3P8EA

Crystal structure of human dimethylarginine dimethylaminohydrolase-1 (ddah-1) covalently bound with n5-(1-iminopentyl)-l-ornithine
Total Genus 90
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
90
sequence length
274
structure length
272
Chain Sequence
AFGRATHAVVRALPESLGQHALRSGEEVDVARAERQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTCCSVLINKK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
publication title Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1.
pubmed doi rcsb
source organism Homo sapiens
total genus 90
structure length 272
sequence length 274
chains with identical sequence B
ec nomenclature ec 3.5.3.18: Dimethylargininase.
pdb deposition date 2010-10-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02274 Amidinotransf Amidinotransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.75.10.10 Alpha Beta 5-stranded Propeller L-arginine/glycine Amidinotransferase; Chain A L-arginine/glycine Amidinotransferase; Chain A 3p8eA00
1WD9A 3JDWA 2A9GA 4N25A 4N20A 1G61A 2DW5A 4N2AA 3APNA 1H70A 4JDWA 1XKNA 4X8CA 7JDWA 4N2LA 2JAIA 4YTGA 4N2BA 5HP5A 1G62A 2JDXA 3P8EA 1JDWA 2CI1A 2DEWX 4BOFA 9JDWA 2CI4A 2DEYX 5JDWA 4N2MA 2JAJA 4E4JA 2DEXX 2CI6A 4N2NA 3H7KA 2CI3A 2CI7A 2ABRA 2Q3UA 5AK7A 6JDWA 2C6ZA 4X8GA 4N24A 1BWDA 3I2EA 4N2KA 4N28A 1WD8A 1WDAA 3HVMA 4DKTA 1JDXA 2JDWA 4N26A 5AK8A 1RXXA 3APMA 2JERA 4N2HA 4N2EA 1ZBRA 4YT9A 4N2DA 3P8PA 1S9RA 2CI5A 3B1TA 4N2IA 1LXYA 4N2CA 1VKPA 2EWOA 2AAFA 2ACIA 5M3QA 3BPBA 4N2GA 2CMUA 4N2FA 3I4AA 3H7CX 5AN9I 8JDWA 3RHYA 3B1UA 4N22A 4YTBA
chains in the Genus database with same CATH superfamily
1WD9A 3JDWA 2A9GA 4N25A 4N20A 1G61A 2DW5A 4N2AA 3APNA 1H70A 4JDWA 1XKNA 4X8CA 7JDWA 1YNFA 4N2LA 2JAIA 4YTGA 4N2BA 5HP5A 1G62A 2JDXA 3P8EA 1JDWA 2CI1A 2DEWX 4BOFA 9JDWA 2CI4A 2DEYX 5JDWA 4N2MA 2JAJA 4E4JA 2DEXX 2CI6A 4N2NA 3H7KA 2CI3A 2CI7A 2ABRA 2Q3UA 5AK7A 6JDWA 2C6ZA 1YNHA 4X8GA 4N24A 1YNIA 1BWDA 3I2EA 4N2KA 4N28A 1WD8A 1WDAA 3HVMA 4DKTA 1JDXA 2JDWA 4N26A 5AK8A 1RXXA 3APMA 2JERA 4N2HA 4N2EA 1ZBRA 4YT9A 4N2DA 3P8PA 1S9RA 2CI5A 3B1TA 4N2IA 1LXYA 4N2CA 1VKPA 2EWOA 2AAFA 2ACIA 5M3QA 3BPBA 4N2GA 2CMUA 4N2FA 3I4AA 3H7CX 5AN9I 8JDWA 3RHYA 3B1UA 4N22A 4YTBA
chains in the Genus database with same CATH topology
1WD9A 3JDWA 2A9GA 4N25A 4N20A 1G61A 2DW5A 4N2AA 3APNA 1H70A 4JDWA 1XKNA 4X8CA 7JDWA 4N2LA 2JAIA 4YTGA 4N2BA 5HP5A 1G62A 2JDXA 3P8EA 1JDWA 2CI1A 2DEWX 4BOFA 9JDWA 2CI4A 2DEYX 5JDWA 4N2MA 2JAJA 4E4JA 2DEXX 2CI6A 4N2NA 3H7KA 2CI3A 2CI7A 2ABRA 2Q3UA 5AK7A 6JDWA 2C6ZA 4X8GA 4N24A 1BWDA 3I2EA 4N2KA 4N28A 1WD8A 1WDAA 3HVMA 4DKTA 1JDXA 2JDWA 4N26A 5AK8A 1RXXA 3APMA 2JERA 4N2HA 4N2EA 1ZBRA 4YT9A 4N2DA 3P8PA 1S9RA 2CI5A 3B1TA 4N2IA 1LXYA 4N2CA 1VKPA 2EWOA 2AAFA 2ACIA 5M3QA 3BPBA 4N2GA 2CMUA 4N2FA 3I4AA 3H7CX 5AN9I 8JDWA 3RHYA 3B1UA 4N22A 4YTBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WD9 A;  3JDW A;  2A9G A;  4N25 A;  4N20 A;  1G61 A;  2DW5 A;  4N2A A;  3APN A;  1H70 A;  4JDW A;  1XKN A;  4X8C A;  7JDW A;  4N2L A;  2JAI A;  4YTG A;  4N2B A;  5HP5 A;  1G62 A;  2JDX A;  3P8E A;  1JDW A;  2CI1 A;  2DEW X;  4BOF A;  9JDW A;  2CI4 A;  2DEY X;  5JDW A;  4N2M A;  2JAJ A;  4E4J A;  2DEX X;  2CI6 A;  4N2N A;  3H7K A;  2CI3 A;  2CI7 A;  2ABR A;  2Q3U A;  5AK7 A;  6JDW A;  2C6Z A;  4X8G A;  4N24 A;  1BWD A;  3I2E A;  4N2K A;  4N28 A;  1WD8 A;  1WDA A;  3HVM A;  4DKT A;  1JDX A;  2JDW A;  4N26 A;  5AK8 A;  1RXX A;  3APM A;  2JER A;  4N2H A;  4N2E A;  1ZBR A;  4YT9 A;  4N2D A;  3P8P A;  1S9R A;  2CI5 A;  3B1T A;  4N2I A;  1LXY A;  4N2C A;  1VKP A;  2EWO A;  2AAF A;  2ACI A;  5M3Q A;  3BPB A;  4N2G A;  2CMU A;  4N2F A;  3I4A A;  3H7C X;  5AN9 I;  8JDW A;  3RHY A;  3B1U A;  4N22 A;  4YTB A; 
#chains in the Genus database with same CATH topology
 1WD9 A;  3JDW A;  2A9G A;  4N25 A;  4N20 A;  1G61 A;  2DW5 A;  4N2A A;  3APN A;  1H70 A;  4JDW A;  1XKN A;  4X8C A;  7JDW A;  1YNF A;  4N2L A;  2JAI A;  4YTG A;  4N2B A;  5HP5 A;  1G62 A;  2JDX A;  3P8E A;  1JDW A;  2CI1 A;  2DEW X;  4BOF A;  9JDW A;  2CI4 A;  2DEY X;  5JDW A;  4N2M A;  2JAJ A;  4E4J A;  2DEX X;  2CI6 A;  4N2N A;  3H7K A;  2CI3 A;  2CI7 A;  2ABR A;  2Q3U A;  5AK7 A;  6JDW A;  2C6Z A;  1YNH A;  4X8G A;  4N24 A;  1YNI A;  1BWD A;  3I2E A;  4N2K A;  4N28 A;  1WD8 A;  1WDA A;  3HVM A;  4DKT A;  1JDX A;  2JDW A;  4N26 A;  5AK8 A;  1RXX A;  3APM A;  2JER A;  4N2H A;  4N2E A;  1ZBR A;  4YT9 A;  4N2D A;  3P8P A;  1S9R A;  2CI5 A;  3B1T A;  4N2I A;  1LXY A;  4N2C A;  1VKP A;  2EWO A;  2AAF A;  2ACI A;  5M3Q A;  3BPB A;  4N2G A;  2CMU A;  4N2F A;  3I4A A;  3H7C X;  5AN9 I;  8JDW A;  3RHY A;  3B1U A;  4N22 A;  4YTB A; 
#chains in the Genus database with same CATH homology
 1WD9 A;  3JDW A;  2A9G A;  4N25 A;  4N20 A;  1G61 A;  2DW5 A;  4N2A A;  3APN A;  1H70 A;  4JDW A;  1XKN A;  4X8C A;  7JDW A;  4N2L A;  2JAI A;  4YTG A;  4N2B A;  5HP5 A;  1G62 A;  2JDX A;  3P8E A;  1JDW A;  2CI1 A;  2DEW X;  4BOF A;  9JDW A;  2CI4 A;  2DEY X;  5JDW A;  4N2M A;  2JAJ A;  4E4J A;  2DEX X;  2CI6 A;  4N2N A;  3H7K A;  2CI3 A;  2CI7 A;  2ABR A;  2Q3U A;  5AK7 A;  6JDW A;  2C6Z A;  4X8G A;  4N24 A;  1BWD A;  3I2E A;  4N2K A;  4N28 A;  1WD8 A;  1WDA A;  3HVM A;  4DKT A;  1JDX A;  2JDW A;  4N26 A;  5AK8 A;  1RXX A;  3APM A;  2JER A;  4N2H A;  4N2E A;  1ZBR A;  4YT9 A;  4N2D A;  3P8P A;  1S9R A;  2CI5 A;  3B1T A;  4N2I A;  1LXY A;  4N2C A;  1VKP A;  2EWO A;  2AAF A;  2ACI A;  5M3Q A;  3BPB A;  4N2G A;  2CMU A;  4N2F A;  3I4A A;  3H7C X;  5AN9 I;  8JDW A;  3RHY A;  3B1U A;  4N22 A;  4YTB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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