3L4HA

Helical box domain and second ww domain of the human e3 ubiquitin-protein ligase hecw1
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
109
structure length
109
Chain Sequence
LLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title The tandem helical box and second WW domains of human HECW1
rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords E3 ubiquitin-protein ligase HECW1
total genus 27
structure length 109
sequence length 109
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2009-12-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF18436 HECW1_helix Helical box domain of E3 ubiquitin-protein ligase HECW1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 3l4hA01
2XPAA 3CNGA 2JX8A 2JV4A 2XPBA 2XP9A 3TCZA 2YSHA 2F21A 2KXQA 1JMQA 3LE4A 5AHTA 2ITKA 2BA1A 2E45A 4U85A 1PINA 3ODKA 2DWVA 2DJYA 2ZQUA 1F8AB 3KAHA 3KADA 3KAFA 3TC5A 3KAGA 3TDBA 3KABA 3L4HA 1WMVA 2ZQVA 2M8IA 2YSIA 2DMVA 2L4JA 4U86A 1I5HW 2M3OW 2ZR5A 1ZCNA 2XP6A 2EZ5W 1K9QA 2ZR6A 3KAIA 2XP3A 1EG4A 3M7NA 2M8JA 4E5RA 2XP5A 2RE3A 3M85A 3OOBA 4QIBA 2ZQTA 2XP8A 1WR7A 2MDIA 1TK7A 4REXA 2JXWA 2Q5AA 1YW5A 2XP4A 2ZAJA 2DK7A 1K9RA 1O6WA 2YSBA 1NMVA 1EG3A 4U84A 2JMFA 2ZQSA 2XP7A 2DK1A 3NTPA 2YSGA 2YSFA 5CQ2A 2LAJA 3KCEA 2ZR4A 3WH0A
chains in the Genus database with same CATH superfamily
2XPAA 3CNGA 2JX8A 2JV4A 2XPBA 2XP9A 3MQGA 3TCZA 2YSHA 2F21A 2KXQA 1JMQA 1TR8A 3LE4A 5AHTA 3LKXB 2ITKA 2BA1A 2E45A 4U85A 1PINA 3ODKA 2DWVA 4A0TA 2DJYA 2ZQUA 1F8AB 3KAHA 3KADA 3KAFA 3TC5A 3KAGA 3TDBA 3KABA 3L4HA 1WMVA 2ZQVA 2M8IA 2WADA 2YSIA 2DMVA 3MCBB 2L4JA 4U86A 2WAEA 1I5HW 2M3OW 2ZR5A 5E5WA 1ZCNA 2XP6A 2Y8NB 5U47A 2EZ5W 1K9QA 5E64A 2ZR6A 3KAIA 4GLXA 2XP3A 1EG4A 3M7NA 2M8JA 4E5RA 2XP5A 2RE3A 3M85A 2OWOA 3OOBA 3MCBA 3MQHA 4A0UA 3PQHA 2QRVA 4QIBA 2ZQTA 3LKXA 2XP8A 1WR7A 2MDIA 1TK7A 4REXA 2JXWA 2Q5AA 5E65A 1YW5A 2XP4A 2ZAJA 2DK7A 1FLCA 1K9RA 5E66A 1O6WA 2YSBA 1NMVA 1EG3A 4U84A 3FSCA 2JMFA 2ZQSA 2XP7A 2DK1A 3FSBA 3NTPA 2YAJB 5E62A 2YSGA 2YSFA 5CQ2A 2LAJA 1RP5A 3FS8A 3KCEA 2ZR4A 3WH0A
chains in the Genus database with same CATH topology
2XPAA 3CNGA 2JX8A 2JV4A 2XPBA 2XP9A 3MQGA 3TCZA 2YSHA 2F21A 2KXQA 1JMQA 1TR8A 3LE4A 5AHTA 3LKXB 2ITKA 2BA1A 2E45A 4U85A 1PINA 3ODKA 2DWVA 4A0TA 2DJYA 2ZQUA 1F8AB 3KAHA 3KADA 3KAFA 3TC5A 3KAGA 3TDBA 3KABA 3L4HA 1WMVA 2ZQVA 2M8IA 2WADA 2YSIA 2DMVA 3MCBB 2L4JA 4U86A 2WAEA 1I5HW 2M3OW 2ZR5A 5E5WA 1ZCNA 2XP6A 2Y8NB 5U47A 2EZ5W 1K9QA 5E64A 2ZR6A 3KAIA 4GLXA 2XP3A 1EG4A 3M7NA 2M8JA 4E5RA 2XP5A 2RE3A 3M85A 2OWOA 3OOBA 3MCBA 3MQHA 4A0UA 3PQHA 2QRVA 4QIBA 2ZQTA 3LKXA 2XP8A 1WR7A 2MDIA 1TK7A 4REXA 2JXWA 2Q5AA 5E65A 1YW5A 2XP4A 2ZAJA 2DK7A 1FLCA 1K9RA 5E66A 1O6WA 2YSBA 1NMVA 1EG3A 4U84A 3FSCA 2JMFA 2ZQSA 2XP7A 2DK1A 3FSBA 3NTPA 2YAJB 5E62A 2YSGA 2YSFA 5CQ2A 2LAJA 1RP5A 3FS8A 3KCEA 2ZR4A 3WH0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XPA A;  3CNG A;  2JX8 A;  2JV4 A;  2XPB A;  2XP9 A;  3TCZ A;  2YSH A;  2F21 A;  2KXQ A;  1JMQ A;  3LE4 A;  5AHT A;  2ITK A;  2BA1 A;  2E45 A;  4U85 A;  1PIN A;  3ODK A;  2DWV A;  2DJY A;  2ZQU A;  1F8A B;  3KAH A;  3KAD A;  3KAF A;  3TC5 A;  3KAG A;  3TDB A;  3KAB A;  3L4H A;  1WMV A;  2ZQV A;  2M8I A;  2YSI A;  2DMV A;  2L4J A;  4U86 A;  1I5H W;  2M3O W;  2ZR5 A;  1ZCN A;  2XP6 A;  2EZ5 W;  1K9Q A;  2ZR6 A;  3KAI A;  2XP3 A;  1EG4 A;  3M7N A;  2M8J A;  4E5R A;  2XP5 A;  2RE3 A;  3M85 A;  3OOB A;  4QIB A;  2ZQT A;  2XP8 A;  1WR7 A;  2MDI A;  1TK7 A;  4REX A;  2JXW A;  2Q5A A;  1YW5 A;  2XP4 A;  2ZAJ A;  2DK7 A;  1K9R A;  1O6W A;  2YSB A;  1NMV A;  1EG3 A;  4U84 A;  2JMF A;  2ZQS A;  2XP7 A;  2DK1 A;  3NTP A;  2YSG A;  2YSF A;  5CQ2 A;  2LAJ A;  3KCE A;  2ZR4 A;  3WH0 A; 
#chains in the Genus database with same CATH topology
 2XPA A;  3CNG A;  2JX8 A;  2JV4 A;  2XPB A;  2XP9 A;  3MQG A;  3TCZ A;  2YSH A;  2F21 A;  2KXQ A;  1JMQ A;  1TR8 A;  3LE4 A;  5AHT A;  3LKX B;  2ITK A;  2BA1 A;  2E45 A;  4U85 A;  1PIN A;  3ODK A;  2DWV A;  4A0T A;  2DJY A;  2ZQU A;  1F8A B;  3KAH A;  3KAD A;  3KAF A;  3TC5 A;  3KAG A;  3TDB A;  3KAB A;  3L4H A;  1WMV A;  2ZQV A;  2M8I A;  2WAD A;  2YSI A;  2DMV A;  3MCB B;  2L4J A;  4U86 A;  2WAE A;  1I5H W;  2M3O W;  2ZR5 A;  5E5W A;  1ZCN A;  2XP6 A;  2Y8N B;  5U47 A;  2EZ5 W;  1K9Q A;  5E64 A;  2ZR6 A;  3KAI A;  4GLX A;  2XP3 A;  1EG4 A;  3M7N A;  2M8J A;  4E5R A;  2XP5 A;  2RE3 A;  3M85 A;  2OWO A;  3OOB A;  3MCB A;  3MQH A;  4A0U A;  3PQH A;  2QRV A;  4QIB A;  2ZQT A;  3LKX A;  2XP8 A;  1WR7 A;  2MDI A;  1TK7 A;  4REX A;  2JXW A;  2Q5A A;  5E65 A;  1YW5 A;  2XP4 A;  2ZAJ A;  2DK7 A;  1FLC A;  1K9R A;  5E66 A;  1O6W A;  2YSB A;  1NMV A;  1EG3 A;  4U84 A;  3FSC A;  2JMF A;  2ZQS A;  2XP7 A;  2DK1 A;  3FSB A;  3NTP A;  2YAJ B;  5E62 A;  2YSG A;  2YSF A;  5CQ2 A;  2LAJ A;  1RP5 A;  3FS8 A;  3KCE A;  2ZR4 A;  3WH0 A; 
#chains in the Genus database with same CATH homology
 2XPA A;  3CNG A;  2JX8 A;  2JV4 A;  2XPB A;  2XP9 A;  3MQG A;  3TCZ A;  2YSH A;  2F21 A;  2KXQ A;  1JMQ A;  1TR8 A;  3LE4 A;  5AHT A;  3LKX B;  2ITK A;  2BA1 A;  2E45 A;  4U85 A;  1PIN A;  3ODK A;  2DWV A;  4A0T A;  2DJY A;  2ZQU A;  1F8A B;  3KAH A;  3KAD A;  3KAF A;  3TC5 A;  3KAG A;  3TDB A;  3KAB A;  3L4H A;  1WMV A;  2ZQV A;  2M8I A;  2WAD A;  2YSI A;  2DMV A;  3MCB B;  2L4J A;  4U86 A;  2WAE A;  1I5H W;  2M3O W;  2ZR5 A;  5E5W A;  1ZCN A;  2XP6 A;  2Y8N B;  5U47 A;  2EZ5 W;  1K9Q A;  5E64 A;  2ZR6 A;  3KAI A;  4GLX A;  2XP3 A;  1EG4 A;  3M7N A;  2M8J A;  4E5R A;  2XP5 A;  2RE3 A;  3M85 A;  2OWO A;  3OOB A;  3MCB A;  3MQH A;  4A0U A;  3PQH A;  2QRV A;  4QIB A;  2ZQT A;  3LKX A;  2XP8 A;  1WR7 A;  2MDI A;  1TK7 A;  4REX A;  2JXW A;  2Q5A A;  5E65 A;  1YW5 A;  2XP4 A;  2ZAJ A;  2DK7 A;  1FLC A;  1K9R A;  5E66 A;  1O6W A;  2YSB A;  1NMV A;  1EG3 A;  4U84 A;  3FSC A;  2JMF A;  2ZQS A;  2XP7 A;  2DK1 A;  3FSB A;  3NTP A;  2YAJ B;  5E62 A;  2YSG A;  2YSF A;  5CQ2 A;  2LAJ A;  1RP5 A;  3FS8 A;  3KCE A;  2ZR4 A;  3WH0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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