA4A 4FLJA 5CDEA 3L24A 1C27A 2OAZA 5JHUA 5FCHA 1W2MA 2BWVA 5FCFA 3I7MA 1B59A 2V3ZA 1CHMA 2NQ7A 1WN1A 3RORA 4ZWOA 2GU5A 4MATA 2GG5A 4FUKA 1KQ9A 3CB5A 1XGOA 2GG3A 4FLIA 5JI6A 3QOCA 2ADUA 3S6BA 2MATA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IDY A;  2BWW A;  2ZSG A;  4IKT A;  2Q95 A;  1YJ3 A;  1XGS A;  1Y1N A;  1R5G A;  3FMR A;  2HOW A;  1W7V A;  3PKD A;  4IPA A;  4RZY A;  2EA2 A;  1WY2 A;  5CNX A;  5E5B A;  1YW7 A;  3OOO A;  2BHB A;  4U75 A;  1WBQ A;  5JFR A;  1B6A A;  2GG8 A;  1R58 A;  2GU4 A;  2V3X A;  5CDL A;  3IG4 A;  2BHA A;  5CDV A;  4U6J A;  1C23 A;  4U70 A;  2B3H A;  4U6Z A;  4JUQ A;  1WLR A;  1KQ0 A;  3IL0 A;  5CE6 A;  3FM3 A;  2BN7 A;  3PKC A;  4IKR A;  4QR8 A;  3BIP A;  1QXW A;  2BB7 A;  1C22 A;  3BIQ A;  2G6P A;  2BWT A;  4EGE A;  3PKA A;  2B3L A;  1R5H A;  4ZWP A;  3OVK A;  2P9A A;  3PEB A;  4FKC A;  1N51 A;  1YVM A;  3D27 A;  1KP0 A;  4HXX A;  3L7G A;  5CLS A;  4IKU A;  1BOA A;  2NQ6 A;  3MX6 A;  1WL6 A;  4U69 A;  3TAV A;  4OOK A;  1O0X A;  3BIT A;  4PV4 A;  3PKB A;  1WL9 A;  4FLL A;  4FO7 A;  2GZ5 A;  4FO8 A;  5D6F A;  1JAW A;  1C21 A;  2GGB A;  3PKE A;  2GG7 A;  3IU7 A;  1QXY A;  2BHD A;  4ZWU A;  4ZNG A;  4U71 A;  4S2T P;  1WKM A;  2BWU A;  3O5V A;  1QXZ A;  4U6C A;  2P99 A;  2GG9 A;  4B28 A;  4IEC A;  4U73 A;  4S00 A;  1PV9 A;  4S2R P;  2BH3 A;  4IF7 A;  2EVO A;  3CTZ A;  2BWS A;  1YW8 A;  2GGC A;  1QZY A;  3TB5 A;  5CIK A;  2GTX A;  2EVM A;  4RGZ 1;  4U1B A;  1XGM A;  2Q94 A;  3RVA A;  3PN9 A;  4U76 A;  2Q93 A;  3MAT A;  2V3Y A;  2GA2 A;  4IU6 A;  5E2C A;  1XNZ A;  4U6W A;  3IU9 A;  2Q96 A;  2Q8K A;  1C24 A;  4A6V A;  2GG2 A;  4U6E A;  4S01 A;  4A6W A;  4PNC A;  1XGN A;  1YW9 A;  4Z7M A;  2Q92 A;  3IU8 A;  4KM3 A;  4R60 A;  3Q6D A;  2DFI A;  1M35 A;  2IW2 A;  3FMQ A;  1BN5 A;  4FLK A;  1MAT A;  2V6C A;  1A16 A;  2BWY A;  2GU7 A;  2P98 A;  4RZZ A;  2OKN A;  2EVC A;  2GU6 A;  2GG0 A;  3CB6 A;  2BHC A;  4IKS A;  2B3K A;  5D6E A;  3MR1 A;  2BWX A;  2EA4 A;  4FLJ A;  5CDE A;  3L24 A;  1C27 A;  2OAZ A;  5JHU A;  5FCH A;  1W2M A;  2BWV A;  5FCF A;  3I7M A;  1B59 A;  2V3Z A;  1CHM A;  2NQ7 A;  1WN1 A;  3ROR A;  4ZWO A;  2GU5 A;  4MAT A;  2GG5 A;  4FUK A;  1KQ9 A;  3CB5 A;  1XGO A;  2GG3 A;  4FLI A;  5JI6 A;  3QOC A;  2ADU A;  3S6B A;  2MAT A; 
#chains in the Genus database with same CATH topology
 4IDY A;  2BWW A;  2ZSG A;  4IKT A;  2Q95 A;  1YJ3 A;  1XGS A;  1Y1N A;  1R5G A;  3FMR A;  2HOW A;  1W7V A;  3PKD A;  4IPA A;  4RZY A;  2EA2 A;  1WY2 A;  5CNX A;  5E5B A;  1YW7 A;  3OOO A;  2BHB A;  4U75 A;  1WBQ A;  5JFR A;  1B6A A;  2GG8 A;  1R58 A;  2GU4 A;  2V3X A;  5CDL A;  3IG4 A;  2BHA A;  5CDV A;  4U6J A;  1C23 A;  4U70 A;  2B3H A;  4U6Z A;  4JUQ A;  1WLR A;  1KQ0 A;  3IL0 A;  5CE6 A;  3FM3 A;  2BN7 A;  3PKC A;  4IKR A;  4QR8 A;  3BIP A;  1QXW A;  2BB7 A;  1C22 A;  3BIQ A;  2G6P A;  2BWT A;  4EGE A;  3PKA A;  2B3L A;  1R5H A;  4ZWP A;  3OVK A;  2P9A A;  3PEB A;  4FKC A;  1N51 A;  1YVM A;  3D27 A;  1KP0 A;  4HXX A;  3L7G A;  5CLS A;  4IKU A;  1BOA A;  2NQ6 A;  3MX6 A;  1WL6 A;  4U69 A;  3TAV A;  4OOK A;  1O0X A;  3BIT A;  4PV4 A;  3PKB A;  1WL9 A;  4FLL A;  4FO7 A;  2GZ5 A;  4FO8 A;  5D6F A;  1JAW A;  1C21 A;  2GGB A;  3PKE A;  2GG7 A;  3IU7 A;  1QXY A;  2BHD A;  4ZWU A;  4ZNG A;  4U71 A;  4S2T P;  1WKM A;  2BWU A;  3O5V A;  1QXZ A;  4U6C A;  2P99 A;  2GG9 A;  4B28 A;  4IEC A;  4U73 A;  4S00 A;  1PV9 A;  4S2R P;  2BH3 A;  4IF7 A;  2EVO A;  3CTZ A;  2BWS A;  1YW8 A;  2GGC A;  1QZY A;  3TB5 A;  5CIK A;  2GTX A;  2EVM A;  4RGZ 1;  4U1B A;  1XGM A;  2Q94 A;  3RVA A;  3PN9 A;  4U76 A;  2Q93 A;  3MAT A;  2V3Y A;  2GA2 A;  4IU6 A;  5E2C A;  1XNZ A;  4U6W A;  3IU9 A;  2Q96 A;  2Q8K A;  1C24 A;  4A6V A;  2GG2 A;  4U6E A;  4S01 A;  4A6W A;  4PNC A;  1XGN A;  1YW9 A;  4Z7M A;  2Q92 A;  3IU8 A;  4KM3 A;  4R60 A;  3Q6D A;  2DFI A;  1M35 A;  2IW2 A;  3FMQ A;  1BN5 A;  4FLK A;  1MAT A;  2V6C A;  1A16 A;  2BWY A;  2GU7 A;  2P98 A;  4RZZ A;  2OKN A;  2EVC A;  2GU6 A;  2GG0 A;  3CB6 A;  2BHC A;  4IKS A;  2B3K A;  5D6E A;  3MR1 A;  2BWX A;  2EA4 A;  4FLJ A;  5CDE A;  3L24 A;  1C27 A;  2OAZ A;  5JHU A;  5FCH A;  1W2M A;  2BWV A;  5FCF A;  3I7M A;  1B59 A;  2V3Z A;  1CHM A;  2NQ7 A;  1WN1 A;  3ROR A;  4ZWO A;  2GU5 A;  4MAT A;  2GG5 A;  4FUK A;  1KQ9 A;  3CB5 A;  1XGO A;  2GG3 A;  4FLI A;  5JI6 A;  3QOC A;  2ADU A;  3S6B A;  2MAT A; 
#chains in the Genus database with same CATH homology
 4IDY A;  2BWW A;  2ZSG A;  4IKT A;  2Q95 A;  1YJ3 A;  1XGS A;  1Y1N A;  1R5G A;  3FMR A;  2HOW A;  1W7V A;  3PKD A;  4IPA A;  4RZY A;  2EA2 A;  1WY2 A;  5CNX A;  5E5B A;  1YW7 A;  3OOO A;  2BHB A;  4U75 A;  1WBQ A;  5JFR A;  1B6A A;  2GG8 A;  1R58 A;  2GU4 A;  2V3X A;  5CDL A;  3IG4 A;  2BHA A;  5CDV A;  4U6J A;  1C23 A;  4U70 A;  2B3H A;  4U6Z A;  4JUQ A;  1WLR A;  1KQ0 A;  3IL0 A;  5CE6 A;  3FM3 A;  2BN7 A;  3PKC A;  4IKR A;  4QR8 A;  3BIP A;  1QXW A;  2BB7 A;  1C22 A;  3BIQ A;  2G6P A;  2BWT A;  4EGE A;  3PKA A;  2B3L A;  1R5H A;  4ZWP A;  3OVK A;  2P9A A;  3PEB A;  4FKC A;  1N51 A;  1YVM A;  3D27 A;  1KP0 A;  4HXX A;  3L7G A;  5CLS A;  4IKU A;  1BOA A;  2NQ6 A;  3MX6 A;  1WL6 A;  4U69 A;  3TAV A;  4OOK A;  1O0X A;  3BIT A;  4PV4 A;  3PKB A;  1WL9 A;  4FLL A;  4FO7 A;  2GZ5 A;  4FO8 A;  5D6F A;  1JAW A;  1C21 A;  2GGB A;  3PKE A;  2GG7 A;  3IU7 A;  1QXY A;  2BHD A;  4ZWU A;  4ZNG A;  4U71 A;  4S2T P;  1WKM A;  2BWU A;  3O5V A;  1QXZ A;  4U6C A;  2P99 A;  2GG9 A;  4B28 A;  4IEC A;  4U73 A;  4S00 A;  1PV9 A;  4S2R P;  2BH3 A;  4IF7 A;  2EVO A;  3CTZ A;  2BWS A;  1YW8 A;  2GGC A;  1QZY A;  3TB5 A;  5CIK A;  2GTX A;  2EVM A;  4RGZ 1;  4U1B A;  1XGM A;  2Q94 A;  3RVA A;  3PN9 A;  4U76 A;  2Q93 A;  3MAT A;  2V3Y A;  2GA2 A;  4IU6 A;  5E2C A;  1XNZ A;  4U6W A;  3IU9 A;  2Q96 A;  2Q8K A;  1C24 A;  4A6V A;  2GG2 A;  4U6E A;  4S01 A;  4A6W A;  4PNC A;  1XGN A;  1YW9 A;  4Z7M A;  2Q92 A;  3IU8 A;  4KM3 A;  4R60 A;  3Q6D A;  2DFI A;  1M35 A;  2IW2 A;  3FMQ A;  1BN5 A;  4FLK A;  1MAT A;  2V6C A;  1A16 A;  2BWY A;  2GU7 A;  2P98 A;  4RZZ A;  2OKN A;  2EVC A;  2GU6 A;  2GG0 A;  3CB6 A;  2BHC A;  4IKS A;  2B3K A;  5D6E A;  3MR1 A;  2BWX A;  2EA4 A;  4FLJ A;  5CDE A;  3L24 A;  1C27 A;  2OAZ A;  5JHU A;  5FCH A;  1W2M A;  2BWV A;  5FCF A;  3I7M A;  1B59 A;  2V3Z A;  1CHM A;  2NQ7 A;  1WN1 A;  3ROR A;  4ZWO A;  2GU5 A;  4MAT A;  2GG5 A;  4FUK A;  1KQ9 A;  3CB5 A;  1XGO A;  2GG3 A;  4FLI A;  5JI6 A;  3QOC A;  2ADU A;  3S6B A;  2MAT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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